Can Non-Opioid painkillers replace opioids after ankle surgery?

NCT ID NCT07154433

Completed Symptom relief Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a non-opioid pain regimen (celecoxib plus acetaminophen) works as well as an opioid regimen (oxycodone plus acetaminophen) for pain after ankle arthroscopy. 112 adults were randomly assigned to one of the two groups. The goal is to find a safer way to manage pain and reduce opioid-related risks like addiction and breathing problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: celecoxib and acetaminophen (non-opioid regimen) vs oxycodone and acetaminophen (opioid regimen)
What this could lead to: If successful, this could show that a non-opioid pain plan works just as well as opioids after ankle surgery, with fewer side effects like addiction or breathing problems.
What could go wrong: This is a small, completed trial with 112 people, so results may not apply to everyone. Non-opioid drugs can still cause side effects like stomach bleeding or liver issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ankle injury osteochondritis dissecans

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANKLE (LIGAMENTS); INSTABILITY (OLD INJURY) ANKLE SPRAIN NON-OPIOID PAIN MANAGEMENT OPIOID ANALGESIA TALUS OSTEOCHONDRAL DEFECT

Contacts and locations

Locations

2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

Hangzhou, Zhejiang, 310000, China

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