Ankle injury

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study tests a surgical technique to cover deep wounds on the lower leg, ankle, heel, or foot. The procedure moves skin and tissue from the outer lower leg to the wound area, using a special blood supply to help it heal. The study will include 30 adults and will measure how w…

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This study will test a new portable device called the Cobra Ankle Arthrometer to see if it can accurately measure ankle joint looseness. Researchers will compare it to ultrasound imaging in 62 young adults, including those with chronic ankle instability, previous sprains, or no a…

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This study tests if using a floor pedal bike at home helps people recover from leg fractures and ankle injuries. Twenty adults with these injuries will get a bike at their first post-surgery visit and be asked to use it regularly. Researchers will track their physical activity an…

This study tests a new ankle orthosis (brace) in 4 people with chronic ankle injuries or nerve damage that limits ankle movement. Participants will wear the new brace for one month and compare it to their usual brace or no brace. The goal is to see if the new device improves ankl…

This study will compare three types of anesthesia for people having ankle surgery: total intravenous anesthesia with a nerve block, general anesthesia with a nerve block, and spinal anesthesia. The goal is to see which method allows patients to recover and leave the hospital the …

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with acute ankle sprains heal better and faster. Researchers will enroll 208 people with recent ankle sprains and compare those who get hyperbaric oxygen to those w…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study compares two methods to keep the surgical area clear during ankle arthroscopy: using a dilute epinephrine solution versus a traditional tourniquet. About 88 people with chronic ankle instability or ligament injuries will be randomly assigned to one method. The goal is …

This study tests whether focusing on hip muscles or ankle muscles during exercise training better improves leg function in athletes with chronic ankle instability. 36 professional athletes will do a 6-week program targeting either the gluteus medius, gluteus maximus, or ankle mus…

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

This study tests a new type of acupuncture called Fu's subcutaneous needling against the usual treatment of wearing a brace and doing exercises for people with recent ankle sprains. The goal is to see which approach better reduces pain, improves ankle function, and prevents the s…

This early-phase trial tests whether injecting a fluid made from stem cells (called secretome) mixed with growth factors from the patient's own blood can safely reduce knee pain and improve function in people with mild knee osteoarthritis. The study will enroll 25 adults aged 30-…

This study tests a program to help Hispanic teen soccer players get timely knee surgery. Many face barriers like language and insurance issues that delay care. The program includes an educational talk and a bilingual navigator to guide families. The goal is to see if this approac…

This study is creating and testing a Turkish version of a questionnaire that measures how people recover from ankle fractures. Researchers will ask 150 adults with ankle fractures to fill out the new Turkish questionnaire along with two other standard forms. The goal is to make s…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study looks at whether pelvic alignment differs between male athletes with and without chronic ankle instability. Researchers will measure ankle stability, balance, and pelvic angles in 38 football players. The goal is to better understand how the pelvis and ankle work toget…

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This study looks at how two common leg injuries—ankle sprains and kneecap pain—affect balance in different directions. Researchers will measure stability in 90 people using a special balance machine. The goal is to find out if each injury causes a unique type of balance problem, …

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study checks if a smartphone app can reliably measure calf muscle strength in people recovering from Achilles tendon rupture or ankle sprain. Researchers will compare results from 70 participants (patients and healthy controls) using the app during calf raise exercises. The …