Ankle injury

This study was designed to see if giving calcium right away to trauma patients who need large blood transfusions could help their blood clot better, reduce the need for more transfusions, and improve survival. The trial was withdrawn before enrolling any participants, so no resul…

This study compares a standard rehab program to a foot-intensive rehab (FIRE) program in 150 adults aged 18-44 with chronic ankle instability. Participants do 2 supervised and 3 home sessions per week for 6 weeks. The goal is to see if FIRE reduces re-injury rates, improves stabi…

This study tests a new heating device called Therm'Up to manage hypothermia in trauma patients. Hypothermia, when body temperature drops below 35°C, can worsen injuries and increase death risk. The trial will enroll 100 adults at risk of hypothermia due to trauma, cold exposure, …

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study looks at whether a fall prevention discharge class can reduce repeat fall-related ER visits in adults aged 60 and older. Researchers will compare those who attended the class to those who did not. The goal is to see if this simple education step can help prevent future…

This study tests two physiotherapy approaches—manual therapy (joint mobilization) and proprioception (balance) exercises—against a placebo to see which best improves balance and prevents ankle sprains in young soccer players. Forty-five boys aged 11-13 who have played soccer for …

This study tests whether a new ankle brace changes how athletes run and cut. Researchers will compare five different bracing conditions. Participants will run on a treadmill, do shuttle runs, and fill out surveys about comfort and stability. The goal is to see if the brace is com…

This study tests a communication tool called Best Case/Worst Case-ICU for older adults (50+) with serious injuries in the ICU. The tool helps doctors, patients, and families discuss possible outcomes and treatment options using simple graphics. Researchers will measure if it impr…

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This study looks at whether reusing walking boots is safe for people recovering from foot or ankle injuries. About 60 patients will be randomly assigned to get either a new boot or a cleaned, reused boot. The main goal is to see if reused boots cause more skin problems like blist…

This study follows about 80 adults who receive the EasyMove total ankle prosthesis for severe ankle arthritis caused by injury, wear-and-tear, or rheumatoid arthritis. Researchers will monitor how often the implant loosens and needs revision, as well as pain, mobility, and functi…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study aimed to compare three medicines (propofol, etomidate, and ketamine) given to adult trauma patients to help them breathe with a breathing tube. The goal was to see which drug leads to the best outcomes, like survival and fewer side effects. However, the study was withd…

This study looks at how the thigh muscles (quadriceps and hamstrings) turn on during movement in people who have had ACL knee surgery. Researchers want to understand if muscle timing problems remain even after standard rehab. The study involves 25 men aged 18-45 who are 6 months …

This study looks at how the body's natural response to severe injury or major surgery can sometimes go wrong, leading to complications. Researchers will collect blood samples from 320 trauma patients and elective surgery patients to measure markers of inflammation and blood clott…

This observational registry will follow 5,000 adults with various wounds—like diabetic foot ulcers, burns, or surgical wounds—to see how different treatments (e.g., hydrocolloid, foam, silver dressings) perform in everyday medical settings. Researchers will measure wound healing,…

This study from the University of Nebraska aims to understand why some people with chronic ankle instability have different problems—some have loose ligaments, others have poor brain control. Researchers will test 42 physically active adults, including healthy controls, people co…

This study is tracking over 600 people who received the GORE VIABAHN stent-graft as part of their normal medical care for conditions like peripheral artery disease or aneurysms. Researchers are monitoring how often serious device-related problems occur. The goal is to see how saf…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study will track 100 people with traumatic hand and wrist injuries at Sohag University Hospital in Egypt from October 2025 to April 2026. Researchers want to learn how these injuries happen and what the outcomes are. It is an observational study, meaning no new treatment is …

This study measures muscle strength, balance, and flexibility in 45 ballet dancers to find out what makes them more likely to hurt their ankles. Researchers compare dancers who had ankle injuries in the past year with those who didn't, plus a group of non-dancers. The goal is to …

This study planned to compare waterproof and standard casts in children with ankle or foot injuries. The goal was to see if waterproof casts lead to more complications. However, the study was withdrawn before enrolling any participants, so no data or conclusions are available.