Beijing Tiantan Hospital

This study tests whether the clot-busting drug tenecteplase can help people who have a stroke caused by a blocked artery in the brain, even when treatment starts 24 to 72 hours after symptoms begin. About 330 adults with moderate to severe stroke will receive either tenecteplase …

This study tests whether a mild electrical stimulation applied to the ear (called taVNS) can safely reduce brain swelling in people who recently had a bleeding stroke. 186 adults with moderate bleeding will be randomly assigned to receive either real or fake stimulation. The main…

This study is testing a new stent system to treat narrowed carotid arteries (the main arteries in the neck) in people who are at high risk for standard surgery. About 212 participants will receive the stent and be followed for one year to see if it prevents strokes, heart attacks…

This study tests whether giving the clot-busting drug tenecteplase directly into the brain's arteries can improve recovery for people with a medium vessel occlusion stroke. About 488 adults who have had a stroke within the last 24 hours will be randomly assigned to receive either…

This study tests whether a surgical procedure that connects lymph vessels in the neck to veins can help people with moderate-to-severe Alzheimer's disease. The surgery is designed to improve the brain's waste-clearing system. 376 participants will be randomly assigned to receive …

This early study tests the safety of a new gene therapy (GA) for people with severe nerve pain that hasn't improved with standard treatments. The therapy involves injecting a gene into a brain area that processes pain, then taking a pill to activate it. Only 6 adults aged 18-65 w…

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for people recovering from a serious brain bleed (aneurysmal subarachnoid hemorrhage) after surgery. RIC uses a blood pressure cuff on the arm to create brief, harmless blood flow interruptions, w…

This study tests whether the antibiotic minocycline can improve recovery in people who have had a brain bleed (intracerebral hemorrhage). About 1,200 adults will receive either minocycline or a placebo within 48 hours of their stroke. The goal is to see if the drug helps more peo…

This study compares two surgical methods for treating chronic subdural hematoma, a condition where blood collects between the brain and its outer covering. The new method uses a tiny camera (neuroendoscopy) to see and remove the clot completely, while the standard method uses a s…

This study tests whether a drug called Aleeto can help people recover better after a moderate to severe stroke caused by a blood clot. About 192 adults aged 30 to 80 who have had a stroke within the last 72 hours will receive either Aleeto or a placebo. The main goal is to see if…

This study tests whether a computer-based decision-support system helps doctors and patients manage cholesterol-lowering medication (evolocumab) more effectively. About 4000 people who recently had a stroke or mini-stroke will take part. The goal is to see if the system helps mor…

This study tests a laser treatment called MRgLITT for people with drug-resistant temporal lobe epilepsy. The goal is to see if it can stop or reduce seizures and improve memory and quality of life. About 120 adults aged 18-65 will take part. The treatment uses heat from a laser t…

This study tests a new drug-coated stent (NxiDIME) for people with severely narrowed brain arteries who have already had a stroke or mini-stroke. About 224 participants will be randomly assigned to get either the new stent or a similar approved stent. The main goal is to see if t…

This study tests whether a non-invasive ultrasound device can safely help clear blood clots in the brain after a hemorrhagic stroke. About 86 adults with small-to-medium sized bleeds will receive either standard care alone or standard care plus ultrasound treatment. The goal is t…

This study tests whether a smartphone-based management system can help people who have had a stroke or mini-stroke avoid future strokes and death. About 4,490 participants will either receive usual care or use a WeChat-based system to track risk factors like blood pressure and bl…

This study compares two treatments for a condition where pressure builds up inside the skull, causing vision problems and headaches. One treatment uses a stent to open a narrowed vein in the brain, while the other uses standard medication. The goal is to see which approach better…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This study tests whether the clot-busting drug tenecteplase can help people with a type of stroke caused by blockages in medium-sized brain arteries. About 600 adults who had a stroke 4.5 to 24 hours earlier will receive either tenecteplase or standard care. The goal is to see if…

This study tests whether a procedure to remove blood clots from medium-sized brain arteries, guided by special brain scans, helps people recover better than standard medical treatment alone. It includes 568 adults who have had a stroke within the last 24 hours. The goal is to see…

This study tests whether a drug called indobufen, combined with clopidogrel, is safer and more effective than the standard aspirin-plus-clopidogrel regimen for preventing strokes after a brain aneurysm is repaired. About 2,500 adults with unruptured brain aneurysms will take one …

This study uses artificial intelligence to analyze facial expressions and speech patterns in people with Parkinson's disease and related conditions. The goal is to create a digital tool that helps doctors diagnose and tell apart these disorders more accurately. Researchers will c…

This study tests whether improved oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with small to moderate brain bleeds will be randomly assigned to receive either standard care or enhanced mouth care plus ant…

This study tests whether the oral medication Venlafaxine can prevent postherpetic neuralgia, a chronic nerve pain that often follows shingles. About 832 adults with moderate to severe shingles pain will receive Venlafaxine or a placebo to see if early treatment reduces the risk o…

This study tests whether a long-acting steroid called dexamethasone palmitate can better prevent nausea and vomiting after brain surgery than the standard drug. About 500 adults having planned brain surgery will receive the drug before their operation. The goal is to see if this …

This study compares the standard drug pregabalin alone versus pregabalin combined with dexmedetomidine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers hope the combination will provide greater pain relief without more side effects. The tria…

This study tests whether adding a newer pain medicine called mirogabalin to standard shingles treatment provides better pain relief than standard treatment alone. Researchers will enroll 750 adults with moderate to severe shingles pain that started within the last 30 days. Partic…

This study compares two injection methods for knee osteoarthritis pain: one into trigger points (muscle knots) and one into the joint space. About 1,036 adults aged 45+ with knee pain will receive either treatment and be followed for 2 years. The goal is to see if the simpler tri…

This early-phase study tests whether a new drug, Aleeto, is safe and tolerable for people with Multiple System Atrophy (MSA), a rare and serious brain disorder. About 20 participants will receive the drug and be monitored for side effects and any signs of symptom improvement. The…

This study tests whether the antidepressant desvenlafaxine can safely reduce pain in people with shingles. Researchers will enroll 750 adults who have had a shingles rash for less than 90 days and are experiencing moderate to severe pain. The goal is to see if this medication off…

This study tests whether a long-acting steroid called dexamethasone palmitate can better prevent nausea and vomiting after minimally invasive surgery compared to standard care. About 588 adults aged 18–65 having laparoscopic or thoracoscopic surgery will receive the drug before t…

This study tests a new pain-relief method for people having lung surgery with small incisions (VATS). It combines two numbing medicines, one long-acting, given as a nerve block before surgery. The goal is to see if it reduces pain and the need for extra painkillers in the first 4…

This study looks at two different ways to program a pain pump that patients control after surgery. The goal is to see if a new method can lower the amount of opioids needed, while still controlling pain well. About 450 adults having various surgeries will take part. The results m…

This study looks at whether adding esketamine to usual fibromyalgia treatments can reduce pain more effectively and faster. About 92 adults with fibromyalgia who haven't gotten enough relief from standard care will take part. Researchers will compare pain scores between those get…

This study tests whether injecting steroids into muscle trigger points can safely ease chronic headache pain. About 1,000 adults with cervicogenic headache will receive either a trigger point injection or a nerve block. Researchers will track pain levels and headache frequency fo…

This study tests whether a flurbiprofen patch, applied to the skin, can safely reduce pain from shingles (herpes zoster). Shingles causes a painful rash, and current pain treatments often don't work well or have side effects. The trial will include 750 adults with moderate to sev…

This study tests a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) to see if it can safely improve thinking and memory in people with cerebral small vessel disease. About 58 adults aged 45-80 with cognitive impairment will receive iTBS …

This study tests whether a medicated patch (loxoprofen sodium) can safely reduce pain from shingles. About 750 adults with moderate to severe shingles pain will apply the patch to the painful area. The goal is to see if the patch provides better pain relief than current treatment…

This study tests whether injecting steroids into muscle trigger points can reduce pain from chronic musculoskeletal pain, migraines, and hip osteoarthritis. About 1,036 adults aged 45 and older with persistent pain will receive either trigger point or joint injections and be foll…

This study is testing whether a non-invasive nerve stimulation on the wrist can help improve thinking and memory in people who have had a traumatic brain injury. The researchers will enroll 30 adults aged 18-64 who have thinking problems after their injury. Participants will rece…

This study compares taking pregabalin alone versus pregabalin plus toludesvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. About 384 adults with moderate to severe pain that hasn't improved with other treatments will participate. The goal is to see i…

This study compares two injection treatments for chronic migraine: one into muscle trigger points and one into a nerve in the neck. About 1,000 adults with long-term migraine will receive one of the two injections and be followed for 2 years. The goal is to see if the simpler mus…

This study tests two different ways of giving pain medicine through a patient-controlled pump after surgery. The goal is to see if a smarter pump that adjusts the dose based on your pain can lower the total amount of opioids needed and reduce side effects. About 1170 adults havin…

This study tests whether injecting a low dose of two pain medicines (flurbiprofen and ropivacaine) into the scalp before brain surgery can reduce pain and the need for stronger opioids afterward. About 216 adults having planned brain surgery will take part. The goal is to see if …

This study tests whether a new, long-acting painkiller (liposomal bupivacaine) combined with a standard painkiller can reduce pain for up to 72 hours after hemorrhoid surgery. About 156 adults aged 18–64 having elective hemorrhoid surgery will take part. The goal is to see if thi…

This study compares two medications, pregabalin and a newer drug called crisugabalin, to see which works better for fibromyalgia pain. Fibromyalgia causes widespread pain, fatigue, and emotional distress. The trial will include 1,116 adults with moderate to severe pain who haven'…

This study tests whether adding a long-acting numbing drug (liposomal bupivacaine) to the usual numbing medicine reduces pain after laparoscopic surgery better than the usual medicine alone. About 190 adults having gallbladder, hernia, or appendix surgery will take part. The goal…

This study tests whether a new, long-acting numbing medicine (liposomal bupivacaine) combined with a standard numbing drug can provide better pain relief after laparoscopic surgery than standard care alone. About 318 adults having gallbladder, hernia, or appendix surgery will rec…

This study tests whether a long-acting painkiller (liposomal bupivacaine) plus a standard painkiller works better than the standard painkiller alone for pain after lung surgery. About 100 adults having lung surgery will be enrolled. The goal is to see if the combination reduces t…

This study tests two medications, pregabalin and mirogabalin, to see which one better reduces pain in people with fibromyalgia, a condition causing widespread pain and fatigue. About 674 adults with moderate to severe fibromyalgia will take one of the drugs and report their pain …

This study tests whether a special long-acting numbing medicine (liposomal bupivacaine) injected into the abdominal wall can provide better pain relief for up to 72 hours after laparoscopic gynecologic cancer surgery. About 110 women aged 18-64 will be randomly assigned to receiv…

This study is testing whether a single low dose of esketamine can reduce symptoms of irritable bowel syndrome (IBS) in 552 adults aged 18-60 who also have anxiety or depression. Participants will receive the drug during a colonoscopy, and their IBS severity and quality of life wi…

This study tests whether a longer-lasting steroid (dexamethasone palmitate) given before open surgery can better prevent nausea and vomiting than standard care. About 500 adults having spine, chest, or abdominal surgery will take part. The goal is to see if this drug reduces symp…

This study tests whether adding a new pain drug called crisugabalin to standard treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus crisugabalin. The g…

This study compares pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The trial will enroll 750 adults with moder…

This study tests whether the muscle relaxant baclofen can safely reduce pain from shingles (herpes zoster). Researchers will enroll 750 adults with moderate to severe pain who have had a shingles rash for less than 90 days. Participants will take baclofen or a placebo, and pain l…

This study compares taking pregabalin alone versus pregabalin combined with desvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will involve 3…

This study compares two types of injections for chronic shoulder pain caused by osteoarthritis. About 1,000 adults aged 45 and older will receive either a trigger point injection or a standard joint injection. Researchers want to see if the simpler trigger point method works just…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent or reduce headaches after a brain aneurysm repair procedure. About 440 adults who are scheduled for stent-assisted coiling will wear the device for 30 minutes twice a day, st…

This study tests whether an oral medication called tulodsesvenlafaxine can safely reduce pain in people with shingles (herpes zoster). Shingles causes a painful rash and can lead to long-term nerve pain. The drug works by affecting brain chemicals that control pain. The trial wil…

This study will follow about 10,000 adults in China who receive the clot-dissolving drug tenecteplase for a stroke. Researchers want to see how well patients recover and if there are any safety issues in real hospital settings, not just controlled trials. The goal is to improve s…

This study looks at whether people with insomnia need different amounts of anesthesia during a digestive endoscopy compared to people who sleep normally. Researchers will enroll 3360 adults aged 18-64. The goal is to measure total anesthetic drug use and track any side effects.

This study looks at whether monitoring the brain's oxygen levels during carotid artery surgery can help prevent strokes. About 560 adults having this surgery will be randomly assigned to standard care or care guided by a brain oxygen monitor. The goal is to see if this approach r…

This study looks at whether people with insomnia need a different amount of the sedative ciprofol during a digestive endoscopy compared to those who sleep normally. Researchers will enroll 840 adults aged 18-64 who are scheduled for the procedure. The goal is to improve sedation …

This study is looking for early signs of moyamoya disease in family members of patients. Moyamoya is a rare condition where arteries in the brain become blocked, raising stroke risk. Researchers will use advanced MRI scans and lab tests to find markers that could predict the dise…

This study looks at whether people with insomnia need more or less of the sedative etomidate during a digestive endoscopy compared to people who sleep normally. Researchers will track the total amount of etomidate used and watch for side effects like low oxygen or low blood press…

This study follows 2000 people with a rare brain aneurysm (vertebrobasilar dissecting aneurysm) to see which treatment works best. Participants may receive conservative care, stenting, or a flow diverter. The goal is to improve future treatment decisions and outcomes.

This study looks at whether people with insomnia need a different amount of the sedative rimazolen during a digestive endoscopy (a scope procedure) compared to people who sleep normally. Researchers will enroll 840 adults aged 18–64 who are scheduled for the procedure. The goal i…

This study will follow 10,000 people aged 12 and older with primary headaches (like migraine or tension-type headache) or medication-overuse headache. Researchers will collect data on genetics, brain scans, thinking skills, and daily life impact. The goal is to better understand …