New steroid shot may keep surgery patients from feeling sick
NCT ID NCT06981754
First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 3 times
Summary
This study tests whether a single injection of dexamethasone palmitate, a long-acting steroid, can better prevent nausea and vomiting after minimally invasive surgery compared to standard dexamethasone. About 588 adults aged 18 to 65 having laparoscopic or thoracoscopic surgery will take part. The goal is to see if the new drug reduces the number of people who feel sick within 24 hours after their operation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dexamethasone palmitate
- What this could lead to
- If it works, this could offer a more effective way to prevent nausea and vomiting after surgery, reducing discomfort for patients.
- What could go wrong
- This is an early-stage trial with no phase specified, so results are uncertain. The improvement over standard dexamethasone may be small, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
588 people
The number who actually took part.
- Started
-
Jun 2025
- Finished
-
May 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18 to 65 years; * Providing written informed consent; * Patients scheduled to undergo elective minimally invasive endoscopic surgery (laparoscopic or thoracoscopic surgery) under general anaesthesia. Exclusion Criteria: * Known to be allergic to dexamethasone; * Any systemic glucocorticoids within 3 months before trial entry; * History of severe heart disease, liver/kidney failure, or systemic rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, et al); * Cognitive impairment or severe mental illness; * Uncontrolled diabetes or infectious diseases; * Pregnancy or breastfeeding.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beijing Tiantan Hospital
Beijing, Beijing Municipality, 100070, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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