HEAD AND NECK CANCER

This study aimed to see if adding low-dose radiation to a targeted-immunotherapy drug combination before surgery could improve outcomes for people with head and neck cancer. It planned to compare the combination against the drug combo alone. The study was withdrawn before enrolli…

This study tests whether adding experimental drugs HB-201 and HB-202 to standard chemotherapy can shrink HPV16-positive throat tumors more effectively. The goal is to reduce the amount of radiation and chemotherapy needed afterward, potentially lowering side effects. About 35 adu…

This study tests an experimental drug called INBRX-106, given alone or with the immunotherapy pembrolizumab (Keytruda), in people with advanced solid tumors (like lung, head and neck, melanoma, stomach, kidney, or bladder cancer) that have stopped responding to standard treatment…

This early-stage study tests whether injecting methylene blue directly into tumors can make radiation more effective for people with head and neck cancer that has come back and is resistant to prior radiation. Ten participants will receive weekly tumor injections of methylene blu…

This study tested whether adding the targeted drug Tarceva to two standard chemotherapy drugs (cisplatin and docetaxel) could shrink tumors in people with head and neck cancer that had spread or come back. Fifty adults with this advanced cancer took part. The main goal was to see…

This study tests whether using home sensors to monitor dehydration risk can reduce hospitalizations and emergency room visits in head and neck cancer patients. About 427 participants will either use the CYCORE system (sensors at home) or receive standard care. The goal is to see …

This study tests two immunotherapy drugs, nivolumab and ipilimumab, given before surgery to people with squamous cell carcinoma of the oral cavity. The goal is to see if these drugs can shrink tumors and are safe to use. About 30 adults with stage T2 or higher tumors or lymph nod…

This study tests an oral drug called APG-157 given before standard treatment (surgery or radiation) for people with newly diagnosed head and neck cancer. The goal is to see if it safely shrinks tumors and boosts the immune response. About 24 adults with early to advanced stage ca…

This study tests whether adding pembrolizumab, a drug that helps the immune system fight cancer, to standard treatment (surgery, radiation, and sometimes chemotherapy) can improve outcomes for people with head and neck cancer. About 96 participants who had surgery to remove their…

This study tests whether adding two experimental immune-boosting drugs (INCAGN02385 and INCAGN02390) to the standard immunotherapy retifanlimab can better control advanced head and neck cancer that has spread or come back. About 176 adults with a specific type of head and neck ca…

This study tests a three-drug combination (cisplatin, nab-paclitaxel, and cetuximab) in 74 people with head and neck cancer that cannot be cured. The goal is to see if this mix works better and causes fewer side effects than the standard treatment. Participants have advanced or r…

This early-phase study tests a personalized cell therapy called T-Plex for people with advanced solid tumors that have not responded to standard treatments. The therapy uses a patient's own immune cells, engineered to recognize and attack cancer cells. The main goal is to check s…

This study tests whether a special scan (SPECT/CT) can map where a head and neck tumor drains lymph fluid. If the scan shows no drainage to the opposite side of the neck, doctors can safely avoid radiating that side, reducing side effects. About 90 patients with newly diagnosed h…

This study tests whether wrapping a nerve in the neck with a porcine (pig) tissue product can help preserve shoulder movement and reduce disability after surgery for head and neck cancer. About 74 adults having neck dissection will be enrolled. The study is currently on hold.

This study tests whether giving a short course of immunotherapy (pembrolizumab) plus targeted radiation before surgery can shrink advanced head and neck cancers. The trial includes 28 adults with stage III or IVA HPV-negative head and neck squamous cell carcinoma. The main goal i…

This study tests whether adding other drugs to tislelizumab can shrink tumors or slow cancer growth in people with advanced head and neck cancer that has come back or spread. About 160 adults whose cancer cannot be cured with local treatments will receive the drug combination as …

This study tests a new combination treatment for people whose head and neck cancer has come back. It combines a short course of radiation called QUAD SHOT with the immunotherapy drug pembrolizumab. The goal is to see if this approach is safe and can help shrink tumors or improve …

This study tests an experimental drug called BT5528, given alone or with another drug (nivolumab), in people with advanced solid tumors that have high levels of a protein called EphA2. The cancers include ovarian, bladder, lung, breast, head and neck, and stomach cancers. The mai…

This study compares two ways of giving the chemotherapy drug cisplatin alongside standard radiation for people with advanced head and neck cancer. One group gets cisplatin every three weeks, the other weekly. The goal is to see which schedule causes fewer severe side effects and …

This early-phase study tests whether injecting the cancer drug nivolumab directly into high-risk mouth lesions is safe and can shrink or control them. The trial involves 18 adults with biopsy-proven oral premalignant lesions. The goal is to prevent progression to cancer by target…

This early-phase study tests a personalized cell therapy for people with certain cancers (bladder, melanoma, head/neck, ovarian, lung, esophageal, stomach, or sarcoma). The therapy takes a patient's own immune cells and genetically equips them to recognize and attack tumors that …

This study offers continued treatment with the cancer drug palbociclib to people who have already benefited from it in earlier Pfizer studies. It includes 35 adults with breast or head/neck cancer. The main goal is to monitor safety and track any serious side effects over time.

This study was designed to find a safe dose of the drug Torisel when added to standard chemotherapy and radiation for people with advanced head and neck cancer. The goal was to see if the combination could be given safely and help prevent the cancer from coming back. However, the…

This study tests a new drug called NT219 combined with either pembrolizumab or cetuximab in people with head and neck cancer that has come back or spread. The goal is to see if the combination can shrink tumors. About 29 adults with incurable head and neck squamous cell carcinoma…

This study looked at whether adding the drug cetuximab to radiation therapy after surgery helps people with advanced head and neck cancer live longer. About 700 patients took part. The main goal was to compare overall survival between those who got radiation alone and those who g…

This study looks at whether exercising the muscles used for coughing and swallowing can help head and neck cancer survivors who had radiation therapy. The goal is to reduce the risk of pneumonia caused by accidentally inhaling saliva. About 175 participants will be followed to se…

This early-phase study tests a personalized cell therapy (ADP-A2M4CD8) for people with advanced cancers like lung, ovarian, or melanoma that have a specific marker called MAGE-A4. The treatment uses the patient's own immune cells, modified to better attack the cancer, and is give…

This study tests the safety of a new drug called PARPi-FL, which is used with a special scan to take pictures of head and neck cancer. The drug has been tested in animals but not yet in people. About 12 adults with head and neck cancer will receive the drug and be monitored for s…

This study tests a new imaging agent called 111In-panitumumab to see if it can safely and accurately find cancer that has spread to lymph nodes in people with head and neck cancer. About 28 participants will receive the agent before surgery, and its performance will be compared t…

This study tests if starting lymphatic treatment early—before any swelling appears—can prevent lymphedema in head and neck cancer survivors. Twenty adults who have finished surgery and radiation will be split into two groups: one uses a home compression device daily, the other re…

This study tests whether wrapping the nerve that controls the shoulder with a special protective cover during neck cancer surgery can reduce pain and weakness a year later. About 90 adults with head and neck cancer who need neck dissection are taking part. The goal is to see if t…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. The goal is to see if remote monitoring and home support can reduce emergency room visits and hospital stays. About 300 adults with certain cancers (like pancreat…

This study tests whether an online tool called Empowered Survivor helps people who have had oral or throat cancer feel more confident managing their health. About 643 cancer survivors will use either the new tool or a standard online program. The goal is to see if the tool improv…

This study tests whether remote monitoring and personalized nutrition advice can reduce malnutrition and improve quality of life in people with head and neck cancer. About 125 adults will be randomly assigned to receive either standard care or extra nutrition support throughout t…

This study tests if acupuncture can prevent dry mouth in 435 head and neck cancer patients receiving radiation. Dry mouth is a common side effect that affects quality of life. Researchers compare different acupuncture approaches to see which works best.

This study tests a computer program called HN-STAR that helps people who finished treatment for head and neck cancer. Survivors use it to report symptoms and concerns before doctor visits, and doctors get recommendations to address them. The goal is to improve well-being and ensu…

This study compares two types of radiation therapy for people with head and neck cancer: proton beam therapy and standard photon therapy (IMRT). The goal is to see if proton therapy causes fewer side effects, especially painful mouth sores. About 108 adults with certain cancers (…

This study tests a new counseling method called Acceptance and Commitment Therapy (ACT) to help people with certain cancers quit smoking. About 51 adults with head and neck, lung, breast, gastrointestinal, or genitourinary cancer who smoke at least one cigarette daily will receiv…

This study tests whether a self-management program can reduce anxiety and depression in people with head and neck cancer. 144 newly diagnosed patients were randomly assigned to either the self-help model or standard care. Trained nurses checked in weekly during treatment and ever…

This study tests whether a chatbot combined with continuous activity monitoring via a smartphone can help detect and manage symptoms early in people undergoing chemotherapy and radiation for lung, gastrointestinal, or head and neck cancers. The goal is to reduce unplanned hospita…

This study compares two approaches to treating lymphedema (swelling) in people who have had head and neck cancer. One group gets standard clinic-based therapy, while the other uses a home-based program with remote support. The goal is to see which method better reduces swelling, …

This early-phase study tests whether injecting a person's own bone marrow stem cells into their salivary glands can safely reduce dry mouth caused by radiation therapy for head and neck cancer. About 23 adults who finished radiation at least 2 years ago and have no active cancer …

This study tests a new way to deliver radiation therapy for head and neck cancer using an MRI machine built into the radiation device. The goal is to see if this approach can reduce severe dry mouth, a common and lasting side effect. About 49 adults with certain head and neck can…

This study was designed to see if using MRI scans to guide radiation therapy can better protect the salivary ducts and reduce dry mouth in people with oropharynx cancer. Dry mouth is a common and lasting side effect of radiation. The plan was to compare patient-reported dry mouth…

This study tests a new, low-cost device to help people who have trouble opening their mouth fully after radiation treatment for head and neck cancer. The device is a jaw stretcher with sensors that measure pressure and how wide the mouth opens, giving real-time feedback. About 35…

This study is testing whether a yoga program done by patients and their family caregivers together can help improve quality of life during radiation therapy for head and neck cancer. It aims to see if the program is practical to run and if it helps with fatigue, sleep, mood, and …

This study follows about 400 adults who previously received A2Bio gene therapy for various solid tumors, including lung, colon, and pancreatic cancers. The main goal is to track long-term safety and see how well the treatment effects last over time. Participants do not receive ne…

This study looks at how tumors evolve when patients with advanced head and neck cancer or melanoma receive immune checkpoint inhibitors. Researchers will analyze DNA from blood samples and tumor biopsies to see how the cancer changes under treatment. The goal is to better underst…

This study examines head and neck cancers that happen during pregnancy or within a year after giving birth. Researchers will check for viruses like HPV and EBV, look at pregnancy complications, and describe tumor types. The goal is to better understand these rare cases, not to te…

This study tests a new imaging tool called HyperSight that takes clearer, faster 3D scans during radiation therapy. The goal is to see if these scans are good enough to help doctors adjust treatment more accurately for cancers of the head/neck, breast, lung, stomach, or pelvis. A…

This study aimed to create a better way to teach family caregivers how to care for a loved one with a tracheostomy after head and neck cancer surgery. The goal was to help caregivers feel more confident and prepared for discharge. However, the study was withdrawn before any parti…

This study tests whether creating a 3D map of a patient's tumor after surgery helps doctors plan radiation therapy more precisely. About 13 adults with head and neck cancer will have standard radiation, but researchers will also create a virtual 3D map to see if it changes the tr…

This study was designed to look at the glossopharyngeal nerve, which helps keep the upper airway open. Researchers planned to measure the nerve's shape and test if electrical stimulation could improve breathing during surgery. The study was withdrawn before enrolling any particip…

This study looks at how radiation therapy for head and neck cancer might affect thinking skills like memory and focus. Researchers will ask 54 newly diagnosed patients to complete thinking tests and questionnaires three times over one year. The goal is to learn whether patients c…

This study is for children and teenagers who had proton beam therapy for head and neck cancer. Researchers want to learn how this treatment affects the teeth and jaw growth over time. Participants will fill out surveys and some may have interviews and dental check-ups. The goal i…

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study is looking at whether extra MRIs and blood tests can help doctors predict how head and neck tumors change during radiation therapy. Researchers will measure tumor growth and look for biomarkers in the blood. Up to 100 people (80 with cancer and 20 healthy volunteers) w…

This study uses advanced MRI techniques to see if they can predict how well head and neck cancer patients will respond to surgery or chemoradiation. About 272 adults with head and neck cancer will get these special scans before and during treatment. The goal is to find early sign…

This study screens up to 1,150 adults with advanced solid tumors (like head and neck, cervical, or lung cancer) to check their genetic markers. Researchers look for specific HLA types and tumor antigens to see if patients might qualify for future cell therapy trials. No treatment…

This early-stage study tested whether giving a condensed course of radiation (just 5 to 10 sessions) before surgery is safe for people with head and neck cancer. It involved 12 adults with a type of cancer not linked to HPV. The main goal was to see if the shorter radiation cause…

This study looks at whether using a numbing solution (tumescence) during skin graft harvesting helps the graft heal better in people having head and neck cancer surgery. About 58 adults will be randomly assigned to receive either the standard method or the numbing technique. The …

This study tests a new program designed to help head and neck cancer patients who feel depressed. The goal is to see if the program is practical and liked by patients, and if it can improve their mood and help them follow through with swallowing exercises and dental care. About 1…

This study is testing whether artificial intelligence can better predict how well head and neck cancer patients will respond to radiation therapy and what side effects they might have. About 50 adults with advanced cancer will have their medical images analyzed by a computer prog…

This study aimed to see if a personalized online education program could help patients and caregivers feel more prepared before and after major head and neck surgery. It also hoped to reduce hospital readmissions and unplanned visits. However, the study was withdrawn before any p…

This study was designed to see if automatic software could accurately outline tumors and healthy organs during radiation therapy for head and neck cancer. It planned to enroll adults with advanced head and neck cancer and compare manual and automatic contouring methods. However, …

This study looks at whether giving doctors information about a patient's genes can help them personalize chemotherapy doses and reduce severe side effects. About 860 adults with certain cancers (like breast, gastrointestinal, or head and neck) will be randomly assigned to have th…

This study was designed to find the best way to give tube feedings to people with head and neck cancer who are also getting chemotherapy and radiation. It planned to compare three methods—bolus, gravity drip, and a feeding pump—to see which one helped patients maintain weight and…

This study was designed to test a mobile health app that helps patients with recurrent head and neck or gynecologic cancers track their symptoms, treatment side effects, and quality of life. The goal was to see if patients find the app easy to use and helpful. However, the study …

This study looks at how a protein called AXL in head and neck tumors responds to a combination of two drugs, imatinib and cetuximab, given before standard treatment like surgery or radiation. About 15 adults with head and neck cancer will receive the drugs for a short time, then …

This study follows 350 head and neck cancer survivors about 7 years after radiation therapy to see how their teeth, gums, and jawbone are doing. Researchers will check for cavities, gum disease, tooth loss, bone damage, and dry mouth. The goal is to understand long-term dental pr…