HEAD AND NECK CANCER

This early-phase study tests a combination of two drugs—decitabine and nivolumab—in people with advanced head and neck cancer that has come back or spread. The goal is to see if decitabine can make cancer cells more visible to the immune system, helping nivolumab work better. Abo…

This study tests whether a special scan (SPECT-CT) can show which side of the neck needs radiation in people with oropharyngeal cancer. Currently, both sides are treated to prevent hidden cancer spread, but this causes more side effects. The trial will include 128 patients and se…

This early-phase study tests a new drug called CRPA1A2 in people with advanced solid tumors (lung, esophagus, head and neck, or liver cancer) that have not responded to standard treatments. The drug is designed to help the body's immune cells attack cancer cells that have a speci…

This study tests a combination of two drugs (XL-092 and pembrolizumab) given before surgery to people with a type of mouth cancer that is not linked to HPV. The goal is to see if this treatment can shrink or eliminate the tumor before it is removed. About 26 adults with early-sta…

This early-phase trial tests a new drug that helps the immune system recognize and attack cancer cells by blocking a 'don't eat me' signal. It is for people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and find the ri…

This study tests a combination of the immunotherapy drug toripalimab with two chemotherapy drugs (cisplatin and docetaxel) as an initial treatment for people with advanced head and neck cancer that has a specific marker (CPS-positive). The goal is to see if this approach is safe …

This study tests whether adding fianlimab to the standard drug cemiplimab can better prevent cancer from returning in people with HPV-positive head and neck cancer who have tiny amounts of cancer still detectable after initial treatment. About 68 adults will receive either cemipl…

This study tests whether extra dental support for head and neck cancer survivors can prevent or reduce late side effects like tooth loss, jaw stiffness, and cavities. About 300 adults who finished cancer treatment will receive an oral care program every three months for three yea…

This study tests if using RECELL®, a spray made from the patient's own skin cells, can help the reconstructed skin better match the natural skin color after head and neck cancer surgery. About 20 adults will be enrolled, and their color match, healing, and satisfaction will be me…

This study compares two skin-protective dressings—a moisturizing cream with foam pad versus a silicone barrier film—to see which better prevents painful skin reactions in head and neck cancer patients receiving TomoTherapy. About 104 adults will be randomly assigned to one of the…

This study tests if a ketamine mouth rinse can relieve pain from mouth sores (mucositis) caused by radiation therapy in head and neck cancer patients. About 62 adults receiving radiation will use the rinse and report their pain levels weekly. The goal is to see if this simple rin…

This study tests whether a common antibiotic ointment applied inside the nose can reduce severe mouth and throat pain caused by radiation therapy for head and neck cancer. About 126 adults receiving high-dose radiation will be randomly assigned to get either the antibiotic or a p…

This study tests whether lowering radiation doses to certain areas can reduce side effects for people with HPV-related throat cancer, which typically has good outcomes. About 132 participants will receive either reduced radiation to low-risk lymph nodes, a lower dose to the tumor…

This study collects blood and tissue samples from 110 adults with advanced lung, head/neck, or mesothelioma cancer who are starting their first treatment. The samples will be stored in a biobank to help researchers study genetic changes and find better ways to predict treatment o…

This study follows 50 adults who have had head and neck cancer and now use a maxillofacial prosthesis (a custom dental or facial device). Researchers will measure how well they chew, speak, and swallow, and how their quality of life changes over time. The goal is to understand th…

This study will use artificial intelligence to create a tool that predicts a person's risk of head and neck cancer. Researchers will analyze data from 3,000 adults, including medical history, lifestyle habits, and laryngoscopy images. The goal is to help doctors catch these cance…

This study tests whether a special type of CT scan (dual-energy CT) can be as good as MRI for outlining tumors and healthy organs before radiation therapy. About 80 adults with brain, bone, head/neck, or lung cancer will get both scans, and doctors will compare how accurately the…