New combo therapy before surgery shows promise for tough head and neck cancers
NCT ID NCT04938609
First seen Apr 11, 2026 · Last updated Jun 16, 2026 · Updated 12 times
Summary
This study tests whether giving a short course of radiation plus an immunotherapy drug (pembrolizumab) before surgery can shrink advanced head and neck cancers more effectively. About 28 adults with stage III or IV HPV-negative head and neck cancer will receive this neoadjuvant treatment, then have surgery. The main goal is to see how many patients have a major or complete tumor response at the time of surgery, while also monitoring side effects and quality of life.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Portland Providence Medical Center
Portland, Oregon, 97213, United States
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Providence St. Vincent Medical Center
Portland, Oregon, 97225, United States
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University of San Diego
San Diego, California, 92037, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.