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7-Year checkup: how radiation affects teeth and gums in cancer survivors

NCT ID NCT05325970

Knowledge-focused Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study follows up with head and neck cancer patients about 7 years after they finished radiation therapy. Researchers will check for cavities, gum disease, tooth loss, bone damage, and saliva flow. The goal is to understand the long-term dental side effects of cancer treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

202 people

The number who actually took part.

Started

Feb 2014

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will be offered to all living ORARAD participants approximately 7 years post-RT. Persons of all races and ethnicities and both females and males will thus be eligible for this study. Because participants will be drawn solely from the participants in the original ORARAD, the racial/ethnic composition of the study population at each center will be determined by the composition of those enrolled in the original ORARAD, which has been documented elsewhere. Since there is no evidence to suggest that dental outcomes in head and neck cancer patients are affected by gender, this expected unequal gender distribution of study participants will not affect the scientific validity of the study. Individuals who meet the eligibility criteria will be invited to participate in the study.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Enrolled in the original ORARAD study * Willing to participate and comply with all study procedures Exclusion Criteria: * Anything that would place the participant at increased risk or preclude the participant's full compliance with or completion of the study (e.g., unable to obtain consent or unable to tolerate an oral examination).

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms neoplasm osteoradionecrosis Stomatognathic Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental diseases Head and neck cancer Osteoradionecrosis

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02120, United States

  • New York University - College of Dentistry

    New York, New York, 10010, United States

  • University of Connecticut Health Center - School of Dental Medicine

    Farmington, Connecticut, 06030, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55414, United States

  • University of North Carolina School of Dentistry

    Chapel Hill, North Carolina, 27514, United States

  • University of Pennsylvania School of Dental Medicine

    Philadelphia, Pennsylvania, 19104-6030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.