Rheumatoid arthritis

This study tests whether the Butantan-Dengue vaccine is safe and works well in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable on low or no immune-suppressing drugs. Participants receive one vaccine dose and are monitored f…

This Phase 1 trial tests surovatamig, a bispecific T-cell engager, in 48 adults with rheumatoid arthritis or systemic lupus erythematosus. The study gives the drug as injections in increasing doses to check safety, side effects, and how the body processes it. It is too early to k…

This study is testing the long-term safety and effectiveness of a drug called afimkibart in people with moderate to severe rheumatoid arthritis. Participants have already taken afimkibart in a previous study and will continue taking it. The goal is to see if the drug remains safe…

Researchers at a Korean hospital are following 210 adults who receive a cementless total hip replacement using the collarless Actis femoral stem. The study focuses on Asian patients, who tend to be younger at surgery and more often need the operation because of lost blood supply …

This trial tests whether nicorandil, a drug currently used for heart conditions, can reduce disease activity and symptoms in people with rheumatoid arthritis. About 70 adults with moderate-to-severe RA will take either nicorandil or a placebo twice daily for three months, while c…

This study tests whether the drug nerandomilast can slow lung scarring in people with autoimmune diseases like rheumatoid arthritis or scleroderma. About 400 adults whose lung function hasn't improved with standard treatment will take either nerandomilast or a placebo twice daily…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This early-stage study tests a single dose of ABBV-519 in 30 adults with moderate lupus or rheumatoid arthritis. Researchers will check how the drug moves through the body, how it affects immune cells, and whether it is safe. Participants will be followed for about a year to moni…

This early study tests a new medicine, MK-1045, in about 21 people with lupus or rheumatoid arthritis. The main goal is to see if it is safe and tolerable at different dose levels. Participants receive the drug through an IV infusion, and researchers monitor for side effects.

This early-stage study tests a new drug called SAR448501 (DR-0201) in 62 adults with lupus or rheumatoid arthritis. The drug is a bispecific antibody designed to target the immune system. The main goal is to check safety and find the right dose, not yet to prove it works. Partici…

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a plac…

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This trial tests whether people with rheumatoid arthritis who have stable disease can stop taking methotrexate or leflunomide while continuing their TNF inhibitor, restarting the drug if needed. Researchers compare this approach to staying on the combination therapy. They track d…

This trial tests an investigational cell therapy called FT839 in people with active autoimmune diseases, including ANCA-associated vasculitis, inflammatory myositis, rheumatoid arthritis, lupus, and systemic sclerosis. Participants receive FT839 as two intravenous infusions, some…

This phase 2 trial tests whether telitacicept, an experimental biologic given as a weekly injection, can improve symptoms in people with difficult-to-treat rheumatoid arthritis. Participants receive either telitacicept plus standard therapy or standard therapy alone for 24 weeks.…

This study tests an experimental drug called Afimkibart (RO7790121) in 160 people with moderate to severe rheumatoid arthritis who did not get better with or could not tolerate standard treatments like TNF or JAK inhibitors. Participants will receive either the drug or a placebo …

This early-stage study tests a new drug, BMS-986528, in 84 adults with rheumatoid arthritis that hasn't responded well to other treatments. The main goal is to check safety and how the body processes the drug. Researchers will also look for signs that it might help control the di…

This early-stage trial tests an experimental treatment called QEL-005 for people with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically…

This study tests two medications, inebilizumab and blinatumomab, in adults with active lupus (with kidney inflammation) or hard-to-treat rheumatoid arthritis. The goal is to see if these drugs are safe and can help control the diseases. About 220 people will take part. This is no…

This program offers early access to upadacitinib (Rinvoq) for people with Crohn's disease, ulcerative colitis, certain types of arthritis, or atopic dermatitis who have no other suitable treatments and cannot join ongoing clinical trials. A doctor must decide if the potential ben…

This study tests whether adding a Chinese herbal formula (Si Miao Xiao Bi Tang) to standard rheumatoid arthritis medication can improve symptoms. About 132 adults with active RA will receive either the herbal medicine or a placebo for 12 weeks. The main goal is to see if more peo…

This study follows 60 adults who receive a total shoulder replacement using the PRIMA humeral stem, either in an anatomic or reverse configuration. The goal is to measure changes in shoulder function, pain, and quality of life over 24 months, as well as how well the implant holds…

This early-stage study tests a new therapy, HN2301, in 30 adults with lupus, scleroderma, or rheumatoid arthritis. The main goal is to check safety and find the right dose. Researchers will also look for early signs that the treatment helps control the disease by measuring immune…

This study tests whether giving sarilumab (Kevzara) through an IV with longer intervals between doses is safe and works well for adults with moderate-to-severe rheumatoid arthritis. Participants receive the drug intravenously, with or without other standard arthritis medications.…

This early-stage trial tests a new drug called KT502 in 27 adults with moderate to severe rheumatoid arthritis. The drug is designed to deplete certain immune cells (B cells) that contribute to joint inflammation. The main goal is to check safety and find the right dose, not yet …

This early-stage trial tests an investigational drug called ABBV-319 in 36 adults with lupus or Sjogren's disease. The drug is designed to deplete overactive B cells, which are part of the immune system that cause inflammation and symptoms. Participants receive two doses by IV, 2…

This trial asks whether people with rheumatoid arthritis who have low disease activity can safely reduce their JAK inhibitor dose without losing control of their symptoms. Participants will either follow a step-by-step dose-tapering plan or continue their usual full-dose medicati…

This study tests a new treatment called NKX019 for people with autoimmune diseases like systemic sclerosis, rheumatoid arthritis, and vasculitis. NKX019 uses specially engineered immune cells to target and calm overactive B cells that cause the disease. The goal is to see if it i…

This phase 2 trial tests whether adding either diosmin or rebamipide to standard rheumatoid arthritis treatment can better reduce disease activity and improve physical function. About 66 adults with active rheumatoid arthritis will be split into three groups: one receiving standa…

This early-stage trial is testing a new biologic drug called plamotamab in 68 adults with moderate to severe rheumatoid arthritis (RA) who haven't gotten enough relief from other treatments. The drug is given as a shot under the skin, and the main goal is to see if it's safe and …

This study tracks the safety and effectiveness of the arthritis drug Xeljanz XR in about 200 adults with moderate to severe rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis. Participants take the drug as prescribed by their doctor, and researchers record any s…

This phase 2 trial tests a therapy called AlloNK, made from donor cord blood immune cells, combined with the drug rituximab. It aims to see if this combination is safe and can help people with severe forms of rheumatoid arthritis, Sjögren's disease, myositis, or scleroderma that …

This study tracks about 678 adults with moderate to severe rheumatoid arthritis in Germany to see how long they stay on either upadacitinib or TNF inhibitors. Doctors choose the treatment before the study starts, based on standard care. The goal is to learn which drug people stic…

This early-stage trial tests a new treatment called AZD0120 for adults with three autoimmune diseases: systemic sclerosis, idiopathic inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. AZD0120 is made from a patient's own immune cells, which are modified in a la…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This trial investigates whether adding Kunxian Capsule, a traditional Chinese herbal remedy, to standard medications (methotrexate and tofacitinib) can improve outcomes for people with refractory rheumatoid arthritis — a form that does not respond well to usual treatments. About …

This early-stage study tests an experimental drug called CND319 in healthy volunteers and people with rheumatoid arthritis or Sjögren's syndrome. The main goal is to check safety and how the body processes the drug. Researchers will also look for early signs that it might help co…

This study tests whether temporarily stopping methotrexate for 2 weeks after receiving a pneumonia vaccine (PCV20) helps the vaccine work better in adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus. About 192 participants with stable, low disease activi…

This early-stage trial tested the safety of a new drug called NTR-1011 in 36 healthy adults and people with lupus or rheumatoid arthritis. The study aimed to find a safe dose and see how the drug behaves in the body. It is a first step toward possibly developing a new treatment f…

This study tests an experimental drug called ELV001 in people with active rheumatoid arthritis who have not gotten enough relief from standard treatments like methotrexate or TNF inhibitors. About 180 to 220 adults will receive either ELV001 or a placebo added to their current me…

This early-phase trial is testing a new drug called BMS-986454 in 46 adults with rheumatoid arthritis who did not fully respond to methotrexate. The main goal is to check the drug's safety, tolerability, and how it moves through the body. Participants will receive either the drug…

This study compares two treatment strategies for people with active rheumatoid arthritis (RA) who have already tried a type of biologic called a TNF inhibitor. Participants are randomly assigned to switch to either a different class of biologic (non-TNFi) or a newer oral medicati…

This early-stage study tests a new drug, CPTX2309, to see if it is safe and tolerable. It involves 64 healthy adults and people with moderate to severe rheumatoid arthritis or lupus. Researchers will monitor side effects, lab results, and immune responses to determine the drug's …

This early-stage study tests a new treatment made from healthy donor immune cells (CAR T cells) for people with severe autoimmune diseases like lupus that haven't responded to standard therapies. The goal is to see if these cells can safely target and calm the overactive immune s…

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This study is testing a new knee replacement system called Persona Revision for people who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. About 380 adults will be followed for two years after surgery.

This phase 2 study tests two experimental drugs, lutikizumab and ravagalimab, alone or together, in about 180 adults with moderate-to-severe rheumatoid arthritis who have not improved with other treatments. The goal is to see if these drugs can reduce joint pain and swelling bett…

This study looks at whether people with rheumatic diseases (like rheumatoid arthritis or lupus) can safely stop their immunosuppressant medications for a shorter time before elective shoulder replacement surgery. The goal is to see if this approach lowers the chance of disease fl…

This study is looking at how well the Zimmer Nexel Total Elbow works for people who need elbow replacement surgery. It includes 134 adults with conditions like severe arthritis, fractures, or joint instability. The main goal is to see how long the implant lasts and if it is safe.

This phase 2 trial tests whether a daily, at-home ultrasound device can safely reduce inflammation and joint pain in people with rheumatoid arthritis. About 40 adults with moderate-to-severe RA will use either an active or a sham device for 8 weeks. The study focuses on safety an…

This study is monitoring the safety and effectiveness of the drug Jyseleca (filgotinib) in Korean patients with rheumatoid arthritis or ulcerative colitis. Researchers will track side effects and disease activity over 24 weeks. About 2,040 participants are being observed during r…

This study follows adults who have received a Tipmed shoulder replacement to see how well the implant works and if any problems arise over the first year. Participants have conditions like severe arthritis, rotator cuff damage, or a broken shoulder bone. Researchers track shoulde…

This study tests a new tool called OPTIBIO that uses blood markers and patient data to help doctors decide if it's safe to reduce biological therapy in rheumatoid arthritis patients who are in remission. About 184 adults with RA in stable remission will be randomly assigned to ha…

This study tests a new medicine called SBT777101 in 24 people with moderate-to-severe rheumatoid arthritis (RA). It is the first time this drug is given to humans, so the main goal is to check safety and side effects. Participants receive a single dose, and the dose is increased …

This study tests whether taking a once-daily JAK inhibitor for rheumatoid arthritis in the evening works better than taking it in the morning. About 90 adults with RA who qualify for this medication will be randomly assigned to morning or evening dosing. Researchers will compare …

This study tests an experimental drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. Participants receive either AZD1163 or a placebo as an injection, along with their usual care. The main goal …

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This early-stage study tests a new drug (GSK5926371) in people with lupus and similar autoimmune diseases. The drug is designed to target and calm specific immune cells that attack the body. The main goal is to check if the drug is safe and how the body handles it, with 54 adults…

This study tests whether nicorandil, a drug usually used for heart conditions, can reduce inflammation and improve symptoms in people with active rheumatoid arthritis. 46 participants will take nicorandil tablets for 3 months. Researchers will measure joint disease activity and p…

This early-stage study is testing whether an oral probiotic called R-2487 is safe for people with rheumatoid arthritis. Researchers will also check if it reduces joint swelling and inflammation. The trial involves 73 adults with active RA who will take the probiotic and be monito…

This study tests whether adding roflumilast to standard treatment can reduce joint pain and swelling in people with active rheumatoid arthritis. About 50 adults aged 18-60 will take either roflumilast or a placebo for 12 weeks. Researchers will measure changes in disease activity…

This phase 2 trial is testing whether adding desloratadine, an allergy medication, to standard rheumatoid arthritis therapy can reduce joint inflammation and disease activity. Sixty adults with active RA will receive either desloratadine or a placebo for 12 weeks. The study measu…

This study follows 50 people who receive a Zimmer Biomet shoulder replacement implant to see if it safely improves pain, movement, and quality of life over two years. Participants have shoulder arthritis, fractures, or other joint damage. The main goal is to measure a meaningful …

This early-stage trial tests a single injection of JADE201 in 36 adults with rheumatoid arthritis. The main goal is to check safety and how the body processes the drug. Participants receive either JADE201 or a placebo, and researchers monitor side effects and drug levels in the b…

This early-stage study tests a new drug called S-4321 in 24 adults with autoimmune diseases like rheumatoid arthritis, psoriasis, lupus, or eczema. The goal is to check safety and how the drug affects the body. Participants receive multiple doses and are monitored for side effect…

This study tests a new drug called CIT-013 in 88 adults with moderately active rheumatoid arthritis. Participants will receive either CIT-013 or a placebo every two weeks for six weeks. The goal is to see if CIT-013 reduces joint swelling and pain better than a placebo, and to ch…

This study tests a new drug called GenSci120 in 450 adults with moderate-to-severe rheumatoid arthritis who haven't improved with standard treatments. Participants receive either GenSci120, an existing drug (adalimumab), or a placebo for 14 weeks, followed by an extension period.…

This study is checking the long-term safety and effectiveness of an experimental drug called TLL-018 for people with rheumatoid arthritis. It is for adults who have already finished a previous study of this drug. The goal is to see how well the drug controls arthritis symptoms ov…

This early-stage study tests a new drug called CLN-978 in about 37 people whose rheumatoid arthritis has not responded to standard treatments. The goal is to see if the drug is safe and can control the disease by reducing certain immune cells (B cells) that drive inflammation. Pa…

This study tests whether adding either roflumilast (a COPD drug) or desloratadine (an allergy drug) to standard rheumatoid arthritis treatment can better control the disease. About 90 adults with active RA will take one of these drugs or a placebo for 12 weeks. The goal is to see…

This study tests whether adding tofacitinib to standard methotrexate works better than methotrexate alone for people with active rheumatoid arthritis who have a specific 'myeloid-stromal' type. 130 adults will be randomly assigned to either the combo or methotrexate-only group fo…

This early-stage trial tests a new medicine called SR-878 in 27 adults with rheumatoid arthritis. The drug works by blocking a protein that controls immune signals. The main goal is to check safety and find a good dose. Participants will be followed for about 16 weeks.

This early-stage study tests a new treatment called HBI0101 CAR T for people with severe autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis that haven't improved with standard treatments. The main goal is to find a safe dose and check for side effects in…

This study tests a new treatment called anti-CD19/BCMA universal CAR-T cells for people with severe autoimmune diseases like rheumatoid arthritis, lupus, and scleroderma. The therapy aims to reset the immune system by targeting and removing faulty B cells. About 72 adults will re…

This study looks at whether taking tofacitinib (a rheumatoid arthritis drug) along with a statin (a cholesterol-lowering drug) can lower the chance of serious heart problems in people with rheumatoid arthritis. The study will compare this combination to another standard treatment…

This study is following 584 people who received Zimmer Biomet shoulder implants to see how well the devices work over 10 years. Participants have shoulder arthritis, fractures, or deformities. Researchers will track implant survival, pain, function, and any side effects. The goal…

This study tests whether fucoidan, a substance from brown seaweed, can help adults with active rheumatoid arthritis who haven't improved enough on standard medications. The trial will enroll 40 people and follow them for 12 weeks to see if joint pain and swelling improve. Fucoida…

This study tests whether a surgical robot (ROSA Knee) can help surgeons adjust their knee replacement plan during the operation based on the condition of the patient's soft tissues. About 80 adults with knee arthritis or rheumatoid arthritis will take part and be followed for 2 y…

This study is testing whether a combination of two drugs, telitacicept and baricitinib, can help people with difficult-to-treat rheumatoid arthritis. The trial will enroll 30 adults aged 18 to 85 who have not responded to other treatments. Researchers will measure joint swelling …

This study is tracking 10,000 Chinese adults with rheumatoid arthritis who are starting or continuing a drug called subcutaneous methotrexate. Researchers want to see how well it works and how safe it is in everyday medical practice, including in patients with additional lung or …

This study compares a robot-assisted system (CORI) to conventional manual instruments for total knee replacement. About 140 participants will be randomly assigned to one of the two methods. The main goal is to see if the robot helps achieve more precise leg alignment after surger…

This study tests whether a 6-week aerobic exercise program can reduce cardiovascular risk in people with chronic kidney disease or rheumatoid arthritis. About 90 participants will be assigned to either an exercise program, educational phone calls, or no intervention. Researchers …

This early-stage study tests a new drug, KT501, in 24 adults with moderate to severe rheumatoid arthritis (RA). The main goal is to check safety and how the body handles the drug after a single injection. Participants must have had RA for at least 6 months and not responded well …

This study compares the effects of Mediterranean and Paleolithic diets on rheumatoid arthritis (RA) symptoms, nutrition, and quality of life. Seventy-five adults aged 40-60 with RA will follow one of these diets or their usual diet for 12 weeks. Researchers will measure disease a…

This early study is testing whether a single injection of special stem cells (hiSCs) into the knee joint is safe and can reduce pain and swelling in people with rheumatoid arthritis. Only 15 adults with active knee arthritis will take part. The main goal is to check for side effe…

This early-phase study tests a new type of CAR-T cell therapy (called KN3601) for people with severe autoimmune diseases like lupus, scleroderma, Sjögren's syndrome, rheumatoid arthritis, and vasculitis that haven't responded to standard treatments. The therapy uses specially eng…

This study tests a new oral drug, TollB-001, in 24 adults aged 18-70 with moderate to severe active rheumatoid arthritis who haven't responded well to standard treatments. Participants take either the drug or a placebo once daily for 4 weeks, with a 1-week follow-up. The goal is …

This study is testing a new type of knee implant that doesn't require bone cement, in 130 people needing total knee replacement. The goal is to see if the implant improves knee function, reduces pain, and helps patients feel more natural after surgery. Researchers will track outc…

This early-stage study tests a new drug called A-319 in 12 people with active rheumatoid arthritis who haven't responded well to other treatments. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body and wh…

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This early-stage trial is testing a new drug called cizutamig in 28 people with severe rheumatoid arthritis that hasn't responded to other treatments. The drug works by directing the immune system to attack certain cells involved in the disease. The main goal is to check safety, …

This study is testing whether an anti-inflammatory diet can help people with rheumatoid arthritis feel better and reduce disease activity. Researchers will compare two different anti-inflammatory diets in 124 adults with low to moderate disease activity. The goal is to see if die…

This study explores whether taking a daily probiotic for 6 weeks can improve symptoms in adults with rheumatoid arthritis. Participants will also provide stool samples to track how the probiotic bacteria settle in the gut. The goal is to see if this simple addition to standard tr…

This study tests a personalized approach to slowly reduce the dose of the biologic drug adalimumab in people with rheumatoid arthritis who are in remission. The goal is to find the best blood level of the drug before each dose reduction to lower the risk of disease flares. 180 ad…

This study is testing a new hip replacement system called Emphasys Hip Solutions in 30 people with hip osteoarthritis. Researchers will use special X-ray imaging to see how well the implant stays in place over two years. The goal is to make sure the implant is stable and works we…

This early-phase study tests a new treatment called ADI-001 for adults with rheumatoid arthritis that hasn't improved with standard therapies. ADI-001 uses specially engineered immune cells from a donor to target and destroy faulty immune cells that drive inflammation. The main g…

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This study tests whether baricitinib, a JAK inhibitor, can heal bone erosion in people with active rheumatoid arthritis. Sixty adults with moderate-to-severe RA and at least one bone erosion will receive either baricitinib or a placebo for 24 weeks. The main goal is to see if the…

This study is testing a new computer navigation system (OrthoPilot with pheno4u software) to help surgeons perform knee replacements more accurately. About 120 people who need a total knee replacement will take part. The goal is to see if the new software improves how well the im…

This Phase 2 trial tests an oral drug called AP1189 in 240 people with early rheumatoid arthritis who have not yet taken disease-modifying drugs. Participants receive one of three doses of AP1189 or a placebo, all alongside standard methotrexate, for 12 weeks. The goal is to see …

This Phase 3 trial tests a sequential treatment strategy for rheumatoid arthritis (RA). Participants first receive a TNF inhibitor for 12 weeks, then switch to abatacept. The goal is to see if this approach leads to more remissions than staying on TNF inhibitors alone. The study …

This study tests whether extra support from a pharmacist—starting in the hospital and continuing after discharge—can help people with rheumatoid arthritis take their disease-modifying medications more consistently. Two hundred participants will either receive this pharmaceutical …

This study is checking how long the Medacta Shoulder System lasts and how well it works in 200 people with shoulder issues like arthritis, fractures, or failed previous shoulder replacements. Participants will be followed over time to measure shoulder function, pain, and movement…

This study is tracking 550 adults aged 18–75 who receive the Medacta SMS femoral stem during total hip replacement. Researchers will monitor how long the implant lasts, how well the hip functions, patient satisfaction, and quality of life. The goal is to confirm the device's safe…

This early study tests whether a device that electrically stimulates the abdominal vagus nerve is safe for people with moderate to severe rheumatoid arthritis that hasn't improved with medication. Five participants will have the device implanted via keyhole surgery and receive da…

This early-stage study is testing a new drug called CIGB-814 for safety and how the body processes it. 70 healthy volunteers aged 18-45 will receive either the drug or a placebo as a single or multiple injections. The goal is to see if it is safe enough to test in people with rhe…

This study looks at whether people with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis who are doing well on a JAK inhibitor can safely reduce their dose. About 200 participants will either lower their dose or stay on the same dose, guided by disease activi…

This early-phase study is testing a new drug called CC312 in 18 adults with severe autoimmune diseases like lupus and rheumatoid arthritis that haven't improved with standard treatments. CC312 is a type of immune therapy designed to target and destroy faulty B cells, similar to C…

This study tests a portable device that sends mild electrical pulses to the vagus nerve through the ear, aiming to calm the immune system and reduce joint inflammation. It involves 128 adults with moderate-to-severe rheumatoid arthritis who have not responded well to standard bio…

This study is testing a silicone implant called KeriFlex® to replace damaged finger joints in people with rheumatoid arthritis, osteoarthritis, or post-traumatic arthritis. The goal is to see if the implant improves hand function and is safe over time. About 86 adults will receiv…

This Phase 2 trial tests whether adding pentoxifylline (a drug usually used for blood flow) to standard methotrexate therapy can reduce inflammation in people with active rheumatoid arthritis. Fifty adults aged 18–70 with moderate-to-severe disease will receive the combination fo…

This study tests whether a quick, non-invasive lung ultrasound can detect interstitial lung disease in people with rheumatoid arthritis. About 280 adults with RA and risk factors for lung disease will get an ultrasound, and results will be compared to standard chest CT scans. If …

This study is testing whether a new laser-based imaging technique, called photoacoustic tomography (PAT), can help diagnose rheumatoid arthritis. Researchers will scan the finger joints of 113 adults—some with arthritis and some healthy—and compare PAT with MRI and ultrasound. Th…

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study is testing a new blood-based test that aims to predict which medication will work best for each person with rheumatic diseases like rheumatoid arthritis or lupus. Researchers will take a blood sample and analyze immune cells to create a personalized treatment profile. …

This study tests whether using a carotid ultrasound (a neck scan) to find hidden plaque in arteries can help prevent heart attacks and strokes in people with inflammatory rheumatic diseases like rheumatoid arthritis or lupus. About 1,944 participants aged 50 and older will be spl…

This study looks at how well the shingles vaccine works in people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects in 300 adults. The goal is to see if the vaccine can effectively prev…

This study tests whether adding lavender aromatherapy massage to standard care can reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 adults with stable medication will be randomly assigned to get the massage or not. Researchers will measure pai…

Researchers are studying the Exactech Vantage Mobile-Bearing Total Ankle System, an implant used to replace a damaged ankle joint. The study enrolls 400 adults with ankle arthritis or related joint failure who are scheduled for total ankle replacement. Participants receive the im…

Researchers are studying the Exactech Vantage Total Ankle System, an implant used to replace a damaged ankle joint in people with arthritis or a failed previous replacement. The study enrolls 370 adults who are candidates for total ankle replacement and follows them for up to 10 …

This early-stage study tests a new drug called F8IL10, given as an injection directly into the joint, for people with rheumatoid arthritis. The main goal is to find a safe dose and see if it helps reduce joint pain and swelling. About 42 adults with active arthritis in a knee, an…

This study tests an online wellness course that teaches diet, exercise, stress reduction, and self-care to people with rheumatoid arthritis, lupus, Sjogren's syndrome, and similar conditions. Researchers want to see if the program reduces fatigue and improves quality of life. Abo…

This early-stage study tests a new drug called LFD-200 in healthy volunteers and people with moderate to severe rheumatoid arthritis (RA). The main goal is to check safety and how the body processes the drug. Researchers will give single or multiple doses and watch for side effec…

This study looks at whether changing what you eat can help with rheumatoid arthritis. 66 adults with RA will follow either a gluten-free diet, a Mediterranean diet, or their usual diet for 12 weeks. Researchers will measure disease activity, quality of life, and inflammation to s…

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (all meat) diet can improve quality of life and reduce symptoms in adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one of t…

This study tests whether a single steroid injection works as well as a three-week course of steroid pills for treating rheumatoid arthritis flares. Researchers will track how patients feel, their ability to function, and their satisfaction with treatment. The goal is to help pati…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study compares two types of computer-assisted knee replacement surgery: one using a navigation system (OrthoPilot) and one using a robotic arm (MAKO). The goal is to see if they provide similar improvements in knee function and pain relief one year after surgery. About 140 a…

This study tests whether a 16-week plant-based diet can reduce disease activity and improve quality of life in 180 adults with rheumatoid arthritis. Participants receive weekly food boxes, diet guidance, and cooking classes, while a control group continues their usual diet. The g…

This pilot study is testing whether a remotely-delivered exercise program is practical and acceptable for people recently diagnosed with rheumatoid arthritis (within 6 months). Fifteen participants will receive intensive aerobic and resistance training via video calls. The main g…

This study tests a new program called INSPIRE, designed to support informal caregivers (like family or friends) of older adults with rheumatoid arthritis and frailty. The program involves three sessions with a healthcare professional over 12 weeks, focusing on emotional support, …

This study tests whether taking vitamin E (alpha-tocopherol) supplements for one month can reduce inflammation and disease activity in people with rheumatoid arthritis. Researchers will compare vitamin E to a placebo in 46 women with early RA. Participants take two capsules daily…

This study tests a self-management program for people recently diagnosed with inflammatory arthritis. The program includes nurse sessions to help patients learn skills to manage their condition. Researchers will compare the program plus usual care to usual care alone in 130 adult…

This study tests whether having a peer coach—someone who also has rheumatoid arthritis (RA)—can lower anxiety and depression in adults with RA. Participants meet with their coach weekly for 9 weeks and complete surveys. The trial compares this to general health coaching from peop…

This study compares two treatments for shoulder pain caused by arthritis or rotator cuff problems: a steroid injection into the joint versus a nerve block. Forty adults with shoulder arthritis will be randomly assigned to one of the two treatments. Researchers will track pain lev…

This study looks at whether giving the painkiller nalbuphine at different times during knee replacement surgery can better control pain and keep the heart stable in patients aged 65 and older. About 162 participants will receive nalbuphine either during anesthesia or after cement…

This early-stage study tests an experimental drug called LPX-TI641 in 48 adults with rheumatoid arthritis or psoriatic arthritis. Participants take the drug or a placebo daily for 28 days. The main goal is to check if the drug is safe and tolerable, and how it moves through the b…

This study tests whether taking krill oil supplements for 12 weeks can improve muscle strength and function in adults with long-term conditions like diabetes, heart disease, or arthritis. Thirty participants will be randomly assigned to receive either krill oil or a placebo. Rese…

This study tests a custom-made thumb brace (thermoplastic orthosis) for people with rheumatoid arthritis who have a boutonniere deformity, a condition where the thumb bends abnormally. About 60 women aged 18-65 will be split into two groups: one gets the custom brace, the other a…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This study looks at how well a non-invasive navigation system helps surgeons place the hip cup during total hip replacement. About 118 people with hip conditions like arthritis or hip dysplasia will take part. The goal is to see if the actual cup position matches the planned posi…

This observational study looks at how physical activity, sedentary time, and sleep relate to early signs of heart and blood vessel disease in adults with rheumatoid arthritis. Participants will wear activity monitors for a week, answer health questionnaires, and undergo heart and…

This study looks at how pain is processed in people with fibromyalgia and rheumatoid arthritis, two conditions that cause long-term pain. Researchers will measure pressure pain thresholds in 150 adults to compare pain mechanisms. The goal is to better understand the differences a…

This observational study aims to understand why some people with rheumatoid arthritis (RA) continue to experience chronic pain even when their inflammation is well-controlled. Researchers will compare two groups of RA patients—those with active disease and those in remission with…

This study looks at whether certain markers of oxidative stress in the blood are linked to early signs of heart disease in people with rheumatoid arthritis. Researchers will measure these markers and check for thickening or stiffness in the carotid arteries. The goal is to better…

This study is a pregnancy registry that gathers information from women with chronic neurological conditions like multiple sclerosis, NMOSD, and myasthenia gravis who are planning pregnancy, currently pregnant, or within one year postpartum. Participants can contribute blood, brea…

This large observational study will follow 10,000 people with rheumatoid arthritis (RA) who are receiving a combination of Traditional Chinese Medicine (TCM) and standard Western medicine. Researchers will collect health data and biological samples over time to understand which t…

This study looks at why people with rheumatoid arthritis (RA) may have trouble swallowing. Researchers will use a small, flexible camera to examine the throat and voice box in 137 adults with RA. They aim to find factors that predict swallowing difficulty and see if joint problem…

People with rheumatoid arthritis have double the risk of heart attack. This study is testing whether a blood test for troponin, along with a heart scan, can catch heart disease early. Researchers will enroll 120 adults aged 40-79 with RA and at least one heart risk factor. The go…

This study looks at how often lung disease occurs in people recently diagnosed with rheumatoid arthritis (RA). Researchers will use CT scans, breathing tests, and blood samples to detect lung changes and search for biomarkers that could predict lung problems. The goal is to bette…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …

This study is testing a new device called BloodTrackR that lets people with rheumatoid arthritis collect a small blood sample at home using a finger prick and a smartphone app. Twenty participants will try the device and answer questions about how easy it is to use. The goal is t…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study is collecting joint fluid and tissue samples from 50 adults with inflammatory or non-inflammatory bone and joint diseases. Researchers will use both standard and advanced lab techniques to find new biomarkers that could help diagnose rheumatic diseases more accurately …

This study is looking for clues to predict how well different rheumatoid arthritis (RA) drugs will work in individual patients. Researchers will give 400 adults with RA one or more standard medications and track their response over 16 weeks. The goal is to find genetic or other f…

This study collects information from 10,000 adults who have had hip or knee replacement surgery at Heidelberg University Hospital. Researchers will follow participants during routine check-ups to see how long the artificial joints last, how well they function, and what problems m…

This study looks at how heavy smartphone use impacts neck posture, muscle strength, balance, and tongue pressure in people with rheumatoid arthritis or ankylosing spondylitis. Researchers will compare these patients to healthy individuals to separate the effects of the disease fr…

This study aims to create better custom insoles for people with rheumatoid arthritis who have foot pain. Researchers will use CT scans and motion analysis to build a digital model of how feet move and apply pressure. The goal is to design insoles that reduce pain and improve comf…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study tests a special dye and camera to look at lymph vessels in the hands of people with rheumatoid arthritis. The dye is injected into the skin and glows under a near-infrared camera, allowing researchers to see how lymph fluid moves. The goal is to better understand how t…

This study looks at 200 adults with well-controlled rheumatoid arthritis to find ways to predict when a disease flare might occur. Researchers will track symptoms and check blood markers every 3 months. The goal is to help doctors adjust treatment early and prevent flares.

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study will use nerve conduction tests to check for nerve damage in 60 adults with rheumatoid arthritis. Half are taking baricitinib (Olumiant), a JAK inhibitor, and the other half are on standard disease-modifying drugs. The goal is to see if baricitinib is linked to a highe…

This study follows 200 adults with rheumatoid arthritis who are already in stable remission from standard medications. Researchers will track their health over up to 5 years using exams, ultrasound, and X-rays to see who stays well and who has a flare. The goal is to learn how to…

This study looks at whether a doctor's computer tool (MedSafer) and patient brochures (EMPOWER) can help reduce the use of potentially harmful medications in adults aged 60 and older with rheumatic diseases who take five or more regular drugs. Researchers will follow 100 particip…

This study looks at 750 people with rheumatoid arthritis (RA) who are 45 or older to find early signs of interstitial lung disease (ILD), a serious lung complication. Researchers will use CT scans and track changes over 3-5 years to identify risk factors. The goal is to better un…

This study is testing whether a mathematical model using blood markers can predict how well rheumatoid arthritis patients will respond to a lower dose of the drug rituximab. Thirty adults with RA who already do well on standard-dose rituximab will switch to a lower dose. Research…

This study looks at 200 adults with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis to see if certain blood markers (related to oxidative stress) can help doctors monitor how the disease changes over a year. Participants give blood samples at the start, 6 mon…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with connective tissue diseases like scleroderma or rheumatoid arthritis. Researchers will analyze tiny particles in the blood called extracellular vesicles and use AI to exami…

This study monitors 36 people who previously received an experimental gene-modified regulatory T cell (Treg) therapy for rheumatoid arthritis or hidradenitis suppurativa. The goal is to check for any delayed side effects and see how long the modified cells last in the body. Parti…

This study aims to better understand why people with inflammatory arthritis experience chronic pain. Researchers will look at how the brain processes pain and how it affects daily life. 350 adults starting or switching arthritis medications will be followed over time. The goal is…

This study aims to better understand rare forms of inflammatory arthritis, including those linked to other autoimmune diseases or cancer immunotherapy. Researchers will analyze joint tissue samples from 100 adults to compare the immune cells and molecules involved. The goal is to…

This study will follow 200 adults with rheumatoid arthritis (RA) that does not respond well to standard treatments, known as refractory RA. The goal is to learn more about why some people have hard-to-treat RA and find clues to better personalize their care. Participants will be …

This study looks at whether palliative and supportive care, usually given to people near the end of life, could also help those with long-term inflammatory arthritis like rheumatoid arthritis. Researchers will interview patients and survey healthcare professionals to understand u…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biomarkers that predict how well a patient responds to treatment. The …

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This pilot study will enroll 600 people getting total knee replacements to test a data platform called Pheno4U. Participants will use a sensor and a smartphone app to track their recovery. The goal is to identify unknown risks or side effects and improve personalized care. The st…

This study follows about 70 people who have already received KYV-101, a CAR T-cell therapy, for autoimmune diseases like lupus and multiple sclerosis. Researchers will monitor participants for up to 15 years to track any delayed side effects, new cancers, or other health problems…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study will follow 300 people with knee osteoarthritis or chronic inflammatory arthritis for up to 10 years. Researchers will collect blood, joint fluid, and platelet-rich plasma samples to look for biomarkers linked to pain, joint damage, and the need for knee replacement. T…

This study is for people with rheumatoid arthritis who are starting a drug called abatacept (Orencia). Researchers want to see how this drug changes certain immune cells (T and B cells) in the blood over 6 months. They will compare these changes to those in people taking other ar…

This study looks at how genetic differences influence the effectiveness and side effects of leflunomide, a common rheumatoid arthritis drug. Researchers will recruit 110 Pakistani patients starting leflunomide and track their disease activity and side effects over six months. By …

This study looks at why people with rheumatoid arthritis often have trouble controlling high blood pressure, which raises their risk of heart disease. Researchers will work with 25 adults to test a program that helps them monitor their blood pressure and share results with their …

This study is for 75 adults with rheumatoid arthritis whose current treatments have stopped working. The goal is to learn how to match each patient to the most effective drug for them, using advanced computer analysis and health data. This is a research study to gather informatio…

This study uses special PET scans to track where an experimental drug called CIT-013 goes in the body of people with rheumatoid arthritis. The drug aims to calm inflammation caused by immune cell traps. About 12 people aged 60-85 will receive a radioactive version of the drug and…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study collects blood and optional spinal fluid samples from 350 people with Parkinson's, ALS, glioblastoma, certain cancers, or rheumatoid arthritis. The goal is to find new genetic markers that could lead to better diagnostic tests for autoimmune encephalitis and paraneopla…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study looks at whether standard breathing exercises and extra muscle-strengthening breathing training can affect a specific gene (HOTAIR) in people with rheumatoid arthritis who also have lung disease. Researchers will compare two groups: one doing standard rehab and one add…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and Crohn's disease. Researchers will take a blood sample and expose the cells to different cannabis ext…

This study will observe 800 adults with rheumatoid arthritis in Austria to create a standard screening method for lung complications. Researchers will use CT scans, lung function tests, and AI analysis to identify those at high risk. The goal is to detect lung problems earlier an…

This study is testing a French version of a questionnaire that measures how well people with rheumatoid arthritis follow their medication plan. Researchers will enroll 150 adults who have been on a stable dose of methotrexate for at least a month. The goal is to make sure the que…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study is testing two different ways to slowly reduce the dose of the steroid prednisone in people with rheumatoid arthritis. One group will taper over 15 days, the other over 150 days. Researchers want to see who develops symptoms or flare-ups during the taper, and why. The …

This study looks at whether adding a family doctor to a rheumatology team can improve care for other health issues in people with rheumatoid arthritis. About 199 adults with rheumatoid arthritis will have their vaccination, heart, and bone health checked by a special family docto…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study looks at whether drugs with anticholinergic effects increase the risk of bone fractures in people with rheumatoid arthritis. Researchers will track 100 patients, measuring their medication burden and bone density. The goal is to better understand how these commonly use…

This study will examine chest CT scans from 500 adults with rheumatoid arthritis, connective tissue diseases, or idiopathic pulmonary fibrosis to better understand lung disease patterns. Researchers want to see which scan features are most common in rheumatoid arthritis-related i…