Injury

This phase 2 trial tests whether a topical cream containing ruxolitinib (OPZELURA) can completely heal painful ulcers in adults with pyoderma gangrenosum, a chronic inflammatory skin condition. About 12 participants will apply the cream twice daily for 24 weeks while continuing s…

This study tests whether bimekizumab, a drug already approved for other skin conditions, can help heal wounds in people with pyoderma gangrenosum (PG), a rare and painful skin disorder. Adults with PG will receive injections of bimekizumab every few weeks for 24 weeks. The main g…

This trial tests whether a lab-grown blood vessel called SYMVESS can safely repair damaged arteries in the arms or legs of adolescents when their own veins aren't suitable. The study enrolls teens up to age 17 with severe arterial injuries that threaten limb loss. Participants re…

This study is testing a lab-grown blood vessel called Symvess in adults who have suffered a serious injury to an artery in their arm or leg. The goal is to see how well the vessel stays open and functions over a year, and whether it helps avoid amputation and infection. Participa…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This trial compares two ways to humidify air for trauma patients on prolonged mechanical ventilation: active heated humidifiers and passive heat-and-moisture exchangers. The goal is to see which method reduces airway complications like mucus plugs and tube blockages, and improves…

This study tests whether MDMA, combined with a type of talk therapy called Acceptance and Commitment Therapy (ACT), can help treat post-traumatic stress disorder (PTSD) in military service members. Participants receive either a full or low dose of MDMA during therapy sessions. Th…

This study tests whether Bioptron light therapy, a type of polarized light, can improve wound healing in women who have had a cesarean section. Thirty women will receive either standard postoperative care or standard care plus daily 15-minute light sessions for five days. Researc…

This study tracks the safety and effectiveness of a stent graft device used to treat aneurysms, dissections, or trauma in the aortic arch (the curved part of the main artery from the heart). Researchers will follow 75 patients in Japan who receive the device, monitoring for compl…

This study looks at whether a specific type of breathing support (adaptive support ventilation) combined with carefully controlled fluid replacement can help adults with severe burns who need a breathing machine. The goal is to see if this approach improves oxygen levels, lung fu…

This trial tests whether closing the surgical wound immediately after cleaning it with a special high-pressure irrigation technique (HIEDI) is as good as or better than waiting a few days to close it. The study involves 200 people aged 12 and older who have open surgery for compl…

This trial tests a culturally adapted program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) for trauma patients who drink alcohol. Emergency department staff in Cameroon will screen patients for risky drinking, offer a short motivational counseling sessi…

This study will test a new powered prosthetic hand system called Point Powered in 10 adults who have lost part of their hand. The device uses muscle signals to control moving fingers. Researchers will compare it to each person's current prosthetic to see if it improves hand funct…

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This pilot study will test a program that combines a trauma-focused therapy (STAIR) with peer-led HIV prevention (PrEP) support for transgender and nonbinary people who have experienced violence. The goal is to see if this combined approach is acceptable, feasible, and helps impr…

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study looks at whether spraying a patient's own skin cells onto second-degree burns, followed by a biological dressing, helps wounds heal faster and with less scarring. About 386 people will take part across multiple hospitals in China. Researchers will compare those getting…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study tests if a new surgical method—gently stretching the bone under the wound and then placing a skin graft—can help diabetic foot ulcers heal better than skin grafts alone. About 104 adults with hard-to-heal foot sores will be randomly assigned to get either the combined …

This early-stage trial tests a lab-grown penile tissue made from a man's own cells to repair severe, irreversible damage to the penis. Ten men aged 18-60 who have failed standard treatments will receive the implant. The main goal is to check safety, not effectiveness.

This study is testing a new dressing called ConvaNiox that releases nitric oxide to help heal diabetic foot ulcers. About 102 adults with diabetes and a foot ulcer will receive the dressing along with standard care. Researchers will measure how much the wound shrinks over time an…

This study looks at a new surgical technique to repair deep cuts in finger tendons without using a splint afterward. Forty adults will have the surgery and start moving their fingers gently right away. The goal is to see if this approach leads to better hand movement and strength…

This study tests whether tranexamic acid (TXA), a drug that helps stop bleeding, can improve recovery in 2000 severely injured children with brain or torso injuries. The goal is to see if TXA reduces bleeding and improves quality of life and thinking skills. The trial is for chil…

This study tests whether giving magnesium sulfate early through an IV can reduce dangerous narrowing of brain arteries after a traumatic brain bleed. About 50 adults with head injuries will receive the treatment within 24 hours. The goal is to see if it lowers the risk of delayed…

This Phase 3 trial will test whether a graft made from donated amniotic tissue can help heal chronic wounds like diabetic foot ulcers and venous leg ulcers better than standard care. About 600 adults with wounds that haven't healed in 4 weeks will take part. The study will measur…

This study tests whether giving dry plasma to people with massive bleeding before they reach the hospital can improve survival. Researchers will compare dry plasma to standard fluids in 650 adults with signs of bleeding shock. The main goal is to see if more people survive the fi…

Severe bleeding after trauma can cause shock, and doctors often give IV fluids to stabilize patients. But only about half of unstable patients improve with fluids, and giving too much or too little can cause harm. This study compares two bedside ultrasound methods, one measuring …

This study tests a blue dye called Bludigo® to help surgeons see if the tubes from the kidneys to the bladder (ureters) are open during surgery in children. About 18 children under 17 will get the dye through an IV, and surgeons will watch for blue urine to confirm the ureters ar…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This study tests whether repositioning a breathing tube every 4 hours versus every 8 hours can prevent mouth injuries in ICU patients. 230 adults on ventilators will be randomly assigned to one of the two schedules and monitored for 14 days. The goal is to find a clear time guide…

This study tests a short, 4-session therapy for burn survivors and their caregivers to prevent posttraumatic stress disorder (PTSD). The therapy, called Promotion of Emotional Disclosure for Burns (PoED-B), helps patients and their loved ones communicate better about the traumati…

This study tests whether a single dose of cold atmospheric plasma applied to the wound during groin surgery can prevent healing complications in 214 high-risk patients with peripheral artery disease. Half will get the real plasma device, half a sham device. Researchers will track…

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This study tests whether a 4-hour resilience workshop can prevent PTSD and depression in 800 first responders in New York and Texas. Participants will be randomly assigned to the workshop or a control group and followed for one year. The goal is to see if the training helps them …

This study tests whether giving anti-epileptic drugs right after a traumatic brain injury can prevent seizures. About 70 adults with moderate to severe head injuries will receive either the drug or standard care. Researchers will track seizure episodes and recovery over 3 months …

This study tests a program where nurses talk to parents of hospitalized children about safely storing firearms and offer free cable locks. The goal is to see if this brief conversation changes how parents store guns at home, potentially preventing accidental shootings and suicide…

This study will test whether an 8-week personalized exercise program can reduce injury risk in 100 university basketball and volleyball players. Athletes who score below certain thresholds on balance, strength, and flexibility tests will receive tailored exercises. Researchers wi…

This study tests whether combining square stepping exercises with BOSU ball training can improve balance and strength in badminton players. Sixty-six players with at least one year of experience will do these exercises for 8 weeks. The goal is to see if this combo helps prevent c…

Researchers at the University of Alabama at Birmingham are testing whether a ketogenic tube feeding, high in fat and low in carbohydrates, is safe and practical for adults aged 55 and older hospitalized with traumatic injuries. They compare it with standard hospital tube feeding …

Researchers at the Medical University of South Carolina are testing a program that adds community health workers to standard trauma recovery services. The study enrolls 100 adult trauma patients who screen positive for PTSD or depression risk and report at least one unmet social …

This trial tests whether using a weighted blanket during a hospital stay can reduce pain and anxiety in adults recovering from traumatic injuries. Half of the 50 participants will receive a weighted blanket, while the other half gets a standard hospital blanket. Researchers will …

This study tests a stepped-care version of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for children with elevated traumatic stress symptoms. The therapy is delivered in pediatric primary care, with intensity matched to each child's needs and caregiver involvement. Resear…

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pa…

This trial compares two types of continuous nerve block catheters—erector spinae plane (ESP) and serratus anterior plane (SAP)—for managing pain in people with traumatic rib fractures. The goal is to see which provides better pain relief, reduces opioid use, and improves breathin…

This study tests a new AI-assisted computer mouse designed to reduce hand movements for people with carpal tunnel syndrome or hand/wrist injuries. Participants complete short computer tasks using both a regular mouse and the AI-mouse while researchers measure muscle activity, pai…

This study develops and tests a program called MBCT-TIP, which combines mindfulness-based cognitive therapy with trauma-informed care for adults who have chronic pain and a history of intimate partner violence. Participants attend eight weekly group sessions and complete assessme…

This study compares two web-based writing programs—compassion-focused and reflective—to see if they improve psychological well-being, self-compassion, and reduce trauma-related stress in midwives working in delivery rooms. About 90 female midwives in Turkey will participate. The …

This study tests whether using ozonated soap and oil after open abdominal surgery leads to better scar quality than standard care alone. About 144 adults having scheduled abdominal surgery will be randomly assigned to either add the ozonated products to their usual wound care or …

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study tests whether a trauma therapy program can help children aged 10 to 17 who have been bullied because of their weight. The therapy is based on Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) and aims to reduce emotional distress, improve body image, and address eat…

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This study tests whether injecting a woman's own platelet-rich plasma (PRP) into an episiotomy cut right after childbirth can improve healing and reduce pain. Two hundred women will be randomly assigned to receive either PRP or standard wound care. Researchers will check wound he…

This study will test a special hydrogel patch containing dexpanthenol (a form of vitamin B5) on small, controlled scrapes in 40 healthy adults. Each person will have two identical scrapes on their forearms: one treated with the new patch and the other with a standard plaster. Res…

This early-stage study tests a gel called LUT017 on small skin wounds from mole removals in healthy adults. Each person gets the gel on one wound and a placebo on another to compare healing. The goal is to see if the gel is safe and might help wounds close faster. Only 9 people w…

This study compares two different skin incisions used during surgery to repair a cut tendon in the finger. Seventy patients will be randomly assigned to receive either a standard zig-zag cut or a modified side zig-zag cut. Researchers will measure pain, swelling, and finger movem…

This study tests whether using a fractionated CO₂ laser on wound edges during Mohs skin cancer surgery can improve scar appearance. Fifty adults having Mohs surgery will have half their wound treated with the laser and the other half left untreated. Researchers will compare scar …

This study will test whether a daily aromatherapy massage, combined with a sensory stimulation program, can improve cognitive function in intensive care patients with brain injuries. Sixty adults on ventilators or oxygen will be randomly assigned to receive the treatment from a f…

This study tests whether adding emotional and social support to standard medical care helps people recover from moderate to severe orthopedic injuries. It involves 804 patients, their care partners, and healthcare workers across multiple hospitals. The goal is to reduce anxiety a…

This study tests whether a special yoga program designed for trauma survivors can reduce trauma symptoms, improve emotion control, and increase body awareness in young women aged 18-25. About 46 women with high trauma scores will be randomly assigned to either the yoga group or a…

This study will compare two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after rib fracture surgery. About 60 adults will take part, and researchers will measure pain levels, opioid use, and side effects. The goal is to find a safer, more effective…

This study compares four types of stitches used after minor oral surgery to see which ones cause the least pain and discomfort. Sixty adults will receive all four suture materials in different parts of their upper jaw and report their experiences over two weeks. The goal is to he…

This study tests whether placing a thin layer of the patient's own fat under a skin graft on the penis leads to better healing, feel, and function. Twenty-four men scheduled for reconstructive penile surgery will be randomly assigned to receive either the standard skin graft alon…

This study tests a single 90-minute therapy session for teens aged 13-18 who have experienced trauma and are waiting for longer treatment. The session teaches coping skills and understanding of trauma cues. About 40 teens in New Zealand will take part to see if this approach is p…

This study will see if adding a cold plasma device to standard scar care helps improve scars like keloids, burn scars, and acne scars. About 800 people will take part, with half getting standard care plus plasma and half standard care alone. Researchers will track changes in scar…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This early-phase study tests whether applying cannabidiol (CBD) with silicone ointment helps scars heal better after paramedian forehead flap surgery. Twenty-two adults will have half their scar treated with CBD plus silicone and the other half with silicone alone. Researchers wi…

This study tests whether 8 sessions of cognitive processing therapy (CPT), delivered online, can help women and birthing people who have post-traumatic stress disorder (PTSD) from a traumatic childbirth. The trial will enroll 29 participants to see if the therapy is practical, ac…

This study tests whether injecting a patient's own fat into chronic wounds can reduce pain better than standard wound care alone. Sixty-two adults with wounds lasting over 3 months will be randomly assigned to receive either fat grafting plus standard care or standard care only. …

This study tests a personalized version of a therapy called Stepped Care Cognitive Behavioral Therapy for children who have experienced trauma. The therapy is adapted for Latino families and involves caregivers helping their children through a step-by-step process. Researchers wi…

This pilot study tests a personalized version of stepped-care cognitive behavioral therapy for PTSD in Latino children aged 7-12. The therapy involves a caregiver-led first step with therapist support, followed by more intensive therapy if needed. The goal is to see if adapting t…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

This study tests whether a type of talk therapy called narrative exposure therapy (NET) is practical and helpful for people with psychosis who have experienced trauma. One participant will receive NET sessions and complete questionnaires about their symptoms and experiences. The …

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This Phase 2a trial will test whether PT150, a drug that blocks a stress-related receptor, can safely reduce PTSD symptoms in 120 US veterans. Participants will receive either PT150 or a placebo for several weeks, and researchers will track changes in PTSD severity and side effec…

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

This study compares a modern silver foam dressing to a traditional dry silver dressing for chronic wound infections. Researchers will track how much the wound shrinks in two weeks and how many wounds fully heal. The goal is to find which dressing works better and costs less for p…

This pilot study tests whether a mobile health app with step-by-step exercise videos can help people recover better after a proximal humerus (shoulder) fracture. Sixty adults with this injury will be split into two groups: one gets standard care, the other gets standard care plus…

This study tests whether task-oriented exercises and mirror therapy can help people regain hand function after flexor tendon repair. 66 adults aged 18-45 will do specific hand tasks and use a mirror to trick the brain into thinking the injured hand is moving normally. The goal is…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

Researchers at Radboud University Medical Center are asking what adults with serious trauma injuries and financial concerns need from physical therapy. The study includes 17 people in the Netherlands who were injured between three months and two years earlier. Through interviews,…

Researchers at the University of Nebraska are studying how older adults heal after having a back tooth removed. Participants will provide saliva, gum fluid, and blood samples before the extraction, then return for checkups at 1 week, 2 weeks, and 3 months to track healing and bon…

Researchers are studying whether adding the FOUR Score, a detailed measure of consciousness, to four existing trauma scoring systems improves their ability to predict death in adult trauma patients. The study enrolls about 2,000 injured adults across multiple hospitals. Participa…

Researchers want to understand what concerns trauma patients most right after an injury. The study enrolls 300 adults who arrive at the emergency department with an acute injury and are stable enough to take part. Participants fill out a questionnaire about their stress, pain, an…

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

Researchers are testing whether standard blood tests can indicate the quality of stem cells taken from the heel bone during foot or ankle surgery. The study includes adults aged 40 to 80, some with type 2 diabetes and diabetic foot ulcers. Before surgery, participants give blood …

This study surveys physiotherapists and team doctors in Sweden's top ice hockey leagues to understand how they perceive and manage hand and wrist injuries. About 50 medical staff will answer questions on injury frequency, underreporting, and return-to-play decisions. The goal is …

This study will use DEXA bone scans to see how the CoreHip hip replacement stem affects bone density around the implant over two years. Forty adults with hip arthritis or other hip conditions will be enrolled. The goal is to understand if the implant's design helps maintain healt…

This study aims to see if it's possible to set up a long-term monitoring program for French soldiers who were physically injured in combat. Researchers will follow about 20 wounded veterans to track their health over time, including quality of life and physical function. The goal…

This study tests a non-invasive decision support system called CRUISE that helps medics identify and manage shock in critically ill adults during helicopter transport. Researchers will compare the system's recommendations to standard care given by paramedics. The goal is to see i…

This study looks at how body weight affects healing after gum graft surgery, where tissue is taken from the roof of the mouth. Researchers will compare two wound treatments: a standard collagen plug and a clot made from the patient's own blood, called platelet-rich fibrin (PRF). …

This observational study looks at whether a woman's natural hormone levels, particularly estradiol, influence how well surgical wounds heal after breast reduction surgery. Researchers will measure hormone levels on the day of surgery and check wound healing 21 days later. The goa…

This study follows 500 adults with open limb injuries from drone attacks to understand why some develop severe wound infections. Researchers will collect detailed medical data to link the extent of tissue damage with infection outcomes. The goal is to improve early identification…

This study looks at whether a gel made from polynucleotides and hyaluronic acid can help gum tissue heal better after a graft is taken from the roof of the mouth. Fifteen adults with gum recession will have grafts taken from both sides of their palate in two separate surgeries, n…

This study will see if using a Garmin smartwatch to continuously track heart rate, breathing rate, and oxygen levels can help doctors spot early warning signs in hospitalized children in Ghana. About 250 children with traumatic injuries or after appendix surgery will wear the wat…

This study looks at how emotional childhood maltreatment (like verbal abuse or neglect) affects social skills, brain structure, and inflammation in people with bipolar disorder. Researchers will compare 80 people with bipolar disorder and 80 healthy controls, using brain scans, b…

This study will follow 200 young male soccer players from Villarreal CF for up to 4 years to understand why some get ACL injuries. Researchers will analyze how they jump, their heart rate, genes, and gut bacteria. The goal is to create a tool that gives each player a personalized…

This study looks at how different ways of packaging a person in a rescue litter affect their breathing. Researchers will measure lung function in 24 healthy adults while lying down, on their side, and upright in a vacuum mattress. The goal is to find the best position to keep air…

This study looks at how environmental factors like heat, cold, and pollution affect wounds, mental health, and drug use in homeless people in Augsburg. Researchers will compare wound care from a mobile unit to a hospital clinic, and use saliva tests to check drug use. The goal is…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study tests a program called EMBER designed to help women who have experienced intimate partner violence build resilience and improve their well-being. Eight women will take part in the program and answer weekly questionnaires about their resilience and health. Researchers w…

This study looks at how well hospitals with limited resources treat severe bleeding from torso injuries. Researchers will track 716 adults to see if delaying fluid resuscitation affects survival and complications. The goal is to learn what works best in these settings, not to tes…

This study will test a new positioning aid called Tru-Vu that helps radiographers take clearer wrist x-rays. About 1,800 adults with wrist injuries or arthritis will be included across three different healthcare centers in Newfoundland and Labrador. Researchers want to see if the…

This study will follow 100 people getting a total knee replacement to see if those with chronic venous insufficiency (poor blood flow in leg veins) have more wound healing problems. Participants will have an ultrasound before surgery to check their veins and then be monitored for…

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This study looks at whether giving both food assistance and psychological counseling helps young adults aged 18-25 who face food insecurity and mental health issues. Participants will receive weekly food aid for a year, and half will also get twice-monthly therapy for six months.…

This study tests a digital tool called WoundPilot that guides nurses through wound assessment and treatment choices. Forty primary care nurses will review wound cases with or without the tool, and their decisions will be compared to expert recommendations. The goal is to see if t…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This observational study will follow 250 adults treated in the emergency department for major trauma. Researchers want to see if early factors like thinking flexibility, social support, and stress levels can predict who develops PTSD within 6 months. Participants fill out questio…

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study looks at whether early ultrasound scans of burn scars can predict which patients will have persistent pain 3 to 6 months later. Researchers will measure scar thickness, blood flow, and nerve involvement in 150 adults with blast or drone-related burns. The goal is to id…

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study will see if using virtual care technologies in hospital units can reduce problems like patient falls, infections, and readmissions, while also improving patient satisfaction. About 10,000 adults admitted to six hospital units will take part, with three units using the …

This study looks at how athletes at risk for patellar tendinopathy (jumper's knee) move during jumps. Researchers will use a camera system to track knee, hip, and ankle angles in 60 male athletes over 12 months. The goal is to find early movement changes that could lead to better…

This study will test a new classification system (BICEP) to grade bladder injuries that happen during a common surgery for bladder cancer called TURBT. Researchers will observe 1,000 patients to see how often injuries occur, how severe they are, and how doctors manage them. The g…

This study follows 40 adults with serious burn injuries to collect blood, tissue samples, and medical record data. Researchers will look for patterns that could help predict who will develop sepsis or other complications. The goal is to build a computer-based 'digital twin' model…

This study follows 80 adults with serious burns to understand how their bodies respond to injury and treatment. Researchers collect blood and tissue samples and review medical records to find patterns that might predict sepsis and other complications. The goal is to build compute…

This study looks at whether activating the breathing muscles can help professional male football players recover better after exercise. Thirty players will be randomly assigned to one of three groups: electrical stimulation of the phrenic nerve, deep breathing against a resistanc…

This pilot study will look at how well bone heals after a tooth is removed and a bone graft is placed, comparing smokers and non-smokers. Twelve adults will be enrolled to measure bone width and height, and analyze gene activity and tissue samples. The goal is to gather initial d…

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study examines how much the tensor fascia latae muscle is damaged during hip replacement surgery through the front approach. Researchers will compare the amount of muscle damage to how well patients recover at 6 weeks and 6 months. The goal is to understand if less muscle da…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study tests whether a special training package and checklist can help doctors better identify serious injuries on CT scans of trauma patients. About 300 medical professionals will review sets of scan images, some with the checklist and some without. The goal is to see if the…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study looks at 126 adults with serious injuries from accidents or violence. Researchers want to see if a simple ultrasound of a large vein (the IVC) can detect low blood volume as reliably as a standard blood test (lactate). If the two measures match, doctors might use the u…

This pilot study tests a 3-5 minute recorded message called PEACE, designed to improve mental wellbeing and public attitudes toward reintegrating former Boko Haram members in Nigeria. Researchers will enroll 74 adults to see if the intervention is acceptable and feasible. The goa…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…