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Can a Blood-Based clot improve mouth healing in people with obesity?

NCT ID NCT07756112

Knowledge-focused Sponsor: University of Iowa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study looks at how body weight affects healing after gum graft surgery, where tissue is taken from the roof of the mouth. Researchers will compare two wound treatments: a standard collagen plug and a clot made from the patient's own blood, called platelet-rich fibrin (PRF). Participants will be grouped by weight (obese or normal) and randomly assigned to receive one of the two treatments. The goal is to see if PRF works as well as the standard care and to understand how obesity influences the healing process.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich fibrin (PRF) clot, a healing material made from the participant's own blood, compared to the standard-of-care collagen plug.
What this could lead to
If PRF proves as effective as collagen plugs, it could offer a natural, personalized option to improve healing after gum grafts, especially for people with obesity.
What could go wrong
This is an early-stage study with a small number of participants, and results may not apply to everyone. Healing outcomes can vary widely, and PRF may not show a clear benefit over the standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 104 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Be an adult who is having tissue taken from the roof of the mouth as part of a gum graft procedure. * Be able and willing to give informed consent on their own. * Have good oral hygiene (keep their teeth and gums clean). * Have a healthy roof of the mouth with no unusual shape, disease, or injury. * Not have any active illness affecting their overall health. * Not have a medical condition that can slow wound healing, such as uncontrolled type 2 diabetes. * Not currently pregnant. * Not have received a blood transfusion in the last 3 months. * For normal-weight group (BMI less than than 30 kg/m2, waist circumference less than 35 inches for women or greater than 40 inches for men) or for obesity group (BMI greater than 30 kg/m2, waist circumference greater than 35 inches for women and greater than 40 inches for men). Exclusion Criteria: * Are unable or unwilling to provide your own informed consent. * Take medications that may affect healing or require changes to the planned surgery. * Have a history of alcohol or drug abuse. * Currently smoke or have smoked in the past. * Have had surgery before in the area where the current procedure will be performed. * Have a history of an autoimmune disease or condition.

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Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Wound healing

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Iowa College of Dentistry and Dental Clinics

    Iowa City, Iowa, 52242, United States

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