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Brain injury patients may avoid seizures with preventive drugs

NCT ID NCT07535736

Prevention Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving anti-epileptic drugs right after a traumatic brain injury can prevent seizures. About 70 adults with moderate to severe head injuries will receive either the drug or standard care. Researchers will track seizure episodes and recovery over 3 months to see if early treatment helps.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Study Population: Patients with TBI admitted to the hospital and evaluated clinically and radiologically on admission. A complete assessment will include: * Medical history (age, gender). * Physical examination (temperature, blood pressure, heart rate, respiratory rate, chest auscultation) * Glasgow Coma Scale (GCS). * Laboratory tests (complete blood count, sodium, potassium, blood urea nitrogen, creatinine, hepatic profile). * Brain computed tomography (CT). * Clinical monitoring, including antiepileptic drug dosing, adverse events, and mortality during hospitalisation.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with a confirmed diagnosis of traumatic brain injury (clinical and/or radiological), including both surgical and conservative management 2. Admission within 24 hours of injury 3. Eligible for antiepileptic prophylaxis according to clinical guidelines 4. Written informed consent obtained. Exclusion Criteria: 1. Pre-existing epilepsy or seizure disorder. 2. Seizure episode before or during admission unrelated to acute TBI. 3. Prior use of antiepileptic drugs before admission. 4. Severe renal impairment (creatinine clearance \<30 mL/min). 5. Hepatic failure. 6. Pregnancy or lactation. 7. Known hypersensitivity to antiepileptic drugs

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Conditions

The condition(s) this trial relates to.

brain injury injury traumatic brain injury post-traumatic epilepsy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antiepileptic efficacy and safety Brain injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.