Institut National De La Santé Et De La Recherche Médicale, France

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at changes after surgery. If successful, this could …

This study is testing whether whole genome sequencing (a complete scan of a person's DNA) can help doctors identify the cause of atypical diabetes—unusual cases that don't fit typical type 1 or type 2 diabetes. Researchers will compare this advanced genetic test to the current st…

This study tests whether combining brain stimulation (rTMS) with a brain-computer interface can help people who had a stroke more than 6 months ago regain arm movement. The brain-computer interface translates thoughts of moving into electrical muscle stimulation. The trial will e…

This study tests whether numbing a nerve in the arm or leg can reduce the severe, hard-to-treat pain some people feel after a stroke. Researchers will give 36 adults either one of two numbing medicines or a saltwater injection, then measure pain changes. The goal is to see if blo…

This study looks at brain activity in a person with a rare genetic condition called PRRT2 mutation, which causes sudden, uncontrollable movements. The participant will undergo brain scans (fMRI and EEG) during and after these episodes, and also when they voluntarily mimic the mov…

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study looks at 174 mothers whose babies were diagnosed with serious heart defects before birth. Researchers will track the mothers' mental health from the third trimester until the baby is one year old, and then test the babies' brain development. The goal is to understand i…

This study uses a special PET scan to look at dopamine pathways in the brains of people who are in a coma after a severe head injury. Researchers will compare three groups: coma patients, patients who have recovered from coma, and healthy volunteers. The goal is to understand how…

This study looks at whether exposure to chlordecone, a pesticide banned in 1993 but still present in the environment, is linked to prostate cancer in men from Martinique. Researchers will compare 3600 men with and without prostate cancer, measuring chlordecone levels in blood and…

This study looks at how imagining movements (mental training) helps healthy adults learn physical skills like finger sequences or arm movements. Researchers use brain stimulation and robotic tools to measure changes in brain activity and performance. The goal is to understand the…

This study aims to find the genetic causes of Developmental Language Disorder (DLD), a condition where children have trouble learning language without other known medical issues. Researchers will analyze DNA from 50 children and their families using advanced genetic tools. The go…

This study follows 500 extremely preterm infants who received paracetamol or placebo in the TREOCAPA trial. Researchers will use a parent questionnaire to assess cognitive development at age 2. The goal is to see if early paracetamol use improves thinking and learning skills in t…

This study tests whether a gentle electrical current applied to the brain (tACS) can improve hand movement in people who had a stroke more than 6 months ago. Researchers will use brain scans and EEG to see how the stimulation changes brain activity. 45 participants (including hea…

This study is recruiting 710 adults with fatty liver disease or alcohol-related liver disease, with or without cirrhosis, to understand why some develop liver cancer. Researchers will analyze genetic markers, immune factors, and imaging data from routine liver biopsies and blood …

This study aims to understand exactly how the drug interferon attacks cancer stem cells in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will analyze blood samples from 80 adults to see why some patients respond well while others do not. T…

This study explores how certain immune cells (MAIT cells) and gut bacteria work together in children who either have type 1 diabetes, are at high genetic risk, or are healthy. Researchers will collect blood and gut samples from 180 children to understand these interactions. The g…

This study looks at how aging changes the way we perceive time. Researchers will use brain scans (EEG, fMRI, and PET) to compare time judgment in healthy young adults (20-35) and older adults (60-85). The goal is to understand the brain mechanisms behind age-related changes in ti…

This study uses virtual reality games and EEG brain scans to understand how people with schizophrenia or bipolar disorder experience the passage of time. Researchers will compare 120 participants (patients and healthy volunteers) as they perform tasks in virtual environments. The…

This study aims to build a database of genetic information from 1,000 people with intellectual disabilities or autism spectrum disorders of known genetic cause. Families will answer online questionnaires to share clinical details, helping researchers understand how different gene…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study looks at immune cells called macrophages in people with ALS, a disease that affects movement. Researchers will compare these cells between ALS patients, healthy people, and those with other motor problems. The goal is to find new targets for future treatments and bette…

This study is looking for new genes and biological markers that cause systemic autoinflammatory diseases (SAIDs), a group of rare conditions that cause repeated fevers and inflammation. Researchers will analyze the DNA and blood of 300 patients to find disease-causing mutations a…

This study aims to understand how our sense of touch works by recording nerve signals in healthy volunteers as they touch different surfaces, temperatures, and textures. Researchers will also test how emotions and age affect touch. The goal is to use this knowledge to create pros…

This study aims to identify genetic factors that affect how severe muscle and heart problems become in people with LMNA gene mutations. Researchers will collect skin and muscle samples from 40 participants and use advanced DNA and RNA analysis to look for protective or aggravatin…

This study looks at how a concussion (mild traumatic brain injury) before age 6 might change brain structure and behavior. Researchers will use MRI scans to compare 30 children who had a concussion with 30 children who had a limb injury. The goal is to better understand the short…

This study aims to test and improve the way 3T MRI scanners capture images of the brain. Researchers will work with 230 healthy adults to optimize scanning sequences, reduce image artifacts, and ensure high-quality data for future research. The goal is to make MRI protocols more …

This study follows 40 men with Fabry disease for three years using a small device implanted under the skin that continuously records heart rhythms. The goal is to see how often dangerous heart rhythm problems occur and how they relate to other changes in the heart and body. No ne…

This observational study will follow 2000 children and adults with imprinting disorders—rare genetic conditions like Silver-Russell and Prader-Willi syndromes. Researchers aim to describe the natural history of these diseases and identify common metabolic profiles, risks for obes…

This observational study will follow up to 1,000 people in France with mucopolysaccharidosis (MPS), a group of rare genetic disorders. Researchers will collect medical data from patient records and ongoing checkups to map how the diseases progress and how current treatments affec…

This study looks at 50 people with OCD or Tourette syndrome to find clear differences between compulsions and tics. Participants wear a smartwatch and a portable brain-wave recorder at home and in the lab. The goal is to help doctors choose the right treatment by using objective …

This study will follow 500 adults and children with Still disease, a rare inflammatory condition causing fever, joint pain, and rash. Researchers aim to compare how the disease affects different age groups, identify early markers, and improve care. No new treatments are being tes…

This study collects blood and tissue samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, such as cell clusters and mouse tumors, to study these diseases and test new treatments. The goal is to improve unders…

This study is for children and adults with interstitial lung disease, a group of conditions that scar the lungs and make breathing hard. Researchers will follow 3000 patients and their relatives for up to 10 years, collecting medical data and genetic information. The goal is to l…

This study follows 800 children born with eye malformations like microphthalmia, anophthalmia, aniridia, or anterior segment defects. Researchers will track their vision, brain development, and overall health for up to 10 years to better predict outcomes. No new treatments are be…

This study aims to understand the full burden of 9 rare skin diseases—including physical, emotional, social, and financial challenges—on patients and their families. Researchers will use special questionnaires to track how these conditions affect daily life and care needs. About …

This study is gathering health and genetic information from 300 people with Primary Ciliary Dyskinesia (PCD), a rare inherited lung condition. Researchers want to identify factors that make the disease more severe, find new genes linked to PCD, and measure how the disease affects…

This European study will follow 400 people with cystinosis, a rare genetic disease that causes cystine buildup in cells. Researchers will collect medical and quality-of-life data to understand how the disease progresses and how care can be improved. The study does not test any ne…

This Phase 1 study is testing whether high doses of the antiviral drug favipiravir are safe and tolerable in healthy volunteers. About 39 participants will receive either favipiravir or a placebo for 14 days, with doses increasing in three groups. Researchers will also measure dr…

This study will use MRI and ultrasound to create detailed reference images of the heart, liver, and blood vessels in 2,400 healthy adults across France. By linking these images with health data, researchers hope to better understand normal aging versus disease, especially for con…

This study is looking at the DNA of 3,800 people with autism to find genetic changes that might be linked to the condition. Researchers hope to better understand which genes are involved and how they affect brain function. The goal is to lay the groundwork for future treatments, …

The CONEXUS study is testing a new type of brain imaging called functional ultrasound (fUS) in 76 newborns at high risk for neurodevelopmental disorders. The technique uses sound waves to measure blood flow changes in the brain, similar to a regular ultrasound but more advanced. …

This study aims to find early markers for ALS by analyzing blood, urine, spinal fluid, tears, and smell tests in 60 people. It includes those with ALS gene mutations but no symptoms, early ALS patients, and healthy controls. The goal is to enable earlier diagnosis and better trea…

This study looks at how trauma experienced by parents can affect their children, both biologically and behaviorally. Researchers will compare families directly exposed to a traumatic event with those who were not. Using brain scans, interviews, and tests, they aim to understand h…

This study follows 1,000 adults who took part in earlier EGEA surveys, comparing those with and without asthma. Researchers will measure heart disease risk markers like the Framingham score and blood biomarkers. The goal is to understand if asthma itself increases cardiovascular …

This study follows 125 women with anorexia nervosa during and after intensive inpatient treatment to understand why relapse happens. Researchers will use brain imaging, genetic tests, and behavioral tasks to look for patterns. The goal is to find factors that help predict who sta…

This study is looking at why the immune system attacks the gut in people with celiac disease and other immune-related gut disorders. Researchers will collect blood and tissue samples from 200 adults to study immune cells and genes. The goal is to better understand what goes wrong…

This study follows 700 people with Alport syndrome, a rare inherited disease that can lead to kidney failure, hearing loss, and eye problems. Researchers will collect health data and samples over time to map how the disease progresses and to find early markers of kidney decline. …

This study follows 7,500 adults who were part of an earlier health study. Researchers will use high-precision ultrasound to measure changes in artery stiffness and thickness over 12 to 16 years. The goal is to understand how arteries age and whether those changes can predict futu…

This study follows 500 adults in France who have either a genetic defect or autoantibodies that weaken their type I interferon immune response. Researchers will collect blood samples and health data over 1 to 4 years to track infections, autoimmune diseases, and cancers. The goal…

This study looks at brain activity in 50 people with epilepsy who already need brain electrodes as part of their care. Researchers add tiny extra electrodes to record signals from single brain cells and brain waves. The goal is to understand what happens in the brain just before,…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…