Institut National De La Santé Et De La Recherche Médicale, France

This early-stage trial is testing a new gene therapy approach for a severe, painful genetic skin condition called Recessive Dystrophic Epidermolysis Bullosa (RDEB). Doctors take a small sample of a patient's skin cells, genetically correct them in a lab to fix the underlying caus…

This large study is testing whether analyzing a patient's tumor genetics can lead to more effective, personalized treatment for advanced soft-tissue sarcoma. About 600 patients will be randomly assigned to either receive treatment based on their genetic test results or receive st…

This study aimed to compare two different vaginal treatments used to soften and prepare the cervix for labor induction in full-term pregnancies. It planned to see which method was more effective at leading to a vaginal birth within 48 hours. The study was withdrawn before any par…

This study aims to create a detailed genetic reference map of the French population. Researchers will analyze DNA from 10,000 people across different regions of France. This map will help doctors filter out common, harmless genetic variations when diagnosing patients, making it e…

This large observational study follows over 10,000 adults in Paris for at least 10 years to understand how heart rate patterns, blood pressure regulation, and artery health affect cardiovascular disease risk. Participants undergo heart monitoring, ultrasound tests, and provide bl…

This study aimed to test a new computer tool designed to measure two key problems in depression: reduced pleasure (liking) and low motivation (wanting). Researchers planned to have people with depression and healthy volunteers look at and compare colorful versus black-and-white p…

This study aims to understand what chemicals and germs women are exposed to while working on dairy cattle farms. Researchers will measure levels of pesticides, disinfectants, and other substances in the urine, hair, and environment of about 60 women in western France. The goal is…

This study aims to understand the natural progression of vascular Ehlers-Danlos syndrome (vEDS), a rare genetic disorder that weakens blood vessels and organs. By observing 340 patients over time, researchers will track the order in which different complications appear and how th…

This study aims to understand the brain basis of social anxiety. Researchers will measure specific slow brain waves in 30 people with social anxiety disorder while they anticipate a stressful social situation. The goal is to see if these brain waves can serve as a biological mark…

This French study aims to understand why multiple sclerosis (MS) progresses differently in different people. Researchers are studying 120 pairs of siblings who both have MS, looking at their genes, immune systems, and brain scans over time. The goal is to find a combination of ma…

This study aims to learn more about LPAC syndrome, a genetic condition that causes painful gallstones. Researchers will follow 650 people with the condition for five years to document their symptoms, test results, and quality of life. The goal is to create a clearer picture of th…