Institut National De La Santé Et De La Recherche Médicale, France

This study aimed to see if teaching people who inject drugs to wash their hands and giving them a single-use alcohol hand rub could lower their risk of skin abscesses. Participants would have been split into two groups: one getting standard harm reduction services plus the hand h…

This trial tests a new approach for recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition that causes fragile, blistering skin. Researchers take a small piece of the patient's own skin, fix the faulty gene in a lab, grow it into a larger sheet, and graft it …

This study aimed to compare a removable vaginal insert containing prostaglandin E2 (PGE2) versus a PGE2 gel for preparing the cervix and starting labor in women with a full-term, single baby in head-down position. The trial was withdrawn before enrolling any participants, so no r…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This study uses brain imaging techniques like MRI and EEG to explore how brain lesions cause cognitive deficits such as reading or visual perception problems. Researchers will study 1,500 patients and healthy volunteers using a detailed single-case approach. The goal is to better…

This study looks at 60 adults with resistant hypertension—high blood pressure that doesn't improve even with multiple medications. Researchers measure artery stiffness using a simple, non-invasive test to see if it can help identify patients who aren't taking their drugs as presc…

This study looks at whether using special personal care products for just 5 days can reduce levels of certain chemicals (phthalates, phenols, glycol ether) in urine. Researchers will track 107 women aged 18-30 in Grenoble, France, measuring chemical levels before, during, and aft…

This study aims to collect DNA from 10,000 volunteers across France to create a reference database of common genetic variations. By sequencing 4,000 of these samples, researchers hope to help doctors filter out harmless genetic changes and focus on those that cause disease. Parti…

This study aims to find a combination of markers—from genetics, immune system, and brain scans—that are linked to how severe multiple sclerosis (MS) becomes. Researchers will follow 120 people with MS and their siblings who also have the condition. Participants undergo neurologic…

This study looks at the chemicals and germs that women working on dairy farms in France may be exposed to through their skin or breathing. Researchers will measure these substances in urine, hair, and feces of about 60 women, as well as in cow hair and air samples. The goal is to…

This study was designed to test a new computer-based tool that uses pictures of food to measure how much pleasure and motivation people with major depression feel. The goal was to compare these responses between depressed patients and healthy volunteers to better understand depre…

This long-term study is following over 10,000 healthy adults aged 50-75 to understand how the body's natural regulation of heart rate and blood pressure relates to future heart disease, stroke, and sudden death. Participants undergo non-invasive tests like a special ECG and carot…

This study looks at whether certain slow brain waves in the prefrontal cortex can be a sign of social anxiety. Researchers will measure brain activity in 30 people with social anxiety disorder while they wait to give a speech. The goal is to better understand the brain's role in …

This study follows 650 children and adults with LPAC syndrome, a rare condition that causes repeated gallstones even after gallbladder removal. Researchers will collect medical history, lab results, and imaging data over 5 years to describe the disease's full range of symptoms an…

This study follows 340 people with vascular Ehlers-Danlos syndrome (vEDS), a rare genetic condition that weakens blood vessels and organs. Researchers will track complications like artery tears, digestive issues, and pregnancy risks to better understand how the disease progresses…