Scientists probe the genetic origins of menstruation by comparing human and primate uterine tissue

NCT ID NCT05412771

Ongoing Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study aims to understand the evolutionary and cellular basis of menstruation, a trait unique to primates. Researchers collect uterine tissue samples from women undergoing surgery for benign conditions and compare them with samples from other primates. By analyzing gene activity and regulatory elements, they hope to identify the genetic changes that led to menstruation and better characterize the uterine lining for future medical insights.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could reveal the evolutionary origins of menstruation and improve understanding of uterine health, potentially informing treatments for menstrual disorders.
What could go wrong: This is a small, observational study focused on basic biology, not a treatment trial. Findings may not directly translate to medical applications.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENSTRUATION

Contacts and locations

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Locations

Pitié salpétrière

Paris, France

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