Institut National De La Santé Et De La Recherche Médicale, France

This study tested a higher dose of a new nasal vaccine (BPZE1) for whooping cough in 54 healthy adults aged 18-32. The goal was to see if the higher dose is safe and helps the vaccine take hold in the nose to trigger protection. Researchers monitored side effects and checked if t…

This study tested an inactivated H1N1 flu vaccine in 122 kidney transplant recipients who were at least 6 months post-transplant and on triple immunosuppression. The goal was to see if the vaccine could safely trigger an immune response. Researchers measured antibody levels and t…

This phase 2 study tested a non-adjuvanted H1N1 flu vaccine in 110 pregnant women to see if it is safe and triggers a good immune response. Participants received two doses of the vaccine and were monitored for side effects. The goal is to protect both mothers and their babies fro…

This study looked at whether combining school education, doctor training, and offering the vaccine at school can increase HPV vaccination among French adolescents aged 11 to 14. Over 30,000 teens from 90 towns took part. The goal was to see if these efforts make more teens get th…

This early-stage study tested a new whooping cough vaccine given as a nasal spray. 48 healthy adult men received either the vaccine or a placebo to check safety and immune response. The goal is to develop a single-dose vaccine that can protect infants from birth, before they get …

This early-stage trial tested a new malaria vaccine called AMA1-DiCo in 66 healthy adults—some in Europe never exposed to malaria, and some in Africa who were. The vaccine was given with one of two adjuvants (GLA-SE or Alhydrogel) to boost immune response. The main goal was to ch…

This early-stage trial tested a vaccine called PRIMVAC, designed to prevent malaria during pregnancy. Researchers gave three different doses to 68 healthy adults in France and Burkina Faso to check safety and immune response. The vaccine targets a protein that helps malaria paras…

This study tests whether combining two types of electrical stimulation can improve hand and arm movement in people who recently had a stroke. One stimulation is applied to the brain (tDCS) and the other to a nerve in the wrist. Participants receive five daily sessions, and their …

This study tested a new way to help broken bones that are taking too long to heal. Doctors took a small sample of the patient's own bone marrow, grew the stem cells in a lab, and then placed them with a special bone-like material at the fracture site. The goal was to see if this …

This study tested whether a special oil called triheptanoin can slow brain damage in people with early Huntington's disease. 100 participants took either the oil or a placebo for 6 months, followed by 6 months where everyone got the oil. The main goal was to see if it reduced bra…

This study tested a malaria drug called artesunate in 20 people with Friedreich ataxia, a rare genetic disorder that affects movement and coordination. The goal was to find a safe dose that could help control iron levels in cells, which may slow the disease. Researchers started w…

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This study tested whether giving C-section newborns a swab coated with their mother's vaginal and perineal fluids could restore the natural gut bacteria they would have gotten during a vaginal birth. Thirty-three mothers and their babies participated, with some babies receiving t…

This early-stage trial tested a single inhaled dose of FLAMOD, a protein that mimics a bacterial signal to activate the immune system, in 46 healthy adults. The goal was to check safety and see if it triggers a local immune response in the lungs. If it works, this approach might …

This study tested whether giving acetaminophen (a common pain and fever medicine) to extremely preterm babies within the first 12 hours after birth can help close a blood vessel in the heart that normally closes on its own. The trial involved 804 babies born between 23 and 28 wee…

This study tested a gene therapy for children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. Five children aged 6 months to 5 years received injections of a harmless virus carrying a working copy of the ARSA gene directly into their brains. …

This study tested a drug called anakinra in 24 children and young adults (ages 2-20) with severe systemic juvenile idiopathic arthritis that did not respond well to steroids. For the first month, half received anakinra and half received a placebo, then all received anakinra for 1…

This study tested a vaccine called Bilhvax, given alongside a standard treatment (praziquantel), to see if it could delay the return of schistosomiasis (a parasitic infection) in children aged 6 to 9 in Senegal. The vaccine was given as three shots plus a booster one year later. …

This study tested whether giving extra support—like cooking classes, motivational talks, and financial help for physical activity—to overweight teens from less advantaged backgrounds helps them manage their weight as well as standard care helps teens from more advantaged backgrou…

This pilot study tested whether triheptanoin oil, a special fat taken by mouth, can reduce the number of sudden paralytic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder. Ten participants aged 15 and older with confirmed ATP1A3 mutation…

This study looked at whether regular follow-up visits with nurses and dietitians help people with type 2 diabetes manage their condition better. 398 adults with type 2 diabetes first received a week of education on diet and exercise. Then half were assigned to frequent check-ins …

This early-phase trial tested whether injecting a man's own bone marrow stem cells into the penis could help restore erections after prostate cancer surgery. The study included 18 men who had normal erections before surgery but developed erectile dysfunction due to blood vessel d…

This completed Phase 2 trial tested the antiviral drug favipiravir in 126 people with Ebola in Guinea. The goal was to see if it could reduce deaths. Participants received high doses of the drug by mouth for up to 10 days. The study aimed to find a practical treatment for Ebola, …

This phase 2 trial tested triheptanoin oil in 20 people with GLUT1 deficiency syndrome, a rare genetic condition that prevents glucose from properly fueling the brain. The goal was to see if this special oil could reduce the number of seizures and abnormal movement episodes. Part…

This early-stage trial tested a DNA vaccine in 10 adults with chronic hepatitis B who had not responded to standard treatments. The vaccine was designed to train the immune system to fight the virus. The main goal was to check safety, with a secondary goal of seeing if the vaccin…

This study compared two antifungal drugs, fluconazole and micafungin, in 100 newborns with suspected or confirmed candidiasis. The goal was to see if micafungin works as well as the standard treatment fluconazole and to check their safety. The study also looked at how the drugs b…

This pilot study tested the safety of giving sitagliptin (Januvia) for three weeks to 14 liver cancer patients before they had surgery to remove their tumors. The idea is that sitagliptin might help immune cells get into the tumor and fight it better. The main goal was to check f…

This study tested whether rapamycin, a drug used in organ transplants, can help people with Inclusion Body Myositis (IBM), a rare muscle disease that causes progressive weakness and has no approved treatment. Forty-four adults with IBM received either rapamycin or a placebo for o…

This phase 2 trial tested three drugs—Xenbilox, Tahor, and resveratrol—in 12 adults with SPG5, a rare genetic condition causing progressive leg weakness. The goal was to lower levels of a toxic cholesterol byproduct called 27-hydroxycholesterol. Each drug was taken for 2 months, …

This study tested whether whole genome sequencing (WGS) can find more genetic causes of intellectual disability than current standard tests. Researchers compared WGS to usual methods in 3825 children and adults with unexplained intellectual disability. The goal was to see if WGS …

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study tested a new MRI technique that lets patients breathe normally during heart scans, instead of holding their breath. Researchers used special software (GRICS) to remove motion artifacts. They compared the free-breathing images to standard breath-hold images in 30 adults…

This study involved 603 hospitalized children aged 2 to 59 months with severe acute malnutrition in Uganda and Zambia. Researchers tested various diagnostic methods—including chest X-rays, lab cultures, and symptom checks—to develop a score that helps doctors decide whether a chi…

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This study tested whether a brain scan (fMRI) can detect early signs of Parkinson's disease by looking at a part of the brain called the superior colliculus. Researchers compared newly diagnosed Parkinson's patients (not yet on medication) with healthy volunteers. The goal is to …

This study looked at whether a protein called EG-VEGF in the blood of pregnant women could predict pre-eclampsia or poor fetal growth. Researchers took blood samples and performed ultrasound scans on 142 women early in pregnancy. The goal was to see if EG-VEGF levels could serve …

This study tested whether a smartphone app called Apneal can accurately diagnose sleep apnea. 491 adults wore the app on their chest during an overnight sleep test, and the app's results were compared to the standard hospital sleep test. The goal is to see if the app can reliably…

This study looked at how well the seasonal flu vaccine works in adults who are hospitalized with severe flu-like illness. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine reduced confirmed flu cases. The goal is …

This study tested whether promoting a free web and mobile tool called StopBlues could reduce suicides and suicide attempts in the general population. Over 100,000 adults in 42 French communities took part, with some communities actively promoting the tool and others not. The goal…

This French study tested whether a patient navigator—someone who calls and guides people through the screening process—could increase participation in colorectal cancer screening. Nearly 29,000 adults aged 50-74 who had not completed screening were included. The goal was to see i…

This pilot study tested a personalized program combining physical activity, cognitive training, and nutritional advice in 210 older adults who were frail or pre-frail. The goal was to see if this multidomain approach could prevent mobility disability, measured by the ability to w…

This study looked at whether taking weekly dance classes for 8 months can help people with Huntington's disease and their caregivers. Researchers measured movement control, emotion, quality of life, and brain changes using tests and MRI scans. The goal was to see if dance trainin…

This study tested whether a blend of online and in-person therapy (called blended CBT) works as well as standard face-to-face therapy for adults with major depression. 105 participants were randomly assigned to either blended CBT or usual care. Researchers measured depression sym…

This study tested whether a mild electrical current applied to the back of the head (cerebellum) can reduce shaking in people with essential tremor. Sixteen adults whose usual treatments weren't working well took part. Researchers measured tremor changes using rating scales and m…

This study tested a device called MyoRegulator® to see if it can reduce muscle stiffness (spasticity) in the lower leg after a stroke. 44 adults who had a stroke at least 6 months earlier took part. Half received real treatment and half received a sham (fake) treatment for 5 days…

This study tested whether a measles vaccine could help control eczema (atopic dermatitis) in adults. Researchers gave 20 adults with moderate-to-severe eczema either the measles vaccine or a placebo and tracked their symptoms for 45 days. The goal was to see if the vaccine could …

This study tested whether combining a drug called galantamine with a specific cognitive training program could improve thinking skills in adults aged 35-70 who had a first stroke 3 months earlier. 47 participants received either the drug or a placebo, plus brain training, and wer…

This study tested whether playing a special video game that involves movement could improve walking and balance in people with Parkinson's disease. Twenty-five patients with stubborn gait problems played either the active game or a placebo game without movement. Researchers measu…

This small pilot study looked at whether caffeine can ease involuntary movements in people with a rare genetic condition called ADCY5-related dyskinesia. Fifteen participants took caffeine and reported how much their symptoms improved. The goal was to see if at least 40% of peopl…

This study tested whether an 8-week mindfulness program could reduce anxiety in 168 older adults who have memory concerns but normal cognitive test scores. Participants were randomly assigned to either mindfulness training or a health education program. The goal was to see if min…

This study tested a program called "Choizitaconso" that teaches people with alcohol use disorder how to control their drinking and reduce harm. About 110 adults took part, learning skills to manage their alcohol use and avoid negative consequences. The goal was to see if the prog…

This study looked at two techniques for removing extra amniotic fluid in pregnant women with polyhydramnios (too much fluid). One method uses a syringe to manually pull out fluid, while the other uses a continuous suction machine. Researchers measured pain, fluid volume removed, …

This study tested whether deep brain stimulation of a specific brain region could improve walking and balance in people with advanced Parkinson's disease. Six participants received both real and sham stimulation in a blinded crossover design. The goal was to see if this approach …

This study tested whether a dietary oil called triheptanoin can improve exercise capacity in adults with McArdle disease, a rare genetic disorder that affects how muscles use stored sugar. Twelve participants received either triheptanoin or a placebo oil for two weeks, then switc…

This small study tested whether a mild electrical current applied to the spinal cord (tsDCS) could help people with primary orthostatic tremor, a rare condition that causes leg shaking when standing. 18 participants received either real or sham stimulation. The main goal was to s…

This completed study looked for genetic changes linked to autism spectrum disorder in over 1,600 participants. Researchers focused on genes involved in brain cell communication, hoping to understand which biological pathways are involved. The goal was to gather knowledge that cou…

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This study followed 324 people who had close contact with a confirmed COVID-19 case to see how long they shed the virus. Participants provided nasal swabs and reported symptoms over 12 days. The goal was to understand transmission risks and help shape public health policies.

This study looked at how the brain uses energy in people with early Huntington disease. Ten adults had an MRI scan to measure brain energy levels while resting and watching flashing lights. The goal was to understand brain metabolism, not to test a new treatment.

This completed study enrolled over 134,000 people aged 15 and older across France to track COVID-19 antibodies and how living conditions affected the epidemic. Participants provided blood samples at home and answered questions about their health, work, and housing. The goal was t…

This study looked at immune cells from 4 healthy people shortly after they got a smallpox vaccine. Researchers wanted to see if these cells already show signs of long-term memory. The goal was to understand how the body builds lasting protection after vaccination.

This study looked at 94 adults to see if following French nutrition guidelines affects blood vessel health. Participants were split into two groups based on their diet quality, and researchers measured artery stiffness and blood flow before and after a standard breakfast. The goa…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This study used advanced MRI scans to look at energy use in the brains of 40 people with multiple sclerosis and 15 healthy volunteers. The goal was to see if energy problems in brain cells can predict nerve damage over two years. Researchers hope this will help understand how MS …

This study looked at how bariatric surgery affects taste receptors and taste perception in 20 obese patients. Researchers measured changes in taste before and 6 months after surgery. The goal was to understand why taste changes happen after weight loss surgery.

This pilot study tested whether wearable sensors can accurately measure apathy in people with frontotemporal dementia. Researchers monitored 14 participants' movements and behaviors in real-life situations. The goal was to see if technology could provide a more objective way to a…

This study used a technique called transcranial magnetic stimulation (TMS) to temporarily quiet specific brain areas in 17 healthy adults. The goal was to see how these areas affect the reflex that keeps your eyes steady when you move your head. The research helps us understand w…

This study followed more than 3,000 adults with moderate to advanced chronic kidney disease (CKD) for up to 5 years. Researchers collected health data and blood/urine samples to identify factors that lead to kidney failure, heart problems, and other complications. The goal was to…

This study looked at 8500 people with intellectual disability to find new genes that might cause it. Researchers used advanced DNA tools to compare patients and their healthy siblings. The goal was to identify unknown genetic causes and improve future diagnosis.

This study collected blood samples from over 2,200 people with Alzheimer's or other dementias, plus healthy volunteers, to search for genes linked to these diseases. Researchers aimed to identify new genetic causes and better understand how genes affect disease risk and progressi…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study tested a decision aid for women with a less active ectopic pregnancy (a pregnancy outside the womb that is not growing quickly). 109 women and their doctors used the tool and then answered questions about how helpful and clear it was. The goal was to see if the tool he…

This study looked at whether advanced genetic testing (called NGS) can be done quickly enough to help guide treatment choices for people with advanced soft-tissue sarcoma. About 600 adults with this rare cancer took part. The goal was to see if using genetic information to pick t…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS) and healthy volunteers. The goal was to see if this inflammation differs between MS types and could serve as an early marker of dise…

This study looks at how alcohol use disorder (AUD) might reorganize the way the brain links words and ideas. Researchers will compare 30 AUD patients and 30 healthy controls using word-association tasks and brain tests. The goal is to see if these mental patterns can help predict…

This study looked at 99 people with high heart risk to understand how a protein called CETP affects plaque buildup in arteries. Researchers measured CETP activity, artery thickness, and calcium scores. The goal was to learn more about heart disease, not to test a new treatment.

This study tested whether methylphenidate (a drug used for ADHD) changes how healthy adults make decisions, put in effort, and learn from rewards. 35 participants completed tasks while on the drug or a placebo. The goal was to understand motivation, not to treat any condition.

This study looks at adults who received low-dose radiation to the brain as children for a non-cancerous skin growth. Researchers want to see if this radiation caused any long-term thinking or memory problems. About 150 participants will take memory and thinking tests to compare t…

This study followed over 3,400 children born very early (before 35 weeks) in France to learn about their health and development. Researchers checked for movement, thinking, and behavior problems when the children were 5 and a half years old. The goal is to better understand the l…

This completed study examined air quality inside airplane cabins during smoke or fume events and whether these events affect the health of flight crew members. Researchers tested 357 crew members with cognitive tests, physical exams, and questionnaires. The goal was to detect any…

This study looked at how blood flow and brain activity are linked in people with CADASIL, a rare genetic disease that causes small strokes. Researchers used MRI and EEG scans to measure these connections in 60 adults. The goal was to better understand the disease, not to test a n…

This study looked at how skin cells from 30 people with recessive dystrophic epidermolysis bullosa (RDEB) grow and repair wounds. RDEB is a rare genetic condition that causes fragile skin and painful blisters. Researchers took small skin samples to study the cells in a lab, aimin…

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study followed survivors of the 2015 Paris terrorist attacks for up to 6 years, using brain scans to see how trauma affects the brain's ability to control unwanted memories. Researchers compared 216 survivors with people who were not exposed to the attacks. The goal was to u…

This study looked at how the brain chemical dopamine behaves in people with idiopathic generalized epilepsy compared to healthy volunteers. Researchers measured yawning and blinking after giving a low dose of apomorphine, a drug that mimics dopamine. The goal was to understand br…

This study examined the DNA of over 2,300 adults who experienced sudden cardiac arrest outside the hospital. Researchers looked for specific genetic variations that might increase the risk of sudden death. The goal is to better identify people at high risk so that future preventi…

This study looked at 16 people with severe facial paralysis to see how their brains change after reconstructive surgery. Using a brain scanning technique called magnetoencephalography (MEG), researchers measured brain activity during facial movements and while recognizing emotion…

This study looked at how many people in homeless shelters in Paris had COVID-19 antibodies after the first wave. Researchers tested 179 residents and staff from three shelters to measure past infections and deaths. The goal was to understand the virus's impact on a vulnerable pop…

This completed study looked at how the cerebellum is involved in movement, thinking, and emotions in people with myoclonus dystonia, a rare movement disorder. Researchers used MRI scans to compare brain activity in 47 participants while they performed small tasks. The goal was to…

This study looked at the DNA of 2500 people, including those with Parkinson's disease and healthy volunteers, to find genetic changes linked to the condition. Researchers focused on specific genes like parkin, DJ-1, PINK1, and LRRK2. The goal was to better understand the disease'…

This study tested whether motivational interviewing—a therapy that helps people find their own reasons to change—can shift brain activity and food choices in people with food addiction. 56 participants, including those with and without obesity, underwent brain scans while making …

This study looked at how nerves in the spine work in people recently diagnosed with ALS compared to healthy volunteers. The goal was to find specific electrical signals that could help doctors understand the disease better and track its progress. 101 participants took part in tes…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers used molecular tests to find active infections and blood tests to check for past infections and immunity. The goal was to understand infection rates, incl…

This study tested whether special sensors could measure changes in urine chemicals to track how chemotherapy affects cancer growth. Researchers collected daily urine samples from 16 people with metastatic colorectal cancer before and after starting chemotherapy. The goal was to s…

This completed study enrolled nearly 97,000 adults from long-running French health studies to track how many people had been infected with the coronavirus. Participants provided blood samples and answered questionnaires. The goal was to measure infection rates and understand what…

This study looked at how Parkinson's disease changes the way people perceive time. Researchers measured eye movements in 40 participants (Parkinson's patients and healthy volunteers) to understand the role of dopamine in timing. Patients were tested both on and off their medicati…

This completed study looked at immune cells in the blood and tumor tissue of 100 people with colon cancer. Researchers measured T cells and other white blood cells to understand the body's immune response. The goal was to gather knowledge, not to test a new treatment. Participant…

This completed study looked at the genetic makeup of liver cancer in 808 patients to better understand the disease. Researchers analyzed tumor samples from people treated with surgery, ablation, or transplant, as well as those with advanced cancer. The goal was to identify key ge…

This study looked at breathing problems in 70 people with severe multiple sclerosis (MS). Participants had sleep and lung tests to check for breathing muscle weakness. The goal was to better understand how MS affects breathing, not to test a new treatment.

This study looked at how brain energy changes in people with Huntington disease. Researchers used a special MRI technique to measure energy-related chemicals in the brain. The goal was to understand the disease better, not to test a treatment. About 50 adults with early-stage Hun…

This study tested two types of non-invasive brain stimulation (called paired associative stimulation) to see if they could help improve hand movement in people who had a stroke. 81 participants (60 stroke survivors and 24 healthy volunteers) took part. The main goal was to unders…

This study looked at Netherton syndrome, a rare genetic skin condition, to better understand how it affects the body and immune system. Researchers studied 18 people with the disease, measuring immune markers in the blood and tracking skin changes. The goal was to find new target…

This study followed 919 pregnant women in Paris to see how often they caught H1N1 flu during the 2009 pandemic and what happened to their pregnancies. Researchers also checked if the flu vaccine was safe. The goal was to better understand the risks of flu during pregnancy.

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This study looked at how people with cervical or myoclonus dystonia perceive their own actions, known as the 'sense of agency.' Researchers used computer tasks and brain scans to measure how accurately participants felt in control of their movements. The goal was to link these fe…

This study measured how children with and without autism look at faces, body movements, and objects using eye-tracking technology. Researchers wanted to see if visual patterns could help understand social differences in autism. 150 children took part, including those with autism …

This completed study observed nearly 27,000 pregnant women in French Caribbean departments during the 2016 Zika epidemic. Researchers tracked Zika infections and their impact on pregnancy, including rates of microcephaly and other fetal abnormalities. The goal was to better under…

This study looked at whether people who have been cured of Cushing's disease for at least a year still have memory problems. Researchers used a special virtual reality test to check memory, along with standard tests. The goal was to better understand these lasting effects and imp…

This study looked at how two brain regions—the cerebellum and striatum—communicate in people with dystonia caused by ADCY5 or PRRT2 gene mutations. Researchers used MRI scans and mild brain stimulation to compare brain activity among patients and healthy volunteers. The goal was …

This study aimed to find genetic markers that could predict which patients will develop vasospasm—a dangerous narrowing of brain arteries—after a bleeding brain aneurysm. Researchers collected blood samples daily from 89 patients for 12 days to analyze their DNA and RNA. The goal…

This study looked at whether a special video game could help improve walking and balance in 10 people with Parkinson's disease who had already had brain surgery. The goal was to see if the game was easy and enjoyable to use. Researchers measured how well participants could walk a…

This study looked at how amyotrophic lateral sclerosis (ALS) affects the brain's ability to process touch and other sensations, even when patients don't notice problems. Researchers used brain imaging and electrical recordings to compare 52 people with ALS and healthy volunteers.…

This study looked at over 1,000 mothers and daughters to understand how bone structure and strength are passed down through families. Researchers compared bone scans and fracture history between mothers who had broken a bone easily and those who hadn't. The goal was to learn more…

This study tested whether special sensors could measure certain molecules in urine to track how cancer treatment is working. Researchers collected urine samples from 32 people with metastatic colorectal cancer and healthy volunteers over two days. The goal was to see if these mol…

This study looked at brain activity in 43 people in a coma after severe brain injury. Researchers used MRI scans to see how different brain regions communicate, aiming to understand what happens in the brain during coma and as people wake up. No treatment was given; the goal was …

This completed study looked at 40 people with spinocerebellar ataxia types 2 and 7, a rare brain disease that affects movement. Researchers used MRI scans and lumbar punctures over one year to track changes in the brain and body. The goal was to find reliable markers that could b…

This completed study looked at how people with autism spectrum disorder (ASD) pay attention to emotional cues and changes in their environment, compared to people without ASD. Researchers used brain imaging (fMRI, DTI) and EEG to measure brain activity in 120 children and adults.…

This study collected umbilical cord blood from 44 newborns whose mothers carry the sickle cell trait. The goal was to study the cells in the lab to better understand the disease and develop ways to modify and preserve them. No treatment was given; this was purely for research pur…

This study looks at how ALS affects the way people start walking and keep their balance. Researchers will compare ALS patients with and without balance issues, plus healthy volunteers, using walking tests and brain scans. The goal is to find out if certain brain changes cause wal…

This study looked at gene activity in the uterine lining during menstruation to understand why humans have periods while some other primates do not. Researchers collected menstrual fluid from 21 healthy women using a silicone cup, a non-invasive method. The goal was to learn more…

This study looked at the brain's lymphatic system in 40 women with idiopathic intracranial hypertension (IIH), a condition causing severe headaches and vision loss. Researchers used a special MRI technique to compare lymphatic vessels in patients and healthy controls. The goal wa…

This study followed 38 adults who survived severe breathing failure from the 2009 H1N1 flu. Researchers compared those who needed a machine to oxygenate their blood (ECMO) with those who did not. They measured lung function, quality of life, and mental health at least 9 months af…

This study used special brain scans (PET imaging) to measure amyloid plaques in 60 people with Alzheimer's disease or related conditions like posterior cortical atrophy and logopenic progressive aphasia. The goal was to understand how age influences the amount of amyloid in the b…

This study followed 364 adults with severe stroke who needed a breathing machine in the ICU. Researchers measured their recovery and disability levels at 3 months and 1 year after ICU admission. The goal was to better understand what happens to these patients over time, not to te…

This completed study in the Democratic Republic of the Congo followed 787 people who survived Ebola and their close contacts. Researchers tracked their health over time, looking for lingering virus, immune responses, and other infections. The goal was to better understand the lon…

This completed study looked at gut bacteria in 90 adults with obesity, type 2 diabetes, or neither. Researchers collected samples from the small intestine and colon during routine endoscopies. They compared these to stool samples to see which bacteria are linked to metabolic heal…

This study takes small tissue samples from people with inflammatory bowel disease (IBD) and healthy volunteers to grow 'mini guts' (organoids) in the lab. Researchers will then expose these organoids to radiation to mimic radiation enteritis and test potential treatments. The goa…

This pilot study tested whether advanced genetic sequencing of tumors can be done quickly enough to guide treatment decisions. Researchers took blood and tumor samples from 24 adults with advanced soft-tissue sarcoma or metastatic colorectal cancer. They measured how long it took…

This study looked at how two different types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive-compulsive disorder (OCD). Thirty-five adults with OCD completed 15 therapy sessions and had brain scans before, during, and after treatment. The goal…

This study looked at how radiation therapy for pediatric brain cancer affects memory and brain structure in children, teens, and young adults. Researchers used MRI scans and memory tests to compare 60 participants. The goal is to better understand which brain areas are harmed by …

This study used fMRI brain scans to understand how shared cultural memories (like collective knowledge of World War II) influence the way individuals form and retrieve their own memories. Twenty-six healthy French adults performed memory tasks while in the scanner, focusing on im…

This completed study looked at how the prefrontal cortex helps us understand analogies and categories. Researchers used brain scans, EEG, and magnetic stimulation in 130 healthy volunteers and patients with frontotemporal dementia or progressive supranuclear palsy. The goal was t…

This study looked at fat tissue from the belly and thighs of 20 healthy women to see if the cells are different. Researchers want to understand why belly fat is linked to health problems while thigh fat may be protective. The findings could help explain how fat distribution affec…

This completed study tested a new ultrasound technique to detect blood flow inside solid bone, which standard ultrasound cannot see. Nineteen healthy volunteers had ultrasound scans of their forearm and shin bone while blood flow was changed using a blood pressure cuff or by chan…

This completed study used eye-tracking to explore how the brain adapts movements in people with dystonia, essential tremor, or Parkinson disease. Researchers measured eye movements before and after a task to look for signs of cerebellar dysfunction. The study included 14 particip…

This completed study looked at how 147 healthy hospital workers responded to the seasonal flu vaccine and the H1N1 pandemic vaccine. Researchers measured antibody and cellular immune responses, focusing on how age and previous flu vaccinations affected those responses. The goal w…

This study investigates how the cerebellum influences brain plasticity in people with dystonia, a movement disorder, and in healthy volunteers. Researchers use non-invasive brain stimulation (TMS) to temporarily change cerebellar activity and measure its effects on brain plastici…

This study uses fMRI to examine how collective cultural memories—like shared knowledge of World War II—influence individual memory recall. Twenty-seven healthy adults who recently visited a war memorial will have their brain activity recorded while remembering pictures from the t…

This study used brain scans and behavioral tests to explore why people with Tourette syndrome often act impulsively. Researchers compared 80 patients (40 on medication, 40 not) with 40 healthy volunteers. The goal was to map brain connections linked to impulsivity, which could he…

This completed study tested nearly 2,800 primary care health workers (like doctors, pharmacists, and dentists) and their household members in France for COVID-19 antibodies. The goal was to find out how many had been exposed to the virus and to understand risk factors. Participan…

This study tested whether healthy volunteers with minimal training could collect their own blood using a finger prick during brief periods of weightlessness on parabolic flights. The goal was to see if the blood samples were good enough to measure caffeine levels. Thirty particip…

This study tested a new laser-based device (Laser Doppler Vibrometer) to measure how stiff the arteries are in 100 people with high blood pressure. The goal was to see if this painless, non-invasive method works as well as the standard techniques (applanation tonometry and echotr…

This study gave 10 healthy volunteers a single dose of 10 common drugs at the same time to see how their bodies break them down. The goal was to measure key factors like drug levels and half-life to understand each person's unique metabolic profile. The results could help persona…

This study looked at whether certain proteins called beta-arrestins can predict how well people with major depression respond to the antidepressant venlafaxine (Effexor). Researchers followed 67 patients for three months, measuring their depression symptoms and checking blood sam…

This study looked at how a common gene variation (TaqIB) affects the function of HDL, or 'good' cholesterol, after a meal. Researchers compared two groups of healthy men with different versions of this gene to see how well their HDL could remove cholesterol from cells. The goal w…

This study looked at how healthy young adults (ages 18-35) suppress negative emotional memories. Researchers used EEG to track brain activity while participants performed memory-suppression tasks. The goal was to better understand the brain's natural ability to forget unpleasant …

This study tested a new, highly sensitive ultrasound technique to map brain activity during surgery in 23 adults with brain tumors or lesions. The method aims to provide real-time images of blood flow changes linked to brain function, without needing contrast agents. Researchers …

This study used advanced MRI scans to look at how water and brain chemicals move in the brain after a stroke. Researchers scanned 24 stroke patients and 24 healthy volunteers to track changes over three months. The goal was to learn more about how brain cells are affected, which …

This study looked at how two brain areas—the cerebellum and the supplementary motor area—help control balance when people start walking. Twenty healthy adults received temporary magnetic pulses to briefly disrupt each brain area, and researchers measured how it affected their wal…

This study tested whether a gentle, non-invasive brain stimulation technique called tDCS could change how the brain controls the diaphragm, the main breathing muscle. Twelve healthy men received three types of stimulation (anodal, cathodal, and placebo) on different days. The res…

This completed study looked at how well the seasonal flu vaccine worked during the 2012-2013 flu season in adults who were hospitalized with flu-like symptoms. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine red…

This completed study compared smell abilities and brain scans between 240 people with bipolar disorder and healthy volunteers. Researchers tested odor threshold, discrimination, and identification to see if smell performance differs and relates to brain structure. The goal is to …