Insel Gruppe Ag, University Hospital Bern

This study looks at whether adding high-dose steroids to standard aspirin treatment helps children who had a stroke due to inflamed brain arteries. About 70 children across 20 hospitals will be randomly assigned to get steroids plus aspirin or aspirin alone. The goal is to see if…

This study looks at whether removing the entire pancreas is better than removing just part of it for people with certain cancers in the head of the pancreas who are at high risk of complications. The main goal is to see if total removal helps patients live longer without hurting …

This study tests whether a fast-acting drug called landiolol can keep heart rate under 90 beats per minute during major surgery, potentially preventing heart injury. About 114 adults aged 45 and older with heart risk factors will take part. The goal is to see if this approach is …

This study tests a simpler approach for people with atrial fibrillation who have had a heart stent. Instead of taking multiple blood thinners together for months, the new strategy uses just one drug at a time: an antiplatelet for the first month, then an anticoagulant alone. The …

This study looks at 320 adults who had a brain bleed (subarachnoid hemorrhage) to see if the type of IV fluid they receive affects their recovery. The goal is to find out if a fluid with a specific salt content can reduce dangerous complications like blood vessel spasms and brain…

This study is for people with atrial fibrillation (an irregular heartbeat) who had a stroke even while taking blood thinners. It tests whether closing a small heart pouch (left atrial appendage) with a device, while continuing blood thinners, can better prevent future strokes, bl…

This study tests whether a computer algorithm can help doctors decide how long patients should take two blood thinners after getting a heart stent. About 2,788 adults who have had a stent placed will be assigned to either standard care or algorithm-guided care. The goal is to see…

This study tests whether placing a balloon in the main artery (aorta) during CPR, along with standard life support, helps restart the heart more often than standard CPR alone. About 98 adults having a cardiac arrest in the hospital will take part. The main goal is to see if the h…

This study compares a new contrast agent, gadopiclenol, to the standard one used in MRI scans for people with suspicious findings in their kidneys or adrenal glands. About 104 adults will be randomly assigned to receive one of the two agents during a single MRI appointment. The g…

This study tests whether a new imaging agent called AzaFol, used with a PET/CT scan, can improve diagnosis of giant cell arteritis (GCA), a condition where blood vessels become inflamed. About 70 adults aged 50 and older with suspected GCA will receive one AzaFol-PET/CT scan. The…

This study tests whether adding a specific laparoscopic stitch (McCall suture) during a routine hysterectomy can prevent the top of the vagina from dropping later on (pelvic organ prolapse). About 114 women having a laparoscopic hysterectomy for non-prolapse reasons will be rando…

This study tests whether an eHealth app that coaches parents can help lower the energy balance in children aged 2-6 who are already above the 97th BMI percentile. About 148 families will be randomly assigned to use the app or receive standard care. The goal is to see if the app c…

This study tests whether an eHealth app can help parents of children under 6 reduce their kids' exposure to second-hand smoke. About 160 families will use the app or receive standard care. The goal is to lower children's urine cotinine levels and prevent asthma and other diseases…

This study compares two long-acting drugs, indapamide and chlorthalidone, to the standard short-acting drug hydrochlorothiazide for preventing calcium kidney stones. About 99 adults who have had at least two kidney stones in the past 10 years will participate. The goal is to see …

This study tests whether a nasal spray containing midazolam can quickly reduce sudden anxiety in adults receiving palliative care. About 36 participants will receive either the drug or a placebo, and researchers will measure anxiety levels before and 30 minutes after treatment. T…

This study looks at whether adding a heat-based treatment (radiofrequency ablation) inside the bile duct is safe for people with advanced bile duct cancer that cannot be removed by surgery. About 36 participants will either get standard care (stent and chemotherapy) or standard c…

This study compares two treatments for insomnia in perimenopausal women: hormone replacement therapy (HRT) and cognitive behavioral therapy (CBT-I). About 54 women will receive either HRT, weekly CBT sessions, or basic sleep tips for 8 weeks. The goal is to see which approach bet…

This study tests whether using a tiny ultrasound camera inside the heart during ablation can reduce or replace X-rays. Ablation uses catheters to fix abnormal heart rhythms, and X-rays are normally used to guide them. Half of the 70 participants will get the ultrasound-guided pro…

This study tests whether a structured 6-8 week exercise and education program, started soon after a hospital stay for a pulmonary embolism (a blood clot in the lungs), can improve quality of life and reduce symptoms like shortness of breath. About 160 adults at higher risk for lo…

This study tests a patient-centered program to help adults aged 65 and older reduce their use of sleeping pills like benzodiazepines. The goal is to improve safety and sleep quality by addressing the challenges of stopping these medications. About 470 participants will take part,…

This study tests a mobile app designed to help children and teens with cancer improve their thinking and physical abilities. The app includes brain games and physical exercises, plus questions to boost self-awareness. Researchers will enroll 40 participants aged 8-16 to see if th…

This study tests whether removing the chest tube on the same day as minor lung surgery is safe. About 304 adults having small lung or chest lining biopsies will be randomly assigned to have their tube removed early or stay overnight. The goal is to see if early removal reduces co…

This study tests whether adding a gentle electrical stimulation glove to standard therapy can improve hand and arm function in children aged 6-18 with hemiparesis (one-sided weakness). For 5 weeks, one group uses the glove at home for 30 minutes a day, 5 days a week, plus their u…

This study tests a new type of deep brain stimulation called Burst-DBS for people with long-term pain after a stroke or facial nerve damage. About 20 adults will receive both the new burst stimulation and standard continuous stimulation to see which works better at reducing pain.…

This study tests a special training program called Mio-Training for children and teens with ADHD. The training combines thinking exercises and physical coordination tasks to improve self-awareness and problem-solving skills. Researchers will enroll 40 participants aged 8 to 16 to…

This study tests whether sleeping on a gently rocking bed (called Somnomat Casa) can help people with Parkinson's disease sleep better and feel better during the day. Fifteen participants will use the bed at home for two months. The goal is to see if the bed is comfortable and ea…

This study looks at how a person's genes and other factors influence pain after surgery. Researchers will follow 5,000 adults having planned operations to see if certain genetic variants are linked to pain levels and painkiller use. The goal is to better understand and potentiall…

This study looks at whether doing core muscle exercises right after abdominal surgery can change the chance of getting an incisional hernia or having long-term pain. About 588 adults having belly surgery will be split into two groups: one doing specific exercises and one getting …

This study is testing whether computer analysis of speech can reliably detect changes in movement, mood, and thinking in people with Parkinson's disease. Researchers will record and analyze voices from 80 participants while they perform tasks, aiming to find patterns linked to me…

This study is a registry that will enroll 816 adults with coronary artery disease. It compares two types of heart scans—CCTA and OCT—to see which one better identifies dangerous plaque and helps doctors plan treatment. The goal is to improve diagnosis and long-term outcomes, not …

This study looks at small molecules called miRNAs in the blood cells of people with septic shock. The goal is to understand why some patients develop a weakened immune system after sepsis. Researchers will compare 56 patients with and without this immune problem to find patterns …

This study looks at whether a new digital education and self-management program is practical and helpful for people with fibrotic interstitial lung disease. About 80 participants will use the program on their phone or computer during rehab or clinic visits. Researchers will check…

This study is creating a large registry of 1,500 people with diabetes in Switzerland to see how well current treatments are working in real life. Researchers will track health over time, including complications, quality of life, and survival. The goal is to understand what helps …

This study is looking at whether a person's genes affect how they recover from surgery. Researchers will track 20,000 adults having surgery to see if certain genetic differences are linked to complications like nausea, pain, or heart problems. The goal is to better understand the…

This study looks at why some stroke survivors develop long-term pain called central poststroke pain (CPP). Researchers will use brain scans to see how brain connections change in people with CPP. The goal is to better understand what causes this pain, which could lead to better t…

This study looks at how well a high-dose eye injection (Eylea 8mg) works in the first two months for people with wet age-related macular degeneration, a condition that causes vision loss. Researchers will use eye scans to measure fluid changes and vision improvements in 50 partic…

This study looks at 200 adults with rectal cancer who had chemoradiotherapy and then chose organ-preserving treatment. Some had a small local surgery to remove the scar, while others did not. Researchers will compare bowel, bladder, and sexual function between the two groups over…

This study looks at whether having surgery to remove a returning glioblastoma brain tumor helps people live longer and feel better compared to not having surgery. About 120 adults whose brain cancer has come back after standard treatment will be randomly assigned to either surger…

This study watches 40,000 adults in European hospitals to see how often breathing tube problems happen during anesthesia. Researchers record patient details and any issues that come up, big or small. The goal is to learn from these events to make anesthesia safer for everyone in …

This study looks at two ways to teach medical residents how to use a special ultrasound technique (VExUS) to check for extra fluid in patients with acute heart failure. About 23 residents will be trained either in-person or remotely, and their skills will be compared to expert do…

This study looks at two ways to check for blocked heart arteries in people getting a new heart valve (TAVI). One way is the usual invasive test, and the other uses non-invasive risk management. The goal is to see which approach leads to better health outcomes over three years. Ab…

This study looks at whether low levels of immunoglobulins (antibodies) are linked to fatigue in people with multiple sclerosis (MS). Researchers will compare fatigue levels and infection rates in 106 MS patients with and without this deficiency. The goal is to understand if treat…

This study looks at whether a structured conversation between doctors and patients helps people with severe aortic stenosis make a better choice between two heart valve replacement options: TAVR (a less invasive procedure) or SAVR (open-heart surgery). About 140 patients aged 70 …

This study aims to make magnetic resonance spectroscopy (MRS) — a technique similar to MRI — more sensitive and reliable for measuring natural chemicals in the body. Researchers will test new methods in about 100 healthy volunteers, including during sleep or after exercise. The g…

This study looks at adults aged 18-70 who have a specific type of broken back (thoracolumbar burst fracture) but no nerve damage. Half will get surgery to fuse the spine, and half will wear a brace for six weeks instead. Researchers want to see if avoiding surgery works just as w…

This study looks at whether adults with Glycogen Storage Disease Type I (GSDI) can safely eat foods with natural fruit sugars (fructose and galactose) without harming their health. Currently, patients must avoid these sugars, which limits food choices. The study will measure bloo…

This study follows 329 adults who have an infection after a hip or knee replacement. Researchers track treatment outcomes to see what helps cure the infection, such as patient health, bacteria type, and treatments used. The goal is to find ways to improve care and increase cure r…

This study tests whether a structured communication protocol called StOP? helps surgical teams talk more clearly during operations. Researchers will compare death rates and other outcomes in 400 patients whose surgeons use the tool versus those who don't. The goal is to see if be…

This study looks at people with small intestinal neuroendocrine tumors that have spread and cannot be fully cured. It compares those who had surgery to remove the main tumor plus other treatments to those who had only other treatments. The goal is to see if surgery helps people l…