Centre Oscar Lambret

This study tested a new way to give radiation for intermediate-risk prostate cancer. 76 men received standard radiation to the prostate and nearby areas, plus an extra, precise radiation boost to the tumor. The goal was to improve cancer control while limiting side effects on the…

This early-phase study tested a combination of two chemotherapy drugs (paclitaxel given weekly by IV and cyclophosphamide taken daily by mouth) in 28 adults with advanced cancer who had no other treatment options. The main goal was to find the safest dose of paclitaxel when used …

This study looked at whether offering a structured program to help patients quit smoking and reduce alcohol use, as part of their initial cancer treatment, works better than just giving advice. It included 133 adults with a first-time head/neck or lung cancer who were still smoki…

This study tested two treatments for people with advanced cancer who had no other options. One group took a low-dose chemotherapy drug (cyclophosphamide) daily, and the other took a hormone pill (megestrol). The goal was to see which treatment could keep the cancer from growing f…

This study tested whether adding the drug nintedanib to standard chemotherapy (docetaxel) helps people with HER2-negative breast cancer that has spread or come back. 51 adults participated. The main goal was to see if the combination slowed cancer growth for at least 6 months. Re…

This study compared two different chemotherapy combinations given with radiation before surgery for people with esophageal or junction cancer. The goal was to see which treatment leads to better tumor removal and fewer serious side effects after surgery. 106 participants were ran…

This study looked at whether taking a break from the chemotherapy drug trabectedin (a drug holiday) is as safe and effective as continuing treatment without a break in people with advanced soft tissue sarcoma. Fifty-three adults whose cancer had not worsened after six cycles of t…

This early-phase study tested a combination of two cancer drugs, imatinib and cyclophosphamide, given continuously at low doses (metronomic schedule) in 26 people with rare, advanced tumors that had no standard treatment options. The main goal was to find the highest safe dose of…

This early-phase study tested a combination of two drugs, Fluvastatin and Celebrex, in 20 children and young adults with certain types of brain tumors (gliomas) that had come back or not responded to standard treatments. The main goal was to find the safest dose of Fluvastatin wh…

This study tested whether adding metformin, a common diabetes drug, to standard chemo-radiation before surgery could improve outcomes for people with locally advanced rectal cancer. 60 participants received the combination treatment. The main goal was to see if the cancer complet…

This study tested a precise type of radiation called stereotaxic radiotherapy (CyberKnife) in 44 adults with early-stage liver cancer that could not be treated with standard methods. Participants received three high-dose radiation sessions over 8 to 10 days. The main goal was to …

This study tested whether the drug regorafenib can help keep metastatic soft tissue sarcoma from growing after initial chemotherapy. 127 adults whose cancer was stable or had shrunk after six cycles of chemo were randomly assigned to take regorafenib or a placebo. The goal was to…

This study tested the drug regorafenib in 219 people with soft tissue sarcoma that had spread and was no longer responding to standard chemotherapy. Participants were randomly assigned to receive either regorafenib or a placebo. The goal was to see if the drug could slow cancer g…

This early-phase study tested the safety of a drug called cilengitide when given together with radiation therapy for children and young adults with a rare, aggressive brain tumor called diffuse intrinsic pontine glioma (DIPG). The main goal was to find the highest safe dose of ci…

This study tested whether adding a targeted drug called bevacizumab to standard chemotherapy (paclitaxel) helps control advanced angiosarcoma, a rare cancer of blood vessels. About 70 adults with inoperable or metastatic disease took part. The main goal was to see how many patien…

This study tested whether a personalized, remote exercise and physical activity coaching program could improve quality of life in women who finished breast cancer treatment. Over 800 women participated, and researchers measured changes in physical and mental well-being after 12 m…

This study tested a special LED lamp to treat painful mouth sores caused by radiation therapy for head and neck cancer. 28 patients with early-stage mouth sores received the light treatment during their radiation. The goal was to see if the light could prevent the sores from gett…

This study looked at whether a special numbing injection called PECS, given during mastectomy (breast removal surgery), can lower the chance of having chronic pain 6 months later. 194 women with breast cancer took part. The goal was to see if this simple pain-blocking technique c…

This study looked at skin problems in 57 adults with advanced head and neck cancer who received radiation therapy along with the drug cetuximab. The main goal was to track and understand skin side effects from this combination treatment. Researchers also measured quality of life …

This study tested whether actively draining gas from the belly after laparoscopic or robotic gynecologic surgery reduces shoulder and rib pain compared to manual gas release. 202 women having surgery for benign or cancerous conditions took part. The goal was to see if the drain m…

This study looked at two oral chemotherapy drugs, Xeloda and UFT with folinic acid, for people with advanced or metastatic colorectal cancer. The main goal was to find out which treatment patients preferred after trying both. The study also checked how safe each drug was. 89 adul…

This study tested whether adding ketoprofen to standard paracetamol better controls pain during and after brachytherapy, a type of internal radiation. It involved 68 adults with cervical or upper airway/digestive tract cancers. The goal was to find a simple, effective pain manage…

This study looked at 386 women with cervical, uterine, or ovarian cancer to compare complication rates between standard keyhole surgery (laparoscopy) and robot-assisted keyhole surgery. The goal was to see which approach leads to fewer problems within the first six months after t…

This study looked at whether the sentinel lymph node technique (a way to check if cancer has spread) works in women who have more than one tumor in the same breast (multifocal breast cancer). 216 women with early-stage, invasive breast cancer that had not spread to the lymph node…

This study looked at how different hormone therapies for breast cancer affect memory in postmenopausal women. 44 women were randomly assigned to take either an aromatase inhibitor (letrozole, anastrozole, or exemestane) or tamoxifen. Researchers tested memory and thinking skills …

This study looked at 65 people who had rectal cancer surgery followed by a second surgery to reconnect the bowel. Researchers measured symptoms and quality of life one year after the second surgery using a standard questionnaire. The goal was to understand common bowel problems a…

This study tested whether using a PET-scan at the start of brachytherapy (a type of internal radiation) is practical for treating locally advanced cervical cancer. Fourteen women who had already received chemo-radiation took part. The main goal was to see if the PET-scan could he…

This study aimed to find protein patterns (proteomic signatures) in tumor samples and blood that could predict how well breast cancer responds to chemotherapy given before surgery. Researchers analyzed samples from 66 women with breast cancer who had not received chemotherapy bef…

This study looked at how emotional skills of young women (45 or younger) with non-metastatic breast cancer and their partners influence their ability to cope with the disease and treatment. About 391 couples participated, completing surveys during chemotherapy and follow-up. The …

This study examined lung cancer tissue from 56 patients to look for specific protein pieces called Met receptor fragments. Researchers used a technique called Western blot to compare tumor tissue with healthy tissue. The goal was to understand how these fragments might relate to …

This study looked at 385 adults diagnosed with their first lung or head and neck cancer to see how many kept using tobacco or alcohol during the first year. Researchers tracked smoking and drinking habits, as well as cancer progression and survival. The goal was to understand ris…

This study analyzed blood samples from breast cancer patients to find genetic markers that might predict how well they respond to chemotherapy. Researchers focused on patients who received common chemo drugs like anthracyclines or taxanes. The goal was to better understand why so…

This study looked at how breast cancer affects the quality of life of young women (under 45) and their life partners. Researchers interviewed 171 couples to understand their experiences and create a questionnaire that helps doctors better assess and support couples facing breast …

This study looked at healthy skin tissue from 58 adults in two age groups (18-40 and 55+) to understand why cancer risk rises with age. Researchers checked for signs of cell aging and DNA damage in skin cells. The goal was to learn more about the aging process, not to test a trea…

This study tested a new questionnaire to measure quality of life in young women (under 45) with non-metastatic breast cancer and their partners. Over 1000 couples participated by filling out surveys at home. The goal was to see if the questionnaire accurately captures their well-…

This study used functional MRI (fMRI) to see how the brain responds to touch on a reconstructed breast compared to the natural one. Researchers enrolled 49 women who had breast reconstruction after mastectomy. The goal was to understand how the brain's sensory map changes after s…

This study looked at spinal fluid from 7 women with breast cancer that may have spread to the lining of the brain. Researchers wanted to see if proteins in the fluid could help diagnose this condition. The goal was to learn more about the disease, not to test a treatment.

This study looked at how common frailty is among people aged 70 and older with solid tumors who visited a cancer center. Researchers used a short questionnaire called VES-13 to screen patients before their doctor visit. They also checked whether the test results matched the docto…

This study looked at 28 women with breast cancer that had spread to their bones. The goal was to see if two types of scans—PET-CT and whole-body MRI—agree on whether the bone tumors are getting better, worse, or staying the same during treatment. The findings could help doctors c…

This study looked at how often a muscle enzyme called CPK increases in people with solid tumors who are taking a type of targeted therapy called tyrosine kinase inhibitors (TKIs). Researchers measured CPK levels in 154 patients during routine blood tests. They also checked if mus…

This study looked at whether cancer patients who join clinical trials feel more anxious or depressed than those getting standard treatment. Researchers asked 125 people with advanced solid tumors or blood cancers to fill out questionnaires about their stress, mood, and quality of…

This study followed over 700 adults with metastatic colorectal cancer who took regorafenib as part of a French compassionate-use program. Researchers measured how long patients lived after starting the drug and looked at factors like tumor location and previous treatments. The go…

This study created a regional database of 518 adults with non-small cell lung cancer who had a gene mutation. Researchers collected detailed clinical information, such as age, smoking history, and cancer stage, to see how these factors relate to different mutations. The goal was …

This study created a medical database of 2914 cancer patients aged 65 and older who visited geriatric oncology clinics. The goal was to collect information about their health, living situations, and care needs to help doctors better understand and treat this group. No new treatme…

This study looked at 139 patients with incurable cancer and their main caregivers to understand the emotional and practical burdens when planning a return home for end-of-life care. Researchers used surveys to measure how both patients and caregivers perceived the caregiver's bur…

This study looked at whether a special PET scan (FDG-PET) can detect early if breast cancer is responding to chemotherapy, after just one cycle instead of waiting for three. Researchers scanned 63 women with breast tumors larger than 2 cm before and after their first chemo round.…