Centre Oscar Lambret

This study tested whether patients with advanced soft tissue sarcoma whose cancer was controlled after six cycles of chemotherapy should continue treatment or take a planned break. Fifty-three patients whose cancer had not progressed were randomly assigned to either keep receivin…

This study tested whether adding a drug called nintedanib to standard chemotherapy (docetaxel) could help control advanced breast cancer for longer. It involved 51 adults with HER2-negative breast cancer that had returned or spread, who were starting their first or second round o…

This study aimed to find out which of two standard chemotherapy combinations works better when given with radiation before surgery for operable esophageal or gastro-esophageal junction cancer. It randomly assigned 106 patients to receive either the FOLFOX regimen or the CarboP-pa…

This study tested whether adding a precise, high-dose radiation boost to standard radiation treatment could better control intermediate-risk prostate cancer. Researchers enrolled 76 men to receive this combined approach and closely monitored them for side effects and cancer contr…

This study aimed to see if robot-assisted surgery is better than standard minimally invasive surgery for women with cervical, uterine, or ovarian cancer. It directly compared the two techniques in 386 patients, focusing on recovery time, complications, and quality of life after s…

This study tested whether adding addiction treatment directly to cancer care helps patients quit smoking and drinking. It involved 133 adults newly diagnosed with head/neck or lung cancer who were regular smokers. Researchers compared patients who received integrated addiction tr…

This study tested a focused, high-dose radiation treatment for people with a single liver tumor who could not receive standard surgery or other therapies. 44 patients received three radiation sessions over 8-10 days using a precise machine called CyberKnife. The main goal was to …

This study tested whether adding the common diabetes drug metformin to standard pre-surgery chemoradiation could improve treatment for locally advanced rectal cancer. It involved 60 patients who received metformin alongside their standard radiation and chemotherapy before surgery…

This early-stage study aimed to find the safest dose of a two-drug combination (Fluvastatin and Celebrex) for children and young adults whose brain tumors had come back or stopped responding to standard treatments. The trial involved 20 participants across multiple French hospita…

This early-stage study aimed to find the safest and most effective dose of a two-drug combination (paclitaxel and cyclophosphamide) for people with advanced cancer who had run out of standard treatment options. It involved 28 adult participants to test how well they tolerated the…

This study tested whether a drug called regorafenib could help keep metastatic soft tissue sarcoma from getting worse after initial chemotherapy. It involved 127 adults whose cancer had stabilized or responded to first-line treatment. Patients were randomly assigned to receive ei…

This study tested whether adding the drug bevacizumab to standard weekly paclitaxel chemotherapy helps control advanced angiosarcoma, a rare and aggressive cancer of blood vessels. It involved 70 adults whose cancer had spread or could not be removed by surgery. Patients were ran…

This study followed 704 French patients with advanced colorectal cancer who received regorafenib through a compassionate access program. Researchers wanted to understand how well the drug worked and what side effects occurred in real-world clinical practice, outside of strict cli…

This study asked patients with advanced colorectal cancer which of two chemotherapy treatments they preferred after trying both. The trial involved 89 participants and aimed to understand patient choice while also comparing the safety of each treatment option. Researchers wanted …

This early-stage study aimed to find the safest dose of an experimental drug called Cilengitide when given alongside standard radiation therapy. It involved 32 children and young adults newly diagnosed with a rare and aggressive brain stem tumor (DIPG), which has very poor surviv…

This study aimed to find the safest dose of a drug called imatinib when given with a low, continuous dose of another drug, cyclophosphamide. It was for people with rare, advanced cancers that had spread or could not be removed by surgery and had no standard treatment options. The…

This study compared two approaches for people with advanced cancer who had run out of standard treatment options. It tested whether low-dose daily chemotherapy (cyclophosphamide) or a hormone therapy (megestrol) was better at keeping the cancer from growing for at least two month…

This study looked at skin side effects in people with advanced head and neck cancer who received a combination of radiation therapy and the drug cetuximab. Researchers tracked how severe these skin reactions were and how they affected patients' quality of life. The goal was to be…

This study tested a technique called sentinel lymph node mapping in women with breast cancer that appeared in multiple spots (multifocal). Researchers wanted to see if this mapping method could accurately identify the first lymph nodes where cancer might spread, to help guide sur…

This study tested if a special PET scan could tell early on whether breast cancer chemotherapy was working. Researchers scanned 63 patients before and after their first chemo cycle. They compared the scan results to the tumor's actual response after three full cycles to see if th…

This study tested whether a specific nerve-block anesthesia technique (called PECS) given during breast removal surgery could reduce chronic pain six months later. It involved 194 women who had mastectomies, some with lymph node removal or breast reconstruction. Researchers track…

This study tested if actively draining leftover gas after gynecologic keyhole surgery reduces common post-op pain in the shoulders and ribs. Researchers compared a small drain to the standard method of manually pushing the gas out. The goal was to see if this simple change could …

This study tested whether a personalized, remote exercise coaching program could improve quality of life for breast cancer survivors. It compared this program to standard supportive care over 12 months. The goal was to see if regular, guided physical activity could help survivors…

This study aimed to better understand non-small cell lung cancer by analyzing specific protein fragments in tumor tissue. Researchers collected and examined tissue samples from 56 patients with lung cancer to see how these proteins are expressed and whether they relate to disease…

This study aimed to find genetic markers in the blood that might predict how well breast cancer patients respond to chemotherapy. Researchers collected blood samples from patients who were receiving standard first-line chemotherapy drugs. The goal was to gather knowledge to help …

This study followed 385 people newly diagnosed with lung or head/neck cancer to understand how many continue using tobacco and alcohol during their first year of treatment. Researchers tracked patients' substance use patterns to identify factors that make quitting difficult. The …

This study followed 65 rectal cancer patients for one year after they had surgery to reconnect their bowel. The goal was to understand how bowel function problems after surgery affect patients' daily lives and quality of life. By tracking symptoms and complications, researchers a…

This study aimed to find better ways to monitor breast cancer that has spread to bones. Researchers compared two imaging methods—PET-CT scans and whole-body MRI—to see if they agreed on whether bone tumors were responding to treatment. The study involved 28 patients with breast c…

This study aimed to understand why older people are more likely to get certain cancers. Researchers collected small samples of healthy skin from 58 people in two age groups (18-40 and 55+) who were having surgery for a different condition. They analyzed these samples in a lab to …

This study aimed to understand how the emotional skills of young women (45 or younger) with non-metastatic breast cancer and their partners affect how they adjust to the disease and its treatments. Researchers observed 391 couples to see how their emotional awareness and communic…

This study created a shared medical database for patients aged 65+ with cancer who had a special geriatric assessment. It aimed to better describe and understand this patient population by collecting their health and social information. The data helps doctors learn more about eld…

This small study explored whether analyzing tiny particles (exosomes) in spinal fluid could help diagnose when breast cancer spreads to the lining of the brain and spinal cord (meningitis). Researchers collected spinal fluid from 7 breast cancer patients with suspected spread and…

This study aimed to understand the emotional burden experienced by terminally ill cancer patients and their primary caregivers when planning a return home for end-of-life care. Researchers surveyed 139 patient-caregiver pairs to measure stress, anxiety, and relationship factors. …

This study aimed to understand how participating in a cancer clinical trial affects a patient's emotional well-being and quality of life. Researchers compared 125 patients with advanced or recurrent cancer who were either in a trial or receiving standard treatment. They measured …

This study aimed to understand how often a muscle enzyme called CPK increases in cancer patients taking a common type of drug called tyrosine kinase inhibitors (TKIs). It involved 154 patients with solid tumors who had been on TKI treatment for at least a week. The researchers ch…

This study created a regional database to track 518 non-small cell lung cancer patients who had specific genetic mutations detected through a central testing lab in Lille. Researchers collected detailed medical information to understand how different mutations affect patients' tr…

This study tested whether it is practical to use a PET scan on the first day of a specific radiation treatment (brachytherapy) for cervical cancer. It involved 14 patients who had already completed initial chemotherapy and radiation. The main goal was to see if the scan could be …

This study compared how different hormone therapies for breast cancer affect memory and thinking skills. Researchers followed 44 postmenopausal women with early-stage breast cancer for one year, comparing standard tamoxifen treatment against newer aromatase inhibitors. The goal w…

This study aimed to understand how breast cancer affects the quality of life of young women and their life partners. Researchers interviewed 171 couples where the woman was under 45 and had non-metastatic breast cancer. The goal was to create a better questionnaire to measure the…