Centre Oscar Lambret

This study tests whether starting chemotherapy earlier and continuing it longer can help adults with glioblastoma, an aggressive brain cancer, live longer. About 486 participants were randomly assigned to either the standard treatment or an intensified plan. The goal is to see if…

This study tests whether adding heated chemotherapy directly into the abdomen during surgery helps people with advanced ovarian cancer live longer without the disease coming back. About 362 participants will either get standard surgery alone or surgery plus the heated chemo. The …

This study tests a combination of the immunotherapy drug nivolumab with low-dose chemotherapy in children and teenagers whose solid tumors have not responded to standard treatments. The goal is to see if the combo is safe and can help control the cancer longer. About 63 participa…

This study tests a precise radiation treatment called SBRT for people with liver cancer or tumors that have spread to the liver. About 280 adults who cannot join other trials will receive SBRT. Researchers will measure how well the treatment controls tumor growth and track any si…

This study aimed to test whether analyzing tiny particles in spinal fluid could help doctors detect when breast cancer has spread to the lining of the brain and spinal cord. Researchers planned to compare this new method against current diagnostic tests in breast cancer patients …

This study tests a surgery called radical fimbriectomy in 123 women with BRCA mutations who are at high risk for ovarian cancer but want to keep their ovaries. The surgery removes the fallopian tubes, where many of these cancers start, while leaving the ovaries intact to maintain…

This study looks at 500 breast cancer patients who receive targeted radiation therapy after surgery to remove their tumor. The goal is to track side effects and quality of life during and after treatment. Researchers want to understand how well patients tolerate this type of radi…

This study looks at how well young women with breast cancer can have children years after chemotherapy, comparing those who also had a procedure to freeze their eggs (controlled ovarian hyperstimulation) and those who did not. Researchers are following 132 patients who took part …

This study looks at why the drug Palbociclib stops working in some people with advanced breast cancer. Researchers will collect blood and breath samples from 25 women over time to track changes in their cancer. The goal is to find patterns that signal when the drug is losing its …

This study aims to create the largest French database of people diagnosed with aggressive fibromatosis (desmoid tumors) since 2016. Researchers will collect medical and genetic information from 628 participants to better understand the disease and its link to familial adenomatous…

This study looks at whether it is safe and possible for young women with early breast cancer to freeze their eggs or embryos before starting chemotherapy. The goal is to understand how well this method works to protect future fertility. About 140 women aged 18 to 38 will take par…

This study looks at what helps people with head and neck or lung cancer stay away from cigarettes after they finish radiation treatment. Researchers will follow 100 patients for a year, checking in at 1, 6, and 12 months after treatment ends. The goal is to understand why some pe…

This study tests whether a less invasive sentinel node biopsy works as well as the usual more extensive lymph node removal for women with early-stage endometrial cancer that has a medium or high chance of coming back. About 262 participants are randomly assigned to either the sen…