Centre Hospitalier Universitaire De Nīmes

This phase 3 trial investigates whether high-dose psilocybin, given alongside psychotherapy, can prevent relapse in people with severe alcohol use disorder who also have depressive symptoms. Participants receive either a high dose (25 mg) or a low dose (3 mg) of psilocybin in two…

This early-stage study tests whether adding an iron-binding drug (MEX-CD1) to dialysis fluid can safely remove extra iron from the blood of adults in the ICU with sepsis and acute kidney injury. Each participant will receive two 24-hour dialysis sessions—one with standard fluid a…

This study compares two types of continuous dialysis used in the ICU for patients with sudden kidney failure. One method uses a citrate-based blood thinner, the other uses heparin. The goal is to see if the citrate method is just as effective at removing waste from the blood. 80 …

This study tests whether removing extra tissue (the mesentery) during standard Crohn's surgery is safe and helps prevent the disease from returning. About 30 adults with Crohn's disease who are already on biotherapy will undergo this procedure. The main goal is to see if the surg…

This study compares two strategies for preventing acid reflux after POEM surgery for achalasia: taking a PPI (Lansoprazole) every day for a year versus taking it only when reflux symptoms occur. About 132 participants will be randomly assigned to one of the two groups. The goal i…

This study tests whether regular, personalized follow-up by a trained case manager can reduce the chance of another psychotic episode over three years in people aged 16 to 30 who have just had their first episode. 256 participants will be randomly assigned to either standard care…

This study tests a new step before rectal cancer surgery: temporarily blocking the main artery to the lower colon with a tiny coil. The idea is to 'precondition' the tissue so it handles surgery better, potentially reducing leaks and other complications. 30 patients with rectal c…

This study is testing a device called Anchorsure, used during surgery to fix pelvic organ prolapse (when organs like the uterus or bladder slip down). The device is meant to make the surgery faster, with less pain and fewer nerve injuries. Researchers will follow 120 women for 3 …

This study explores whether measuring heart rate variability—the natural ups and downs in heartbeat timing—can help detect complications like leaks or abscesses after planned colorectal surgery. Researchers will monitor patients for a week after surgery and compare heart rate pat…

This study tests whether a quick, routine ultrasound measurement (called the resistance index) can accurately identify people with narrowed neck arteries who have normal brain blood flow response. If it works, many patients could avoid a time-consuming, specialized test. The stud…

This study is testing a new, portable breath test called eBAM-CoV to see if it can detect COVID-19 as accurately as the standard nasal swab test (RT-PCR). The breath test is less invasive and gives immediate results. Researchers will compare the two tests in 250 adults who have s…

This study is looking at whether a protein called L-PGDS can be used to diagnose adenomyosis, a condition where uterine tissue grows into the muscle wall, causing pain and heavy bleeding. Researchers will measure L-PGDS levels in vaginal swabs, blood, and urine from 60 women with…

This study tests a portable DNA device called MinION that can identify bacteria and fungi in foot wounds of people with diabetes in under 4 hours. Standard lab cultures take longer and may miss some germs. The goal is to see if this faster method gives a more complete picture of …

This study tests a new way to see if patients in shock need intravenous fluids. Doctors will use a heart ultrasound measurement (E') before and after giving fluids to see if it can predict who will respond. The goal is to make fluid decisions faster and more accurate in the emerg…

This study compares virtual reality training to standard treadmill walking for improving balance in people who have lost a leg below the knee. Twenty participants will be assigned to one of two groups. The goal is to see if the high-tech approach leads to better stability and wal…

This study tests a program to help cancer patients transition from hospital to home. It includes a meeting with a nurse before leaving, an app to report symptoms, and a follow-up phone call. The goal is to see if this approach is feasible and improves patient satisfaction and qua…

This study looks at whether keeping or removing the posterior cruciate ligament during robotic knee replacement helps patients feel more natural after surgery. About 300 adults having their first robotic knee replacement will be randomly assigned to one of the two methods. The ma…

This early study tests a new urine collection device called PEASY in 20 hospitalized men with incontinence. Unlike current devices that use sticky adhesives, PEASY uses a gentle clamp on the foreskin to stay in place. The goal is to see if it causes less pain, itching, and discom…

This study tests whether listening to music through a special app (Music Care®) can calm anxiety as well as a gas mixture (EMONO) during a CT-guided injection for low back pain. The gas can cause nausea and dizziness, and the music app has no side effects. Researchers will compar…

This study tests a 12-week group therapy program called ECCCLORE for people who have both post-traumatic stress disorder (PTSD) and addiction. The program combines skills for managing emotions, distress, and relationships. Researchers want to see if it is feasible and acceptable …

This study tests whether music therapy delivered by the BeatMove device can help people with leg artery disease walk farther during a 3-month outpatient walking program. Fifty-four participants will either get real music therapy or a sham version while doing 36 walking sessions. …

This study tests whether a special geriatric care program before and after colorectal cancer surgery helps patients aged 70 and older recover their daily functioning better than standard care. The program includes early nutrition support, early mobilization, and careful managemen…

This study tests a 10-week therapy program called SINTYA for young adults aged 16-25 with borderline personality disorder (BPD). The program combines group and individual sessions to reduce impulsivity and related symptoms like emotional distress, self-harm, and suicide risk. Res…

This study looks at MRI scans of 128 people who have had a brain hemorrhage (bleeding in the brain). Researchers want to see if a specific contrast pattern called a 'spot sign' can help predict which bleeds might get worse. By understanding these patterns, doctors hope to identif…

This study tests whether a rapid finger-prick test for C-reactive protein (CRP) can help doctors decide if a child with fever needs emergency care or can be safely managed at home. About 420 children aged 2-9 with fever will be enrolled. The goal is to reduce unnecessary ER visit…

This observational study is recruiting 200 adults with lower limb amputations to understand what factors limit their walking ability. Researchers will measure energy use, balance, and gait patterns using motion capture and a mask that analyzes breathing. The goal is to identify h…

This study aims to find out how often Muir-Torre syndrome (MTS) occurs in people who already have Lynch syndrome, a genetic condition that raises cancer risk. Researchers will examine skin lesions and tumors from 150 participants to see if they are linked to MTS. The goal is to b…

This study is looking at 180 women with advanced cervical cancer who were treated with radiation and chemotherapy. Researchers want to see if high levels of certain proteins (called IAPs) in the original tumor biopsy can predict whether the cancer will come back within two years.…

This study compares how a 60-minute treadmill walk changes blood clotting in people who have had a blood clot (venous thromboembolism) and those who haven't. Researchers will measure clotting markers before and after exercise in 94 participants. The goal is to better understand h…

This study is testing whether monthly blood tests for a nerve damage marker (neurofilament light chain) can detect hidden disease activity in people with relapsing-remitting multiple sclerosis (MS) earlier than standard yearly MRI scans. The goal is to reduce the need for gadolin…

This study examines the medical records of 400 people diagnosed with various types of lymphoma at a French hospital between 1999 and 2018. Researchers want to see how long patients survived and whether the care they received matched what medical guidelines recommend. The goal is …

This study tracks 800 obese patients at Nîmes University Hospital to see if they develop alcohol or other addictions during obesity treatment, especially after bariatric surgery. Researchers will use questionnaires and blood tests to understand these behaviors. The goal is to imp…

This study looks at how lumbar surgery changes the way people with chronic low back pain walk. Researchers will measure walking complexity (how adaptable your stride is) before and 3 to 6 months after surgery in 32 patients. The goal is to see if pain relief from surgery outweigh…

This study examines how cells in the placenta manage waste and self-destruction in women with pregnancy complications like pre-eclampsia and intrauterine growth restriction. Researchers will take blood and urine samples from 50 pregnant women throughout their pregnancy and at del…

This study looks at how people with a leg amputation adjust their walking patterns. Researchers will measure body movements, muscle activity, and balance in 75 participants while they walk on different surfaces. The goal is to better understand these adaptations, which could help…

This study looks at gut bacteria diversity in children aged 1 to 3 who take long-term antibiotics for a condition called vesicoureteral reflux (urine flowing backward into the kidneys). Researchers will compare their gut bacteria to two other groups: children with the same condit…

This study looks at whether working unusual hours or having idle time at work makes people more likely to gamble in risky ways. Researchers will interview 25 adults who currently have or have had gambling problems and who have worked in the past year. The goal is to understand ho…

This study is testing a new lab test called SPHERTEST to see if it can predict how well bladder cancer patients will respond to immunotherapy. Researchers will take blood and tumor samples from 32 patients with advanced bladder cancer to see if the test's prediction matches real …

This study aims to find what factors—like physical, mental, or social issues—predict whether a person with chronic low back pain will benefit from a rehab program. Researchers will follow 333 adults with pain lasting at least three months. The goal is to personalize treatments an…

This study looks at MRI scans from 120 women with advanced cervical cancer to see if a computer model can predict how well their tumors respond to standard chemotherapy and radiation. The goal is to identify women who might need different or stronger treatments early on. Research…

This study looks at how a blood transfusion changes heart function in anemic patients aged 65 and older who come to the emergency room. Researchers will use ultrasound to check the heart before, right after, and 15 minutes after the transfusion. The goal is to see which heart mea…

This study looks at sleep inertia—the grogginess and poor attention right after waking—in people with major depression. Researchers will test reaction times and monitor sleep in 110 participants, including depressed patients with and without sleep inertia, plus healthy controls. …

This pilot study uses MRI scans to investigate whether a small brain area called the inferior colliculi plays a role in auditory hallucinations in people with schizophrenia. Researchers will compare brain activity in 40 participants—20 with hallucinations and 20 without—while the…

This study is testing a French version of a questionnaire that measures how well people with rheumatoid arthritis follow their medication plan. Researchers will enroll 150 adults who have been on a stable dose of methotrexate for at least a month. The goal is to make sure the que…

This study is looking at how the gut bacteria (microbiome) change in children with juvenile spondyloarthritis as they receive different treatments. Researchers will collect stool and blood samples from 25 children over several months to see if certain bacteria affect how well the…

This study looks at whether changes in gut bacteria and increased intestinal permeability can trigger inflammation that damages brain cells in people with type 1 narcolepsy. Researchers will collect blood, stool, and spinal fluid samples from 120 participants to measure bacterial…

This study looks at how the spine and pelvis line up when children with cerebral palsy sit. Researchers will take X-rays of 100 children aged 4 to 17 who have limited walking ability. The goal is to better understand these alignments and create a standard way to take these X-rays…