POST TRAUMATIC STRESS DISORDER

This study followed 44 people with PTSD who had already completed a prior methylone (TSND-201) trial. Over 52 weeks, researchers checked their symptoms and safety each month. If PTSD symptoms returned, participants could receive more methylone treatment. The goal was to see if th…

This study tested a drug called methylone in 62 adults with severe PTSD. Participants received the drug once a week for 3 to 4 weeks, then were followed for up to 8 weeks. The goal was to see if methylone could safely reduce PTSD symptoms and depression.

This pilot study tested whether a therapy called written exposure therapy, delivered via video calls, could help reduce PTSD symptoms in women who recently experienced a sexual assault. Thirty women who visited a Sexual Assault Nurse Examiner (SANE) clinic within 7 days of the as…

This study tested whether methylone, a substance similar to MDMA, can safely reduce PTSD symptoms in adults. 79 participants with moderate to severe PTSD received either methylone or a placebo once a week for four weeks, then were followed for six more weeks. The goal was to see …

This study tested if Written Exposure Therapy (WET) can work when delivered online in a group setting for military and police with PTSD. 29 participants took part to see if the treatment was acceptable and if it reduced trauma symptoms. The goal was to find a more accessible way …

This study tested a talking therapy called Cognitive Processing Therapy (CPT) in 36 adults who experienced the 2023 earthquakes in Turkey. The goal was to see if CPT could reduce symptoms of PTSD, depression, and anxiety, and improve overall well-being. Participants were randomly…

This study tested a type of talk therapy called Acceptance and Commitment Therapy (ACT) to help veterans with PTSD improve their social support and relationships. 107 veterans took part, and the therapy focused on helping them feel less isolated and more connected to family and f…

This study tested a trauma-focused therapy (TF-CBT) for young people aged 8 to 19 who had experienced trauma and had PTSD symptoms. The therapy was delivered in schools to make it easier for students to get help. Researchers also tested a strategy to help school clinicians adopt …

This study tested whether a smartphone-based attention training program can reduce symptoms of post-traumatic stress disorder (PTSD). Over 1,300 adults with significant PTSD symptoms completed 14 sessions of either the active training or a placebo version. Researchers measured ch…

This study tested a modified version of Goal Management Training, called Trauma-Informed GMT, designed to be more sensitive to people with PTSD. 33 adults with PTSD took part in a 9-week online group program. Researchers measured changes in thinking skills and PTSD symptoms right…

This study tested a 5-week group program called Rare Group Problem Management Plus (PM+) for parents or guardians of children with rare diseases. The program, delivered by video, aims to help with practical and emotional problems like anxiety, depression, and stress. Eight caregi…

This study looked at whether a 6-month supervised exercise program could help older veterans with PTSD. About 80 veterans took part, doing regular exercise to see if it would reduce their PTSD symptoms and improve physical health. The goal was to find a safe, drug-free way to hel…

This small study tested whether a non-invasive brain stimulation technique called TMS could help lower blood pressure and ease PTSD symptoms in women aged 18 to 44. Four participants with both high blood pressure and PTSD symptoms received TMS, and researchers measured changes in…

This study tested a short virtual reality (VR) program called SHINE-VR to help teenagers who feel deep shame after sexual abuse. Six teens aged 12-17 who were already in PTSD treatment took part. The goal was to see if VR could reduce their trauma-related shame and boost self-com…

This study looked at whether mindfulness training can reduce anger and aggression in veterans with PTSD. 61 veterans who struggled with anger took part. The goal was to see if learning mindfulness techniques helps them regulate difficult emotions and lower aggressive behavior.

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This study tested whether minocycline, an antibiotic, could reduce the frequency and intensity of intrusive memories in people with PTSD or cocaine use disorder. 138 adults participated, and researchers measured changes in memory-related brain activity and self-reported distress.…

This study looked at whether giving a special therapy called EMDR to people in the emergency room right after a traumatic event could help prevent post-traumatic stress disorder (PTSD). About 110 adults who were at high risk for PTSD took part. The therapy uses eye movements to h…

This study looked at whether a simple aerobic exercise program could help earthquake survivors who were struggling with PTSD and poor sleep. 82 adults living in temporary shelters were randomly assigned to either a supervised exercise group (twice a week for three weeks) or a con…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study looked at whether adding lofexidine to standard buprenorphine treatment can improve symptoms of both PTSD and opioid use disorder in veterans. 84 veterans on stable buprenorphine therapy were enrolled. The goal was to see if the combination reduced opioid use and PTSD …

This study tested whether a racecar-simulation program could help veterans with PTSD manage their emotions and improve quality of life. One veteran completed the program, which combined mental training with driving in a simulated racecar. The goal was to see if skills learned in …

This study tested three ways to deliver a type of therapy called Acceptance and Commitment Therapy (ACT) for adults with mild to moderate PTSD. Thirty participants were split into groups: standard clinic therapy, clinic therapy plus a web app, or fully online therapy with the app…

This study tested a therapist-assisted self-management program for veterans who had already completed trauma-focused therapy for PTSD and seen improvement. The goal was to help them maintain or build on their progress, feel more confident managing symptoms, and reduce the number …

This study looked at whether learning to train a future service dog, along with standard care, can improve symptoms of post-traumatic stress (PTS), traumatic brain injury (TBI), and related issues like anxiety and depression. 156 military members and their families took part. Res…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a new way of delivering care for people with anxiety and depression in Danish general practices. 302 adults with conditions like panic disorder, social anxiety, or PTSD took part. The model involved a team of doctors, nurses, and therapists working together, and…

This study tested a program called MOSAIC Plus for pregnant women and mothers of children under 5 who have experienced intimate partner violence and have symptoms of depression or PTSD. The program pairs women with community advocates who provide support and teach skills to impro…

This study tested two online courses designed to help paramedics in Singapore manage stress, anxiety, depression, and burnout during the COVID-19 pandemic. 63 paramedics took part, completing six weekly online modules. The goal was to see which course better improved mental healt…

This study tested whether transcranial magnetic stimulation (TMS) can improve PTSD symptoms and change related brain activity and startle responses. Fifty adults with partial PTSD received TMS treatment. Researchers measured changes in brain scans and skin conductance to see if t…

This small pilot study tested the Safe and Sound Protocol (SSP), a passive listening program, in 45 adults with PTSD or anxiety. Participants listened to specially filtered music as a 'neural exercise' to help regulate their body's stress response. The study measured changes in P…

This study tested whether interpersonal psychotherapy (IPT) works as well as proven therapies like prolonged exposure and relaxation for people with chronic post-traumatic stress disorder (PTSD). Researchers enrolled 110 adults with at least moderately severe PTSD. The goal was t…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The goal was to reduce distress and help them reintegrate into civilian life. 176 veterans participated, and the wo…

This study tested whether adding a mild brain stimulation technique called tDCS to standard trauma-focused therapy can better reduce PTSD symptoms. 63 adults with chronic PTSD took part. The goal was to see if the stimulation helps the therapy work more effectively, offering a ne…

This study looked at whether a web-based program called webSTAIR can help people with PTSD who are waiting for treatment. The program teaches skills to manage emotions and relationships. Researchers tested it with 70 adults on a waitlist at Boston Medical Center to see if it was …

This study looked at whether a natural probiotic called Lactobacillus rhamnosus GG could help veterans with PTSD by reducing inflammation in the body and brain. Researchers measured changes in blood markers, gut health, and PTSD symptoms over time. The goal was to see if this sim…

This study tested whether a simple technique called progressive muscle relaxation training can reduce symptoms of post-traumatic stress disorder (PTSD) in people affected by the February 6 Kahramanmaraş earthquake. 44 adults with PTSD took part. The training involves tensing and …

This study looked at how negative emotions and stress influence alcohol use in 81 women veterans, including those with PTSD. Researchers measured cravings, heart rate, and drinking patterns, and also examined how these effects change across the menstrual cycle. The goal was to be…

This study looked at how cannabinoids influence the way the brain processes fear in people with PTSD. Researchers measured brain activity and fear responses in 86 adults, including those with PTSD, trauma-exposed individuals without PTSD, and healthy controls. The goal was to und…

This study tested whether a smartphone app could passively track activity, sociability, and sleep in 87 veterans with serious mental illnesses like schizophrenia and bipolar disorder. The goal was to see if phone data could detect early warning signs of worsening symptoms. The st…

This study looked at how mindfulness-based cognitive therapy (MBCT) changes brain connections in people with PTSD. 61 adults with PTSD received either MBCT or a comparison therapy. Researchers used brain scans to measure changes in brain activity and connectivity, aiming to under…

This study looked at whether a free mobile app called BounceBack Now could help people with trauma-related mental health issues like PTSD, depression, and anxiety. Researchers worked with 29 adults in primary care, including many from underserved communities, to see if the app wa…

This study looked at how people with PTSD pay attention to their surroundings. Researchers used a change blindness test to see if patients are quicker to notice changes, especially emotional ones. 80 adults with PTSD and healthy controls participated. The goal was to understand t…

This study looked at whether a special planning form (called POST) helps older adults, including those with dementia, receive medical care at the end of life that matches their personal wishes. Researchers worked with 389 people aged 65 and older who were at higher risk of dying …

This study looked at a program called KEEP that trains foster and kinship parents to better support children in their care. The goal was to see if the program could reduce depression, anxiety, PTSD, self-harm, and behavior problems in youth from Native, Hispanic, Black, and LGBTQ…

This study followed 14 people who called a special crisis hotline after terrorist attacks in Paris, London, Barcelona, and Strasbourg. Researchers wanted to see how their symptoms of post-traumatic stress and depression changed over time and what kind of help they sought. The goa…

This study looked at 460 adults who came to the emergency room after a traumatic event, like a serious injury or threat of death. The goal was to find out which factors—biological, psychological, and social—can predict who will develop post-traumatic stress disorder (PTSD) three …

This study looked at whether adding social support (like help with jobs and housing) to standard mental health treatment helps refugees with PTSD. About 200 unemployed refugees took part. The goal was to see if this combined approach improves daily functioning and reduces symptom…

This study looks at how often patients and their family members develop post-traumatic stress disorder (PTSD) after surviving a sudden cardiac arrest. Researchers will interview 20 survivors and 20 relatives within one week of the event and again three months later using standard…

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder, depression, and burnout using standard questionnaires. The goal was to understand how common t…

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This study looked at how people with post-traumatic stress disorder (PTSD) predict their emotional reactions to future events. Researchers compared 97 adults with PTSD to those without the condition. They found that people with PTSD tend to expect stronger negative emotions than …

This study followed 216 survivors of the 2015 Paris terrorist attacks for up to 6 years, using brain scans to see how their brains process traumatic memories. Researchers compared them to people who were not at the attacks. The goal was to understand why some people develop PTSD …

This study looked at 300 adults to better understand complex post-traumatic stress disorder (PTSD). Researchers used questionnaires to measure dissociation, emotional control, and trauma symptoms. The goal was to identify what makes complex PTSD different from regular PTSD, helpi…

This study tested a coaching program for doctors to improve how they talk with Black and Latinx families during hospital rounds. The goal was to build trust, respect, and partnership. 51 caregivers and clinicians took part, and researchers measured communication quality, satisfac…

This study tested the safety and how the body processes methylone in 40 healthy adults aged 25 to 55. Researchers measured drug levels in the blood and tracked any side effects. The goal was to gather basic safety information to support future studies in people with PTSD.

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…