POST-TRAUMATIC STRESS DISORDER

This study follows about 1,700 adults who were part of an earlier trial comparing two sedatives (ketamine and etomidate) given during emergency breathing tube placement. Researchers want to see if ketamine reduces PTSD symptoms one year later, since ketamine may block the formati…

This study tests whether a few sessions of a special type of counseling, given soon after a rape, can prevent post-traumatic stress disorder (PTSD). About 166 women who have experienced sexual assault will receive either this early counseling or the usual care. The goal is to see…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether a trauma-informed program called Strength at Home works better than the usual state-approved program for reducing intimate partner violence. About 800 men who are court-ordered to attend such programs, along with their partners, will take part. Researcher…

This study tests a therapy called Deep Brain Reorienting (DBR) for people with post-traumatic stress disorder (PTSD). 234 adults will be randomly assigned to receive DBR or be placed on a waitlist. The main goal is to see if DBR reduces PTSD symptoms more than waiting for treatme…

This study tests whether fluoxetine, a common antidepressant, can reduce PTSD symptoms in active-duty service members, veterans, and civilians. About 200 participants will receive either fluoxetine or a placebo for 12 weeks, and researchers will measure changes in symptom severit…

This study tests a short therapy called Brief Prolonged Exposure (Brief PE) to see if it can reduce post-traumatic stress in people who have had a spinal cord injury. About 200 adults in inpatient rehab will either get this therapy or standard care. The goal is to ease PTSD sympt…

This study aimed to see if a voice-changing device could make exposure therapy easier for people with PTSD. Patients would read their trauma story aloud while software altered their voice's emotional tone, hoping to reduce distress. The study was withdrawn before any participants…

This study tests a treatment called repetitive Transcranial Magnetic Stimulation (rTMS) to reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will take part; half will get real rTMS and half a placebo, with 10 sessions over two …

This study compares a new, shorter therapy for Post-Traumatic Stress Disorder (PTSD) to standard treatments. Researchers want to see if the brief approach works just as well at reducing symptoms. About 82 adults with PTSD will take part. The main goal is to measure changes in PTS…

This study aimed to see if the blood pressure drug propranolol could help teenagers with PTSD by weakening traumatic memories during a therapy session. It planned to enroll teens aged 12 to 18 who had PTSD for at least three months. However, the trial was withdrawn before any par…

This study tests whether a mobile neurofeedback program can help new mothers who have experienced trauma feel better, reduce stress, and improve bonding with their babies. About 40 mothers with PTSD symptoms and a baby aged 3-9 months will use the app for 12 weeks. Researchers wi…

This study tests whether a numbing injection near a nerve cluster in the neck (stellate ganglion block) can reduce PTSD symptoms like hyperarousal. About 79 adults with chronic PTSD will receive either the active injection or a placebo (saline). Researchers will measure changes i…

This study tests an experimental drug called SLS-002 to see if it can safely reduce PTSD symptoms in active-duty service members, veterans, and civilians. About 200 participants will receive either the drug or a placebo twice a week for 8 weeks, then once a week for 4 more weeks.…

This study looks at whether unlicensed professionals can effectively provide cognitive behavioral therapy (CBT) to people with conditions like OCD, anxiety, depression, and PTSD. About 250 adults at Massachusetts General Hospital will receive CBT from these providers. The goal is…

This study tests whether a stellate ganglion block—a numbing injection in the neck—can quickly reduce PTSD symptoms in veterans. About 410 veterans who still have PTSD after trying standard treatments will receive either the real injection or a sham (fake) one. Researchers will m…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) can safely help adults with long-term PTSD who are already taking antidepressants. Twenty participants will receive psilocybin, and some will also get trauma-focused talk therapy. The goal …

This study tests a community-based program called CRISOL Mente to help Latinos in the Philadelphia area who have symptoms of depression, anxiety, or PTSD. The program offers culturally sensitive support to overcome barriers like language, cost, and stigma. About 600 adults will t…

This study explores whether a brain training technique called neurofeedback can help new mothers who have experienced trauma feel better and manage their emotions. Twenty mothers between 3 and 24 months after childbirth will try the training alongside their usual care. Researcher…

This study aimed to see how MDMA changes brain activity in people with PTSD, especially in areas that handle emotions. Researchers planned to give MDMA to a small group and measure brain scans and PTSD symptoms. However, the study was withdrawn before any participants were enroll…

This study explores whether artificial intelligence can analyze speech patterns to help diagnose mental health conditions like ADHD, autism, depression, anxiety, and schizophrenia. Researchers will collect voice samples from 500 people aged 16-60 who are already being evaluated f…

This study was designed to see if a program called PCIP could help teens with PTSD when offered in a primary care setting, either in person or by video. Researchers planned to enroll 44 teens and their caregivers to measure changes in PTSD knowledge, symptoms, and coping skills. …

This study looks at brain changes in people with major depression or PTSD using special PET scans. Researchers want to see if a single dose of ketamine can reverse the loss of brain connections (synapses) linked to these conditions. The study involves 130 adults who will have MRI…