Could a party drug ease PTSD? new trial tests methylone

NCT ID NCT05741710

Completed Symptom relief Sponsor: Transcend Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether methylone, a substance similar to MDMA, can safely reduce PTSD symptoms in adults. 79 participants with moderate to severe PTSD received either methylone or a placebo once a week for four weeks, then were followed for six more weeks. The goal was to see if the drug helps lower symptom severity and is well-tolerated.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-TRAUMATIC STRESS DISORDER

Contacts and locations

Locations

Accel Research Sites

Maitland, Florida, 32751, United States
Boston Clinical Trials

Boston, Massachusetts, 02131, United States
Cambridge University Hospitals NHS Foundation Trust

Cambridge, United Kingdom
Cedar Clinical Research

Murray, Utah, 84107, United States
Cenexel HRI

Berlin, New Jersey, 08009, United States
Clerkenwell Health

London, United Kingdom
Clinical Neuroscience Solutions - Jacksonville

Jacksonville, Florida, 32256, United States
Glasgow Clinical Research Facility, QEUH

Glasgow, United Kingdom
King's College

London, United Kingdom
La Nua Day Hospital Mental Health Centre

Galway, Ireland
Mirabilis Health

Belfast, Northern Ireland, United Kingdom
Mountain View Clinical Research

Denver, Colorado, 80209, United States
Oxford Health NHS Foundation Trust

Oxford, United Kingdom
Sunstone Therapies

Rockville, Maryland, 20850, United States
Tallaght Adult Mental Health Services

Dublin, Ireland
The Rivus Wellness & Research Institute

Oklahoma City, Oklahoma, 73112, United States

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