HIGH GRADE GLIOMA

This study tests a vaccine called PEP-CMV in 120 children and young adults with certain aggressive brain tumors (high-grade glioma, DIPG, or recurrent medulloblastoma). The vaccine targets a common virus (CMV) found in these tumors, aiming to train the immune system to attack the…

This early-phase trial tests a personalized RNA vaccine made from each patient's own tumor. It aims to train the immune system to fight aggressive brain cancers like glioblastoma and high-grade glioma in children and adults. The study focuses on safety, manufacturing feasibility,…

This study tests an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have a specific change in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The study will first measure how much …

This study tests an experimental drug called LAM561 in children under 18 with advanced brain tumors (like high-grade glioma) or other solid cancers that have stopped responding to standard treatments. The goal is to find a safe dose and check for side effects. Up to 28 children w…

This study tests two drug combinations given after radiation for children and young adults with aggressive brain tumors (high-grade glioma or DIPG). One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The goal is to see if these combinations …

This study tests the drug lorlatinib in children (ages 1 to 21) with a newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given with or after other …

This early-phase study tests a new gene therapy for people with aggressive brain tumors that have a protein called GD2. Researchers take a patient's own T cells, add a special receptor to help them recognize and attack GD2 on cancer cells, plus a gene that helps the T cells live …

This study is testing a drug called Lutathera in people aged 4 to 39 with certain aggressive brain tumors or meningiomas that have come back or are growing. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dose…

This early-stage trial tests a new treatment for children and young adults (up to age 21) with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a p…

This study tests a daily pill called entrectinib for children under 3 with certain types of brain or spinal cord tumors. The drug targets specific gene changes (NTRK or ROS1) to shrink tumors and delay growth. About 52 children will take part, and doctors will measure how well th…

This early-phase study tests whether adding the drug azeliragon to radiation therapy is safe for people with cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). About 32 adults with solid tumors or high-grade gliomas will receive the com…

This study tests a drug called larotrectinib in children (up to age 21) with a rare, aggressive brain tumor (high-grade glioma) that has a specific genetic change (NTRK fusion). The goal is to see if the drug can shrink or control the tumor after two cycles, and to check its safe…

This study offers continued access to dabrafenib and/or trametinib for up to 100 patients with melanoma, lung cancer, or other solid tumors who were already benefiting from these drugs in a prior Novartis or GSK trial. The main goal is to monitor long-term safety and side effects…

This early-phase study tests a new treatment for adults with glioblastoma or high-grade glioma that has come back after standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to target two different markers on tumor cells at once, which may h…

This study tests whether adding two experimental drugs, DB107-RRV and DB107-FC, to standard treatment (radiation and chemotherapy) can help people with newly diagnosed high grade glioma, a fast-growing brain cancer. About 70 adults aged 18-75 will receive the drugs during and aft…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This early-phase trial tests a new treatment called TX103 CAR-T for people with a severe and fast-growing brain cancer (grade 4 glioma) that has come back or gotten worse. The therapy uses the patient's own immune cells, modified to better attack the cancer. The main goals are to…

This early-phase study tests a new drug called XRD-0394 combined with radiation therapy for people with high-grade gliomas, a fast-growing type of brain tumor. The main goal is to find a safe dose and check for side effects. About 39 adults with newly diagnosed or returning tumor…

This study is testing whether a special PET-MRI scan using 18F-Fluciclovine can help doctors tell the difference between actual tumor growth and harmless changes that happen after treatment in children with high-grade glioma. About 30 children aged 1 to 21 with this type of brain…

This study collects tumor tissue from 50 adults with low- or high-grade glioma during surgery to grow mini-tumors (organoids) in the lab. Researchers will compare these organoids with the original tumors to learn why gliomas are so hard to treat. The goal is to find new ways to p…

This study is for children, teens, and young adults (ages 1 to 39) newly diagnosed with a high-grade glioma, a serious type of brain tumor. Researchers will analyze the tumor's genetic makeup to see if it matches a specific treatment plan in a future study. The goal is to learn m…

This study is testing a new fiber optic system that fits inside a standard biopsy needle to help doctors see tumor tissue and blood vessels during brain surgery. The goal is to make biopsies for high-grade glioma safer and more accurate. The study involves 20 adults whose surgery…

This study looks at whether PET scans and blood tests can predict changes in memory and attention after radiation therapy for high-grade glioma. Researchers will follow 16 adults receiving chemoradiation, using brain scans, spinal taps, and cognitive tests. The goal is to better …

This early-phase study tests if recording electrical activity in and around high-grade glioma tumors during surgery is safe and feasible. Researchers will take small tissue samples from areas with unusual activity and track tumor progression on follow-up MRI scans. The goal is to…

This study tests a special version of the cancer drug nivolumab that has a fluorescent dye attached, called nivo800. The dye makes the drug glow, so doctors can see where it collects in brain tumors during surgery. The goal is to learn if this is safe and helps surgeons see tumor…

This early study tests a new type of PET/MRI scan to see if it can find active high-grade glioma (a serious brain cancer) after standard radiation therapy. About 20 children and adults will get this special scan. The goal is to see if the scan can detect leftover tumor and help d…