HIGH GRADE GLIOMA

This early-phase study tests a new drug called DSP-0390 in 39 adults whose high-grade glioma (a fast-growing brain cancer) has come back after prior treatment. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants must be…

This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after prior treatment. The study aims to find the highest dose that causes fewest s…

This study tests the drug nivolumab in 62 adults with a type of brain tumor (glioma) that has specific gene changes (IDH mutations). The goal is to see if nivolumab can stop or slow tumor growth. Participants receive the drug through an IV every few weeks and are monitored with s…

This study is testing a new drug called CLR 131, a targeted radiotherapy, in children, teens, and young adults (ages 10 to 25) with a type of brain cancer called high-grade glioma that has come back or not responded to treatment. The main goals are to find the best dose and check…

This study was designed for children with a type of aggressive brain cancer (high-grade glioma) that has come back after initial treatment. It planned to test an experimental virus therapy, G207, injected directly into the tumor, along with a single dose of radiation. The goal wa…

This early-phase study tests whether a new type of immune cell therapy is safe and possible to make for people with aggressive brain tumors called high-grade gliomas. The therapy uses a patient's own immune cells, modified to recognize and attack tumor cells that carry a specific…

This early-stage study is testing the safety of a drug called PTC596 (Unesbulin) when given alongside radiation therapy to children and young adults (ages 1 to 21) newly diagnosed with aggressive brain tumors like DIPG or high-grade glioma. The main goals are to find a safe dose …

This early-phase study tests whether a special PET scan (68Ga-PSMA-11) can detect tumor activity in people with high-grade glioma or brain metastases. Eleven adults with suspected or confirmed tumors will receive the scan before a planned biopsy or surgery. The goal is to measure…

This study involves 70 adults with high-grade gliomas, a serious type of brain cancer. Researchers are collecting blood samples to detect and analyze tumor DNA that circulates in the bloodstream. The goal is to develop a simple blood test that can monitor how the tumor changes ov…

This study looks at people with a type of brain cancer called glioma that has a specific gene change (IDH mutation). Researchers use special MRI scans to measure a substance called 2-HG in the brain over time, which may show when the tumor becomes more aggressive. The goal is to …