HIGH GRADE GLIOMA

This is an early-stage study to test the safety and find the right dose of an experimental oral drug called DSP-0390. It is for adults whose aggressive brain tumors (high-grade gliomas) have come back after previous treatment. The main goals are to see how safe the drug is and ho…

This early-stage study is testing a new targeted radiation drug called CLR 131 in children and young adults (ages 10-25) with aggressive brain tumors that have returned or not responded to other treatments and cannot be removed by surgery. The main goals are to find a safe and ef…

This early-stage study is testing a new, personalized vaccine made from a patient's own tumor RNA. It aims to see if this vaccine is safe and to find the best dose for adults with a type of brain cancer called glioblastoma and for children with high-grade brain tumors. The vaccin…

This study is testing the safety of a new oral drug called PTC596 (Unesbulin) when given alongside standard radiation therapy to children and young adults newly diagnosed with aggressive brain tumors, including a very hard-to-treat type called DIPG. The main goals are to find the…

This study is testing whether the immunotherapy drug nivolumab can help control the growth of certain brain tumors (gliomas) that have specific genetic changes. It is enrolling 62 adults whose tumors have either a very high number of mutations or a normal number. The main goal is…

This early-stage study is testing whether modified immune cells can be safely used to treat aggressive brain tumors in children and adults. Researchers are collecting patients' own immune cells, modifying them to target a specific protein found on tumor cells, and then reinfusing…

This trial aimed to test an experimental virus therapy called G207 for children whose aggressive brain tumors had returned. The virus is designed to infect and kill cancer cells while sparing healthy ones. Doctors planned to inject the virus directly into the tumor and follow it …

This study is testing a new type of PET scan to see if it can effectively show activity in aggressive brain tumors. It involves adults with high-grade gliomas or brain metastases who are already scheduled for a biopsy or surgery. The goal is to see if this scan can provide cleare…

This study aims to develop a better 'liquid biopsy'—a blood test—to monitor high-grade brain tumors without repeated surgeries. Researchers will collect blood samples from 70 patients before and after their radiation treatment to see if tumor DNA in the blood can be reliably dete…

This study aims to understand how certain brain tumors change and become more aggressive over time. Researchers will use special brain scans to track chemical levels in the tumors of adults with specific genetic mutations. The goal is to learn if these chemical changes can signal…