New drug combo targets childhood brain cancers in early trial
NCT ID NCT03605550
First seen Mar 29, 2026 · Last updated Apr 25, 2026 · Updated 4 times
Summary
This early-stage study is testing the safety of a drug called PTC596 (Unesbulin) when given alongside radiation therapy to children and young adults (ages 1 to 21) newly diagnosed with aggressive brain tumors like DIPG or high-grade glioma. The main goals are to find a safe dose and understand how the drug moves through the body. Participants take the drug twice a week during radiation, then continue it alone in later cycles.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
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The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
Conditions
Explore the condition pages connected to this study.