New hope for young brain cancer patients: targeted radiotherapy trial launches

NCT ID NCT05610891

First seen Apr 01, 2026 · Last updated Apr 30, 2026 · Updated 4 times

Summary

This early-stage study tests a new targeted radiotherapy (CLR 131) in 50 children, teens, and young adults (ages 10-25) with a type of brain cancer called high-grade glioma that has come back or not responded to treatment. The goal is to find the safest and most effective dose by monitoring side effects and tumor shrinkage on MRI scans. Participants must have a confirmed diagnosis and be in reasonably good health otherwise.

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Contacts and locations

Locations

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Stanford University

    Palo Alto, California, 94304, United States

  • Texas Children's Cancer Center, Baylor College of Medicine

    Houston, Texas, 77030, United States

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Wisconsin, Carbone Cancer Center

    Madison, Wisconsin, 53705, United States

Conditions

Explore the condition pages connected to this study.