Vascular occlusion disorder

This study compares two treatments for a severe type of stroke caused by a blockage in a major artery at the base of the brain. Some patients will get a clot-busting drug through a vein followed by a procedure to remove the clot, while others will have the clot removal procedure …

This trial tests a device called Tigertriever 13 to treat distal ischemic strokes, where a blood clot blocks a small artery deep in the brain. About 168 patients with disabling symptoms will receive either the device or standard medical care within 24 hours of stroke onset. The g…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This study tests the safety of an experimental eye injection called ONS-5010 (bevacizumab) in people with vision loss from wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion. Participants receive the injection and are monitored for side…

This study is testing a new device called the Ladera LBC System that uses stitches to close the hole in the femoral artery after catheter-based heart or blood vessel procedures. The study will enroll 55 adults who are scheduled for elective procedures using large sheaths (10 to 2…

This study tests a device called the Penumbra System with Thunderbolt Aspiration Tubing to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. The goal is to see if the device can safely and effectively restore blood flow within 8 hou…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This study tested a higher dose (8 mg) of the drug aflibercept against the standard dose (2 mg) in 892 adults with macular edema from a blocked retinal vein. The goal was to see if the higher dose works as well or better while allowing fewer injections. Participants received inje…

This study tested a special stent graft (WRAPSODY) against the usual balloon treatment for vein blockages in people on dialysis. The goal was to see if the stent graft could keep the vein open longer and reduce the need for repeat procedures. A total of 357 patients took part acr…

This study tested a special balloon coated with the drug everolimus to treat blockages in the leg's main arteries. The balloon is inflated inside the artery to push the blockage open and release the drug to help prevent the artery from narrowing again. The trial included 75 peopl…

This study tested whether a pre-filled syringe of the medicine SB11 (a biosimilar to ranibizumab) is easy for eye doctors to use. Thirty adults with wet age-related macular degeneration, macular edema from retinal vein occlusion, or myopic choroidal neovascularization received on…

This study tested whether adding sodium sivelestat, a drug that reduces inflammation, to standard mechanical thrombectomy could improve outcomes in 20 stroke patients with large vessel occlusion. The drug aims to prevent 'futile recanalization,' where blood flow is restored but p…

This study tested whether giving the blood-thinning drug tirofiban after mechanical clot removal improves outcomes for people with severe stroke. Over 1,300 participants were randomly assigned to receive tirofiban or a placebo. The goal was to see if more patients could live inde…

This completed study tested two strategies to reduce bleeding and artery blockage after a common heart procedure. 451 patients received either a standard or lower dose of heparin and a different compression band. The goal was to see if the new approach could shorten recovery and …

This study tested an experimental drug called KUS121, given as an eye injection, for people who suddenly lost vision due to a blocked artery in the eye (central retinal artery occlusion). The goal was to see if the injection could improve vision better than a sham procedure. The …

This study tested whether giving a clot-busting drug (tenecteplase) before mechanical clot removal helps people with a severe type of stroke caused by a blockage in the basilar artery. The trial included 330 adults who were treated between 4.5 and 24 hours after stroke symptoms b…

This study tested a new tool called the AngioSafe Peripheral CTO Crossing System in 79 people with blocked leg arteries (peripheral artery disease). The goal was to see if the device could safely help doctors place a guidewire through the blockage. The study measured how often th…

This study tested the INDIGO Aspiration System, a device that uses a vacuum to remove blood clots from arteries and veins. It included 500 patients in Japan with acute limb ischemia, mesenteric artery occlusion, or severe deep vein thrombosis. The goal was to confirm the device's…

This study compared angioplasty for one blocked leg artery versus multiple blocked arteries in 40 people with critical limb ischemia, a severe condition that can lead to amputation. The goal was to see which approach better saves limbs and heals wounds. Researchers tracked whethe…

This study tested a new medicine called 601 against an existing drug, ranibizumab, for people with vision loss due to a blocked vein in the eye (branch retinal vein occlusion). 351 adults received injections into the eye to reduce swelling and improve sight. The goal was to see i…

This study tested a device called the JETi system to remove blood clots from veins or arteries in the arms or legs. It included 12 adults of Asian descent in Hong Kong. The goal was to see how well the device cleared clots and if it caused serious side effects like bleeding or re…

This study tested a virtual cardiac rehabilitation program using a smartphone app, a fitness wristband, and a blood pressure monitor for people who recently had a heart attack, heart surgery, or a stent. The goal was to see if this home-based program could improve walking ability…

This study looked at whether raising the head after a stroke procedure helps patients recover better. Over 1,300 adults with severe strokes were followed for 90 days to see if head elevation improved their ability to function. The goal was to find a simple, low-cost way to boost …

This phase 3 trial tested a drug called tenecteplase in 452 people with a severe type of stroke caused by a blockage in the basilar artery at the back of the brain. Participants received either tenecteplase or the current best treatment (which could include another clot-buster or…

This study looked at 345 people with a severe stroke caused by a blockage in the basilar artery, a major blood vessel in the brain. It compared two treatments: giving a clot-busting drug followed by a procedure to remove the clot, versus doing the procedure alone. The goal was to…

This study tested a simple method to prevent wrist artery blockage after a common heart procedure. Over 1500 patients had their wrist artery pressed with a special thick gauze pad plus a standard device, or just the device alone. The goal was to see if the gauze method reduced ar…

This Phase 3 trial tested whether the clot-busting drug tenecteplase could improve vision in people with a central retinal artery occlusion (eye stroke). 81 participants received either tenecteplase or aspirin within 4.5 hours of symptoms. The main goal was to see if more patient…

This study looked at whether adding a dexamethasone implant (Ozurdex) to standard bevacizumab (Avastin) eye injections could reduce the number of injections needed for people with non-ischemic central retinal vein occlusion. Sixty-eight participants received either Avastin plus a…

This study tested a device called Cross-Seal that helps close large holes in the main leg artery after heart procedures. It involved 147 adults who needed artery access with large sheaths. The goal was to see if the device could stop bleeding quickly and safely without major comp…

This study tested whether an AI tool can help eye doctors diagnose four common retinal diseases (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma) more accurately and quickly. Ten doctors from five hospitals read fundus images both with…

This study looked at whether a special MRI scan can accurately measure how well a transplanted kidney is working. Researchers compared the MRI results to the standard method (Cr51-EDTA) in 71 kidney transplant patients. The goal was to find a simpler, non-invasive way to monitor …

This study tested a computer program called Heuron CTA that looks at brain CT scans to find large blockages in blood vessels. Researchers compared the software's results to diagnoses made by medical experts using scans from 270 adults. If accurate, this tool could help doctors di…

This study tested whether special MRI scans can better detect signs of central retinal artery occlusion (CRAO), also known as an eye stroke. Researchers enrolled 63 adults with CRAO and performed detailed brain and eye imaging. The goal was to find imaging clues that help diagnos…

This study looked at whether a panel of blood biomarkers can quickly identify stroke patients who have a large vessel occlusion (a major blockage) and would benefit from a specialized clot-removal procedure. Researchers enrolled nearly 3,900 adults with stroke symptoms and tested…

This study tested a new imaging device called OCT angiography (OCTA) that takes 3D pictures of blood vessels in the back of the eye without needing dye injections. Researchers compared OCTA images to standard dye-based imaging in 88 people with retinal blood vessel problems or no…

This study looked at 1168 adults who had a heart catheterization through the wrist. It compared two methods to stop bleeding and prevent a common complication called radial artery occlusion: manual compression (hand pressure) and a pneumatic device that gradually releases pressur…

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This study aims to understand if COVID-19 vaccines have any impact on brain health in healthy people. Researchers will use MRI scans to look for changes in the brain's blood vessels and structure. The study will follow 500 adults from Hong Kong who have already had a baseline bra…

This study compares two ways to access blocked leg arteries during a procedure to restore blood flow: through the arm (brachial artery) or the groin (femoral artery). The goal is to see which approach leads to fewer complications, such as bleeding or artery damage. Participants a…

This study tested whether doctors could safely and correctly use a new prefilled syringe (SCD411) for eye injections. It included 33 adults with wet age-related macular degeneration, retinal vein occlusion, diabetic macular edema, or diabetic retinopathy. The main goal was to see…

This completed study looked at how clear aligners and fixed braces affect bite forces after treating mild front-tooth crowding. Twelve people aged 14-22 with mild crowding and no extractions were treated with either clear aligners or fixed braces. The goal was to see which method…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This study compared two ways to reach the heart's arteries through the wrist during a heart catheterization. The goal was to see if a newer method (distal radial access) causes fewer blockages in the wrist artery than the standard method. 350 adults from three hospitals took part…

This study looked at whether indocyanine green angiography (ICGA), a dye-based imaging test, can help doctors assess blood flow in the face after a rare but serious complication from hyaluronic acid filler injections. Researchers reviewed medical records and images from 19 patien…

This study looked at how much of a burden patients feel from repeated anti-VEGF eye injections for three different eye diseases: wet age-related macular degeneration, retinal vein occlusion, and diabetic macular edema. Researchers surveyed 393 patients about their treatment burde…

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study used artificial intelligence to learn the patterns of reduced blood flow to the brain during planned surgeries. 60 patients having carotid artery surgery or stroke clot removal were monitored with non-invasive devices. The goal was to teach AI to recognize these patter…

This study tested a 12-item checklist used by nurses to predict neurological complications like bleeding or re-blockage after endovascular therapy for stroke or aneurysms. Researchers compared 213 patients who were checked with the list to 213 who received standard care. The goal…

This study looked at over 550,000 people who received Eylea® injections for eye conditions to find out how often retinal vasculitis (a rare eye inflammation) occurs. Researchers used a large US registry and medical records to confirm cases. The goal was to better understand the s…

This study looked back at the medical records of 400 people with neovascular glaucoma, a severe eye condition. Researchers wanted to see how it relates to other diseases, lifestyle factors, and inflammation. The goal is to better understand the condition and guide future treatmen…