Varicose disease

This trial tests whether microscopic surgery to repair varicoceles (enlarged veins in the scrotum) works better than antioxidant medication for men with cryptozoospermia—a condition where very few sperm are present in semen. About 69 men with clinical varicoceles will be randomly…

This trial tests whether adding vacuum compression therapy — a device that applies cycles of pressure and suction to the leg — can improve healing of chronic lower limb ulcers. Adults with ulcers that have not healed despite standard care will receive either standard wound care a…

This study looked at two common treatments for grade I-III internal hemorrhoids: injection sclerotherapy and rubber band ligation. Researchers followed 984 patients across multiple hospitals to see which treatment worked better and had fewer side effects. The goal is to help doct…

This study looked at whether giving antibiotics before an endoscopic procedure helps prevent fever and rebleeding in people with cirrhosis who have had variceal bleeding before. 226 patients were randomly assigned to receive the antibiotic ceftriaxone or no antibiotics before the…

This study tested whether a special blood test (ROTEM) can better guide blood transfusions in people with acute-on-chronic liver failure who are bleeding from enlarged veins. 262 participants were randomly assigned to receive transfusions based on either the new test or standard …

This study compared open surgery versus laparoscopic (keyhole) surgery for varicocele, a condition where veins around the testicle become enlarged. 100 men aged 20–60 were randomly assigned to one of the two procedures. Researchers measured how long the operation took, how many d…

This study tested two surgical methods to repair varicoceles (enlarged veins in the scrotum) in 60 men with fertility issues or pain. One group had a loupe-assisted surgery with a nitroglycerin spray to help see blood vessels, while the other had standard microscopic surgery. The…

This study tested a new method called SALFOAM 3% for treating varicose veins in the legs. It involved 35 adults and compared the new method to the standard foam treatment. The goal was to see if the new method closes veins better and causes less skin darkening.

This study is testing whether a new type of MRI (4D flow MRI) can detect dangerous veins in the stomach and esophagus of people with cirrhosis, which can cause fatal bleeding. Currently, doctors use a camera down the throat (endoscopy) to check, but that is invasive and often unn…

This study tested whether an AI app (IVENUS) could correctly classify the severity of chronic vein disease from leg photos. Over 1,600 patients had their legs photographed, and the app's diagnosis was compared to that of experienced doctors. The goal was to see if the app could r…

This study tested a new questionnaire (HDQ) to help diagnose hemorrhoids in Russia. Researchers enrolled 725 adults visiting a coloproctologist. The goal was to see how well the questionnaire identifies hemorrhoids compared to a doctor's exam, aiming to improve screening and pati…

This study tested whether a wired magnetic capsule endoscopy system produces fewer airborne droplets than traditional endoscopy when checking for esophageal varices in people with biliary atresia. Fifty participants underwent either the capsule or standard procedure. The main goa…

This clinical trial investigates whether two existing medications, allopurinol and atorvastatin, can help prevent serious complications in people with stable liver cirrhosis. The study will compare these drugs against a placebo to see if they reduce the number of acute decompensa…

This trial tests whether a short 5-day course of the blood thinners rivaroxaban (Xarelto) or apixaban (Eliquis) can prevent blood clots that sometimes form after laser treatment for varicose veins. Adults with symptomatic vein reflux undergoing laser ablation of the great sapheno…

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. Ninety adults will receive one of the drugs or a placebo before spinal anesthesia. Researchers will measure anxiety levels and pain sc…

This trial tests whether a topical ointment containing two numbing agents (lidocaine and tetracaine) can reduce pain after hemorrhoid surgery. Adults scheduled for elective hemorrhoidectomy will apply the ointment or a placebo every 12 hours for 10 days after surgery. Researchers…

This trial compares a newer, minimally invasive laser procedure to standard surgery for grade II and III hemorrhoids. The laser technique aims to shrink hemorrhoid tissue with less pain and faster recovery. Researchers will measure postoperative pain, patient satisfaction, and ho…

This study compared two common treatments for second-degree hemorrhoids: injection sclerotherapy and rubber band ligation. Researchers looked at how well each method stopped bleeding and worked overall. The study involved 128 adults aged 18 to 75 with second-degree hemorrhoids.

This study tested two creams for painful hemorrhoids: carraghenates cream and Mayinglong musk hemorrhoid ointment. 123 participants used one of the creams twice daily for 6 days. Researchers measured how quickly pain eased and how well symptoms like bleeding and swelling improved…

This study looked at two surgical approaches for varicose veins: removing the main faulty vein and the visible varicose veins all at once, or removing just the main vein first and the varicose veins later. Researchers wanted to see which approach leads to better symptom relief an…

This study tested a new, minimally invasive procedure for people with grade II or III hemorrhoids. Instead of surgery, doctors used tiny coils to block the main artery supplying blood to the hemorrhoids, aiming to shrink them and reduce pain. The study included 26 participants an…

This study compared two surgical treatments for grade III hemorrhoids: open hemorrhoidectomy and transanal hemorrhoidal desarterialization (THD). Fifty adults were randomly assigned to one of the two procedures and tracked for a year. The main goal was to see which surgery better…

This study compared two ways to numb the leg for outpatient vein ablation surgery: a femoral nerve block (injecting lidocaine near the groin) and low-dose spinal anesthesia (injecting bupivacaine into the spine). Forty adults aged 18-80 with mild to moderate health status took pa…

This study tested whether a mild electrical stimulation at specific acupoints (TEAS) helps people with cirrhosis tolerate an urgent endoscopy for suspected variceal bleeding. 180 patients were split into three groups: active TEAS, sham TEAS (electrodes but no current), or standar…

This study looked at 90 adults with severe prolapsed hemorrhoids to compare three surgical techniques: traditional surgery, a stapling device, and a vessel-sealing device. The main goal was to measure pain after surgery and track complications like bleeding or urine retention. Th…

This completed trial tested a medical device cream called PROCTOeze® PLUS in 50 adults with mild to moderate hemorrhoids (Grade I-II). Participants applied the cream at home for 14 days to see if it improved symptoms and quality of life. The study measured changes using a short h…

This study tested whether a herbal capsule called Trĩ Thiên Dược can stop bleeding from grade II internal hemorrhoids better than a standard drug (diosmin). 172 adults with bleeding hemorrhoids took either the herbal capsule or diosmin for 28 days, then were followed for another …

This study looked at how well phlebotonics—drugs that strengthen blood vessels and reduce swelling—help people with mild to moderate hemorrhoids. Researchers tracked 131 Italian patients with symptoms like bleeding and pain. The goal was to see if these drugs improve quality of l…

This study looked at whether numbing the anal area with an injection of ropivacaine is necessary during a newer, less invasive radiofrequency procedure for hemorrhoids. 134 adults having this procedure were randomly assigned to receive the injection or not. The main goal was to s…

This study tested whether adding a small cut to relax the anal muscle during standard hemorrhoid surgery helps reduce pain and bleeding after the operation. 120 adults with advanced hemorrhoids were randomly assigned to get either the standard surgery or the surgery with the extr…

This completed study looked at 200 adults having hemorrhoid surgery. Half also had a small cut in a muscle around the anus (lateral internal sphincterotomy). Researchers measured pain and accidental leakage of gas or stool after surgery. The goal was to see if the extra cut helps…

This completed study tested a tablet containing horse chestnut, smartweed, sarsaparilla, and rutin in 120 adults with mild to moderate hemorrhoids. Over 60 days, researchers measured changes in symptoms like pain, bleeding, and itching using a symptom score. The goal was to see i…

This study looked at whether applying ice packs for 10 minutes after hemorrhoid surgery helps reduce pain and the need for strong painkillers. Researchers compared 429 patients who either received ice packing or standard care. The goal was to see if this simple, low-cost method c…

This study explores whether using minimally invasive surgery tools during standard hemorrhoid removal can reduce pain and speed up recovery. It involves a small group of adults with grade III hemorrhoids who are scheduled for surgery. The main goal is to see if the technique is t…

This study looks at whether levels of a protein called zonulin, found in blood and semen, differ between infertile men with and without varicocele (enlarged veins in the scrotum). Researchers will measure zonulin in 119 men and compare it with standard semen quality measures like…

This study watches and records pain levels at four key moments during radiofrequency ablation for varicose veins—from needle insertion to the end of the procedure. Researchers will look at how factors like age, gender, and body mass index relate to pain. The goal is to find patte…

This study looked at 480 cirrhosis patients who had variceal bleeding and were getting an endoscopy to prevent future bleeding. Half got antibiotics before the procedure, half did not. The goal was to see if antibiotics reduce infections after the procedure. The study is retrospe…

This study looked at 412 people with cirrhosis who had bleeding from veins in the esophagus or stomach. Half got an endoscopy within 6 hours, the other half between 6 and 24 hours. The goal was to see if faster treatment lowered the chance of rebleeding within 42 days. The result…

This study looked at 40 adults undergoing radiofrequency ablation for varicose veins to compare two types of regional anesthesia: spinal anesthesia and a fascia iliaca block. The goal was to see which method leads to better recovery quality, less pain, and faster mobility after t…

This completed study looked at 26,000 patients who had outpatient procedures for blood vessel problems like peripheral artery disease, varicose veins, or dialysis access issues. The goal was to see how safe and effective these procedures are when done in an office-based angiosuit…

This study tested a new way to measure blood pressure in stomach veins of 25 people with liver cirrhosis and enlarged veins (varices). Doctors used an endoscope with ultrasound to see if this method could better predict bleeding risk than standard tests. The goal was to see if th…

This study looked at whether combined oral contraceptives (birth control pills) influence the development or worsening of chronic venous diseases, like varicose veins. Researchers followed 116 women taking different types of birth control pills. The goal was to see if these pills…

This study looked at whether measuring liver pressure during an endoscopy is more accurate when patients lie on their left side versus flat on their back. Researchers tested 30 hospitalized patients with liver cirrhosis. The goal was to see if the two positions give consistent re…

This completed study examined how to best manage early-stage upper gastrointestinal cancer in patients who also have liver cirrhosis and enlarged veins in the esophagus (varices). Researchers compared outcomes of a keyhole-like endoscopic surgery (ESD) between 206 patients with a…