Spinal stenosis

This trial tests whether wearing a hard cervical collar for 6 weeks after posterior cervical fusion surgery improves recovery compared to no collar. Adults with degenerative cervical spine disease undergoing fusion will be randomly assigned to wear a collar or not. Researchers wi…

This trial investigates whether barbed sutures are a safe and effective way to close deep tissue incisions in obese patients undergoing posterior cervical spine surgery. Researchers will measure changes in spinal function, neck disability, and pain levels, as well as monitor for …

This study tests whether a precise, individualized version of a common spinal surgery can safely improve function and reduce pain in people with cervical spinal stenosis. Researchers will compare outcomes in 500 patients who receive the standardized open-door procedure with a tit…

This study looks at how the angle of the opened bone and other surgical details affect recovery in people with cervical spinal stenosis who undergo a single open-door surgery. Researchers will review records from 500 patients across multiple centers to see which factors lead to b…

This trial tests whether a novel surgical technique called vertebropexy—which uses a donor ligament to stabilize the spine—can match or outperform standard decompression or fusion surgery for degenerative lumbar spinal disease. The study enrolls adults needing single- or two-leve…

This study compares a new nerve monitoring device, NeuroVision®, to standard hospital monitoring during spine surgery. The goal is to see if NeuroVision® reduces the chance of nerve injury. About 148 adults having lateral spine surgery will be randomly assigned to one of the two …

This study looks at how well a spine implant (VIPER PRIME/Expedium) combined with a special bone graft putty (Fibergraft BG) helps bones fuse together after spine surgery. About 100 adults with spine problems like slipped vertebrae or disc degeneration will be followed for two ye…

This study is testing a device called the Minuteman G5 Fusion Plate, which is already approved for use, to see how well it helps people with chronic low back pain caused by degenerative spine conditions. About 150 adults who are candidates for this surgery will be followed for a …

This study will check how common peripheral artery disease (PAD) is in people who need surgery for lumbar spinal stenosis (LSS). Both conditions can cause leg pain, making PAD hard to spot. Researchers will use a special CT scan to find PAD and compare it with simpler tests like …

This study looks at tissue removed during back surgery to find early signs of a heart condition called ATTR cardiac amyloidosis. Researchers will test spine samples from 1,663 older adults for abnormal protein deposits. If found, participants will get further heart tests to confi…

This study tests whether a modified version of the muscle relaxant metaxalone (640 mg) can reduce low back and leg pain in people with acute sciatica or spinal stenosis. Fifty adults aged 18 to 80 with new-onset pain will take either the drug or a placebo for 7 days. Researchers …

This study tests a simple, non-surgical program for older veterans with lumbar spinal stenosis, a common cause of back and leg pain when walking or standing. The program includes using a modified rolling walker and changing sleep positions to relieve symptoms. Researchers will tr…

This early-stage study tests whether a new drug called EC5026 is safe and can reduce nerve pain in people with spinal cord injury. About 36 adults with pain from traumatic or non-traumatic spinal cord injury will take either the drug or a placebo daily for 14 days. Researchers wi…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study tests a new, smaller surgical tool called LUSE-TLIF against the current standard minimally invasive fusion (MIS-TLIF) for people with lumbar spinal stenosis. The new tool is a flexible endoscope only 1.8 mm wide, designed to give surgeons a better view and reduce muscl…

This study tests whether placing a steroid (Depo-Medrol) directly on the spine during back surgery can lower pain and the need for opioid painkillers afterward. About 150 adults having one- or two-level lumbar decompression will be randomly assigned to get the steroid or a placeb…

This study looks at whether avoiding opioids during back surgery can still control pain and reduce side effects like nausea and constipation. About 75 adults having elective lumbar spine surgery will be placed into one of three groups based on their anesthesia plan. The goal is t…

This study tests whether local anesthesia with sedation works as well as general anesthesia for 1-3 level lumbar decompression surgery. Researchers will measure changes in pain and disability in 100 adults aged 40-95. The goal is to find a safer, effective alternative to general …

This study tests a new, less invasive surgery called Posterior Uniportal Endoscopic Cervical Decompression for people with cervical spinal stenosis—a condition that pinches nerves in the neck, causing pain, numbness, or weakness. The surgery uses a small incision and a tiny camer…

This study tests a minimally invasive surgery called ULBLD for people with lumbar spinal stenosis—a condition that narrows the spine and causes pain or numbness. The surgery uses a small incision and a camera to relieve pressure on nerves. Researchers will track 78 patients in Me…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study tests two different nerve blocks to see which one works better for pain after single-level lumbar disc surgery. 70 adults will receive one of the blocks before surgery, and their pain and opioid use will be tracked for 24 hours. The goal is to find a more effective way…

This study compares two surgeries for lumbar spinal stenosis, a condition that narrows the spinal canal and causes back pain, leg pain, and trouble walking. Researchers will randomly assign 60 adults aged 30-60 to receive either decompressive laminectomy alone or with screw fixat…

This study tests whether taking a special probiotic (OMNi-BiOTiC® Hetox) can improve healing, reduce pain, and lower complications after neurosurgery for back or neck problems. About 110 adults having spine surgery will be randomly assigned to receive either the probiotic or a pl…

This study tests whether using a connected exercise bike at home, along with usual care, can improve daily activities for people with lumbar spinal stenosis—a condition that causes leg and back pain when walking. About 302 adults aged 50 and older with confirmed spinal narrowing …

This study tests whether a specific nerve block (erector spinae plane block) can lower the amount of strong pain medicine patients need after minimally invasive lower back surgery. About 48 adults having a one-level lumbar fusion will be randomly assigned to receive the block or …

This study tests whether giving a single dose of the steroid dexamethasone just before minimally invasive spine fusion surgery can lower back pain afterward and reduce the need for strong painkillers like morphine. Sixty adults aged 50–80 having one- or two-level spine fusion wil…

This study explores whether inflammation from fat tissue around the spine contributes to spinal stenosis, a condition that narrows the spinal canal and causes pain. Researchers will collect tissue and blood samples from 100 patients undergoing spinal surgery to measure levels of …

This study will follow 8,000 Medicare patients with lumbar spinal stenosis who receive either the MILD procedure or interspinous process decompression. Researchers will track complications and whether patients need additional surgery within two years. The goal is to see which app…

This study tests whether changing the pulse-width of electrical stimulation during pedicle screw placement affects nerve response thresholds. Researchers will stimulate screws with three different pulse-widths (0.4, 0.2, and 0.05 milliseconds) and record the intensity needed to t…

This registry is following 450 adults undergoing spine fusion surgery who receive an OssDsign bone graft substitute. The goal is to see how well the bones fuse together and how patients' quality of life changes over time. It is an observational study, meaning no new treatment is …

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study tracks 80 elderly patients (65+) with lumbar spinal stenosis who are scheduled for decompressive surgery. Researchers will measure their activity levels using a device before and after surgery, and follow them for two years. The goal is to see if surgery objectively im…

This study looks at how decompressive surgery for lumbar spinal stenosis affects balance in people aged 65 and older. Researchers will measure balance before and after surgery, and track changes over two years. The goal is to understand if surgery can improve balance and quality …

This study is tracking 561 people who have already had spine surgery using METROSAN spinal implants and BONEGRAFT bone fillers. Researchers want to see how well these devices work and if any new safety issues pop up over a year. It's an observational study, meaning patients get s…

This study aims to create better criteria for deciding when to operate on Chinese patients with degenerative cervical myelopathy, a condition where the spinal cord is compressed. Researchers will test 100 surgical candidates using simple physical performance tests like hand grip …

This study looks at whether the natural pulsation of the spinal cord is linked to pain and disability in people with lumbar spinal stenosis (a narrowing of the spine). Researchers will measure pain, function, and MRI images in 100 adults aged 18-85. The goal is to better understa…

This study compares two surgical approaches for single-level lumbar spinal stenosis: decompression alone versus decompression with spinal fusion. Researchers will track 86 patients aged 45-75 over two years to see if the simpler procedure works just as well. The goal is to determ…

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will study 225 adults with recent or long-term injuries, as well as those with related conditions. The goal is to better understand nerve activity below the inju…

This study is building a database of information from 300 adults who have had spine surgery using a special device called the Implanet Jazz System. The goal is to collect measurements like pain levels and quality of life to help doctors learn more and improve future treatments. P…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…