Paroxysmal atrial fibrillation

This study follows 580 adults with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to fix irregular heartbeats. Researchers will monitor participants for 36 months to see how well the procedure prevents heart rhythm proble…

This study tests a new device called FARAFLEX that uses electrical pulses to treat atrial fibrillation (AF), a condition where the heart beats irregularly. About 571 adults with AF that hasn't improved with medication will get this procedure. The goal is to see if it safely resto…

This early study tests a new balloon device that uses pulsed electric fields to treat atrial fibrillation, a common heart rhythm disorder. 75 people with short-duration AF who haven't had prior ablation will receive the procedure and be followed for one year. The goal is to see i…

This study tests a new catheter system (Sphere-9) for a repeat heart ablation procedure in 400 people whose atrial fibrillation came back after an earlier ablation. The procedure uses radiofrequency and pulsed field energy to correct faulty heart signals. Participants will be fol…

This study is checking the long-term safety and effectiveness of the VARIPULSE catheter, a device already approved by the FDA, for treating people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 276 participants who have symptoms and haven't respon…

This study tracks 500 Chinese patients with paroxysmal atrial fibrillation who are treated with the FARAPULSE pulsed field ablation system as part of their normal care. Researchers will monitor safety and effectiveness for up to three years. The goal is to see how well the device…

This study tests a new procedure using pulsed field energy to treat atrial fibrillation (AFib), a common heart rhythm problem. The procedure isolates the pulmonary veins and the back wall of the left atrium to stop abnormal signals. About 442 adults with symptomatic AFib will be …

This study tests new waveforms delivered by the FARAPULSE PFA system to treat atrial fibrillation, a common heart rhythm problem. About 200 adults with paroxysmal or persistent atrial fibrillation will receive the procedure. The goal is to see if these new waveforms are safe and …

This study is testing a new device called the FARAFLEX system, which uses targeted electrical pulses to treat atrial fibrillation, a common heart rhythm problem. About 250 adults with persistent or paroxysmal atrial fibrillation will take part. The goal is to see if the device is…

This study tests a new device that uses heat to destroy tiny areas in the heart causing short bursts of irregular heartbeat (paroxysmal atrial fibrillation). About 300 adults with this condition will receive the procedure and be monitored for a year. The goal is to see if the tre…

This study follows 200 people with paroxysmal atrial fibrillation (AF) who undergo a procedure using a freezing catheter to isolate the pulmonary veins. The goal is to see how many remain free from AF, atrial flutter, or atrial tachycardia for up to 3 years, and to track safety e…

This study tests a new device that uses short bursts of electricity to treat atrial fibrillation (AF), a common heart rhythm problem. About 360 adults with AF will receive the procedure to see if it safely restores a normal heartbeat. The goal is to improve symptoms and quality o…

This study tests doing two procedures at once for people with atrial fibrillation (AFib): a catheter ablation to restore normal heart rhythm and a device implant to close off a part of the heart where clots form. The goal is to see if this combined approach is safe and effective …

This study is testing a new system (VARIPULSE catheter and TRUPULSE generator) with updated software to treat atrial fibrillation, a condition where the heart beats irregularly. The goal is to see how well the system works in a real-world setting, measuring procedure times and sa…

This registry tracks 20,000 people with atrial fibrillation or ventricular arrhythmias who undergo catheter ablation using advanced CARTO mapping technologies. The goal is to see how safe and effective these procedures are in everyday medical practice. Researchers will monitor he…

This study tests a new mapping catheter and software to help doctors treat atrial fibrillation, a common heart rhythm problem. About 200 Chinese patients will receive a standard ablation procedure, but doctors will use the new tools to guide them. The goal is to see if the new de…

This study is tracking 300 people with paroxysmal or persistent atrial fibrillation (AFib) who are treated with the Volt PFA System, a balloon-based device that uses pulsed field ablation to correct irregular heart rhythms. Researchers are monitoring safety—looking for serious si…

This study tests a new, faster method for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). About 150 adults will receive a heart ablation using very high power for short durations, aiming to reduce procedure time. The goal is to see if this approach is as …

This study looks at people with paroxysmal atrial fibrillation (a type of irregular heartbeat) that came back after a previous treatment. It compares two approaches during a repeat procedure: isolating the superior vena cava alone versus also adding ethanol (alcohol) infusion int…

This study tests a new device called the CellFX nsPFA catheter, which uses short electrical pulses instead of heat to treat paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if it is safe and effective at restoring normal rhythm in 215 adults who …

This study tests a new device called the CellFX Nano-PFA 360 catheter, which uses very short electrical pulses to treat atrial fibrillation (an irregular heartbeat). About 60 adults aged 18 to 75 with paroxysmal atrial fibrillation will receive this procedure. The goal is to see …

This study compares a new, tailored ablation approach to the standard treatment for people with paroxysmal atrial fibrillation (AFib), a common heart rhythm problem. About 556 adults with AFib will be randomly assigned to either standard pulmonary vein isolation or a procedure th…

This study tests a digital toolkit called the Corrie Virtual Atrial Fibrillation Management Program, designed to help people with atrial fibrillation learn about treatment options, stick to therapies, and manage episodes. Researchers will enroll 248 adults with AFib and a BMI of …

This study is testing a procedure called pulsed field ablation (PFA) to treat atrial fibrillation, a common heart rhythm problem, in patients from racial and ethnic minority groups. About 275 participants will receive the standard PFA treatment using FDA-approved catheters, and r…

This study tests if people with atrial fibrillation (an irregular heartbeat) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults with a low-to-moderate stroke risk will be randomly assigned to either standard daily bloo…

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (an irregular heart rhythm). About 28 adults with both conditions will wear a heart monitor and complete quality-of-life surveys. The goa…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study is testing a new device that uses pulsed electric fields to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The procedure aims to isolate the pulmonary veins to restore normal rhythm. Researchers will enroll 440 people who have not …

This study tests a new device called the SpherePVI catheter, which uses heat to isolate the veins that trigger atrial fibrillation. About 100 adults with symptomatic AF who haven't responded to medication will be enrolled. The main goals are to see if the procedure is safe and ca…

This study tests a new catheter system called SpherePVI that uses heat to destroy tiny areas of heart tissue causing atrial fibrillation (an irregular heartbeat). About 150 people with symptomatic atrial fibrillation will undergo the procedure. The goal is to see if the device ca…

This pilot study is testing a new procedure called electroporation ablation (using the FARAPULSE system) to treat atrial fibrillation in 200 people who also have heart failure with preserved ejection fraction. Half will get the procedure, half will get standard medical care. The …

This study tests whether blood thinners (NOACs) can prevent stroke in people who develop atrial fibrillation only during stressful events like surgery or serious illness. About 2,270 participants will be randomly assigned to take a blood thinner or not, and researchers will track…

This study tests whether adding a special pacing test during heart ablation can lower the chance of atrial fibrillation coming back. About 240 adults with paroxysmal AF (short, self-stopping episodes) will be randomly assigned to standard ablation or standard ablation plus extra …

This study tests a new device called the VariPulse catheter, which uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. Twenty adults with AF will get this treatment, and after 2-3 months, doctors will check if the treated veins are still…

This study looks at the long-term safety and effectiveness of a device called QDOT MICRO, used with VISITAG SURPOINT, to treat a type of irregular heartbeat called paroxysmal atrial fibrillation. About 250 adults who have symptoms that don't get better with medication will be fol…

This study looks at whether screening for and treating sleep apnea can reduce the burden of atrial fibrillation (AFib) in patients who are candidates for heart ablation. Fifty adults with paroxysmal or persistent AFib that hasn't responded to medication will be screened for sleep…

This study tests a new approach for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). It combines two procedures: pulsed-field ablation to isolate the pulmonary veins, plus targeted thermal ablation of a nerve cluster near the heart. The goal is to see if a…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study evaluates a new multichannel ECG system designed to detect early signs of cardiovascular disease (CVD) in people who may have no symptoms yet. The system uses advanced algorithms to analyze electrical signals from the heart, looking for subtle abnormalities that could …

This trial is testing whether a mild sedation combination of remimazolam and fentanyl can be used instead of general anesthesia during a pulsed-field ablation procedure for atrial fibrillation. The study will enroll 20 adults with paroxysmal or persistent AF and monitor how well …

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study compares two types of catheter ablation for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if a newer method called pulse field ablation preserves heart muscle function better than the standard cryoablation. Eighty adults…

This study tests whether a smartwatch and text message system can encourage people with paroxysmal atrial fibrillation (a type of irregular heartbeat) to be more physically active. The trial has two phases: first, a small group will help design the messages and test the smartwatc…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms like palpitations and shortness of breath in people with atrial fibrillation (AF). Researchers will enroll 120 adults with paroxysmal AF who are not very active. Participants will use a dig…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study looks at whether using a CPAP machine in a personalized way can reduce the amount of time people with atrial fibrillation (AFib) spend in an irregular heart rhythm. Twenty adults with both moderate-to-severe sleep apnea and AFib will alternate two weeks on and two week…

This study tests whether a 12-week digital MediYoga program—combining deep breathing, gentle yoga, and meditation—can improve quality of life, lower blood pressure, and reduce heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get …

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with various heart rhythm disorders like atrial fibrillation and ventricular tachycardia. The device has many sensors to create a detailed map of the heart's chambers. The …

This study tests a new software module that analyzes heart signals during a procedure called pulsed field ablation, used to treat atrial fibrillation. The goal is to see if the software can accurately tell doctors when the targeted heart veins are fully isolated. One hundred adul…

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. About 50 adults will take part to see if the system works well and…

This study is testing a new 3D imaging system that helps doctors see inside the heart during a procedure to treat atrial flutter and atrial fibrillation. About 50 adults who are already scheduled for a catheter ablation will have their procedure guided by this system. The goal is…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers want to see how AF changes over two years by monitoring heart activity, blood markers, and heart structure. The goal is to better understan…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in 50 people with paroxysmal atrial fibrillation (a type of irregular heartbeat). Researchers will use ultrasound images taken during the procedure to measure changes in heart f…

This study follows 50 adults with paroxysmal atrial fibrillation (AFib) who are scheduled for catheter ablation. Researchers will use exercise tests, heart MRIs, and echocardiograms to measure how well the heart's left atrium works during exercise before and 5-6 months after the …

This study looks at how well the Micra AV2 pacemaker can detect atrial fibrillation (AFib) in people who already have a history of paroxysmal AFib. Researchers will monitor 50 patients using the pacemaker's signals and a special Holter monitor. The goal is to understand how often…

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study looks at whether avoiding alcohol reduces the chance of an atrial fibrillation (AFib) episode in people with paroxysmal AFib. One hundred participants will be randomly assigned each day to either avoid or be allowed to drink alcohol. They will wear heart monitors, fitn…

This study looks at sleep quality in 100 people with atrial fibrillation (AFib) who are scheduled for a heart procedure called pulmonary vein isolation. Participants will have four non-invasive sleep tests—two before and two after the procedure—to measure breathing, heart rate, a…

This study looks at how two different catheters used to treat atrial fibrillation (a type of irregular heartbeat) affect the temperature of the esophagus (the tube connecting the mouth to the stomach) and the risk of injury to it. About 30 adults with paroxysmal atrial fibrillati…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…