Intracerebral hemorrhage

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This phase 2 trial tests whether baricitinib, an anti-inflammatory drug, can improve neurological outcomes in people who have had a spontaneous intracerebral hemorrhage (a type of stroke caused by bleeding in the brain). About 110 adults in China will receive either baricitinib p…

This study tested a new way of caring for stroke patients that brings together doctors, nurses, and family members using technology and teamwork. About 1,200 adults who had a stroke took part. The goal was to see if this coordinated care helps people recover better and have a hig…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This completed study looked at whether a fixed dose of a drug called 4F-PCC is safe and effective for reversing the effects of common blood thinners (rivaroxaban or apixaban) in patients with brain bleeding. Researchers compared this fixed-dose approach to the standard weight-bas…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study tested a device called Artemis that removes blood clots from the brain through a small hole, instead of open surgery. It included 236 adults aged 18 to 80 with a specific type of brain hemorrhage. The goal was to see if this less invasive approach leads to better recov…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This pilot study tested a procedure to close the left atrial appendage—a small pouch in the heart where clots often form—in 58 patients with atrial fibrillation who had a prior brain bleed and cannot take standard blood thinners. The goal was to see if this approach could reduce …

This study looked at whether using a device to measure pressure inside the skull helps doctors treat people with a large brain bleed. 193 patients were randomly assigned to get either standard care or care guided by the pressure monitor. The goal was to see if the monitor helped …

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study looked at whether a special type of CT scan (dual-energy CT) can more accurately tell the difference between bleeding and harmless contrast dye in the brains of stroke patients after treatment. About 189 adults who had a stroke and received clot-busting drugs or a clot…

This study tested whether a special ultrasound of the eye's main artery can help doctors diagnose increased pressure inside the skull. Researchers measured blood flow in the central retinal artery of 66 patients with stroke or traumatic brain injury. The goal was to see if change…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study tested whether giving the seizure drug levetiracetam right away can prevent seizures in people who had a brain bleed (hemorrhagic stroke). About 50 adults with a recent brain bleed received either the drug or a placebo. The goal was to see if the drug could reduce seiz…

This large, completed phase 3 trial tested whether a single pill containing three low-dose blood pressure medicines (telmisartan, amlodipine, and indapamide) could prevent another stroke in 1,671 people who had previously had a bleeding stroke (intracerebral haemorrhage) and had …

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This pilot study tests a home-based rehabilitation program called TASSRET for stroke survivors who have limited access to physiotherapy. Fifty participants will use either a video or a manual guide to practice specific tasks aimed at improving arm and leg function, balance, and q…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested a simple, non-invasive procedure called ischemic conditioning in 132 chronic stroke survivors. The procedure involves inflating a blood pressure cuff on the affected leg to briefly stop blood flow, then releasing it, repeated several times. Researchers measured …

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study looked at 118 patients with brain bleeding who needed a breathing tube in their windpipe. Researchers compared two ways of giving liquid nutrition: a standard tube through the nose into the stomach, and a newer tube through the mouth into the esophagus. The goal was to…

This study tested whether adding ear acupuncture (auricular thumbtack needle therapy) to standard care and nerve stimulation could help people with traumatic brain injury regain consciousness. Sixty patients with a Glasgow Coma Scale score of 4-8 were randomly assigned to receive…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study looked at ways to help people who had a stroke use a CPAP machine for sleep apnea during their rehab stay. Sleep apnea is common after stroke and can slow recovery. The researchers tested different approaches to improve how often patients used the CPAP machine over thr…

This study tested whether a non-invasive brain stimulation technique called tDCS, combined with balance and walking exercises, could help stroke survivors improve their mobility and thinking. Thirty adults who had a stroke participated. The results suggest tDCS may enhance rehabi…

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study aims to create a simple rule that emergency call handlers can use to predict whether an older adult (65+) who has fallen and hit their head is at risk of a brain bleed. Researchers will collect information from 1,100 calls to the SAMU emergency center in Toulouse, Fran…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study observed 141 people in German stroke units who had a brain bleed while taking the blood thinners rivaroxaban or apixaban. Researchers wanted to see if giving the reversal drug andexanet alfa could stop the bleed from getting bigger. They tracked changes in bleed size o…

This pilot study tested a web-based tool designed to improve communication and decision-making between doctors and families of patients with severe acute brain injuries, such as stroke or traumatic brain injury. The tool helps prepare families for their role as decision-makers an…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study looked at 455 stroke patients to see if a continuous finger blood pressure monitor (Clearsight) or standard arm cuff measurements better predict brain bleeding after clot removal. Each patient had both methods used within 24 hours after treatment. The goal was to see w…

This study looked at 70 people who had a brain hemorrhage (bleeding stroke) to see if a special PET scan could tell whether the bleeding was caused by amyloid buildup in blood vessels or by high blood pressure. Participants received an injection of a radioactive tracer called Flo…

This study looked at 29 children with brain injuries to test two new methods for checking how well the brain controls its own blood flow. The goal was to see if these methods could help doctors better understand and treat brain injuries. The study did not test a treatment, but ai…

This study looked at 160 adults having planned brain surgery to see if raising blood pressure during the operation makes it harder for surgeons to stop bleeding. Doctors increased blood pressure slightly with a medicine and noted if extra steps were needed to control bleeding. Th…

This study observed how breathing machines (mechanical ventilation) are used in 2,299 brain-injured patients in intensive care units worldwide. Researchers collected data on different ventilation strategies and their link to patient recovery. No new treatments were tested; the go…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This study looked at whether doctors, nurses, or standard risk scores are better at predicting long-term recovery after a brain hemorrhage. Over 1,000 patients were followed for 6 months. The goal is to improve how we estimate outcomes for these serious conditions.

This study looked at whether online training can improve how well emergency department doctors interpret CT head scans. 173 clinicians from 6 UK hospitals took part. One group received training early, while a control group got it later. The goal was to see if training boosts accu…

This study tested a simple rule to help doctors decide if older patients (65+) who fall need a brain CT scan to check for bleeding. The rule looks at factors like head trauma, memory loss, and frailty. Researchers checked how well the rule worked in 800 patients to see if it coul…

This study looked at how different types of exercise (interval vs. continuous) and intensity levels (moderate vs. high) affect aerobic fitness and blood vessel health in people who have had a stroke. 59 participants used a seated stepper that moves both arms and legs. The goal wa…

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study followed 170 older adults who had a type of stroke caused by cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels. Researchers wanted to see if a specific finding on MRI scans, called cortical superficial siderosis (cSS), could …

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study tested a new, noninvasive device that uses light to monitor blood flow and oxygen in the brains of extremely premature babies. Researchers followed 100 infants born before 29 weeks to see if the device could detect problems linked to brain bleeding. The goal is to give…

This study tested whether an artificial intelligence (AI) tool called qER 2.0 EU helps doctors and other health professionals read head CT scans more accurately and quickly. Thirty-three readers, including radiologists, emergency doctors, and radiographers, reviewed 150 scans wit…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This study looked back at medical records of 123 adults hospitalized with a brain bleed while taking a type of blood thinner called a factor Xa inhibitor. The goal was to understand what happens to these patients and how they are treated in countries where a specific reversal dru…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study gathered brain monitoring data from 162 patients with serious brain injuries, such as traumatic brain injury or stroke. Using a noninvasive ultrasound device, researchers recorded blood flow signals to build a database. The goal is to develop algorithms that could one …

This study tested whether it is safe to get patients with severe brain injuries out of bed early in the intensive care unit. 22 patients were moved using a special device called the Sara Combilizer, and researchers measured brain oxygen levels and other vital signs. The goal was …

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…