Ductal breast carcinoma in situ

This early-phase trial tests a vaccine called H2NVAC in people with a very early form of breast cancer called DCIS that has the HER2 protein. The vaccine is given before surgery to see if it can train the immune system to fight the cancer. The main goals are to check for side eff…

This study is testing whether a shorter, higher-dose radiation treatment (APBI) given over just three days is safe and effective for women with early-stage breast cancer or DCIS who have had a lumpectomy. The goal is to see if this approach causes fewer or milder side effects com…

This study is for women aged 51 or older whose breast cancer has returned or who have a new cancer in the same breast. The goal is to see if giving a focused, short course of radiation before surgery is safe and effective enough to allow breast-conserving treatment instead of mas…

This study tests a new, ultra-short radiation schedule for early-stage breast cancer. Instead of the usual 3 weeks, patients receive 5 radiation sessions over one week, with an extra boost to the tumor site given at the same time. The goal is to see if this approach is safe, redu…

This trial tests whether time-restricted eating (TRE) — a 16:8 fasting schedule — is feasible for patients with HER2-negative breast cancer undergoing neoadjuvant chemotherapy. Participants will follow TRE for 16 weeks while receiving chemo, and researchers will measure how many …

This study looks at whether women over 45 with a low-risk type of early breast cancer (DCIS) can avoid radiation after breast-conserving surgery. A genetic test helps identify those with a very low chance of the cancer coming back. The goal is to see if skipping radiation is safe…

This trial is testing whether young women under 40 with a very early, low-risk form of breast cancer called ductal carcinoma in situ (DCIS) can safely avoid radiation therapy after having breast-conserving surgery. Instead of radiation, participants will be closely monitored, and…

This trial is asking whether women with a very early, non-invasive breast condition called ductal carcinoma in situ (DCIS) can safely skip radiation therapy after having breast-conserving surgery. The study focuses on women aged 40 and older with low- or intermediate-risk DCIS th…

This study is for women whose breast cancer has come back after initial breast-conserving surgery and whole breast radiation. The standard treatment after repeat surgery is radiation twice a day for 30 sessions. This trial tests whether giving radiation once a day for 15 sessions…

This study tests whether active surveillance (close monitoring) combined with hormonal therapy can safely manage ductal carcinoma in situ (DCIS), a very early form of breast cancer. About 400 women with hormone-positive DCIS will receive either standard or investigational hormone…

This trial tests whether a custom-made breast holder called VENUS SHELL™ can improve positioning and comfort during radiotherapy for early-stage breast cancer. Participants lie on their stomach while the device holds the breast in place, aiming to deliver precise radiation in sho…

This trial tests a new device called the EndoSCell Scanner, which uses fluorescence imaging to help surgeons see if any cancer cells remain after removing a breast tumor. About 172 women with breast cancer will have their surgical cavity scanned during surgery. If the scanner det…

This study tests a new radiation approach for early breast cancer that uses real-time MRI guidance to deliver just three high-dose sessions over one week, instead of the usual several weeks. The goal is to see if this shorter treatment is safe, preserves the breast's appearance, …

This study compares standard surgery alone versus a short course of radiotherapy followed by surgery for women with ductal carcinoma in situ (DCIS), a very early form of breast cancer. The goal is to see if pre-surgery radiation can completely eliminate the cancer cells in the re…

This study tests a precise type of radiation called proton beam therapy for women whose breast cancer has returned after a previous lumpectomy and radiation. The goal is to control the cancer while keeping side effects low. Twenty participants will receive 15 daily treatments, an…

This study looks at how different group exercise programs affect fitness and body composition in women who have finished breast cancer treatment. About 15 women will try one of four supervised resistance training regimens. The goal is to see which approach best improves heart-lun…

This study is testing whether adding calorie restriction to a precise, high-dose radiation treatment (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to either standard dietary advic…

This study is testing a handheld robotic tool called HandX to help surgeons perform a nipple-sparing mastectomy through a single small incision. The goal is to remove breast tissue while keeping the skin and nipple, leading to less scarring and better cosmetic results. About 15 w…

This study tests a special scanner that helps surgeons see if any cancer cells are left behind during breast-conserving surgery. The goal is to remove all cancer in one go and avoid a second operation. About 100 women with invasive or in-situ breast cancer will take part. The sca…

This study tests whether giving radiation in 3 treatments over 1.5 days is safe and effective for women with early-stage breast cancer after lumpectomy. About 170 women aged 45-79 will participate. The goal is to see if this shorter course causes fewer side effects and maintains …

This registry study is following 500 women with early-stage breast cancer who receive a single dose of radiation directly to the tumor site during surgery (IORT). The goal is to see how well this approach controls cancer locally and what side effects occur. Participants are women…

This study tests whether giving a single dose of radiation during breast-conserving surgery works as well as standard weeks-long radiation for early-stage, HER2-negative breast cancer. About 620 women aged 55 and older will take part. The goal is to see if this approach lowers th…

This study tests proton radiation therapy for women with early-stage breast cancer. The goal is to see if targeting only the tumor area can keep cancer from coming back while causing fewer side effects. About 132 women aged 50 and older will take part. Researchers will track recu…

This study tests a new glowing needle that helps doctors find and sample very small abnormal areas inside breast ducts during surgery. The needle uses a special coating that lights up, making it easier to see and remove the right tissue. Researchers will compare how well this met…

This study tests a new imaging method called FAPI-PET/MRI to see if it can detect hidden invasive breast cancer in 30 people diagnosed with ductal carcinoma in situ (DCIS), a common pre-stage of breast cancer. Participants receive a weakly radioactive drug and lie in a scanner fo…

This study tests a new handheld device that uses light and artificial intelligence to check for leftover cancer cells right after a breast lump is removed. The goal is to help surgeons remove all cancer in one go, avoiding a second surgery. About 104 women having breast-conservin…

This study is testing a new blood test called Oncoliq to see if it can find breast cancer early. Researchers will collect blood from 300 women, some with breast cancer and some without, to check for tiny molecules called miRNAs that tumors release. The goal is to create a simple,…

This study compares annual mammograms to a personalized screening schedule based on each woman's breast cancer risk. Participants choose or are assigned to either annual screening or risk-based screening, which uses genetic testing and personal history. The goal is to see if pers…

This early-stage trial is testing whether a vaccine targeting the MUC1 protein, combined with hormone therapy, can help prevent ductal carcinoma in situ (DCIS) from becoming invasive breast cancer. Fifty women with ER-positive DCIS will receive either hormone therapy alone or hor…

This study tests whether adding high-dose omega-3 fatty acids to low-dose tamoxifen can lower breast cancer risk more than tamoxifen alone. It includes 66 overweight or obese postmenopausal women at increased risk for breast cancer. The goal is to see if the combination improves …

This study is for premenopausal women at higher-than-average risk for breast cancer. It tests whether a low dose of tamoxifen can safely reduce breast density, which is linked to cancer risk. About 200 women will take tamoxifen, and doctors will adjust the dose if needed to get t…

This study tests whether acolbifene or a low dose of tamoxifen can reduce breast cancer risk in premenopausal women at high risk. Both drugs block estrogen from reaching breast cells. Researchers will measure changes in breast tissue, blood, and mammograms over six months in 80 w…

This study tests whether two different exercise programs—one combining resistance training with cardio, the other with conditioning—have similar effects on muscle mass, fat mass, and blood pressure in women who have completed breast cancer treatment. Participants will exercise th…

This study looks at whether a structured 12-week exercise program can improve fitness and recovery in women who have had DIEP flap breast reconstruction after mastectomy. Half of the 78 participants will follow the exercise program, while the other half will receive standard care…

This study compares two ways to perform nipple-sparing mastectomy with immediate DIEP flap breast reconstruction: robotic-assisted surgery through a single small incision, versus the standard open surgery with a larger cut. The goal is to see which approach leads to better patien…

This study is testing a new surgical technique for breast cancer called endoscopic nipple-sparing mastectomy, done through just one small cut in the armpit. The goal is to remove breast tissue while sparing the nipple and avoiding a large scar on the breast. Ten women with early-…

This study compares two standard exercise programs to see which one better helps women increase muscle mass after breast cancer treatment. Thirty women aged 20-89 who have completed treatment (except chemotherapy) will follow either standard resistance training or a special 6-12-…

This study tests whether a 5-day course of whole breast radiation works as well as a 9-day course for women with early-stage breast cancer. About 144 participants will be randomly assigned to one of the two schedules. The main goal is to see if the shorter treatment leads to simi…

This study tests a special ink called Magic Ink that is only visible under UV light, used to mark the skin for daily radiation treatment in breast cancer patients. The goal is to see if it is as safe and effective as standard permanent tattoo ink, while being less noticeable. Thi…

Surgeons use imaging-guided techniques to locate breast tumors they cannot feel, aiming to remove the cancer completely while sparing healthy tissue. This large observational study compares several methods, including wire-guided localization, intraoperative ultrasound, magnetic s…

This study tests a new way to mark the area where a breast tumor was removed, so radiation therapy can be more accurately aimed afterward. About 50 adults with early-stage breast cancer or a precancerous condition called DCIS will take part. The goal is to see if this marking hel…

This study tests a decision aid called BREASTChoice in 20 breast cancer patients who had breast surgery. Participants use the tool on their phones and share their thoughts in interviews. Researchers measure how much patients learn about reconstruction options using a knowledge su…

This study is looking at how hormone treatments for breast cancer, called aromatase inhibitors and tamoxifen, affect blood sugar control and diabetes risk in postmenopausal women. Researchers will compare blood sugar measures in women taking these drugs to healthy women not on tr…

This study tests whether measuring calcium buildup in heart arteries from routine radiotherapy planning CT scans can identify breast cancer patients at risk for heart disease. Researchers will share this personalized risk information with patients and their doctors to see if it i…

This study offers free genetic testing to the general public to identify people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers aim to see if broad testing is more effective than only testing those with a family history. Up…

This study tests whether a decision aid tool called RECONJOINT is practical for helping women choose breast reconstruction after mastectomy. About 131 women with breast cancer or a genetic risk will use the tool. The goal is to see if a larger study can be done to improve shared …

This study follows 960 women at high risk for breast cancer to see if their diet's inflammatory potential is linked to cancer risk. Participants complete questionnaires and physical exams over time. The goal is to identify modifiable risk factors to improve prevention and early d…

This study looks at how the COVID-19 pandemic impacted out-of-pocket costs, lost wages, and unemployment for 600 breast cancer patients undergoing surgery. Participants will fill out questionnaires about their financial experiences. The goal is to understand the financial toxicit…

This study aims to understand the current state of breast cancer care by surveying both patients and doctors. The goal is to identify gaps in communication and time management, and to develop new, patient-focused care models. About 2000 adults with breast cancer and their physici…

This study is observing how a genetic test called DCISionRT influences treatment decisions for people with ductal carcinoma in situ (DCIS), a very early form of breast cancer. The test predicts the risk of the cancer returning over 10 years and whether radiation therapy would be …

This study tests a decision-making tool for women newly diagnosed with early-stage breast cancer who are considering removing the healthy breast as a preventive measure. The tool aims to improve knowledge and reduce uncertainty about the choice. Only 15 participants are enrolled,…

This study tests whether a new 3D imaging method used during breast cancer surgery helps surgeons remove all cancer cells the first time. About 314 women having breast-conserving surgery will be randomly assigned to either standard 2D imaging or the new 3D imaging. The goal is to…

This study reviews data from 250 women who had a special type of breast-conserving surgery for early-stage breast cancer. The surgery uses nearby skin and fat flaps to fill the area where the tumor was removed, aiming to avoid visible scars and keep the breast looking natural. Re…

This pilot study looks at how social determinants of health—like housing, food, and transportation—relate to inflammation in women newly diagnosed with breast cancer. Participants fill out surveys and give a blood sample at a single visit. The goal is to understand these connecti…

This study is testing a patient navigation program for women newly diagnosed with breast cancer. The program helps patients understand their care options, connect to support services, and manage barriers like transportation or finances. Researchers want to see if this approach im…