Could hormone pills replace surgery for some early breast cancers?

NCT ID NCT06075953

Recruiting now Disease control Sponsor: QuantumLeap Healthcare Collaborative Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study tests whether active surveillance (close monitoring) combined with hormonal therapy can safely manage ductal carcinoma in situ (DCIS), a very early form of breast cancer. About 400 women with hormone-positive DCIS will receive either standard or investigational hormone therapy and undergo MRI scans at 3 and 6 months. If the scans show low risk, they may continue monitoring instead of immediate surgery.

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Conditions

The condition(s) this trial relates to.

ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DUCTAL CARCINOMA IN SITU

Contacts and locations

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Locations

Atrium Health Wake Forest Baptist Comprehensive Cancer Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Berkeley Outpatient Center
RECRUITING

Berkeley, California, 94158, United States
Bryn Mawr Hospital
ACTIVE_NOT_RECRUITING

Bryn Mawr, Pennsylvania, 19010, United States
City of Hope
RECRUITING

South Pasadena, California, 91030, United States
City of Hope - Lennar Foundation Cancer Center
RECRUITING

Irvine, California, 92618, United States
City of Hope -Duarte Cancer Center
RECRUITING

Duarte, California, 91010, United States
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27710, United States
Englewood Hospital and Medical Center
RECRUITING

Englewood, New Jersey, 07631, United States
Health Partners - Frauenshuh Cancer Center
RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Health Partners - Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Hennepin Healthcare -Minneapolis
RECRUITING

Minneapolis, Minnesota, 55404, United States
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
John Muir Health
RECRUITING

Walnut Creek, California, 94598, United States
Lankenau Medical Center
ACTIVE_NOT_RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Maple Grove Cancer Center
RECRUITING

Maple Grove, Minnesota, 55369, United States

Contact Email: •••••@•••••
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Mount Sinai Chelsea
RECRUITING

New York, New York, 10011, United States
Mount Sinai Union Square
RECRUITING

New York, New York, 10003, United States
Mount Sinai West
RECRUITING

New York, New York, 10019, United States
Paoli Hospital
ACTIVE_NOT_RECRUITING

Paoli, Pennsylvania, 19301, United States
UCLA
RECRUITING

Los Angeles, California, 90095, United States
UCSF
RECRUITING

San Francisco, California, 94158, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States

Contact Email: •••••@•••••
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States
Winship Cancer Institute, Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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