Genetic test may spare thousands of women from unnecessary radiation
NCT ID NCT04797299
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times
Summary
This study looks at whether women over 45 with a low-risk type of early breast cancer (DCIS) can avoid radiation after breast-conserving surgery. A genetic test helps identify those with a very low chance of the cancer coming back. The goal is to see if skipping radiation is safe and still keeps the cancer from returning.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Allan Blair Cancer Centre
RECRUITINGRegina, Saskatchewan, S4T 7T1, Canada
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Arthur J.E. Child Comprehensive Cancer Centre
RECRUITINGCalgary, Alberta, T2N 5G2, Canada
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BC Cancer - Abbotsford Centre
RECRUITINGAbbotsford British Columbia, British Columbia, V2S 0C2, Canada
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BC Cancer - Centre for the North (Prince George)
RECRUITINGPrince George, British Columbia, V2M 7E9, Canada
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BC Cancer - Fraser Valley Centre
RECRUITINGSurrey, British Columbia, V3V 1Z2, Canada
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BC Cancer - Vancouver Centre
RECRUITINGVancouver, British Columbia, V5Z 4E6, Canada
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BC Cancer - Victoria
RECRUITINGVictoria, British Columbia, V8R 6V5, Canada
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CHUM - Centre Hospitalier de L'Université de Montréal
RECRUITINGMontreal, Quebec, H2L 4M1, Canada
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CancerCare Manitoba
RECRUITINGWinnipeg, Manitoba, R3E 0V9, Canada
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Cape Breton Cancer Centre
RECRUITINGSydney, Nova Scotia, B1P 1P3, Canada
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Centre Intégré Universitaire de Santé et de Services Sociaux de la Mauricie- Centre-du-Québec (CIUSSS MCQ) - Trois-Rivières
RECRUITINGTrois-Rivières, Quebec, G8Z 3R9, Canada
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Centre intégré de cancérologie du CHU de Québec - Université Laval
RECRUITINGQuébec, Quebec, G1J 1Z4, Canada
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Cross Cancer Institute
RECRUITINGEdmonton, Alberta, T6G 1Z2, Canada
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Hôpital Charles Le Moyne (CISSS de la Montérégie-Centre)
RECRUITINGGreenfield Park, Quebec, J4V 2H1, Canada
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Jewish General Hospital
WITHDRAWNMontreal, Quebec, H3T 1E2, Canada
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Juravinski Cancer Centre
RECRUITINGHamilton, Ontario, L8V 5C2, Canada
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London Regional Cancer Program
RECRUITINGLondon, Ontario, N6A 4L6, Canada
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McGill University Health Centre
RECRUITINGMontreal, Quebec, H4A 3J1, Canada
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QE II HSC - Nova Scotia Cancer Centre
RECRUITINGHalifax, Nova Scotia, B3H 1V7, Canada
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Regional Cancer Care, Thunder Bay Regional Health Sciences Centre
RECRUITINGThunder Bay, Ontario, P7B 6V4, Canada
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Royal Victoria Regional Health Centre
RECRUITINGBarrie, Ontario, L4M 6M2, Canada
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Saskatoon Cancer Centre
RECRUITINGSaskatoon, Saskatchewan, S7N4H4, Canada
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Sunnybrook Health Science Centre -Odette Cancer Centre
RECRUITINGToronto, Ontario, M4N 3M5, Canada
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University Health Network - Princess Margaret Cancer Centre
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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Windsor Regional Cancer Centre
RECRUITINGWindsor, Ontario, N8W 2X3, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- One-Week radiation for breast cancer: MRI precision may cut side effects
- New test may help tailor treatment for early breast cancer
- New genetic test may help women with early breast cancer avoid unnecessary treatment
- One-Week radiation shows promise for breast cancer patients
- Could monitoring replace surgery for some breast lesions?
- Breast cancer overdiagnosis? landmark trial tests monitoring vs. surgery for Low-Risk DCIS