Diastolic heart failure

This early-stage trial is testing a new gene therapy called AB-1002 in people with advanced heart failure (NYHA Class III). The therapy is given as a single infusion directly into the heart's blood vessels, aiming to deliver a gene that may help heart muscle pump more effectively…

This study tests whether a 12-week low-calorie meal replacement diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who are also obese. 63 adults will be randomly assigned to either the diet or standard care. …

This study tested whether the drug sotagliflozin can improve heart function in people with a type of heart failure called HFpEF who do not have diabetes. Eighty-eight participants took either the drug or a placebo for six months. Researchers used heart scans and exercise tests to…

This study tested whether adding sacubitril-valsartan to standard care helps people with heart failure (with preserved pumping ability) and a leaky mitral valve. 84 participants were randomly assigned to get the drug or standard care alone. Researchers measured heart function and…

This study tested whether the drug sacubitril/valsartan can improve heart function in people with heart failure who are on chronic hemodialysis. 52 patients were split into two groups: one received the drug, the other standard care. Researchers measured changes in heart ultrasoun…

This study tested whether a slow-release form of the beta-blocker carvedilol can improve heart function in people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff. 63 adults with high blood pressure and signs…

This study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise ability and blood vessel function in people with heart failure. Ten participants took either the probiotic or a placebo. The goal was to see if the probiotic could…

This study looked at the safety of using levosimendan over a longer period in people who have both pulmonary hypertension and heart failure with preserved ejection fraction. 35 patients who had already been in a related study received the drug and were monitored for side effects.…

This study tested a 12-week cardiac rehabilitation program in 65 elderly patients (70+) with heart failure. The program included strength and aerobic exercises twice a week. Researchers measured changes in movement, heart function, and fitness. The goal was to see if exercise can…

This study tested whether a drug called sacubitril-valsartan (Entresto) can improve early signs of heart failure in people with HIV. The 39 participants had well-controlled HIV but showed subtle heart changes on scans. The goal was to see if the drug could reduce inflammation and…

This completed study looked at over 28,000 people with type 2 diabetes and a type of heart failure called HFpEF. Researchers compared two drugs, tirzepatide and semaglutide, to see which one better reduces the risk of death or hospitalization for heart failure. The study used rea…

This study tested two common blood pressure medications—amlodipine and metoprolol—in 50 adults with heart failure with preserved ejection fraction (HFpEF) and hypertension. Participants took each drug for a period, and researchers measured their home blood pressure readings. The …

This completed study tested whether empagliflozin, a diabetes drug, can improve heart structure and function in 50 non-diabetic patients with heart failure with preserved ejection fraction. Participants took either empagliflozin or a placebo daily. Researchers measured heart stre…

This study tested whether a weekly injection of semaglutide (2.4 mg) can improve heart failure symptoms and reduce body weight in 617 people with obesity-related heart failure with preserved ejection fraction and type 2 diabetes. Participants received either semaglutide or a plac…

This Phase 2 study tested the safety and effectiveness of tovinontrine, an experimental drug, compared to a placebo in 303 adults with chronic heart failure with preserved ejection fraction. The main goal was to see if tovinontrine could lower a key biomarker (NT-proBNP) in the b…

This study tested whether a special clinic (GDMT Clinic) helps heart failure patients get the right medications compared to usual care. About 300 adults with heart failure took part over 12 weeks. The clinic aimed to improve medication use, health status, and heart function.

Heart failure is a serious condition with high death and rehospitalization rates. This study tested whether using a blood marker called ST2 to guide treatment could reduce hospital readmissions within one month. Researchers compared standard care with a strategy that adjusts medi…

This study tested whether a special type of heart MRI, called T1 mapping, can accurately diagnose cardiac amyloidosis—a condition where abnormal proteins build up in the heart muscle. Researchers studied 112 older adults with heart failure and thickened heart walls. They compared…

This study tested a new MRI technique using a contrast agent called mangafodipir to measure how well heart cells take up manganese, which reflects cell function. It included 44 participants: healthy volunteers and people with heart failure with preserved ejection fraction caused …

This study looked at whether taking extra ultrasound images during a standard stress echocardiogram can help doctors figure out if chest pain or shortness of breath is caused by a stiff heart (heart failure with preserved ejection fraction, or HFpEF). Researchers enrolled 30 peop…

This study aimed to create better diagnostic tools for a type of heart failure called heart failure with preserved ejection fraction (HFpEF), which is common in older adults but hard to diagnose. Researchers tested a combination of five blood markers in 91 participants to see if …

This study tested whether a low-salt, heart-healthy diet (DASH diet) can prevent heart failure in veterans with high blood pressure and metabolic syndrome. 71 veterans received counseling and some also got tailored messages via smartphone or email. The goal was to see if the diet…

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher and heart failure with preserved ejection fraction will receive either sem…

This study tests whether a 12-week home-based breathing exercise program (inspiratory muscle training) can improve physical function, fatigue, and quality of life in adults aged 70 and older with advanced heart failure who are receiving palliative care. Participants use a handhel…

This study tested whether using a device that electrically stimulates the thigh muscles at home, for 4 weeks after a hospital stay, could help people with heart failure walk farther and feel stronger. Only 8 people took part, so the results are very early. The goal is to find a s…

This study tested whether metformin, a standard diabetes drug, could help older adults with a specific type of heart failure (HFpEF) feel better and move more easily. Over 20 weeks, 86 participants took either metformin or a placebo. Researchers measured exercise capacity, qualit…

This study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking distance, and heart stress markers ov…

This study tested whether colchicine, an anti-inflammatory drug, can lower inflammation in people with a specific type of heart failure called HFpEF. 42 adults with heart failure symptoms and signs of inflammation took part. The goal was to see if colchicine could reduce markers …

This study tested a gentle electrical stimulation of a nerve in the ear (called tVNS) to see if it could reduce inflammation and improve heart function and exercise ability in people with a type of heart failure called HFpEF. 52 adults with HFpEF received either the real stimulat…

This pilot study tested whether sleep coaching and sleep hygiene training could help people with a common type of heart failure (HFpEF) sleep better and feel better. Ten participants wore activity trackers and kept sleep diaries to see if they could gradually extend their sleep t…

This study looks at how weight loss surgery (gastric sleeve) affects exercise ability in people with or at risk for heart failure with preserved ejection fraction (HFpEF). Researchers will measure oxygen use during exercise before and 12 months after surgery. The goal is to under…

This study uses healthcare claims data from nearly 40,000 people to see if the results of a major clinical trial (EMPEROR-Preserved) can be reproduced in a real-world setting. Researchers are comparing two diabetes drugs, empagliflozin and sitagliptin, in patients with heart fail…

This completed study looked at blood samples from 47 patients in France (part of a larger European study) to find biological markers linked to diastolic heart failure in people with metabolic syndrome. The goal was to confirm earlier findings about these markers. Participants had…

This study looked at why people with a certain type of heart failure (HFpEF) have trouble exercising and feel short of breath. Researchers tested whether different exercise programs (using the whole body or just one leg) could improve fitness. The study involved 93 adults aged 60…

This study looked at how often cardiac amyloidosis occurs in older Tunisian patients with a type of heart failure called HFpEF. Researchers used heart scans and imaging to find cases and identify early warning signs. The goal is to make diagnosis easier and faster for this seriou…

This study followed 520 French adults with central or mixed sleep apnea to see how a treatment called adaptive servo-ventilation (ASV) improved their sleep quality. Participants used a breathing device that adjusts pressure in real time. The goal was to measure changes in sleep q…

This completed study with over 1,000 participants looked at whether patient surveys and interviews can help doctors spot changes in heart failure. Researchers also collected blood samples to explore links between biology and quality of life. The goal was to see if these tools are…

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This completed observational study looked at how often heart failure patients in a French nationwide remote monitoring program were prescribed SGLT2 inhibitors between 2021 and 2024. Researchers analyzed data from over 13,600 adults to see how prescription rates changed over time…

This study looked at 40 people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but still causes symptoms. Researchers used a special exercise test on a bike to measure how the heart, lungs, and muscles work together during a…

This completed study looked at healthcare claims data from over 58,000 people to see if it could reproduce the results of the STEP-HFpEF DM trial, which tested semaglutide for heart failure with preserved ejection fraction in people with type 2 diabetes. Researchers compared new …

This completed study looked at whether information from healthcare claims (like insurance records) can be used to get similar results as a real clinical trial. Researchers compared people with type 2 diabetes and heart failure who started taking tirzepatide to those who started t…

This study looked at how applying positive or negative pressure around the body affects exercise in people with heart failure with preserved ejection fraction. 27 participants, including healthy volunteers and heart failure patients, were tested non-invasively and some invasively…

This study looked at medical records of 4,000 heart failure patients to see if combining routine blood tests (like NT-proBNP) with heart scan results (like fat density around the heart) can better predict who is at risk of dying within a year. The goal is to improve personalized …

This study looked at over 1,000 adults with a type of heart failure called HFpEF, where the heart pumps normally but is too stiff. Researchers measured the fat around the heart using ultrasound and checked how well the heart was working. The goal was to see if more heart fat is l…

This study analyzed data from nearly 5,000 Japanese patients with chronic heart failure who started taking vericiguat as part of their regular care. Researchers tracked outcomes like hospital stays and deaths over one year to see how the drug performs in everyday practice. The go…