Cocaine dependence

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study tests whether a non-invasive brain stimulation technique called rTMS, given before cognitive-behavioral therapy, can help adults with cocaine use disorder quit. Thirty participants will receive either real or sham rTMS daily for 3 weeks, followed by 12 weeks of weekly …

This study tests whether a rotigotine skin patch (Neupro), already approved for Parkinson's disease, can help people with cocaine use disorder cut back on cocaine use when combined with behavioral therapy. Forty adults aged 25 to 70 with moderate to severe cocaine use disorder wi…

This study examines whether adding structured high-intensity physical exercise to a 3-month residential treatment program for substance use disorder improves patients' physical health, mental health, and quality of life. Researchers measure changes in oxygen uptake, leg strength,…

This trial tests whether a helmet that delivers focused ultrasound waves can safely change brain activity in people with moderate-to-severe substance use disorder who haven't responded to medication. Participants receive two MRI-guided sessions targeting brain regions linked to a…

This early-stage trial is testing whether low-intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. The device sends sound waves to specific brain areas to calm cravings. 29 adults in outpatient treatment will receive both real a…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study tests a combination of two treatments for people with cocaine use disorder: deep transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, and contingency management, a program that rewards participants for staying cocaine-free. The go…

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This study tests whether pentoxifylline, an anti-inflammatory drug, can reduce how rewarding cocaine feels. Thirty adults with cocaine use disorder who are not seeking treatment will take the drug and then choose between cocaine and money. The goal is to see if calming immune inf…

This study tests whether a slow-release form of dexamphetamine, a drug used for ADHD, can help people with cocaine and opioid addiction reduce their cocaine use. About 204 adults who are already on methadone for opioid addiction will receive either dexamphetamine or a placebo for…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with cocaine use disorder reduce their cocaine use. About 75 adults will receive semaglutide along with counseling. Researchers will measure changes in brain responses, cravings, and d…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating reward…

This study tests a computer training called Approach Bias Modification (ABM) to see if it can reduce cocaine cravings and increase days of abstinence. Sixty adults with cocaine use disorder will either receive ABM training plus usual care or usual care alone. The training involve…

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This study tests a vaccine called dAd5GNE in 150 people who are dependent on cocaine. The vaccine is designed to train the immune system to attack cocaine, preventing it from reaching the brain and causing a high. The main goal is to check if the vaccine is safe, while also measu…

This study tests whether a 'practice coaching' program can help opioid treatment clinics offer more HIV and hepatitis C testing to their patients. Clinics are randomly assigned to receive either coaching focused on HIV testing, coaching that adds hepatitis C testing, or just info…

This pilot trial tests a counseling program called CHOICES-PLEAS for women in a jail-based substance use treatment program. The goal is to reduce the risk of substance-exposed pregnancies by helping women change their substance use and risky sexual behaviors. Participants receive…

This study tests whether adding a trained family advocate to a proven parenting program can help prevent substance use and reduce childhood trauma. About 360 families from 36 high-risk communities in New Jersey will take part. The goal is to see if extra support makes the program…

This study tests a web-based platform called KulaMind-Recovery designed to help loved ones of people recovering from substance use disorders. The platform offers skill-building modules, one-on-one video sessions, text-based coaching, and a community forum. Researchers will see if…

This study tests whether bright light therapy can help people going through cocaine withdrawal in a hospital. Cocaine withdrawal often disrupts sleep, mood, and daily rhythms, making it hard to stay drug-free. The therapy uses a special lamp to mimic daylight, which may improve s…

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This study tests whether a gentle brain stimulation technique (tDCS) combined with cognitive training can reduce cravings in people with cocaine addiction. 120 participants will receive either real or sham stimulation for 20 minutes a day, three times a week, for five weeks. Rese…

This study tests whether clonidine, a blood pressure medicine, can help reduce cravings in people hospitalized for cocaine or crack use disorder. 36 participants will receive either clonidine or an active placebo (clonazepam) to compare effects. The main goal is to see if craving…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether peer support workers—people with lived experience of substance use—can help people who use drugs feel safer and stay in the emergency department until their care is complete. The study will compare what happens when peer workers are on shift versus when t…

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study follows 700 people with substance use disorders over two years to see how addiction symptoms, especially craving, are connected and whether those connections change as addiction severity shifts. Participants complete annual diagnostic assessments and two-week periods o…

This study tests a bundle of smartphone-based tools, including a mobile health app and other online resources, to see if they are practical and helpful for people who use drugs. The goal is to lower overdose risk by improving access to prevention services. Forty participants will…

This study uses brain scans (PET) to measure how much dopamine is released after a low dose of amphetamine in people with cocaine use disorder. Researchers want to understand brain changes linked to addiction. About 30 adults aged 18-55 with cocaine use disorder will participate.…

This study uses brain scans to see how stress hormones interact with certain brain receptors in people with cocaine use disorder. Researchers will compare 80 adults with and without the disorder to understand these interactions and whether they predict relapse. The goal is to lea…

This study follows 32 people with cocaine use disorder as they go through detox. Researchers use wearable sleep monitors, questionnaires, and urine tests to track sleep quality and body rhythms during active use, early withdrawal, and late withdrawal. The goal is to understand ho…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study looks at whether using a special counseling style called Motivational Interviewing during the first visit can help people stay in addiction treatment. Researchers will compare this approach to the usual intake process. About 150 adults seeking outpatient addiction trea…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study aims to observe a specific behavior called behavioral sensitization in people addicted to crack-cocaine. Researchers will track the movement and sleep patterns of 20 participants over 3 weeks using a wearable device called an actimeter. The goal is to see how crack use…

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete in…

This study aims to develop and test a supervision strategy for clinical supervisors in substance use disorder treatment programs. The goal is to reduce counselor burnout and turnover, and improve their well-being and performance. About 43 supervisors and counselors from residenti…

This study is testing a cooking and nutrition program for 50 people in Texas who are recovering from opioid use and living in recovery homes while on medication therapy. The program aims to improve their eating habits and confidence in cooking skills. Participants will fill out q…

This study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…

This study uses PET scans with a special tracer to measure brain synapse density in 80 people—some with cocaine use disorder and some healthy controls. Researchers aim to see if cocaine changes brain connections, especially in areas linked to decision-making and addiction. Partic…