Cocaine dependence

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This study tests whether a telehealth-delivered counseling program, called VetReach, can help veterans with opioid use disorder engage in treatment and improve their outcomes. The program combines motivational interviewing and cognitive behavioral therapy, delivered remotely. Res…

This study tests a program called Just Care for Families, designed to help parents in rural Oregon who are involved with child welfare services and struggle with opioid or methamphetamine use. The program combines substance use treatment, mental health support, parenting training…

This study tests whether a brief screening and a telehealth counseling session in the emergency department can help people reduce their use of drugs or alcohol. About 650 adults who are at low or moderate risk for substance use problems will take part. The goal is to see if this …

This study looks at whether adding a six-session group recovery program and a 90-day home telehealth program can help veterans with substance use disorders drink less and use fewer drugs. About 195 veterans from a VA psychiatric unit will be randomly assigned to one of three grou…

This study tests whether an app that gives financial rewards for drug-negative saliva tests works for older adults with opioid, cocaine, or methamphetamine use disorder. Researchers will compare results between older and younger participants to see if age affects how well the app…

This early-stage study tests a gene therapy given through an IV for adults with cocaine use disorder who are in remission. The therapy helps the body produce an enzyme that breaks down cocaine quickly, reducing the drug's pleasurable effects. The main goal is to check safety, wit…

This study tests whether a smartphone app can help people who are already on methadone treatment cut down on opioid and cocaine use. The app asks participants to take random drug tests at home and rewards them with money for negative results. Researchers want to see if app users …

This pilot study tests a web-based program called LDART for adults with stimulant use disorder (cocaine or methamphetamine). The program includes daily goal setting, motivational messages from people in recovery, and links to support groups. Researchers want to see if it's feasib…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study aimed to test whether exenatide (Bydureon), a drug approved for type 2 diabetes, could safely reduce the urge to use cocaine. Researchers planned to give the drug or a placebo to people with cocaine use disorder and measure how many cocaine doses they chose to take. Ho…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study aims to eliminate hepatitis C among people who use drugs in Paris, Marseille, Lyon, and Fort-de-France. Researchers will screen participants, provide immediate treatment, and use a peer-referral system to reach more people. The goal is to see if this community-based ap…

This study asks whether standard residential treatment for substance use disorders can improve a person's ability to empathize with others. Researchers will measure empathy levels in about 108 adults before and after they complete a residential program followed by partial hospita…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study looks at whether a single 25 mg dose of psilocybin (the active ingredient in magic mushrooms) can be safely given to people with cocaine use disorder who want to quit. Ten adults from Los Angeles will take the drug in a comfortable room with two clinicians present, and…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This study adapts a proven PTSD therapy (STAIR-NT) for people in methadone treatment who also use cocaine and opioids. Researchers will test if the adapted program is practical and acceptable, and whether it reduces substance use and PTSD symptoms. About 80 participants will be r…

This study tests a new imaging tracer called [18F]fluortriopride to see if it can clearly show D3 dopamine receptors in the brain. Researchers will compare brain scans from healthy volunteers and people with cocaine dependence, and also check how consistent the tracer's signals a…

This study from Mayo Clinic tests whether a smartphone app called Senyo Health can help connect people with substance use disorders to treatment through their primary care doctor. Sixty participants will use the app for 12 weeks, which includes therapy modules, weekly check-ins w…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study aimed to understand how a person's socioeconomic status (like income and education) affects their recovery from substance use disorder. Researchers planned to follow adults in early recovery for up to 3 years, measuring changes in social functioning, quality of life, a…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This study tests whether a "Care Navigator" — a personal guide — can help people with substance use problems start and stay in treatment. About 360 adults who call a mental health access center will be randomly assigned to get usual care or extra help from a navigator. The goal i…

This early study is testing whether focused ultrasound, a non-invasive technique that uses sound waves to target specific brain areas, is safe and feasible for people with opioid or other substance use disorders. The study involves 20 adults aged 22-60 who are currently in treatm…

This study was designed to test whether a drug called lorcaserin could help people with cocaine dependence by rebalancing serotonin in the brain. Researchers planned to use brain scans to see if the drug reduced cravings and impulsivity. However, the study was withdrawn before en…

This study aimed to see if a brain training method called ZQLN could improve brain activity and thinking skills in people with cocaine use disorder. It planned to enroll adults aged 21 to 51 who had completed detox. However, the study was withdrawn before any participants were en…

This study tests whether methylphenidate (Ritalin) can help weaken memories that link drug cues to cocaine use. Fifty-one adults with cocaine use disorder will receive either methylphenidate or a placebo before recalling drug-related memories, while brain activity and skin respon…