Brain disorder
MONDO:0005560A disease affecting the brain or part of the brain.
Also known as: brain disease, brain disease or disorder, disease of brain, disease or disorder of brain, disorder of brain, encephalopathy
16709 clinical trials for this condition and its sub-types, 137 tagged with Brain disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Brain disorder
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Mental disorder 250 trials · 7,390 incl. sub-types
14 sub-types
- Anxiety disorder 2,034 trials · 3,121 incl. sub-types Sub-types →
- Mood disorder 184 trials · 2,673 incl. sub-types Sub-types →
- Developmental disorder of mental health 1 trial · 1,590 incl. sub-types Sub-types →
- Psychotic disorder 201 trials · 769 incl. sub-types Sub-types →
- Pain agnosia 146 trials
- Psychosexual disorder 4 trials · 47 incl. sub-types Sub-types →
- Adjustment disorder 34 trials
- Disruptive behavior disorder 34 trials
- Alcohol-induced mental disorder 0 trials · 24 incl. sub-types Sub-types →
- Drug-induced mental disorder 1 trial · 8 incl. sub-types Sub-types →
- Visual agnosia 0 trials · 2 incl. sub-types Sub-types →
- Akinetopsia 0 trials
- Cortical deafness 0 trials
- Tactile agnosia 0 trials
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Cerebrovascular disorder 108 trials · 3,292 incl. sub-types
24 sub-types
- Stroke disorder 2,037 trials · 2,854 incl. sub-types Sub-types →
- Brain ischemia 55 trials · 283 incl. sub-types Sub-types →
- Intracranial arterial disease 26 trials · 206 incl. sub-types Sub-types →
- Brain infarction 26 trials · 151 incl. sub-types Sub-types →
- Carotid artery disorder 41 trials · 114 incl. sub-types Sub-types →
- Vascular dementia 72 trials Sub-types →
- Cerebral artery stenosis 23 trials · 71 incl. sub-types Sub-types →
- Occlusion precerebral artery 0 trials · 25 incl. sub-types Sub-types →
- Pseudotumor cerebri 22 trials
- Cerebral amyloid angiopathy 16 trials · 17 incl. sub-types Sub-types →
- Cerebral sinovenous thrombosis 16 trials
- Intracranial thrombosis 12 trials · 13 incl. sub-types Sub-types →
- Intracranial vasospasm 13 trials
- APP-related brain and vascular amyloidosis 0 trials · 5 incl. sub-types Sub-types →
- Basal ganglia cerebrovascular disorder 5 trials
- Internal carotid artery stenosis 5 trials
- Familial porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Vascular brain injury 3 trials
- HTRA1-related autosomal dominant cerebral small vessel disease 2 trials
- Subclavian steal syndrome 1 trial
- Cathepsin a-related arteriopathy-strokes-leukoencephalopathy 0 trials
- Cerebral arteritis 0 trials
- Microangiopathy and leukoencephalopathy, pontine, autosomal dominant 0 trials
- Precerebral artery stenosis 0 trials
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Basal ganglia disorder 9 trials · 1,322 incl. sub-types
4 sub-types
- Parkinsonian disorder 67 trials · 1,315 incl. sub-types Sub-types →
- Basal ganglia cerebrovascular disorder 5 trials
- Bilateral striopallidodentate calcinosis 1 trial Sub-types →
- Biotin-responsive basal ganglia disease 1 trial
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Brain neoplasm 247 trials · 1,080 incl. sub-types
17 sub-types
- Brain cancer 682 trials · 902 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 115 incl. sub-types Sub-types →
- Infratentorial neoplasm 6 trials · 115 incl. sub-types Sub-types →
- Brainstem neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Primary brain neoplasm 87 trials · 92 incl. sub-types Sub-types →
- Hypothalamic neoplasm 3 trials · 85 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Choroid plexus neoplasm 5 trials · 18 incl. sub-types Sub-types →
- Neoplasm of cerebral hemisphere 3 trials · 14 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cerebellopontine angle tumor 1 trial Sub-types →
- Dysembryoplastic neuroepithelial tumor 1 trial
- Childhood brain meningioma 0 trials
- Olfactory groove meningioma 0 trials
- Optic tract meningioma 0 trials Sub-types →
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Multiple sclerosis 770 trials · 858 incl. sub-types
4 sub-types
- Relapsing-remitting multiple sclerosis 265 trials
- Chronic progressive multiple sclerosis 83 trials · 115 incl. sub-types Sub-types →
- Pediatric multiple sclerosis 5 trials
- Marburg acute multiple sclerosis 0 trials
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Insomnia 823 trials · 827 incl. sub-types
1 sub-type
- Fatal familial insomnia 4 trials
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Cerebral cortex disorder 0 trials · 723 incl. sub-types
6 sub-types
- Cerebral palsy 443 trials · 499 incl. sub-types Sub-types →
- Visual cortex disorder 0 trials · 187 incl. sub-types Sub-types →
- Pick disease 35 trials
- Hippocampal sclerosis of aging 3 trials
- Occipital lobe neoplasm 0 trials
- Primary motor cortex epilepsy 0 trials
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Brain injury 220 trials · 693 incl. sub-types
2 sub-types
- Traumatic brain injury 559 trials
- Vascular brain injury 3 trials
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Epilepsy 461 trials · 645 incl. sub-types
13 sub-types
- Epilepsy syndrome 2 trials · 181 incl. sub-types Sub-types →
- Reflex epilepsy 1 trial · 155 incl. sub-types Sub-types →
- Focal epilepsy 101 trials · 135 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy 29 trials · 98 incl. sub-types Sub-types →
- Generalized epilepsy 9 trials · 39 incl. sub-types Sub-types →
- Monogenic epilepsy 0 trials · 12 incl. sub-types Sub-types →
- Metabolic epilepsy 0 trials · 8 incl. sub-types Sub-types →
- Post-traumatic epilepsy 6 trials
- Structural epilepsy 5 trials
- Immune epilepsy 0 trials · 1 incl. sub-types Sub-types →
- Infantile-onset epilepsy 1 trial Sub-types →
- Epilepsy, unknown whether focal or generalized 0 trials
- Extratemporal epilepsy 0 trials
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Migraine disorder 393 trials · 414 incl. sub-types
2 sub-types
- Migraine with aura 30 trials · 44 incl. sub-types Sub-types →
- Migraine without aura 42 trials
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Cerebellar disorder 9 trials · 271 incl. sub-types
5 sub-types
- Cerebellar degeneration 6 trials · 150 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 115 incl. sub-types Sub-types →
- Dandy-Walker syndrome 1 trial Sub-types →
- Behrens Baumann dust syndrome 0 trials
- Miller Fisher syndrome 0 trials
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Visual pathway disorder 1 trial · 201 incl. sub-types
5 sub-types
- Visual cortex disorder 0 trials · 187 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Coloboma of optic nerve 1 trial Sub-types →
- Retinal nerve fiber layer disorder 1 trial Sub-types →
- Optic tract meningioma 0 trials Sub-types →
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Pituitary gland disorder 18 trials · 175 incl. sub-types
9 sub-types
- Pituitary tumor 23 trials · 83 incl. sub-types Sub-types →
- Anterior pituitary gland disorder 1 trial · 60 incl. sub-types Sub-types →
- Hypopituitarism 5 trials · 46 incl. sub-types Sub-types →
- Neurohypophyseal diabetes insipidus 9 trials
- Inappropriate ADH syndrome 5 trials
- Hypophysitis 2 trials Sub-types →
- Necrosis of pituitary 0 trials · 1 incl. sub-types Sub-types →
- Empty sella syndrome 0 trials
- Pituitary hypoplasia 0 trials
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Thalamic disorder 0 trials · 110 incl. sub-types
3 sub-types
- Hypothalamic disorder 3 trials · 88 incl. sub-types Sub-types →
- Thalamic cancer 1 trial · 24 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
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Intracranial hypertension 51 trials · 97 incl. sub-types
2 sub-types
- Hypertensive encephalopathy 1 trial · 28 incl. sub-types Sub-types →
- Pseudotumor cerebri 22 trials
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Encephalitis 26 trials · 96 incl. sub-types
7 sub-types
- Infectious encephalitis 3 trials · 50 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Anti-NMDA receptor encephalitis 9 trials
- Meningoencephalitis 6 trials
- Limbic encephalitis 1 trial · 2 incl. sub-types Sub-types →
- Paraneoplastic isolated brainstem encephalitis 0 trials
- Post-vaccinal encephalitis 0 trials
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Hydrocephalus 52 trials · 79 incl. sub-types
7 sub-types
- Communicating hydrocephalus 3 trials · 38 incl. sub-types Sub-types →
- Obstructive hydrocephalus 6 trials
- Congenital hydrocephalus 1 trial · 3 incl. sub-types Sub-types →
- Baker Vinters syndrome 0 trials
- Craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome 0 trials
- Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome 0 trials Sub-types →
- Palmer pagon syndrome 0 trials
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Cerebral degeneration 0 trials · 61 incl. sub-types
2 sub-types
- Pick disease 35 trials
- Corticobasal degeneration disorder 28 trials
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Hepatic encephalopathy 45 trials
1 sub-type
- Hepatic coma 0 trials
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Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types
3 sub-types
- Narcolepsy 1 5 trials
- Narcolepsy 3 0 trials
- Narcolepsy 7 0 trials
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Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types
8 sub-types
- Sandhoff disease 13 trials Sub-types →
- Tay-Sachs disease 13 trials Sub-types →
- Gaucher disease type I 12 trials
- Cerebrotendinous xanthomatosis 6 trials
- Juvenile neuronal ceroid lipofuscinosis 6 trials Sub-types →
- Adult Krabbe disease 0 trials
- Adult neuronal ceroid lipofuscinosis 0 trials Sub-types →
- Infantile neuronal ceroid lipofuscinosis 0 trials Sub-types →
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Intracranial hypotension 32 trials
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Cluster headache syndrome 26 trials
1 sub-type
- Cluster headache, familial 0 trials
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Brain edema 23 trials
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Narcolepsy without cataplexy 22 trials
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Encephalomalacia 1 trial · 13 incl. sub-types
1 sub-type
- Periventricular leukomalacia 12 trials
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Olfactory nerve disorder 8 trials · 12 incl. sub-types
1 sub-type
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
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Traumatic encephalopathy 11 trials
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Prion disease 5 trials · 11 incl. sub-types
10 sub-types
- Creutzfeldt Jacob disease 4 trials · 7 incl. sub-types Sub-types →
- Fatal familial insomnia 4 trials
- Gerstmann-Straussler-Scheinker syndrome 1 trial
- Huntington disease-like 1 0 trials
- PrP systemic amyloidosis 0 trials
- Familial Alzheimer-like prion disease 0 trials
- Kuru 0 trials
- Scrapie 0 trials
- Spongiform encephalopathy with neuropsychiatric features 0 trials
- Sporadic fatal insomnia 0 trials
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Cerebral cortical dysplasia 2 trials · 7 incl. sub-types
2 sub-types
- Isolated focal cortical dysplasia 5 trials · 6 incl. sub-types Sub-types →
- Central bilateral macrogyria 0 trials
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Progressive bulbar palsy 5 trials
1 sub-type
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Akinetic mutism 3 trials
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Bilirubin encephalopathy 3 trials
1 sub-type
- Kernicterus due to isoimmunization 0 trials
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Central nervous system cyst 3 trials
1 sub-type
- Choroid plexus cyst 0 trials
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Megalencephaly 3 trials
4 sub-types
- Bagatelle Cassidy syndrome 0 trials
- Isolated megalencephaly 0 trials
- Macrocephaly/megalencephaly syndrome, autosomal recessive 0 trials
- Megalencephaly, autosomal dominant 0 trials
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Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types
1 sub-type
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Encephaloclastic disorder 0 trials · 3 incl. sub-types
3 sub-types
- Porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Hydranencephaly 0 trials Sub-types →
- Schizencephaly 0 trials Sub-types →
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Cerebral malaria 2 trials
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Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types
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Wernicke encephalopathy 1 trial
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Brain compression 1 trial
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Cerebral sarcoidosis 1 trial
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Reye syndrome 0 trials
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XK aprosencephaly 0 trials
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Acute bilirubin encephalopathy 0 trials
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Aprosencephaly 0 trials
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Atelencephaly 0 trials
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Bulbar polio 0 trials
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Cerebritis 0 trials
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Chronic bilirubin encephalopathy 0 trials
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Colpocephaly 0 trials
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12 sub-types
- Complex cortical dysplasia with other brain malformations 1 0 trials
- Complex cortical dysplasia with other brain malformations 2 0 trials
- Complex cortical dysplasia with other brain malformations 3 0 trials
- Complex cortical dysplasia with other brain malformations 4 0 trials
- Complex cortical dysplasia with other brain malformations 5 0 trials
- Complex cortical dysplasia with other brain malformations 6 0 trials
- Complex cortical dysplasia with other brain malformations 7 0 trials
- Cortical dysplasia, complex, with other brain malformations 10 0 trials
- Cortical dysplasia, complex, with other brain malformations 11 0 trials
- Cortical dysplasia, complex, with other brain malformations 12 0 trials
- Cortical dysplasia, complex, with other brain malformations 9 0 trials
- Polymicrogyria with optic nerve hypoplasia 0 trials
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Diabetic encephalopathy 0 trials
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Disorder of optic chiasm 0 trials
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Encephalopathy, acute transient 0 trials
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Glycine encephalopathy 0 trials
5 sub-types
- Atypical glycine encephalopathy 0 trials
- Glycine encephalopathy 1 0 trials
- Glycine encephalopathy 2 0 trials
- Infantile glycine encephalopathy 0 trials
- Neonatal glycine encephalopathy 0 trials
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Meningoencephalocele 0 trials
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Midbrain disorder 0 trials
Most studied deeper sub-types
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Experimental Alzheimer's drug aims to lower brain 'Tangles' in Early-Stage patients
Disease control OngoingThis early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…
Phase 1 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Can a dopamine-blocking drug safely control tourette syndrome over years?
Disease control OngoingThis trial investigates the long-term safety of ecopipam, a drug that blocks dopamine D1 and D5 receptors, in children, adolescents, and adults with Tourette syndrome. Participants who completed a prior study may enroll and receive ecopipam for up to 24 weeks or longer. The main …
Phase 3 • Sponsor: Emalex Biosciences Inc. • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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Could a new drug slow Alzheimer's? large trial underway
Disease control OngoingThis phase 3 study tests whether donanemab, an antibody given through an IV, can safely slow cognitive decline in 1500 people with early Alzheimer's. Participants receive either the drug or a placebo for up to 93 weeks. The main goal is to measure changes in thinking and daily fu…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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New dosing strategy aims to make Alzheimer's drug safer and more effective
Disease control OngoingThis study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small blee…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Brain injection aims to slow Huntington's
Disease control OngoingThis early-stage study tests a gene therapy called AB-1001 in 5 adults with early Huntington's disease. The treatment is injected directly into the brain to potentially slow the disease. The main goal is to check safety, but researchers will also look at brain changes on MRI and …
Phase 1/2 • Sponsor: AskBio France, SAS, a subsidiary of AskBio Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Gene therapy boost for krabbe patients after transplant
Disease control OngoingThis early-phase trial tests a single infusion of a gene therapy called FBX-101 in 9 people with Krabbe disease who have already received a stem cell transplant. The therapy uses a harmless virus to deliver a working copy of the GALC gene, aiming to improve motor function and saf…
Phase 1/2 • Sponsor: Forge Biologics, Inc • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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New hope for Alzheimer's psychosis: Long-Term drug trial underway
Symptom relief By invitation onlyThis study is testing the long-term safety of a drug called ML007C-MA for people with Alzheimer's disease who also have hallucinations and delusions. About 210 adults who completed a previous study will take the drug twice daily for up to 52 weeks. The goal is to see if the drug …
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Symptom relief
Last updated Aug 09, 2026 00:00 UTC
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Could a pill help restore speech in progressive aphasia?
Symptom relief OngoingThis study tests a drug called neflamapimod in 20 people with a language disorder called nonfluent variant primary progressive aphasia (nfvPPA). The goal is to see if the drug is safe and if it can improve language symptoms. Participants will receive either the drug or a placebo …
Phase 2 • Sponsor: EIP Pharma Inc • Aim: Symptom relief
Last updated Jul 08, 2026 00:00 UTC
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Can brain recordings make DBS safer for thinking and memory?
Knowledge-focused OngoingThis study tracks brain activity in 160 Parkinson's patients who have or will receive deep brain stimulation (DBS). Researchers record signals from the brain during memory tasks, with the stimulator on and off, to find patterns linked to cognitive side effects. The goal is to ide…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Sep 21, 2026 17:00 UTC
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Can a blood marker tell fever from infection in stroke?
Knowledge-focused CancelledThis study follows adults hospitalized with hemorrhagic stroke to see how procalcitonin, a blood marker, changes over the first few days. The goal is to determine if procalcitonin can help doctors tell whether a fever is due to a bacterial infection or another cause, potentially …
Sponsor: CAMC Health System • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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Breathing carbon dioxide to uncover hidden stroke risks in kids
Knowledge-focused OngoingThis study looks at how blood flow and metabolism affect brain development in children with sickle cell anemia. Researchers will use MRI scans and a special mask to have participants breathe carbon dioxide, which helps measure how well brain blood vessels expand. The goal is to u…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Radioactive tracer reveals tau tangles in Alzheimer's brains
Knowledge-focused By invitation onlyThis study tests a new radioactive compound called F 18 T807 that lights up tau tangles in the brain during a PET scan. Researchers want to see if the amount of tau relates to memory and thinking problems in people with a rare, inherited form of Alzheimer's disease. About 130 adu…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Brain tissue collection aims to fuel future discoveries
Knowledge-focused By invitation onlyThis study collects brain tissue samples from up to 2,500 adults and children undergoing brain surgery. The samples are stored in a tissue bank for use in future approved research projects. The goal is to provide a valuable resource for scientists studying brain diseases.
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Smart glove and board could revolutionize arm function testing in brain disorder patients
Knowledge-focused OngoingThis study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…
Sponsor: Samsung Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Trauma ICU survivors: new study tracks hidden brain decline
Knowledge-focused OngoingThis study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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300 volunteers help create medical image bank for science
Knowledge-focused OngoingThis study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…
Sponsor: Mario Negri Institute for Pharmacological Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:28 UTC