Brain disorder
MONDO:0005560A disease affecting the brain or part of the brain.
Also known as: brain disease, brain disease or disorder, disease of brain, disease or disorder of brain, disorder of brain, encephalopathy
16709 clinical trials for this condition and its sub-types, 137 tagged with Brain disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Brain disorder
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Mental disorder 250 trials · 7,390 incl. sub-types
14 sub-types
- Anxiety disorder 2,034 trials · 3,121 incl. sub-types Sub-types →
- Mood disorder 184 trials · 2,673 incl. sub-types Sub-types →
- Developmental disorder of mental health 1 trial · 1,590 incl. sub-types Sub-types →
- Psychotic disorder 201 trials · 769 incl. sub-types Sub-types →
- Pain agnosia 146 trials
- Psychosexual disorder 4 trials · 47 incl. sub-types Sub-types →
- Adjustment disorder 34 trials
- Disruptive behavior disorder 34 trials
- Alcohol-induced mental disorder 0 trials · 24 incl. sub-types Sub-types →
- Drug-induced mental disorder 1 trial · 8 incl. sub-types Sub-types →
- Visual agnosia 0 trials · 2 incl. sub-types Sub-types →
- Akinetopsia 0 trials
- Cortical deafness 0 trials
- Tactile agnosia 0 trials
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Cerebrovascular disorder 108 trials · 3,292 incl. sub-types
24 sub-types
- Stroke disorder 2,037 trials · 2,854 incl. sub-types Sub-types →
- Brain ischemia 55 trials · 283 incl. sub-types Sub-types →
- Intracranial arterial disease 26 trials · 206 incl. sub-types Sub-types →
- Brain infarction 26 trials · 151 incl. sub-types Sub-types →
- Carotid artery disorder 41 trials · 114 incl. sub-types Sub-types →
- Vascular dementia 72 trials Sub-types →
- Cerebral artery stenosis 23 trials · 71 incl. sub-types Sub-types →
- Occlusion precerebral artery 0 trials · 25 incl. sub-types Sub-types →
- Pseudotumor cerebri 22 trials
- Cerebral amyloid angiopathy 16 trials · 17 incl. sub-types Sub-types →
- Cerebral sinovenous thrombosis 16 trials
- Intracranial thrombosis 12 trials · 13 incl. sub-types Sub-types →
- Intracranial vasospasm 13 trials
- APP-related brain and vascular amyloidosis 0 trials · 5 incl. sub-types Sub-types →
- Basal ganglia cerebrovascular disorder 5 trials
- Internal carotid artery stenosis 5 trials
- Familial porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Vascular brain injury 3 trials
- HTRA1-related autosomal dominant cerebral small vessel disease 2 trials
- Subclavian steal syndrome 1 trial
- Cathepsin a-related arteriopathy-strokes-leukoencephalopathy 0 trials
- Cerebral arteritis 0 trials
- Microangiopathy and leukoencephalopathy, pontine, autosomal dominant 0 trials
- Precerebral artery stenosis 0 trials
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Basal ganglia disorder 9 trials · 1,322 incl. sub-types
4 sub-types
- Parkinsonian disorder 67 trials · 1,315 incl. sub-types Sub-types →
- Basal ganglia cerebrovascular disorder 5 trials
- Bilateral striopallidodentate calcinosis 1 trial Sub-types →
- Biotin-responsive basal ganglia disease 1 trial
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Brain neoplasm 247 trials · 1,080 incl. sub-types
17 sub-types
- Brain cancer 682 trials · 902 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 115 incl. sub-types Sub-types →
- Infratentorial neoplasm 6 trials · 115 incl. sub-types Sub-types →
- Brainstem neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Primary brain neoplasm 87 trials · 92 incl. sub-types Sub-types →
- Hypothalamic neoplasm 3 trials · 85 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Choroid plexus neoplasm 5 trials · 18 incl. sub-types Sub-types →
- Neoplasm of cerebral hemisphere 3 trials · 14 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cerebellopontine angle tumor 1 trial Sub-types →
- Dysembryoplastic neuroepithelial tumor 1 trial
- Childhood brain meningioma 0 trials
- Olfactory groove meningioma 0 trials
- Optic tract meningioma 0 trials Sub-types →
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Multiple sclerosis 770 trials · 858 incl. sub-types
4 sub-types
- Relapsing-remitting multiple sclerosis 265 trials
- Chronic progressive multiple sclerosis 83 trials · 115 incl. sub-types Sub-types →
- Pediatric multiple sclerosis 5 trials
- Marburg acute multiple sclerosis 0 trials
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Insomnia 823 trials · 827 incl. sub-types
1 sub-type
- Fatal familial insomnia 4 trials
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Cerebral cortex disorder 0 trials · 723 incl. sub-types
6 sub-types
- Cerebral palsy 443 trials · 499 incl. sub-types Sub-types →
- Visual cortex disorder 0 trials · 187 incl. sub-types Sub-types →
- Pick disease 35 trials
- Hippocampal sclerosis of aging 3 trials
- Occipital lobe neoplasm 0 trials
- Primary motor cortex epilepsy 0 trials
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Brain injury 220 trials · 693 incl. sub-types
2 sub-types
- Traumatic brain injury 559 trials
- Vascular brain injury 3 trials
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Epilepsy 461 trials · 645 incl. sub-types
13 sub-types
- Epilepsy syndrome 2 trials · 181 incl. sub-types Sub-types →
- Reflex epilepsy 1 trial · 155 incl. sub-types Sub-types →
- Focal epilepsy 101 trials · 135 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy 29 trials · 98 incl. sub-types Sub-types →
- Generalized epilepsy 9 trials · 39 incl. sub-types Sub-types →
- Monogenic epilepsy 0 trials · 12 incl. sub-types Sub-types →
- Metabolic epilepsy 0 trials · 8 incl. sub-types Sub-types →
- Post-traumatic epilepsy 6 trials
- Structural epilepsy 5 trials
- Immune epilepsy 0 trials · 1 incl. sub-types Sub-types →
- Infantile-onset epilepsy 1 trial Sub-types →
- Epilepsy, unknown whether focal or generalized 0 trials
- Extratemporal epilepsy 0 trials
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Migraine disorder 393 trials · 414 incl. sub-types
2 sub-types
- Migraine with aura 30 trials · 44 incl. sub-types Sub-types →
- Migraine without aura 42 trials
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Cerebellar disorder 9 trials · 271 incl. sub-types
5 sub-types
- Cerebellar degeneration 6 trials · 150 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 115 incl. sub-types Sub-types →
- Dandy-Walker syndrome 1 trial Sub-types →
- Behrens Baumann dust syndrome 0 trials
- Miller Fisher syndrome 0 trials
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Visual pathway disorder 1 trial · 201 incl. sub-types
5 sub-types
- Visual cortex disorder 0 trials · 187 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Coloboma of optic nerve 1 trial Sub-types →
- Retinal nerve fiber layer disorder 1 trial Sub-types →
- Optic tract meningioma 0 trials Sub-types →
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Pituitary gland disorder 18 trials · 175 incl. sub-types
9 sub-types
- Pituitary tumor 23 trials · 83 incl. sub-types Sub-types →
- Anterior pituitary gland disorder 1 trial · 60 incl. sub-types Sub-types →
- Hypopituitarism 5 trials · 46 incl. sub-types Sub-types →
- Neurohypophyseal diabetes insipidus 9 trials
- Inappropriate ADH syndrome 5 trials
- Hypophysitis 2 trials Sub-types →
- Necrosis of pituitary 0 trials · 1 incl. sub-types Sub-types →
- Empty sella syndrome 0 trials
- Pituitary hypoplasia 0 trials
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Thalamic disorder 0 trials · 110 incl. sub-types
3 sub-types
- Hypothalamic disorder 3 trials · 88 incl. sub-types Sub-types →
- Thalamic cancer 1 trial · 24 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
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Intracranial hypertension 51 trials · 97 incl. sub-types
2 sub-types
- Hypertensive encephalopathy 1 trial · 28 incl. sub-types Sub-types →
- Pseudotumor cerebri 22 trials
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Encephalitis 26 trials · 96 incl. sub-types
7 sub-types
- Infectious encephalitis 3 trials · 50 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Anti-NMDA receptor encephalitis 9 trials
- Meningoencephalitis 6 trials
- Limbic encephalitis 1 trial · 2 incl. sub-types Sub-types →
- Paraneoplastic isolated brainstem encephalitis 0 trials
- Post-vaccinal encephalitis 0 trials
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Hydrocephalus 52 trials · 79 incl. sub-types
7 sub-types
- Communicating hydrocephalus 3 trials · 38 incl. sub-types Sub-types →
- Obstructive hydrocephalus 6 trials
- Congenital hydrocephalus 1 trial · 3 incl. sub-types Sub-types →
- Baker Vinters syndrome 0 trials
- Craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome 0 trials
- Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome 0 trials Sub-types →
- Palmer pagon syndrome 0 trials
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Cerebral degeneration 0 trials · 61 incl. sub-types
2 sub-types
- Pick disease 35 trials
- Corticobasal degeneration disorder 28 trials
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Hepatic encephalopathy 45 trials
1 sub-type
- Hepatic coma 0 trials
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Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types
3 sub-types
- Narcolepsy 1 5 trials
- Narcolepsy 3 0 trials
- Narcolepsy 7 0 trials
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Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types
8 sub-types
- Sandhoff disease 13 trials Sub-types →
- Tay-Sachs disease 13 trials Sub-types →
- Gaucher disease type I 12 trials
- Cerebrotendinous xanthomatosis 6 trials
- Juvenile neuronal ceroid lipofuscinosis 6 trials Sub-types →
- Adult Krabbe disease 0 trials
- Adult neuronal ceroid lipofuscinosis 0 trials Sub-types →
- Infantile neuronal ceroid lipofuscinosis 0 trials Sub-types →
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Intracranial hypotension 32 trials
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Cluster headache syndrome 26 trials
1 sub-type
- Cluster headache, familial 0 trials
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Brain edema 23 trials
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Narcolepsy without cataplexy 22 trials
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Encephalomalacia 1 trial · 13 incl. sub-types
1 sub-type
- Periventricular leukomalacia 12 trials
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Olfactory nerve disorder 8 trials · 12 incl. sub-types
1 sub-type
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
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Traumatic encephalopathy 11 trials
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Prion disease 5 trials · 11 incl. sub-types
10 sub-types
- Creutzfeldt Jacob disease 4 trials · 7 incl. sub-types Sub-types →
- Fatal familial insomnia 4 trials
- Gerstmann-Straussler-Scheinker syndrome 1 trial
- Huntington disease-like 1 0 trials
- PrP systemic amyloidosis 0 trials
- Familial Alzheimer-like prion disease 0 trials
- Kuru 0 trials
- Scrapie 0 trials
- Spongiform encephalopathy with neuropsychiatric features 0 trials
- Sporadic fatal insomnia 0 trials
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Cerebral cortical dysplasia 2 trials · 7 incl. sub-types
2 sub-types
- Isolated focal cortical dysplasia 5 trials · 6 incl. sub-types Sub-types →
- Central bilateral macrogyria 0 trials
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Progressive bulbar palsy 5 trials
1 sub-type
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Akinetic mutism 3 trials
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Bilirubin encephalopathy 3 trials
1 sub-type
- Kernicterus due to isoimmunization 0 trials
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Central nervous system cyst 3 trials
1 sub-type
- Choroid plexus cyst 0 trials
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Megalencephaly 3 trials
4 sub-types
- Bagatelle Cassidy syndrome 0 trials
- Isolated megalencephaly 0 trials
- Macrocephaly/megalencephaly syndrome, autosomal recessive 0 trials
- Megalencephaly, autosomal dominant 0 trials
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Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types
1 sub-type
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Encephaloclastic disorder 0 trials · 3 incl. sub-types
3 sub-types
- Porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Hydranencephaly 0 trials Sub-types →
- Schizencephaly 0 trials Sub-types →
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Cerebral malaria 2 trials
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Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types
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Wernicke encephalopathy 1 trial
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Brain compression 1 trial
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Cerebral sarcoidosis 1 trial
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Reye syndrome 0 trials
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XK aprosencephaly 0 trials
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Acute bilirubin encephalopathy 0 trials
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Aprosencephaly 0 trials
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Atelencephaly 0 trials
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Bulbar polio 0 trials
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Cerebritis 0 trials
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Chronic bilirubin encephalopathy 0 trials
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Colpocephaly 0 trials
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12 sub-types
- Complex cortical dysplasia with other brain malformations 1 0 trials
- Complex cortical dysplasia with other brain malformations 2 0 trials
- Complex cortical dysplasia with other brain malformations 3 0 trials
- Complex cortical dysplasia with other brain malformations 4 0 trials
- Complex cortical dysplasia with other brain malformations 5 0 trials
- Complex cortical dysplasia with other brain malformations 6 0 trials
- Complex cortical dysplasia with other brain malformations 7 0 trials
- Cortical dysplasia, complex, with other brain malformations 10 0 trials
- Cortical dysplasia, complex, with other brain malformations 11 0 trials
- Cortical dysplasia, complex, with other brain malformations 12 0 trials
- Cortical dysplasia, complex, with other brain malformations 9 0 trials
- Polymicrogyria with optic nerve hypoplasia 0 trials
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Diabetic encephalopathy 0 trials
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Disorder of optic chiasm 0 trials
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Encephalopathy, acute transient 0 trials
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Glycine encephalopathy 0 trials
5 sub-types
- Atypical glycine encephalopathy 0 trials
- Glycine encephalopathy 1 0 trials
- Glycine encephalopathy 2 0 trials
- Infantile glycine encephalopathy 0 trials
- Neonatal glycine encephalopathy 0 trials
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Meningoencephalocele 0 trials
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Midbrain disorder 0 trials
Most studied deeper sub-types
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Robot scalpels take on Alzheimer's: could clearing neck lymph nodes slow the disease?
Disease control Not yet recruitingThis study tests whether a robotic surgical system can safely perform delicate microsurgery on deep lymph nodes in the neck of people with Alzheimer's disease. The idea is that improving lymph drainage from the brain might help clear harmful proteins linked to Alzheimer's. The tr…
Sponsor: MMI (Medical Microinstruments, Inc.) • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Stroke-Clot zapper: new device could save brains within 24 hours
Disease control Not yet recruitingThis trial tests a new device called Supernova that removes blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. The study will include 3,000 participants and measure how well the device works and…
Sponsor: Gravity Medical Technology, INC • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Can tiny tablets replace protein powder for kids with PKU?
Symptom relief Not yet recruitingThis trial tests whether XPhe Piccos, a slow-release protein substitute in tiny tablets without phenylalanine, is acceptable and well-tolerated in children aged 3 and older with phenylketonuria (PKU) or hyperphenylalaninemia. Participants replace some or all of their usual protei…
Sponsor: metaX Institut fuer Diatetik GmbH • Aim: Symptom relief
Last updated Sep 05, 2026 00:00 UTC
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Could a Parkinson's drug ease radiation brain damage?
Symptom relief Not yet recruitingThis trial tests whether Gocovri, an extended-release form of amantadine, can reduce disability and improve cognitive function in adults who have brain damage from radiation therapy. Participants take the drug daily for about 24 weeks, with the dose increasing after the first mon…
Phase 2 • Sponsor: Weill Medical College of Cornell University • Aim: Symptom relief
Last updated Aug 05, 2026 00:00 UTC
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Can a home workout boost brain and body in Parkinson's?
Symptom relief Not yet recruitingThis study tests a 16-week home-based exercise program for people with Parkinson's disease. Fifty participants will either do aerobic and resistance training or just stretching. The goal is to see if the program increases daily physical activity, improves thinking, and enhances q…
Sponsor: University of Illinois at Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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New hope for kids with CP: shorter therapy might be just as good
Symptom relief Not yet recruitingThis study looks at whether a combined program of 35 hours of therapy plus 15 hours of home practice works as well as 50 hours of standard therapy for improving how children aged 3 to 5 with cerebral palsy use both hands. About 66 children will take part. The goal is to make ther…
Sponsor: Fondation Ildys • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Which early signs foretell recovery in childhood encephalitis?
Knowledge-focused Not yet recruitingResearchers at Assiut University Children Hospital are tracking 88 children with encephalitis to see which clinical, laboratory, and imaging findings at admission relate to early neurological outcomes. The study measures functional status at discharge using a standard scale, alon…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Sep 21, 2026 16:00 UTC
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Brain waves may reveal which children recover from encephalopathy
Knowledge-focused Not yet recruitingResearchers at Assiut University Children Hospital are studying whether abnormal brain-wave patterns on an EEG can predict how well children with encephalopathy recover. The study follows 147 children aged 1 month to 18 years who have altered consciousness from encephalopathy. Ea…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Sep 19, 2026 00:00 UTC
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Massive german study to map stroke care from ambulance to recovery
Knowledge-focused Not yet recruitingThis study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …
Sponsor: Charite University, Berlin, Germany • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC
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Brain study in kids with epilepsy could unlock learning secrets
Knowledge-focused Not yet recruitingThis study looks at how the brain works in 200 children with hard-to-treat epilepsy who are already scheduled for brain monitoring. Researchers will measure brain activity during tasks like learning and decision-making. The goal is to better understand thinking and memory, which …
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Brain watch: new study tracks ICU Patients' brain waves without interference
Knowledge-focused Not yet recruitingThis study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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New study seeks clues to recovery in rare childhood brain condition
Knowledge-focused Not yet recruitingThis study aims to find what factors predict recovery in children with acute disseminated encephalomyelitis (ADEM), a rare brain condition. Researchers will follow 25 children aged 6 months to 18 years to see how many recover fully and how many have relapses. The study does not t…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:09 UTC
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Brain scans reveal how stroke patients recover arm movement
Knowledge-focused Not yet recruitingThis study will follow 30 adults who have had a stroke and have arm weakness. Researchers will use functional MRI scans at several time points over six months to see how the brain reorganizes itself. The goal is to link different patterns of brain activity to different levels of …
Sponsor: Rennes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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630-Patient study aims to unlock secrets of brain aneurysms and AVMs
Knowledge-focused Not yet recruitingThis observational study will follow 630 people with cerebral arteriovenous malformations (AVMs) and intracranial aneurysms to learn how these conditions progress and how different treatments perform. Researchers will track imaging success rates and complications over time. The g…
Sponsor: Duan Chuanzhi • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Headache trigger test: could amylin be the culprit?
Knowledge-focused Not yet recruitingThis study gives people with persistent post-traumatic headache a hormone called amylin (or a placebo) to see if it triggers migraine-like headaches. The goal is to understand why headaches continue after a mild brain injury. Only 21 adults will take part, and the results may hel…
Sponsor: Danish Headache Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Scientists investigate if amylin analogue sparks migraines
Knowledge-focused Not yet recruitingThis study looks at whether pramlintide, a drug similar to the hormone amylin, can cause migraine attacks in people who get migraines without aura. Researchers will give 21 participants either pramlintide or a placebo and watch for headaches over 12 hours. The goal is to understa…
Sponsor: Danish Headache Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Can a camera help surgeons spot healthy brain tissue?
Knowledge-focused Not yet recruitingThis study tests whether a camera can record useful video of the brain during neurosurgery to help surgeons tell healthy tissue from diseased tissue. Researchers will record 50 adult patients undergoing brain surgery for tumors, epilepsy, or other conditions. The goal is to see i…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC