Bacterial urinary tract infection

This study looks at whether an extra cleaning step before a routine bladder check during laparoscopic hysterectomy can lower the chance of urinary tract infections after surgery. About 98 women having the surgery for non-cancer reasons will be observed. The goal is to see if this…

This study tested a new antibiotic combination, cefepime-zidebactam, against a standard antibiotic (meropenem) in adults hospitalized with complicated urinary tract infections or kidney infections. About 530 participants received either the new drug or the standard one for 7 to 1…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study tested whether a visual storytelling sticker on antibiotic packaging helps adults with urinary tract infections (UTIs) take all their medicine. 358 adults in Pakistan were randomly assigned to get either the sticker or usual care. The goal was to see if the sticker imp…

This study tested two new antibiotic combinations (cefepime/nacubactam and aztreonam/nacubactam) against the best available treatments for adults with serious infections like urinary tract infections, pneumonia, and abdominal infections caused by carbapenem-resistant bacteria. Th…

This study tested whether tamsulosin (Flomax) can reduce the risk of urinary retention and catheter-related infections in men aged 50 and older after elective surgery. Participants received either tamsulosin or a placebo after their catheter was removed. The goal was to see if th…

This study tested a closed-system bladder irrigation device designed to reduce urinary tract infections after endoscopic urologic surgery. 240 patients undergoing prostate or bladder tumor surgery were randomly assigned to use the new device or standard irrigation. The device all…

This early-stage trial tested an experimental antibiotic called GSK3882347 in 140 women with uncomplicated urinary tract infections (UTIs). Participants received either the new drug, a standard antibiotic (nitrofurantoin), or a placebo for 5 days. The study measured how well the …

This study tested an oral antibiotic (tebipenem pivoxil hydrobromide) against a standard IV antibiotic in 1,690 hospitalized adults with complicated urinary tract infections or kidney infections. The goal was to see if the oral pill works as well as the IV treatment in curing the…

This study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…

This study looked at whether giving pomegranate seed oil supplements for 24 weeks could help prevent urinary tract infections and pneumonia in people with advanced dementia who are in palliative care. It also checked if the supplement helped reduce or stop antipsychotic medicatio…

This phase 3 trial tested two new antibiotic combinations—cefepime/nacubactam and aztreonam/nacubactam—against a standard antibiotic (imipenem/cilastatin) in 614 adults with complicated urinary tract infections or acute kidney infections. The goal was to see if the new combos are…

This study tested if the antibiotic temocillin works as well as a stronger antibiotic (carbapenem) for treating urinary tract infections caused by resistant bacteria. 29 hospitalized adults took part. The goal was to see if both treatments could clear the infection and symptoms. …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This completed Phase 2 trial tested fecal microbiota transfer (FMT) – a freeze-dried product made from healthy donor stool – in 40 women with recurrent urinary tract infections (UTIs). The goal was to see if FMT could prevent future UTIs by restoring healthy gut bacteria. Researc…

This study tested whether taking a probiotic called Lactobacillus reuteri could reduce the number of repeat urinary tract infections (UTIs) in adult women who had recently finished antibiotic treatment for a UTI. 140 women with a history of recurrent UTIs took either the probioti…

This pilot study tested whether women with kidney infections could safely stop antibiotics once their symptoms resolved, instead of taking a full 10-day course. 35 women were randomly assigned to either standard treatment or a patient-directed approach. The main goal was to see i…

This study tested four different short antibiotic courses in 1,000 women with uncomplicated lower urinary tract infections. Participants received either a two-day course of fosfomycin, a three-day course of pivmecillinam, a five-day course of nitrofurantoin, or a single dose of f…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether a rapid 30-minute desktop test for gonorrhea and chlamydia could help doctors make better treatment decisions compared to the current standard (a gram stain). 98 adults with symptoms of urethritis or cervicitis took part. The goal was to see if the rapid…

This early-phase trial tests whether taking a daily probiotic (Saccharomyces boulardii) and using a targeted antibiotic (ciprofloxacin) only when a UTI occurs can reduce the number of repeat infections in children aged 2 to 17. Participants have had at least three UTIs in the pas…

This study tested whether putting the antibiotic gentamicin directly into the bladder can prevent recurrent urinary tract infections (UTIs) in postmenopausal women. Twenty women were split into two groups: one received gentamicin via a catheter into the bladder, and the other too…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This completed Phase 3 trial tested the antibiotic gepotidacin in 97 adolescent and adult women with uncomplicated urinary tract infections (UTIs). The goal was to see if symptoms like pain and urgency improved within 24 hours. Researchers measured symptom scores and safety. The …

This study looked at whether women who had surgery for prolapse or incontinence could safely remove their urinary catheter at home one day after surgery, instead of waiting 3-4 days. 128 women who failed a voiding trial before leaving the hospital took part. The main goal was to …

This study tested whether a probiotic called Bifidobacterium breve PRL2020 could reduce stomach issues like diarrhea in 121 children aged 3-12 who were taking amoxicillin antibiotics. The children took the probiotic alongside their antibiotic treatment. The goal was to see if it …

This study tested whether hygiene education using the 'teach-back' method (where women explain what they learned) improves genital hygiene behaviors and reduces symptoms in pregnant women diagnosed with urinary tract infections. 36 pregnant women participated, with half receiving…

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This completed study looked at antibiotic resistance in bacteria causing urinary tract infections (UTIs) in Uganda. Researchers compared resistance patterns in patients who sought care at community drug shops versus hospitals. By studying 890 participants, they aim to understand …

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study looked at whether information from national health insurance cards—like past antibiotic use and hospital stays—can predict if a person's urinary tract infection will be resistant to common antibiotics. Researchers analyzed data from over 1,100 patients with community-a…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This study checks if men who had a treated urethritis infection still have signs of long-term inflammation and cell damage in their genital tract. Researchers measured a protein called elastase and markers of oxidative stress in semen 6 and 12 months after treatment. They compare…

This study looked at whether a blood test that measures immune response to CMV can predict infection risk in children who have received a heart, kidney, or liver transplant. Researchers tested blood samples from 161 children within the first year after transplant. The goal is to …

This study tested whether adding infectious disease experts to primary care teams helps reduce unnecessary antibiotic use. Over 1,300 patients from six clinics in Spain took part. Doctors in the expert-advised group could call or meet with specialists to discuss tricky cases. The…

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…

This study tested a new system (PA-100 AST) to help doctors quickly choose the right antibiotic for women with urinary tract infections (UTIs). About 199 non-pregnant women with UTI symptoms provided urine samples, which were tested with the new system. The goal was to see if usi…

This study followed 603 pregnant women in South Africa to see if infections or bacteria in the vagina are linked to how early they give birth. Researchers tested for sexually transmitted infections, yeast, and other germs at the start of pregnancy and again at 30-34 weeks. The go…