University Of California, Davis

This early-phase trial tests a new treatment called PPM for people with non-muscle invasive bladder cancer that has come back or not responded to standard care. PPM uses tiny particles coated with a targeting molecule to deliver a chemotherapy drug directly to cancer cells in the…

This study tests whether a home monitoring program using text messages and a smartphone app can help people with coronary artery disease manage their health after a stent procedure. 200 participants will either receive standard care or the digital program, which includes remote b…

This early-stage study tests whether combining a precise laser treatment (LITT) with the chemotherapy drug lomustine is safe and doable for adults whose glioblastoma has come back. About 20 participants will receive the laser procedure followed by chemo within a week. The main go…

This study looks at two ways to heal wounds on the scalp after Mohs surgery for skin cancer. One method lets the wound heal naturally, which can take 8 weeks or more. The other uses a pinch graft, where a thin piece of skin from the groin is placed into the wound to help it heal …

This study tests a procedure called FETO for babies with a severe diaphragmatic hernia, where organs move into the chest and harm lung growth. A tiny balloon is placed in the baby's windpipe while still in the womb to help the lungs grow. The study involves 10 pregnant women and …

This study tests whether adding stem cells from the placenta to fetal surgery can help babies with spina bifida walk better and have better bowel and bladder control. About 55 pregnant women carrying babies with spina bifida will receive the stem cell-enhanced surgery. The goal i…

This early-phase trial tests a new vaccine (IO102-IO103) plus the immunotherapy drug pembrolizumab in 30 adults with a type of bladder cancer that did not respond to or could not tolerate standard BCG therapy. The vaccine aims to train the body's immune cells to recognize and att…

This study looks at whether eating grapes every day can improve gut health, reduce inflammation, and help blood vessels work better in overweight adults aged 45 to 70. Participants will drink grape powder or a placebo twice daily for three weeks. Researchers will measure changes …

This study tests a two-step treatment for adults with a specific type of acute myeloid leukemia (AML) that has a mutation in the IDH1 gene. First, patients receive a combination of two drugs (olutasidenib and azacitidine) to control the cancer. Then, they continue on a maintenanc…

This study looks at whether using a continuous glucose monitor (CGM) can help people who have had a kidney transplant and have type 2 diabetes keep their blood sugar in a healthy range. About 80 adults who received a kidney transplant in the past year and use insulin will wear a …

This early-phase study tests a two-part system: one radioactive substance helps doctors see pancreatic cancer tumors on scans, and another delivers targeted radiation therapy. The goal is to check safety and find the right dose in 30 adults with advanced pancreatic cancer that ha…

This early-stage study tests a two-part approach for people with metastatic cancer. First, a special dye helps doctors see tumors on a scan. Then, a targeted treatment delivers radiation directly to those tumors. The goal is to check safety and whether the treatment can shrink or…

This early-phase study tests whether combining a blood pressure drug (losartan), an immunotherapy (pembrolizumab), and precise radiation (SBRT) is safe and effective for people with head and neck cancer that has come back or spread. About 24 adults with limited metastatic disease…

This study tests a stent graft that doctors modify by hand to treat complex aortic aneurysms in patients who cannot use standard FDA-approved devices. About 40 high-risk adults will be enrolled, and the main goal is to see if the graft is safe and works well at one year. The appr…

This study tests whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take the supplement and undergo tests like e…

This early-stage study tests a new approach to treat metastatic non-small cell lung cancer. A special radioactive compound is designed to seek out and deliver radiation directly to cancer cells, while a companion imaging agent helps see where the cancer is. The goal is to check s…

This study tests an experimental drug, senicapoc, in people with mild or early Alzheimer's disease. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks. This is an early-phase …

This early-stage study tests whether injecting cyclosporine directly into bald patches can safely regrow hair in people with alopecia areata, an autoimmune condition causing patchy hair loss. About 12 adults with mild to moderate hair loss will receive either the drug or a placeb…

This study is testing whether alendronate, a drug used for osteoporosis, can help treat bone damage (osteonecrosis) in adults with sickle cell disease. About 30 participants will take the drug for 6 months to see if it reduces pain and improves quality of life. The study also che…

This study tests two medicines, dopamine and norepinephrine, in newborns with lung and heart failure who also have low blood pressure. The goal is to see which medicine raises blood pressure without making lung problems worse. About 30 babies born at 35 weeks or later will take p…

This study looks at whether follow-up care for opioid use disorder works better through telehealth or in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person cl…

This early-stage study tests a new chemotherapy drug, TR-002, in about 52 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. The study also looks at whether the drug can shr…

This study tests whether using a protein-based test to choose treatment can help people with advanced non-small cell lung cancer live longer without their cancer getting worse. About 56 adults with stage IIIC or IV lung cancer will be randomly assigned to either standard therapy …

This early-phase study tests a new radioactive tracer called [68Ga]Ga DOTA-5G for PET/CT scans in 30 people with advanced invasive lobular breast cancer. The goal is to see if it can better detect cancer spread than standard scans. Researchers will also check for side effects wit…

This early-phase study is testing a new radioactive tracer for PET scans that may better detect non-small cell lung cancer that has spread to the brain. About 20 adults with this type of lung cancer and brain metastases will receive the tracer and undergo imaging. The goal is to …

This study tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice during thei…

This study aims to create better breastfeeding support for women who had gestational diabetes, with the goal of preventing type 2 diabetes later in life. Researchers will work with patients, healthcare providers, and hospital leaders to design a practical support strategy. Only 1…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults who are at risk for dementia and diabetes. One group will do aerobic exercise classes, and the other will get dietary counseling to follow the MIND diet (rich in berries, vegetable…

This study tests whether short, documentary-style videos can motivate firefighters to take safety steps that lower their cancer risk. About 1,000 active California firefighters will watch one of five videos and answer surveys before and after. The goal is to see if the videos inc…

This study tests which imaging method—fluoroscopy (X-ray) or ultrasound—works better for a procedure called cooled radiofrequency ablation that targets nerves around the knee to reduce pain. The goal is to improve pain relief and function in people with knee osteoarthritis who ha…

This study compares the side effects of two standard treatments for advanced prostate cancer: abiraterone plus prednisone versus darolutamide alone. About 75 men with prostate cancer that has spread will take one of these medications. The goal is to see which treatment causes few…

This study tests if injecting steroids outside the tendon sheath works as well as injecting inside it for De Quervain's tenosynovitis, a painful thumb condition. About 80 adults will receive one injection and report their pain levels before and after. The goal is to find a simple…

This study tests whether a natural supplement can increase collagen production in the body when taken with collagen protein. Researchers will measure collagen markers in the blood of 20 healthy young adults after exercise. They will also use participants' blood to see if it stren…

This study tests a new way to use deep brain stimulation (DBS) for Parkinson's disease. Standard DBS helps movement but can sometimes cause thinking or mood problems. The researchers want to see if adding a low-frequency signal to a different part of the brain, along with the usu…

This study tests whether a numbing injection through the nose can better relieve severe headaches caused by a brain bleed (subarachnoid hemorrhage). About 40 adults with a secured aneurysm will receive either the nerve block plus standard pain meds or standard meds alone. The goa…

This study tests two ways of closing skin wounds with purse-string stitches to see which gives a better-looking scar. About 73 adults having skin surgery will have half their wound closed one way and the other half the other way. Three months later, doctors and patients will rate…

This study looks at whether giving magnesium sulfate through an IV can help manage pain and reduce the need for strong painkillers in trauma patients in the intensive care unit (ICU). About 156 adults with injuries will receive either magnesium or a saltwater solution. The goal i…

This study tests whether spraying a cooling liquid (ethyl chloride) on the skin before a numbing injection can reduce pain during Mohs surgery for skin cancer. About 80 adults will have half of their surgical site pre-cooled and the other half not, then rate the pain of each inje…

This study tests whether a special locking stitch reduces scarring better than the standard stitch used to close surgical wounds on the head or neck. Half of each wound will get one stitch type, and the other half the other, so doctors can directly compare the scars. About 50 adu…

This study tests whether adding a special gauze dressing (called a tie-over bolster) on top of regular stitches can reduce scarring after surgery on the head or neck. Half of each wound will get the extra dressing, and the other half will not, so doctors can compare the results. …

This study tests whether almond oil can improve facial pigmentation as well as the standard treatment hydroquinone. Researchers will also check how each treatment affects the skin's natural bacteria. The study involves 50 premenopausal women with darker skin tones (Fitzpatrick ty…

This study looks at why some people with knee osteoarthritis get more pain relief from a topical gel (diclofenac) than others. Researchers will track 220 adults aged 50+ over 8 weeks, collecting questionnaires and blood samples. The goal is to see if patient traits, clinic visit …

This study tests a non-invasive brain stimulation treatment called TMS for teens and young adults (ages 15-25) with depression and suicidal thoughts. The treatment is given over 5 days and uses MRI to guide targeting. Researchers want to see if it reduces depression and suicide r…

This study looks at whether giving gabapentin before and after chest surgery can reduce the amount of strong painkillers (opioids) that children need. About 60 children under 18 having heart or lung surgery will take part. The goal is to manage pain with fewer opioids, which can …

This study compares a skin patch to standard pills for treating bladder pain and urgency in children aged 4-8 after bladder surgery. About 100 participants will be assigned to either the patch or pill form of the drug oxybutynin. The goal is to see which method better reduces pai…

This study tests two different numbing injections for pain after kidney transplant surgery. One group gets a single long-lasting shot, and the other gets a shot plus a small tube that delivers numbing medicine for a longer time. The goal is to see which method reduces the need fo…

This study looks at whether a stepped-care program can help identify and treat young people (ages 12-25) who are at high risk for psychosis in community mental health centers. The program starts with simple steps and increases support as needed. Researchers will track how many yo…

This study tests whether a 6-week balanced diet can lower inflammation in people with psoriasis, using a new total-body PET scanner. Five adults with psoriasis and a typical Western diet will get scans before and after the diet change. The goal is to see if the diet reduces skin …

This observational study aims to see if a new, standardized physical exam technique can reliably identify joint motion problems in healthy adults and people hospitalized after a stroke or mini-stroke (TIA). Researchers will compare motion patterns between these groups and check i…

This study looks at whether a 2-week exercise and nutrition program before head and neck cancer surgery is safe and doable. About 20 adults with a new head and neck cancer diagnosis will take part. The goal is to see if patients can complete the program and if they find it accept…

This study looks at whether eating pecans daily for three months can improve metabolism, blood fats, inflammation, blood pressure, thinking skills, and gut bacteria in healthy adults aged 45 to 75. Participants will eat pecans for one period and avoid them for another, with blood…

This study looks at how well the pneumonia vaccine works in people who have injured their spleen. The spleen helps fight infections, so people without a working spleen are at higher risk. Researchers will compare the vaccine response in patients who had different treatments for t…

This study looks at whether eating mangoes every day for 4 weeks, instead of high-calorie snacks like cookies and chips, can improve gut health, reduce inflammation, and boost heart health in Hispanic/Latino teens. Researchers will measure changes in blood vessels, gut bacteria b…

This study aims to understand how the brain recognizes and remembers places, which is often impaired in people with temporal lobe epilepsy. Researchers will use a virtual tour task and brain recordings (EEG, intracranial EEG) in 620 participants, including epilepsy surgery patien…

This study looks at a small part of the brain called the locus coeruleus, which helps control attention. Researchers will use special MRI scans and a safe drug to see how this area works in 40 healthy adults aged 18-60. The goal is to better understand attention, which could help…

This study looks at whether a bedside ultrasound called FAST can safely lower the number of CT scans needed for children with blunt belly injuries. About 4,346 kids under 18 will be randomly assigned to get either standard care or standard care plus a FAST exam. The goal is to se…

This study looks at how two common sweeteners, erythritol and aspartame, affect blood clotting and blood vessel inflammation. Twenty-four adults with a BMI of 27 or higher will drink beverages sweetened with each sweetener for two weeks, in a random order. The goal is to see if e…

This study looks at whether a safe, non-invasive technique called transcranial direct current stimulation (tDCS) can help with attention, learning, and memory problems in people with schizophrenia. Researchers will test 160 participants to see if applying a tiny electrical curren…

This study looks at whether adding beans to your daily diet can improve bowel and metabolic health. Overweight adults aged 30-80 who are scheduled for a colonoscopy will drink a bean smoothie for two weeks. Researchers will measure changes in gut bacteria, blood markers, and colo…

This study looks at how common skin creams—like antifungals, mild steroids, and moisturizers—change the community of tiny organisms living on your skin. Researchers will test these creams on healthy adults to see if they alter the types and amounts of bacteria present. The goal i…

This study collects information from children diagnosed with Antiphospholipid Syndrome (APS) to better understand the disease and how it is treated. Researchers will follow up to 50 participants over time to track long-term survival. No new treatments are being tested; the goal i…

This study reviews medical records of 5,000 adults who had heart surgery at UC Davis Medical Center. Researchers want to find out which factors influence recovery and survival after surgery. The goal is to use this information to improve care and outcomes for future heart surgery…

This study looks at how young children's experiences with waiting (like for a treat) relate to their thinking skills, behavior, and school readiness. About 200 typically developing children will complete games and tasks, and return after one year for follow-up. The goal is to und…

This study tests a new way to use a standard PET scan tracer (FDG) to measure both blood flow and sugar use in the heart at the same time. Researchers will compare these measurements to those from a separate tracer that only measures blood flow. The goal is to simplify heart imag…

This early study looks at whether products made from Chardonnay grape leftovers (marc) can improve heart and blood vessel health. Five adults with higher body weight and slightly reduced blood vessel function will take these products. Researchers will measure blood vessel flexibi…

This study looks at how well young women absorb zinc and iron from four types of common beans. Researchers want to see if natural compounds in beans, like phytate and polyphenols, affect mineral absorption. Fifteen healthy women who eat beans regularly will participate in a cross…

This study looks at how a person's beliefs about a treatment can change their mood, motivation, and reactions to rewards. Healthy volunteers aged 15-25 will receive a fake (sham) version of a brain stimulation treatment called accelerated TMS, which delivers no active stimulation…

This study looks at how eating kimchi (fermented cabbage) affects the gut health of healthy adults. Researchers will compare people who eat kimchi daily with those who eat plain cabbage daily for 3 weeks. They will measure changes in gut bacteria, digestion markers, and heart hea…

This study is for teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (concussion). Researchers want to see if they can predict which teens will develop new or worse depression or anxiety in the months after their injury. Participants and their p…

This study looks at genetic and chemical markers in fat tissue from 500 people with severe obesity who are having weight-loss surgery. Researchers want to compare fat from people with and without diabetes or other health problems to better understand why some obese people are hea…

This study looks at whether fidgeting can help adults with ADHD pay attention and manage emotions better. About 109 adults with ADHD who fidget will use a special device in a lab while doing thinking and emotional tasks. The goal is to see if movement and touch can boost focus an…

This study uses a special full-body PET/CT scan to look at immune activity and blood vessel changes in people with Long COVID (PASC). About 51 adults will get scans and blood tests to see where the body's immune system is out of balance. The goal is to better understand Long COVI…

This study is testing a new single-port robotic system for colorectal surgeries, such as for cancer or rectal prolapse. It involves 25 adults and aims to see if the robot is safe and effective compared to current multi-port robots. The focus is on measuring complications and reco…

This study looks at how different types of rewards—like praise for effort versus rewards for good grades—affect children's interest in taking on challenging tasks. About 180 children aged 9 to 13 will complete puzzles and games, and their parents will answer questions about how t…

This study uses a gentle electrical current (tDCS) on the scalp to see how it changes brain activity during thinking tasks. Researchers will measure attention, memory, and brain waves in 75 healthy adults and people with schizophrenia. The goal is to understand how different brai…

This study aims to understand why multiple myeloma affects African American, Latino, Asian American, and non-Hispanic White people differently. Researchers will survey 4000 patients in California about their experiences and health outcomes. The goal is to find better ways to stud…

This study aims to better understand heart failure by using advanced testing (multi-omics) to identify people at higher risk for serious problems like hospitalization or death. Researchers will also test a remote monitoring program to help doctors optimize medications. The study …

This study looks at how certain dietary supplements might change the immune system in healthy adults aged 18 to 45. Participants will take supplements or a placebo and give blood samples to measure immune proteins. The goal is to understand how these supplements affect the body's…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improve blood vessel function. Researchers will measure zinc inside cells and how well blood vessels work. The goal is to understand how beef's…

This study looks at whether whole milk or low-fat (1%) milk is better for preventing obesity in toddlers. Researchers will follow 625 children ages 1-2 for one year, measuring changes in waist size and body mass index. Families will be randomly assigned to give their child only w…

This study tests whether the Early Start Denver Model (ESDM), a therapy for young autistic children, works well in community programs. Researchers will work with 600 participants, including 300 children ages 1-5 with autism, their families, and staff from community agencies acros…

This study looks at whether eating honey-flavored yogurt every day for 4 weeks can lower low-grade inflammation and improve gut health in overweight women aged 45 to 65. Researchers will measure markers of inflammation and gut bacteria changes. The goal is to understand how diet …

This study tests a job support program called IPS-AUT for autistic adults aged 18-40 who are not currently working but want a job. The program helps people find and keep competitive jobs in the community. Researchers will check if the program is practical, acceptable, and effecti…

This study is for people who have had their voice box removed (total laryngectomy) and use a special device called a tracheoesophageal prosthesis (TEP) to speak. Researchers want to see if women and men have different voice quality and speech outcomes after this surgery. The stud…

This study aims to find the genetic changes that cause moles (melanocytic nevi) to form. Researchers will analyze DNA from skin biopsy samples and blood from 50 adults. The goal is to better understand mole biology, not to test a treatment.

This study looks at whether it is possible to start feeding newborn babies with gastroschisis (a condition where the intestines are outside the belly) soon after surgery. Researchers will enroll 20 infants to see if parents agree to the study and if the feeding plan can be follow…

This study looks at how a 36-hour water-only fast changes the immune system in healthy adults aged 20-40. Researchers will measure immune cells and gene activity in blood samples. Only 4 men are being enrolled, so results will be very early and limited.