Could almond oil beat a Skin-Lightening cream?
NCT ID NCT04875715
First seen Jun 26, 2026 · Last updated Sep 15, 2026 · Updated 2 times
Summary
This study compares almond oil to hydroquinone cream for treating facial pigmentation in women with darker skin tones. Researchers will also check how each treatment affects the skin's microbiome. The goal is to see if almond oil is a safer, natural alternative to the standard treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- almond oil and hydroquinone cream
- What this could lead to
- If almond oil works as well as hydroquinone, it could offer a gentler, natural option for reducing facial pigmentation without harsh chemicals.
- What could go wrong
- This is a small, early-phase study with only 50 participants, so results may not apply to everyone. Almond oil may be less effective than hydroquinone, and those with nut allergies cannot participate.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2021
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Premenopausal women of Fitzpatrick skin types 3 to 6 Exclusion Criteria: * Those with a nut allergy * Smoking is an independent risk factor and serves as a confounder for the development of facial aging \[18\]. Therefore current smokers, those that have smoked within the past year, and former smokers with greater than a 20 pack year history of smoking will be excluded. * Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndrome) will be excluded as this can be a confounder for facial photoaging. * Hormonal medications or therapies will not be allowed unless they have been stable on their medications for at least 2 months. Examples include oral contraceptives, progesterone-based injections, and estrogen based hormonal replacement therapy. * Those who have undergone any cosmetic procedures to the face in the 4 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment will also not be eligible. * Individuals who are unwilling to discontinue vitamin E containing supplements and food sources during the washout and intervention. * Individual who are unwilling to discontinue topical cosmetic products during the duration of the study. * Individuals who are not willing to engage in a two-week washout on topical treatments known to affect facial pigmentation and these agents will be restricted during the study period as well. These include topicals that contain: * Retinoids such as tretinoin, adapalene, retinol. * Antioxidant ingredients such as vitamin C or vitamin E. * Pigment-reducing agents such as hydroquinone, azelaic acid, kojic acid per the discretion of the investigator except for the hydroquinone that is provided in this study. * Topicals that contain a nut oil or nut extract as part of their ingredient list. * Furthermore, subjects will be asked to refrain from use of any other topical products for one week prior to each visit apart from the study agents supplied from this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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UC Davis Department of Dermatology, Clinical Trials Unit
RECRUITINGSacramento, California, 95816, United States
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