Novartis Pharmaceuticals

This study tested the safety and effectiveness of EGATEN (triclabendazole) in 301 people aged 6 and older with fascioliasis, a parasitic liver infection. Participants received two doses of the drug 12 hours apart and were monitored for 90 days. The goal was to see if the treatmen…

This study looked at whether people with chronic myeloid leukemia (CML) could safely stop taking the drug nilotinib (Tasigna) if their cancer was already deeply suppressed. Participants had been on nilotinib for at least 2 years and had very low levels of leukemia cells. The main…

This study tested a new anti-malarial drug called INE963 in 52 adults with uncomplicated Plasmodium falciparum malaria. The goal was to see how quickly the drug cleared the malaria parasite from the blood and how well it was tolerated. Participants took the drug by mouth and were…

This study tested a targeted pill called capmatinib in 50 Indian adults with advanced non-small cell lung cancer that has a specific genetic change (MET exon 14 skipping mutation). The goal was to see how safe the drug is and how well it shrinks tumors. Participants could be newl…

This early-stage study tested two versions of the drug ianalumab in 48 adults with active rheumatoid arthritis. The goal was to see if both forms are safe and work similarly in the body. Participants received multiple injections, and researchers monitored side effects and drug le…

This study looked at the long-term safety and effectiveness of the drug secukinumab in children with two types of juvenile idiopathic arthritis: juvenile psoriatic arthritis and enthesitis related arthritis. 55 children who had already completed a previous study continued taking …

This study looked at the safety and effectiveness of asciminib, a newer drug, in 85 Indian adults with a type of leukemia called Ph+ CML-CP. Participants had either a specific gene mutation or had already tried two or more other treatments. The goal was to confirm that asciminib …

This study looked at how well and how safely ofatumumab (Kesimpta®) works for people with relapsing multiple sclerosis in Spain. Researchers followed 310 patients who had been on the drug for at least a year. The main goal was to see if the number of relapses (flare-ups of sympto…

This study tested two drugs—inclisiran (a shot) and bempedoic acid (a pill)—in 402 adults with heart disease and high LDL cholesterol despite taking statins. The goal was to see which drug lowers cholesterol more effectively. Participants were already on maximum statin therapy, a…

This study tested two drugs, secukinumab and ustekinumab, in 119 adults with active psoriatic arthritis who had not responded to or could not tolerate TNFα-inhibitor treatments. The goal was to see which drug better improves physical function and skin symptoms over 28 weeks. Part…

This study tested a new drug called VAY736 in 68 adults with autoimmune hepatitis, a condition where the immune system attacks the liver. Participants had not responded well to or could not tolerate standard treatments. The goal was to see if VAY736 could help normalize liver enz…

This study looked at how a newer cholesterol-lowering drug called inclisiran (Leqvio®) and other oral medications work in real-life medical care. About 1,868 adults with high cholesterol took part, but no new treatments were given—just routine care was observed. The goal was to s…

This study tested a personalized treatment plan using the drug brolucizumab for people with a specific eye condition called polypoidal choroidal vasculopathy (PCV), which causes vision problems. 148 adults who had not received prior treatment for PCV took part. The goal was to se…

This study looked at adding a new drug, asciminib, to the standard treatment imatinib for people with chronic myeloid leukemia (CML) who hadn't reached very low levels of cancer cells. 104 adults who had been on imatinib for at least a year were randomly assigned to add asciminib…

This study checked how safe and effective Xolair is for adults with chronic sinusitis and nasal polyps that don't get better with standard treatments. It included 135 people in routine medical care. The main goal was to track side effects, and the study also measured how symptoms…

This study tested a drug called iptacopan (LNP023) in 518 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal was to see if the drug could reduce protein in the urine and slow the loss of kidney function compared to a placebo. All participants …

This study tested an experimental drug called LNA043, given as injections into the knee, to see if it can help regrow cartilage in people with knee cartilage damage or osteoarthritis. The trial involved 142 adults and used MRI scans to measure changes in cartilage quality and vol…

This study tested whether adding the drug QAW039 to standard asthma treatments helps people whose asthma is still not under control. Over 700 adults and teens took either QAW039 or a placebo for 12 weeks. The main goal was to see if their lung function improved, measured by how m…

This study looked at how well two types of cholesterol-lowering drugs (inclisiran and PCSK9 mAbs) work in everyday medical practice in China. Researchers analyzed health records from over 11,000 adults with high cholesterol. The goal was to see how much these drugs lower 'bad' ch…

This study tested a new drug called siremadlin added to two standard medicines (venetoclax and azacitidine) in adults with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy. The goal was to see if the combination could improve response in patients wh…

This study tested whether taking two targeted drugs (dabrafenib and trametinib) for 12 months after melanoma surgery could prevent the cancer from coming back. It involved 870 adults with high-risk stage III melanoma that had a specific BRAF V600 mutation. Participants were rando…

This study tested a new malaria drug, KLU156, against the standard treatment Coartem in over 1,700 adults and children with uncomplicated malaria. The goal was to see if KLU156 works as well and is safe. Results showed KLU156 is non-inferior to Coartem, meaning it is a comparable…

This study tested a new inhaler (QMF149) against a standard one (MF Twisthaler) in 802 adults and teens with mild asthma that was not well controlled. The goal was to see if the new inhaler improved lung function and symptom control over 12 weeks. Participants took one puff each …

This study tested a drug called inclisiran in teenagers aged 12 to 18 who have a genetic condition that causes very high cholesterol. The goal was to see if the drug safely lowers bad cholesterol (LDL-C) compared to a placebo. Participants received either inclisiran or placebo fo…

This study tested a drug called remibrutinib in 144 adults with chronic spontaneous urticaria (long-term hives) that don't get better with standard allergy pills. The main goal was to check if the drug affects blood pressure over 12 weeks, while also seeing if it helps control hi…

This study looked at how well the drug Beovu (brolucizumab) works in everyday medical practice for people with two eye diseases: wet age-related macular degeneration and diabetic macular edema. Researchers followed 572 patients who were already prescribed Beovu by their doctor, t…

This study tested a drug called canakinumab in 14 Japanese adults with Adult-Onset Still's Disease, a rare inflammatory condition causing fever, joint pain, and rash. Participants received injections every 4 weeks for at least 48 weeks. The goal was to see if the drug could reduc…

This study followed 72 adults in Taiwan with lupus nephritis who were taking Myfortic (mycophenolate sodium) for the first time. Over 12 months, researchers tracked side effects and serious events to see how safe the drug is. The goal was to better understand the drug's safety in…

This study tested the drug nilotinib in 34 adults with advanced gastrointestinal stromal tumors (GIST) that could not be removed by surgery. The goal was to see if the drug could shrink or stop the growth of tumors. The results showed that some patients had their tumors shrink or…

This study tested whether a drug called sacubitril/valsartan works better than enalapril for people with heart failure caused by Chagas disease. About 922 adults with weakened hearts took part. The goal was to see if the new drug could reduce heart-related deaths, hospital stays,…

This study tested a drug called secukinumab in 137 Chinese adults with a form of spinal arthritis that doesn't show on X-rays (non-radiographic axial spondyloarthritis). The goal was to see if the drug reduces pain, stiffness, and swelling better than a placebo after 16 weeks, an…

This study tested a drug called inclisiran in 207 Chinese adults with high LDL (bad) cholesterol who were not on other cholesterol medicines. Participants received either inclisiran or a placebo for 6 months, followed by 6 months where everyone got inclisiran. The main goal was t…

This study looked at whether people with chronic myeloid leukemia (CML) who have been on the drug nilotinib for at least 3 years can safely reduce their dose or stop treatment entirely. It involved 124 adults and tested two approaches: first, cutting the nilotinib dose in half fo…

This study tested a drug called crizanlizumab in 36 men with sickle cell disease who experience frequent, painful erections (priapism). The goal was to see if the drug could reduce the number of these episodes over 26 weeks. Participants reported their erections using an electron…

This study tested a twice-daily pill called iptacopan in 52 adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder. Participants switched from their usual infusion treatments (eculizumab or ravulizumab) to iptacopan. The main goal was to see if iptacopan cou…

This study tested a personalized cell therapy called tisagenlecleucel (a CAR-T treatment) against usual treatments for adults with a fast-growing type of blood cancer (aggressive B-cell Non-Hodgkin Lymphoma) that did not respond to or came back after initial chemotherapy. 330 par…

This study tested a drug called 177Lu-PSMA-617 in 94 people in Japan with a type of advanced prostate cancer that had stopped responding to hormone therapy. The drug delivers radiation directly to cancer cells. The goal was to see if it could shrink tumors and how safe it was. Th…

This study tested an oral medication called iptacopan in 34 adults with a rare kidney disease, atypical hemolytic uremic syndrome (aHUS), who had not received prior treatment. The goal was to see if the drug could stop blood clots and improve kidney function. Participants took th…

This study tested the drug ofatumumab in 99 Chinese adults with relapsing multiple sclerosis (RMS). The goal was to see if monthly injections could reduce the number of relapses and how safe the treatment was over one year. Participants received 20 mg of ofatumumab under the skin…

This study tested a drug called eltrombopag in 20 Chinese adults with severe aplastic anemia, a rare condition where the bone marrow stops making enough blood cells. Participants had not improved after standard treatments. The drug was given daily for up to a year, with the dose …

This study tested the safety and proper dosing of a drug called crizanlizumab in children aged 2 to 18 with sickle cell disease who have had painful vaso-occlusive crises. The drug, already shown to work in adults, aims to reduce these painful events. Over two years, researchers …

This study looked at whether a clinic focused on guideline-recommended medications helps heart failure patients. Researchers analyzed data from 342 patients with heart failure and a weak heart pump. They compared patients who went to the special clinic to those who received usual…

This study looked at the safety of the drug sacubitril/valsartan in Japanese children with heart failure. Eight children who had already finished a previous study took part. The goal was to collect more safety information and give them access to the drug until a child-friendly ve…

This study looked at health records of 1,249 heart failure patients in Portugal to compare two types of medication: sacubitril/valsartan versus older drugs (ACE inhibitors or ARBs). The goal was to see which treatment better prevents death from heart problems or hospital stays du…

This study tested two experimental drugs, VAY736 and CFZ533, in 107 people with systemic lupus erythematosus (SLE). The goal was to see if these treatments could reduce lupus disease activity and allow patients to lower their steroid doses. Participants received either one of the…

This study tested a personalized cell therapy called tisagenlecleucel (a CAR-T treatment) in 98 adults with follicular lymphoma that returned or didn't respond to prior therapies. The treatment involves collecting a patient's own immune cells, reprogramming them to attack cancer,…

This study tested whether adding the experimental drug NIS793 to standard chemotherapy could help people with metastatic pancreatic cancer live longer. The trial enrolled 511 adults whose cancer had spread and could not be removed by surgery. Researchers aimed to see if blocking …

This study tested an experimental drug called RHH646 in 82 adults with knee osteoarthritis. The goal was to see if it could help regrow cartilage in the knee and check for side effects. Participants received either the drug or a placebo, and researchers measured cartilage changes…

This study tested a drug called secukinumab in 354 people with giant cell arteritis, a condition where blood vessels become inflamed. The goal was to see if secukinumab could help patients achieve remission while reducing their need for steroids. Participants received either secu…

This study tested a new medicine called inclisiran in 350 adults with high cholesterol who were not taking any other cholesterol-lowering drugs. The goal was to see if inclisiran could lower 'bad' LDL cholesterol more than a placebo or another drug called ezetimibe. Participants …

This study tested whether adding eltrombopag to standard treatment (anti-thymocyte globulin and cyclosporine) helps East-Asian patients with severe aplastic anemia, a condition where the bone marrow fails to produce enough blood cells. 36 adults and children received the combinat…

This study tested whether adding inclisiran (a twice-yearly injection) to standard cholesterol-lowering therapy helps more high-risk patients reach their LDL cholesterol goals. About 1,770 adults with very high or high cardiovascular risk participated. The main goal was to see ho…

This study tested a daily pill called asciminib in 199 adults with chronic myeloid leukemia (CML) whose cancer had not responded well to at least two prior treatments. The goal was to see how many patients achieved a major molecular response (a key sign of disease control) after …

This study tested a drug called asciminib in 56 adults with chronic myeloid leukemia (CML) that had not responded well to other treatments. The goal was to check safety and side effects over 24 to 48 weeks. Participants took asciminib alone, and the study included people with a s…

This study tested an experimental drug called XXB750 in 189 adults with resistant hypertension—high blood pressure that stays high despite taking three or more standard medications. Participants received different doses of XXB750 or a placebo as a shot under the skin, on top of t…

This study looked at how well the drug ribociclib works in real-world settings for Indian women with a common type of advanced breast cancer (HR+, HER2-). Researchers reviewed medical records from 335 patients across 18 hospitals in India. The goal was to see how long the drug ke…

This study tested a new combination of two drugs, KAF156 and lumefantrine, in 295 children aged 6 months to 18 years with uncomplicated malaria. The goal was to see if the treatment works well and is safe, and to offer a new option that may help prevent drug resistance. The study…

This study tested a drug called atrasentan in 54 adults with IgA nephropathy, a kidney disease. All participants were already on standard treatments including SGLT2 inhibitors. The goal was to see if atrasentan could reduce protein in the urine, a sign of kidney damage, compared …

This study tested a combination of two targeted drugs, dabrafenib and trametinib, in 40 Chinese adults with a specific type of advanced lung cancer (BRAF V600E mutation-positive, stage IV non-small cell lung cancer). The goal was to see how well the treatment shrank tumors and to…

This study tested a one-time gene therapy called OAV101 in 27 children aged 2 to 18 with spinal muscular atrophy (SMA) who had stopped taking other SMA medications. The main goals were to check safety and see if the treatment helped improve muscle strength and movement. The thera…

This study looked at how the body handles an IV form of secukinumab, a drug that targets inflammation, in 65 adults with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). The main goals were to measure drug levels in the blood and check for side effects. Results will he…

This study looked at 781 adults with moderate to severe plaque psoriasis who also had metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Participants either received the drug Secukinumab alone or Secukinumab plus a lifestyle intervention. The goal …

This study tested the drug ofatumumab in 180 adults aged 18-35 with very early relapsing-remitting multiple sclerosis (MS). The goal was to see if the drug could stop all signs of disease activity, including relapses, disability progression, and new brain lesions seen on MRI. Res…

This study tested a hospital care plan that includes a cholesterol-lowering drug called inclisiran for people who recently had a heart attack or unstable angina (acute coronary syndrome). About 400 participants with high LDL cholesterol despite statin therapy were enrolled. The g…

This study tested the safety of combining two drugs, alpelisib and fulvestrant, in 40 men and post-menopausal women with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has a PIK3CA mutation and has stopped responding to hormone therapy. The goal was to…

This study tested a drug called pelacarsen in Black/African American and Hispanic patients with high Lp(a) — a genetic risk factor for heart disease. The goal was to see if the drug safely lowers Lp(a) levels after 12 months of treatment. All 422 participants had existing heart d…

This study tested a monthly injection called ofatumumab against standard daily or weekly pills for people newly diagnosed with relapsing multiple sclerosis (MS). The goal was to see which treatment better controls the disease by preventing relapses, new brain lesions, and worseni…

This study tested an oral medication called DFV890 in 24 adults with coronary heart disease and high inflammation levels (measured by hsCRP). Participants took the drug daily for 12 weeks to see if it could lower inflammatory markers like IL-6 and IL-18. The goal is to control in…

This study looked at 111 adults with relapsing multiple sclerosis who switched from an IV anti-CD20 medication to a self-injected drug called ofatumumab. The goal was to see if the new treatment could keep their disease under control. After 12 months, most participants had no new…

This study tested a drug called inclisiran in teenagers aged 12 to 18 with a rare genetic condition that causes very high cholesterol. The goal was to see if the drug is safe and can lower bad cholesterol levels. Participants received either inclisiran or a placebo for one year, …

This study tested a new drug, alpelisib, combined with hormone therapy in 383 people with advanced breast cancer that has a specific genetic change (PIK3CA mutation). The goal was to see if the combination could stop the cancer from growing for at least 6 months. Results showed t…

This study tested two different dosing schedules of the drug brolucizumab in 52 adults aged 50 and older with age-related macular degeneration (AMD) who had not responded well to previous treatment. The goal was to see which schedule better maintains or improves vision over 52 we…

This study tested a combination of two anti-malarial drugs, cipargamin and KLU156, in 60 people aged 12 and older with uncomplicated Plasmodium falciparum malaria. The main goal was to see if the treatment could clear the malaria parasite from the blood by day 29 without the infe…

This study tested an experimental drug called LRX712 in 45 people with mild to moderate knee osteoarthritis. The goal was to see if multiple injections into the knee could safely help regrow cartilage, the cushioning tissue that wears down in arthritis. While the treatment aims t…

This study tested a drug called brolucizumab, given as an eye injection, against standard laser treatment for people with proliferative diabetic retinopathy, a serious eye condition caused by diabetes that can lead to vision loss. About 689 adults with type 1 or 2 diabetes took p…

This study looked at the safety of Kesimpta, a drug for multiple sclerosis (MS), in 367 people with relapsing-remitting MS or active secondary progressive MS. Researchers tracked side effects and how doctors rated symptom changes. The goal was to monitor real-world use, not to te…

This study observed 107 Swiss adults with relapsing multiple sclerosis who were already taking Kesimpta (ofatumumab) for at least 3 months. Researchers tracked how well the drug controlled their disease, looking for signs like relapses, new brain lesions, or worsening disability.…

This study tested whether adding amlodipine to the blood pressure drug LCZ696 works better than LCZ696 alone. About 718 adults with mild to moderate high blood pressure that wasn't well controlled on LCZ696 took part. The goal was to see if the combination lowered blood pressure …

This study tested a drug called secukinumab in 381 adults aged 50 and older with polymyalgia rheumatica (PMR), a condition causing muscle pain and stiffness. Participants received either secukinumab or a placebo, along with a gradual steroid taper over 24 weeks. The goal was to s…

This study looked at the safety of a drug called iscalimab in 206 people with Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. Participants had already completed a previous study and received iscalimab injections at two different doses. The main goal was …

This study observed 175 adults with HR+/HER2- advanced or metastatic breast cancer in the Middle East who received ribociclib plus hormone therapy. Researchers tracked side effects and how long the cancer stayed under control. The goal was to see how well this treatment works in …

This study tested a new intravenous drug called cipargamin in 254 adults and children with severe malaria. The goal was to find a safe and effective dose, especially for cases where standard treatments may not work due to drug resistance. The drug works by quickly clearing malari…

This study looked at how safe and effective Tabrecta is for people with a certain type of advanced lung cancer (MET exon 14 skipping mutation). 109 patients were followed for up to a year. The goal was to track side effects and see how well the drug controlled the cancer.

This study provided continued access to imatinib for 155 patients with gastrointestinal stromal tumors (GIST) or chronic myeloid leukemia (CML) who were already benefiting from the drug in a previous Novartis trial. The main goal was to track long-term safety and ensure patients …

This study tested a new drug called CFZ533 (iscalimab) in 273 adults with Sjogren's syndrome, an autoimmune disease causing dryness and pain. The goal was to see if the drug could safely reduce disease activity and improve symptoms like fatigue and dryness. Participants received …

This study tested a reduced starting dose (400 mg) of the drug ribociclib combined with standard hormone therapy (letrozole or anastrozole) in 376 women with advanced hormone receptor-positive, HER2-negative breast cancer who had not received prior treatment for advanced disease.…

This study looked at how well and how safely the drug fingolimod (Gilenya) works for people in China with relapsing multiple sclerosis (RMS). It included 98 patients aged 10 to 65 who had never taken fingolimod before. Over 24 months, researchers measured the number of MS relapse…

This study tested two experimental drugs, DFV890 (a daily pill) and MAS825 (a single shot), to see if they could lower inflammation in 31 adults with coronary heart disease and a genetic blood condition called CHIP. The goal was to reduce markers like IL-6 and IL-18 that are link…

This study tested an experimental drug called QAW039 in 675 adults and teens with asthma that wasn't well controlled by their current medications. Participants took either QAW039 or a placebo pill alongside their usual asthma treatments for 12 weeks. The main goal was to see if Q…

This study tested a one-time gene therapy called OAV101 in 126 children aged 2 to 18 with type 2 spinal muscular atrophy (SMA), a genetic condition that causes muscle weakness. Participants received either the therapy or a sham procedure. The goal was to see if the treatment impr…

This study looked at the safety of the drug LUTATHERA in 347 people with a type of cancer called neuroendocrine tumors. Researchers monitored patients for serious side effects like kidney problems, low blood counts, and certain blood cancers. The goal was to understand how safe t…

This study followed 164 adults with advanced gut or pancreas neuroendocrine tumors (GEP-NETs) who were given Lutathera as part of their regular care. The goal was to see how long the treatment kept tumors from growing and how many patients saw their tumors shrink. Results help do…

This study tested a drug called brolucizumab, given as eye injections, in 66 adults with diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The goal was to check safety and how well it works in a real-world setting in India. Participants re…

This study tested a new drug called CFZ533 against the standard medicine tacrolimus to see if it could prevent kidney transplant rejection. About 418 kidney transplant patients took part. The goal was to compare how well each drug prevented rejection, graft loss, or death over 12…

This study looked at how safe and effective the drug inclisiran is for Indian adults with high cholesterol or mixed dyslipidemia. Sixty-five participants received the drug as a shot under the skin. Researchers tracked side effects and measured how much LDL (bad) cholesterol dropp…

This study tested an oral targeted drug called capmatinib in 36 Chinese adults with advanced non-small cell lung cancer that has a specific MET gene mutation (exon 14 skipping). The drug aims to block cancer growth by targeting this faulty gene. Researchers measured how many pati…

This study looked at how well ofatumumab works in 562 people with relapsing multiple sclerosis who switched from other MS drugs (fumarates or fingolimod) because their disease was still active. The main goal was to see how many relapses occurred per year. Researchers also tracked…

This study followed 134 adults in Italy with active secondary progressive multiple sclerosis who were prescribed siponimod as part of their routine care. Over 36 months, researchers measured how many patients had a confirmed worsening of disability or thinking skills. The goal wa…

This study looked at the safety of a drug called crizanlizumab in 140 Indian patients aged 16 and older with sickle cell disease who have had painful crises. The drug is meant to reduce the frequency of these crises. Researchers monitored serious side effects and other adverse ev…

This study tested adding the drug ruxolitinib to standard steroid treatment for children aged 28 days to under 18 years who had moderate to severe chronic graft-versus-host disease (cGvHD) after a stem cell transplant. cGvHD is a condition where donor immune cells attack the chil…

This study followed 42 children aged 6 to 17 with moderate to severe plaque psoriasis in China who were treated with Cosentyx (secukinumab) for up to 52 weeks. Researchers tracked side effects and how well the drug cleared skin symptoms. The goal was to see if Cosentyx is safe an…

This early-phase study tested a drug called gevokizumab alongside standard cancer treatments in 167 adults with advanced colorectal, stomach, or kidney cancer. The goal was to find a safe dose and see if the combination helps control tumor growth. While not a cure, it aims to imp…

This study tested whether adding the drug ribociclib to standard hormone therapy helps slow the growth of advanced breast cancer in Chinese women. The cancer type was hormone receptor positive and HER2 negative. 327 women took part, and the main goal was to see how long the cance…

This study reviewed medical records of 13 Korean children with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. Researchers wanted to see if adding eltrombopag to standard immunosuppressive therapy was safe and effective over 6 months. Th…

This study tested a drug called secukinumab in 151 adults with newly diagnosed giant cell arteritis, a condition that causes inflamed arteries. Participants were in remission and taking steroids. The goal was to see if adding secukinumab could prevent the disease from coming back…

This study looked at whether people with chronic myeloid leukemia (CML) who had a deep response to the drug nilotinib could safely stop taking it without the cancer coming back. 215 adults who had been on nilotinib for at least two years were enrolled. The main finding was that m…

This study tested a new imaging agent called [18F]CTT1057 for PET scans to find prostate cancer that has come back after initial treatment. About 190 men with rising PSA levels (a sign of possible recurrence) took part. The goal was to see how accurately the scan could locate can…

This study tested a special PET/CT scan using a radioactive tracer called [68Ga]Ga-DOTA-TATE to see if it could better detect neuroendocrine tumors compared to standard imaging. 71 adults in Japan, including patients with known or suspected tumors and healthy volunteers, took par…

This study tested a new PET imaging agent called [18F]CTT1057 to see how well it can find prostate cancer tumors. 195 high-risk patients who were scheduled for surgery received the scan, and the results were compared to tissue samples taken during surgery. The goal was to see if …

This study tested an experimental drug called DFV890 in 115 people with painful knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo. Participants were aged 50 to 80 and had moderate to severe pain. The study is now complete…

This study tested a drug called canakinumab (ACZ885) in 49 children and young adults (ages 8-20) with sickle cell anemia to see if it could reduce their daily pain. Participants rated their pain on a scale of 0 to 10, and researchers compared changes over 12 weeks between those w…

This study tested a drug called secukinumab in 62 adults with moderate to severe rotator cuff tendinopathy (shoulder tendon pain) that did not improve with usual treatments. Participants received either the drug or a placebo for 24 weeks. The main goal was to see if the drug impr…

This early-stage study tested a new drug called XXB750 in 27 adults with chronic heart failure and reduced heart pumping ability. The main goal was to check if the drug is safe and tolerable. Participants received either the drug or a placebo, and researchers monitored for side e…

This study looked at how people with multiple sclerosis felt about their first injection of either Kesimpta or a new under-the-skin version of Ocrevus. 134 adults who were just starting one of these drugs answered questions about pain, redness, swelling, and itching at the inject…

This study tested a monthly injection called erenumab in 557 Asian adults with chronic migraine (15+ headache days per month). Over 12 weeks, researchers measured how much the drug reduced the number of migraine days compared to a placebo. The goal was to see if the shot could sa…

This study tested a drug called omalizumab in 337 adults and teenagers with severe Japanese cedar pollen allergy that standard treatments couldn't control. Participants received either omalizumab or a placebo alongside their usual allergy medicines. The goal was to see if omalizu…

This study tested a drug called ligelizumab in 49 teens aged 12 to 18 with chronic spontaneous urticaria (long-lasting hives with no clear trigger). The goal was to see if adding ligelizumab to standard antihistamines could reduce itching and welts better than a placebo. Particip…

This study looked at the safety and effectiveness of the drug Xolair in teenagers aged 12 to 17 with severe seasonal allergies (hay fever) that didn't get better with standard treatments. Researchers tracked side effects and how well the drug worked in 50 participants. The goal w…

This study tested a single injection of tiny particles (NGI226) to see if it is safe and can help repair the Achilles tendon in people with chronic mid-portion tendon pain. 45 adults with this condition received either the active injection or a placebo. The main goals were to che…

This study looked at whether Xolair (omalizumab) is safe and effective for Chinese teenagers with chronic spontaneous urticaria (long-lasting hives and itching) that don't get better with standard antihistamines. Fifty-five teens took part, receiving Xolair for 12 weeks and then …

This early-stage trial tested the safety of a new drug called NIO752 in 59 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and balance. Participants received multiple doses of the drug or a placebo injected into the spinal fluid. The …

This study looked at medical records of over 2,600 people with multiple sclerosis (MS) to compare two drugs: Kesimpta and Ocrevus. The goal was to see which one better prevents relapses and reduces healthcare costs. Researchers used existing data from insurance claims, not a new …

This study looked at 1,247 patients in the United States with a type of advanced prostate cancer called metastatic castration-resistant prostate cancer (mCRPC) who were treated with a drug called Lutetium-177 vipivotide tetraxetan (177Lu-PSMA-617). The goal was to understand the …

This study interviewed 28 adults who had sepsis-associated acute kidney injury to learn about their symptoms, treatment journey, and how the condition affected their daily lives. The goal was to capture the patient's perspective to help researchers better understand the real-worl…

This study observed over 2,600 women in Germany with advanced HR-positive, HER2-negative breast cancer to see how well different first treatments work in real-world settings. Doctors chose to give either a combination of ribociclib with hormone therapy, hormone therapy alone, or …

This study looked at medical records of 213 children with spinal muscular atrophy (SMA) in the Czech and Slovak Republics. Researchers wanted to see how treatments are actually used in real life and what health outcomes children experience. The goal was to learn more about care p…

This study looked at how the drug remibrutinib is processed in people with severe kidney disease compared to healthy people. Researchers measured drug levels in blood and urine to see if kidney problems affect how the drug works. The goal is to help doctors decide the right dose …

This study looked at blood and urine samples from 236 Japanese adults with chronic heart failure and reduced ejection fraction. Researchers wanted to see how certain biomarkers, like BNP, changed during treatment with sacubitril valsartan compared to enalapril. The goal was to be…

This study looked at 595 people in India with a certain type of advanced breast cancer (HR-positive, HER2-negative). Researchers checked for changes in the PIK3CA gene and tracked how patients did on the drug alpelisib. No new treatments were given—doctors made all decisions as u…

This study looked at medical records from over 218,000 people in England with a common type of breast cancer (HR+/HER2-). Researchers tracked which treatments patients received, how the disease progressed over time, and how healthcare resources were used. The goal was to better u…

This study reviewed medical records of 1,480 adults with chronic-phase chronic myeloid leukemia (CML-CP) treated in US community oncology clinics between 2016 and 2022. Researchers looked at which drugs were used, how doses were adjusted, and how well patients responded. The goal…

This study examined over 2,500 people with chronic myeloid leukemia (CML) to see how often side effects from their medications (tyrosine kinase inhibitors) happen and how those side effects lead to changes in treatment or extra healthcare costs. Researchers used insurance claims …

This study followed 103 adults with relapsing multiple sclerosis who were taking Kesimpta (ofatumumab). Researchers used a mobile app to track how often patients took their medication on time and compared their reported symptoms with clinical results. The goal was to better under…

This study analyzed medical records of over 6,400 prostate cancer patients to see who received a new treatment called 177Lu-PSMA-617 and how they fared. Researchers looked at patient traits, treatment patterns, and survival rates. The goal was to understand early real-world use o…

This study looked at medical records of 606 people with secondary progressive multiple sclerosis (SPMS) in Russia who were taking the drug siponimod. Researchers wanted to understand patient characteristics, how long they had MS, and what treatments they used before siponimod. Th…

This completed study surveyed 335 healthcare professionals and people with multiple sclerosis (or their caregivers) in Europe. The goal was to see if they understood the safety steps needed when using the drug Mayzent (siponimod). Participants answered questions about proper use,…

This study used national health data to estimate how many US adults might be eligible for a new cholesterol-lowering drug called inclisiran. Researchers looked at people with high cholesterol despite taking statins and calculated how many heart attacks and strokes could be preven…

This early-phase study tested the safety of a single dose of an experimental drug called QCZ484 in 56 healthy adults and people with mild hypertension. Participants were randomly assigned to receive either the drug or a placebo, and researchers monitored for side effects and how …

This study followed over 2,300 adults with moderate to severe plaque psoriasis to see how safe and effective the drug secukinumab is in real-world settings. Researchers tracked side effects and how well the drug cleared skin symptoms. The goal was to gather practical evidence to …

This study used French hospital records from 2015 to 2022 to estimate how many people have a group of rare genetic disorders called PROS. Researchers looked at over 3,600 patients to understand their age, sex, other health problems, and the costs of their care. The goal was to ge…

This study looked back at the medical records of 355 people with myelofibrosis in Turkey who were treated with the drug ruxolitinib for at least 3 months. The goal was to understand patient characteristics, treatment patterns, and side effects in everyday medical practice. No new…

This study followed 127 adults with moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, or non-radiographic axial spondyloarthritis for 2 years. Researchers collected real-life data on how long patients stayed on secukinumab treatment and how their q…

This study examined medical records of 754 people with chronic myeloid leukemia (CML) in Japan to see how they were treated with targeted drugs called TKIs. Researchers looked at which drugs were used, how often patients switched or stopped treatment, and the costs involved. The …

This study analyzed insurance claims from over 4,000 people with spinal muscular atrophy (SMA) to see how three approved treatments (Zolgensma, Spinraza, and Evrysdi) are actually used in daily practice. Researchers looked at dosing patterns and healthcare costs over several year…

This study analyzed health records of over 4,800 people with spinal muscular atrophy (SMA) to see how they responded to three different disease-modifying therapies in everyday medical practice. Researchers looked at complications, medical equipment use, and hospital visits before…

This study analyzed medical records from 2,298 Medicare patients newly diagnosed with chronic myeloid leukemia (CML) to see how they were treated with targeted drugs called tyrosine kinase inhibitors (TKIs). Researchers looked at treatment switches, medication adherence, and heal…

This study observed over 2,400 women in Russia with advanced HR+/HER2- breast cancer who were already receiving standard treatments like ribociclib, alpelisib, hormone therapy, or chemotherapy. Researchers tracked how long each treatment worked before it stopped being effective o…

This study examined how well hospitals in Germany follow recommended treatments for heart failure with reduced ejection fraction (HFrEF) after a patient's condition worsens. Researchers looked at 899 patients across different types of heart failure centers and non-specialized cen…

This study looked at how the drug ianalumab affects the salivary glands of people with Sjögren's syndrome, an autoimmune disease causing dry eyes and mouth. Researchers took small tissue samples (biopsies) from 21 adults to measure changes in immune cells and check for side effec…

This study tested a new drug called TIN816 in 20 adults in the intensive care unit who had kidney injury from sepsis. The main goal was to see how the drug behaves in the body and whether it is safe. Researchers measured drug levels and watched for side effects. This was an early…

This study observed 39 patients in Turkey who had high-risk stage III melanoma removed by surgery and were then treated with dabrafenib and trametinib. Researchers tracked how long patients stayed cancer-free and how long they took the medication. The goal was to see how well the…

This study looked at 480 patients with a common type of advanced breast cancer (HR+, HER2-) to see how doctors actually use a class of drugs called CDK4/6 inhibitors in everyday practice. Researchers collected information on patient characteristics, treatment patterns, and outcom…

This study looked at how different levels of liver function affect the way the body processes the drug JDQ443. Researchers gave a single dose to 33 people with small cell lung cancer who had mild, moderate, or severe liver problems, and compared them to healthy volunteers. The go…

This study looked at pregnancy and baby outcomes in 13 women with sickle cell disease who were treated with Adakveo (crizanlizumab) during pregnancy or shortly before. Researchers tracked rates of miscarriage, stillbirth, and birth defects to better understand the drug's safety d…

This study examined how the drug omalizumab is prescribed to adults with chronic urticaria (long-term hives) in China. Researchers analyzed electronic health records from 3,485 patients to see which doses were most common. The goal was to understand real-world treatment patterns,…

This study examined how CDK4/6 inhibitors, a type of targeted therapy, are actually used in hospitals across Portugal for advanced or metastatic breast cancer. Researchers looked at data from 16 public hospitals involving nearly 2,000 patients to understand treatment patterns, ho…