New hope for pancreatic cancer? drug combo trial shows promise

NCT ID NCT04935359

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen May 23, 2026 · Last updated May 23, 2026

Summary

This study tested whether adding the experimental drug NIS793 to standard chemotherapy could help people with metastatic pancreatic cancer live longer. The trial enrolled 511 adults whose cancer had spread and could not be removed by surgery. Researchers aimed to see if blocking a protein called TGFβ could make chemotherapy work better and improve survival.

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Contacts and locations

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Locations

AdventHealth

Orlando, Florida, 32804, United States
Fort Wayne Medical Oncology Hematology Inc

Fort Wayne, Indiana, 46815, United States
Highlands Oncology Group

Fayetteville, Arkansas, 72703, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
NYU Clinical Cancer Center

New York, New York, 10016, United States
Novartis Investigative Site

Adelaide, South Australia, 5000, Australia
Novartis Investigative Site

Perth, Western Australia, 6009, Australia
Novartis Investigative Site

Bonheiden, 2820, Belgium
Novartis Investigative Site

Brussels, 1200, Belgium
Novartis Investigative Site

Edegem, 2650, Belgium
Novartis Investigative Site

Leuven, 3000, Belgium
Novartis Investigative Site

Brasília, Federal District, 70200-730, Brazil
Novartis Investigative Site

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90560-032, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 04014-002, Brazil
Novartis Investigative Site

Brampton, Ontario, L6R 3J7, Canada
Novartis Investigative Site

Cambridge, Ontario, N1R 3G2, Canada
Novartis Investigative Site

Toronto, Ontario, M4N 3M5, Canada
Novartis Investigative Site

Guangzhou, Guangdong, 510000, China
Novartis Investigative Site

Harbin, Heilongjiang, 150081, China
Novartis Investigative Site

Nanjing, Jiangsu, 210029, China
Novartis Investigative Site

Dalian, Liaoning, 116001, China
Novartis Investigative Site

Jining, Shandong, 272000, China
Novartis Investigative Site

Xian, Shanxi, 710061, China
Novartis Investigative Site

Chengdu, Sichuan, 610041, China
Novartis Investigative Site

Hangzhou, Zhejiang, 310022, China
Novartis Investigative Site

Beijing, 100021, China
Novartis Investigative Site

Beijing, 100036, China
Novartis Investigative Site

Beijing, 100730, China
Novartis Investigative Site

Shanghai, 200025, China
Novartis Investigative Site

Shanghai, 200032, China
Novartis Investigative Site

Shanghai, 200127, China
Novartis Investigative Site

Shanghai, 200433, China
Novartis Investigative Site

Tianjin, 300480, China
Novartis Investigative Site

Brno, 656 53, Czechia
Novartis Investigative Site

Hradec Králové, 500 05, Czechia
Novartis Investigative Site

Nový Jičín, 741 01, Czechia
Novartis Investigative Site

Prague, 140 59, Czechia
Novartis Investigative Site

Helsinki, 00290, Finland
Novartis Investigative Site

Tampere, FIN-33521, Finland
Novartis Investigative Site

Nice, Alpes Maritimes, 06189, France
Novartis Investigative Site

Avignon, 84082, France
Novartis Investigative Site

Besançon, 25030, France
Novartis Investigative Site

Créteil, 94010, France
Novartis Investigative Site

Lyon 08, 69373, France
Novartis Investigative Site

Marseille, 13273, France
Novartis Investigative Site

Montpellier, 34295, France
Novartis Investigative Site

Nantes, 44093, France
Novartis Investigative Site

Paris, 75015, France
Novartis Investigative Site

Frankfurt am Main, Hesse, 60488, Germany
Novartis Investigative Site

Halle, Saxony-Anhalt, 06120, Germany
Novartis Investigative Site

Berlin, 13353, Germany
Novartis Investigative Site

Bochum, 44791, Germany
Novartis Investigative Site

Essen, 45147, Germany
Novartis Investigative Site

Hamburg, 20249, Germany
Novartis Investigative Site

Ulm, 89081, Germany
Novartis Investigative Site

Thessaloniki, 540 07, Greece
Novartis Investigative Site

Thessaloniki, 570 01, Greece
Novartis Investigative Site

Debrecen, Hajdu Bihar Megye, 4032, Hungary
Novartis Investigative Site

Budapest, H 1122, Hungary
Novartis Investigative Site

Budapest, H-1097, Hungary
Novartis Investigative Site

Jerusalem, 9112001, Israel
Novartis Investigative Site

Ramat Gan, 5265601, Israel
Novartis Investigative Site

Tel Aviv, 6423906, Israel
Novartis Investigative Site

Florence, FI, 50134, Italy
Novartis Investigative Site

Milan, MI, 20133, Italy
Novartis Investigative Site

Milan, MI, 20162, Italy
Novartis Investigative Site

Verona, VR, 37134, Italy
Novartis Investigative Site

Nagoya, Aichi-ken, 4648681, Japan
Novartis Investigative Site

Kashiwa, Chiba, 277-8577, Japan
Novartis Investigative Site

Yokohama, Kanagawa, 241-8515, Japan
Novartis Investigative Site

Osaka, Osaka, 5418567, Japan
Novartis Investigative Site

Chuo Ku, Tokyo, 1040045, Japan
Novartis Investigative Site

Koto Ku, Tokyo, 1358550, Japan
Novartis Investigative Site

Utrecht, 3543 AZ, Netherlands
Novartis Investigative Site

Nordbyhagen, Oslo, 1478, Norway
Novartis Investigative Site

Oslo, NO-0407, Norway
Novartis Investigative Site

Omsk, 644013, Russia
Novartis Investigative Site

Saint Petersburg, 196603, Russia
Novartis Investigative Site

Singapore, 168583, Singapore
Novartis Investigative Site

Banská Bystrica, 975 17, Slovakia
Novartis Investigative Site

Bratislava, 83310, Slovakia
Novartis Investigative Site

Košice, 041 91, Slovakia
Novartis Investigative Site

Seoul, 03080, South Korea
Novartis Investigative Site

Seoul, 05505, South Korea
Novartis Investigative Site

Seoul, 06591, South Korea
Novartis Investigative Site

Santiago Compostela, A Coruna, 15706, Spain
Novartis Investigative Site

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Novartis Investigative Site

Barcelona, 08035, Spain
Novartis Investigative Site

Madrid, 28009, Spain
Novartis Investigative Site

Madrid, 28034, Spain
Novartis Investigative Site

Madrid, 28040, Spain
Novartis Investigative Site

Malmö, SE-205 02, Sweden
Novartis Investigative Site

Umeå, 901 85, Sweden
Novartis Investigative Site

Bellinzona, 6500, Switzerland
Novartis Investigative Site

Geneva, 1211, Switzerland
Novartis Investigative Site

Sankt Gallen, 9007, Switzerland
Novartis Investigative Site

Taipei, 10002, Taiwan
Novartis Investigative Site

Taipei, 11217, Taiwan
Novartis Investigative Site

Taoyuan, 33305, Taiwan
Novartis Investigative Site

Istanbul, Kadikoy, 34722, Turkey (Türkiye)
Novartis Investigative Site

Ankara, Sihhiye-Altindag, 06230, Turkey (Türkiye)
Novartis Investigative Site

Adana, Yuregir, 01250, Turkey (Türkiye)
Novartis Investigative Site

Izmir, 35100, Turkey (Türkiye)
Novartis Investigative Site

Sutton, Surrey, SM2 5PT, United Kingdom
Novartis Investigative Site

Cambridge, CB2 0QQ, United Kingdom
Novartis Investigative Site

Liverpool, CH63 4JY, United Kingdom
Novartis Investigative Site

London, EC1A 7BE, United Kingdom
Novartis Investigative Site

Oxford, OX3 7LE, United Kingdom
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
US Oncology Research Dallas

Dallas, Texas, 75204, United States
University of California LA

Los Angeles, California, 90095, United States

Conditions

Explore the condition pages connected to this study.

METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA