WEIGHT LOSS

This study looked at whether combining digital tools (like an app for tracking health and communicating with doctors) with regular in-person visits works as well as standard care for children and teens with obesity. About 100 families in Sweden took part. The goal was to see if t…

This study tested two popular diets—intermittent fasting (16:8 schedule) and the Mediterranean diet—in 120 adults with obesity. Both groups cut 500 calories daily for 4 weeks. Researchers measured weight and BMI changes to see which approach worked better.

This study looked at three different weight loss strategies for adults with chronic spinal cord injury who are overweight. The goal was to find which approach—prepackaged meals, better self-monitoring, or a combined program—works best. 110 participants tried each method for 13 we…

This study tested a 16-week online program called Sleep GOALS to help new mothers lose weight by improving their sleep, diet, and physical activity. Forty women who were 3 to 6 months postpartum and overweight joined the study. The program provided online modules and self-monitor…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve diabetes and kidney health in teens aged 12-21 with type 2 diabetes. Researchers measured how well the pancreas and kidneys worked before and after surgery. The goal was to see if surgery c…

This study tested a 24-week program that combines WeightWatchers behavioral support with medical weight management (including prescription drugs like Wegovy or Mounjaro). 180 adults with obesity or overweight plus related conditions took part. The goal was to see how much weight …

This study tested if a mobile app (Care4Today®) helps people with severe obesity lose weight before gastric bypass surgery. 142 adults used either the app or standard care. The goal was to see if the app leads to more weight loss and better patient knowledge and satisfaction befo…

This study tested a 12-month healthy weight program for 112 youth aged 8-18 with serious emotional disturbance who were overweight or obese. The program paired them with a health coach who provided lifestyle counseling and support for weight management, diet, and physical activit…

This study looked at whether giving people personalized lifestyle advice based on their genetic test results helps them lose more weight than standard advice. Overweight or obese Korean adults were split into two groups: one received tailored guidance, the other general tips. The…

This study tested an experimental daily pill, VK2735, to help adults with obesity or overweight (plus a weight-related health issue) lose weight. About 280 participants took either the pill or a placebo for 13 weeks. The main goal was to see how much weight they lost and if the p…

This study looked at three ways to help older adults (65+) with type 2 diabetes: a home exercise program, a plant-based Mediterranean diet, or a diabetes pill called empagliflozin. After 10 weeks, those on the diet or pill also started exercising. The goal was to see which approa…

This study looked at whether eating only during a set window each day (time-restricted eating) and doing short, intense workouts (high-intensity interval training) can help people with metabolic syndrome. 200 overweight or obese adults with metabolic syndrome took part for 16 wee…

This study looked at 100 people who were still obese 6 months after weight-loss surgery. Researchers wanted to see if starting the drug liraglutide early helps with more weight loss. The goal is to find the best time to add this medication for better results.

This study looked at whether losing weight before in vitro fertilization (IVF) helps overweight and obese women have a live birth. Researchers followed 197 women aged 20-36 who were having their first IVF treatment. Some women followed a diet and exercise program for 3 months bef…

This study tested whether a weight-loss drug (semaglutide) combined with a very low-calorie diet could help people with idiopathic intracranial hypertension (IIH), a condition where high brain pressure causes headaches and vision problems. 38 adults with new-onset IIH and obesity…

This study tested a virtual reality (VR) diet program for adults with fatty liver disease. 20 participants used the VR program along with video counseling to learn about healthy eating and weight loss. The goal was to see if this approach is practical and can help people lose wei…

This study tested whether lifestyle coaching delivered through a hospital's online patient portal helps adults maintain weight loss and prevent diabetes. 269 adults who had already lost at least 5% of their body weight took part. Some received coaching from regular clinic staff, …

This study tested whether an online family skills training program is practical and well-liked by Black adults trying to lose weight. 21 participants joined with a family member and attended online sessions. The goal was to see if this approach could support healthier eating and …

This study compares two surgeries for Superior Mesenteric Artery Syndrome (SMAS), a rare condition where the duodenum is squeezed between arteries, causing severe nausea, vomiting, and weight loss. 20 participants were randomly assigned to either a gastric bypass or a duodeno-jej…

This study tested a new weight loss program called Med-South, which adapts the Mediterranean diet for Southern tastes, against the popular WW (Weight Watchers) program. Over 360 adults with obesity took part for 2 years. The goal was to see which approach leads to more weight los…

This study looked at whether eating only during a 9-hour window each day, along with cutting calories, helps overweight older women lose weight and keep their bones healthy. Researchers compared this to just cutting calories alone. They also checked changes in gut bacteria. The s…

This study looked at whether losing weight and making major lifestyle changes can help people with type 2 diabetes who have nerve damage in their feet (diabetic peripheral neuropathy). Researchers measured nerve speed and strength in 50 adults before and after the program. The go…

This study tested whether a mindfulness-based training program could help adults who had lost weight avoid regaining it. Researchers enrolled 48 people who had lost weight through bariatric surgery, medical programs, or lifestyle changes. Participants practiced mindfulness techni…

This study tested whether fasting for a longer period each night could help overweight people with early signs of blood cancer (MGUS, smoldering multiple myeloma, or smoldering Waldenstrom macroglobulinemia) lose weight and possibly prevent the disease from progressing. Twenty-th…

This study tested whether using social networks could help Hispanic and Somali immigrants in Minnesota lose weight and lower their heart disease risk. About 475 people took part, and researchers measured weight, waist size, and heart health over 6 to 12 months. The goal was to se…

This study tested whether a fully-automated digital diabetes prevention program works as well as standard human coach-based programs. 368 adults with prediabetes and overweight took part. The goal was to see if the digital program could help people lose weight, increase physical …

This study tested a program that connects community resources with doctor's offices to help South Asian adults with pre-diabetes lose weight. The goal was to prevent diabetes by helping participants lose at least 5% of their body weight in 6 months. Nearly 1,000 people took part …

This study looked at whether following a very low calorie diet before bariatric (weight-loss) surgery can help patients lose more weight before the operation and feel happier with their care. A total of 85 adults who were eligible for bariatric surgery took part. Researchers meas…

This study looked at whether adding a low-carb, high-protein diet (like Atkins) to the weight-loss drug semaglutide helps people lose more weight. Sixty overweight or obese adults were split into two groups: one followed a low-carb diet, the other a low-fat diet, for 3 months. Re…

This study tested whether adding mindfulness and acceptance skills to standard weight loss counseling helps people lose more weight. 276 adults with overweight or obesity participated. Researchers compared different combinations of awareness, acceptance, and values-clarity exerci…

This study tested whether ondansetron, a common nausea medicine, helps children aged 2 to 20 tolerate the bowel preparation needed before a colonoscopy. Researchers measured how clean the bowel was and how much pain, bloating, nausea, and vomiting the children felt. The goal was …

This study tested whether using two different injectable treatments together—Sculptra and Restylane—can improve cheek volume, wrinkles, and skin quality in adults with moderate-to-severe aging signs. 41 participants who had used or were using weight-loss medications received the …

This study looked at how different fiber snack bars affect stomach and bowel symptoms in adults who are already taking weight loss medications like Mounjaro, Ozempic, or Saxenda. Fifty participants tried three types of fiber bars and a control bar for one week each, reporting sym…

This study looked at why many children and their families stop attending weight management programs, where dropout rates can be as high as 73%. Researchers collected information from over 1,200 children and parents to build a tool that predicts who might leave early. The goal is …

This study tested whether adding moderate aerobic exercise to Ramadan fasting helps overweight adults lose more body fat and improve heart health markers. 28 participants were split into two groups: one fasting only, the other fasting plus supervised exercise. Researchers measure…

This study looked at whether shared medical appointments (group visits) are helpful for people trying to manage their weight. 43 adults from Duke's weight management center were randomly assigned to either group visits with cooking classes or online learning modules. The main goa…

This study looked at how different amounts of protein in the diet affect bone health in overweight or obese postmenopausal women during weight loss. Researchers measured changes in bone density and quality, as well as diet quality. The goal was to understand the relationship, not…

This study looked at how short-term rapid weight loss and exercise change blood cells and immune markers in 9 elite male wrestlers. The wrestlers lost about 4.3% of their body weight over five days. Researchers took blood samples before and after exercise, both with and without w…

This study looked at how muscle energy use differs in women with ovarian or endometrial cancer who have lost weight, depending on their body mass index (BMI). Researchers took small muscle samples during surgery to measure how cells make energy. The goal was to understand the bod…

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. Researchers tracked 15 adults with overweight or obesity to understand what helps or hinders weight management. The goal was to gather infor…

This study looked at how losing weight affects bone health in overweight or obese men. Researchers measured changes in bone density and quality. The goal was to better understand the relationship between weight loss and bone strength.

This study looked at why people have trouble sticking to a diet and exercise plan during a weight loss program. Researchers used smartphone surveys and Fitbits to track 119 adults with overweight or obesity. The goal was to find out what causes these slip-ups in daily life, so fu…

This study aimed to understand why some people gain or lose weight more easily than others. Researchers measured how participants' bodies burned calories during periods of controlled overeating and fasting. The goal was to see if these measurements could predict an individual's w…