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Can losing weight change how your body burns fuel during exercise?

NCT ID NCT05370222

Knowledge-focused Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study looks at how weight loss changes the way the body uses energy during exercise. Healthy normal-weight adults will either lose weight through diet or have their weight loss simulated using a special treadmill. The goal is to see if real weight loss affects exercise metabolism differently than just carrying less weight. The findings could help tailor diet and exercise advice for people trying to manage their weight.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dietary weight loss intervention (caloric restriction and dietary rebalancing)
What this could lead to
If successful, this could clarify how weight loss alters exercise energy use, potentially informing better weight management and exercise recommendations for healthy individuals.
What could go wrong
This is an early-stage, small study (64 participants) focused on healthy normal-weight adults, so results may not apply to other populations. The dietary intervention's effectiveness and adherence could vary, and the simulated weight loss may not fully mimic real metabolic changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

May 2022

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Body mass index (BMI) between 18.5 and 24.9 kg/m², * Subjects abled to understand the information note and abled to sign the consent form, * Subjects with stable body weight (variation \< 3% of body weight) until at least 6 months, * Subjects subjected to a social security plan. Non-Criteria: * Have achieved a minimal BMI \< 18.5 or maximal BMI ≥ 25 kg/m² in adult life, * Subjects with high levels of physical activity (\> 5 h of exercise per week), * Presence of comorbidities or medical conditions that may interfere with study data, * Subjects undergoing energy restriction or physical activity weight loss program at the time of inclusion or within the past 6 months, * Taking medication that may interfere with study results, * Surgery within the last 3 months, * Person under guardianship, curatorship, or safeguard of justice; or not subject to a social security plan, * Pregnant or breastfeeding women, * Refusal to sign the consent form, * Person in a period of exclusion from another study, * Regular consumption of tobacco or alcohol, * Voluntary weight loss in the last 6 months, * Present or past eating disorders.

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Conditions

The condition(s) this trial relates to.

Body Weight Feeding Behavior Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Body weight Diet habit Healthy Healthy nutrition Weight loss

Contacts and locations

Locations

  • CHU Clermont-Ferrand

    Clermont-Ferrand, AURA, 63000, France

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