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Scientists probe muscle mysteries in cancer weight loss

NCT ID NCT03027479

Knowledge-focused Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at how muscle energy use differs in women with ovarian or endometrial cancer who are losing weight, depending on their body mass index (BMI). Researchers took blood samples, muscle biopsies, and fat tissue from 70 women during surgery. The goal was to understand the biological changes behind cancer-related weight loss, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors understand why some cancer patients lose muscle and weight, potentially pointing to future ways to prevent or treat this wasting.
What could go wrong
This is an observational study with only 70 participants, so results may not apply to all patients. It does not test any treatment, so no direct benefit is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Mar 2017

Finished

Jul 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Case group selection criteria: Inclusion Criteria: * Women aged 18 years old and more * Ovarian and/or endometrial cancer * weight loss related to cancer (weight loss \> 5% weight in one month or 10% in 6 months) * Indication to therapeutic surgery * Women affiliated to social security scheme * Women who can understand French and able to sign Informed consent Exclusion Criteria: * Unbalanced Diabetes * Chronic neuromuscular disorder * Any severe uncontrolled medical condition Control group selection criteria: Inclusion Criteria: * Women aged 18 years and more * Surgery Indication for a benign endometrial and/ or ovarian disease * Patient affiliated to social security scheme * Women who can understand French and able to sign Informed consent Exclusion Criteria: * Unbalanced Diabetes * Chronic neuromuscular disorder * Any severe uncontrolled medical condition

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Conditions

The condition(s) this trial relates to.

endometrial carcinoma endometrium neoplasm Obesity ovarian cancer ovarian carcinoma Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometrial carcinoma Ovarian carcinoma Weight loss

Contacts and locations

Locations

  • Gynecology Department, University Teaching Hospital, Tours

    Tours, 37044, France

More trials for these conditions

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