WEIGHT LOSS

This study looks at 234 adults who had sleeve gastrectomy but regained weight. It compares three different follow-up surgeries (SADI-S, RYGB, and OAGB) to see which one leads to the most weight loss, has the fewest complications, and improves nutrition and health problems. The go…

This study tests whether extra support from a dietitian helps active duty women lose weight after their first baby. About 74 women will either get virtual diet coaching or standard care for 12 months. The goal is to see if more women can meet military weight and fitness standards…

This study tests whether a 6-month lifestyle program or the drug metformin is better for helping mothers lose weight after having a baby with gestational diabetes. About 60 women who are 3 to 12 months postpartum will track their diet and activity, attend online group sessions, a…

This study tests whether adding essential amino acids to a low-calorie, low-protein diet helps people with severe obesity lose more weight and maintain muscle mass. Sixty adults aged 45-65 with a BMI over 35 will be randomly assigned to receive either the amino acid supplement or…

This study tests a procedure called transoral outlet reduction (TORe) combined with intensive lifestyle changes for people who have regained weight after gastric bypass surgery. About 108 participants will be randomly assigned to either receive the TORe procedure plus lifestyle c…

This study looks at whether limiting when you eat each day (time-restricted eating) can help adults who have recently lost weight keep it off and avoid regaining fat. About 110 adults aged 25-65 who lost at least 5% of their body weight in the last 3 months will be randomly assig…

This study tests whether a postbiotic supplement (an inactivated microorganism in a gummy) can help overweight or obese adults lose body fat and improve metabolism. About 114 participants will receive either the supplement or a placebo for 12 weeks, along with nutritional advice.…

This study looks at whether changing gut bacteria with antibiotics can help people keep weight off after losing at least 10% of their body weight. About 200 adults with obesity (BMI 28-35) will take either antibiotics or a placebo after weight loss. Researchers will track weight,…

This study tests whether adding sleep health coaching to a diet and exercise program can improve heart health, especially blood pressure. About 150 adults with elevated blood pressure from underserved NYC neighborhoods will take part. The program includes sleep education, a Fitbi…

This study tests a drug called efsubaglutide alfa to help people who remain obese six months after weight-loss surgery. About 60 adults aged 18-55 with a BMI of 28 or higher will receive either the drug or a placebo. The main goal is to see how much weight they lose and if the dr…

This early study tests whether semaglutide, a medication used for diabetes and weight loss, can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take semaglutide for three months and be followed for three more months to see if…

This study looks at whether doing aerobic exercise before eating (fasted) is better for heart health and weight loss than exercising after a meal. Over 16 weeks, 40 adults with overweight or obesity will be assigned to either fasted or fed exercise. Researchers will measure chang…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study tests a 26-week program designed to help people who have intentionally lost weight keep it off. Participants receive educational texts, complete weekly surveys, and weigh themselves at home. Some may also get health coaching. The goal is to see if this personalized app…

This study aims to find the best weight-loss medication for people with bipolar disorder by matching drugs to specific obesity types (like 'hungry brain' or 'hungry gut'). About 100 adults aged 18-65 with bipolar or schizoaffective disorder and obesity will receive one of three F…

This study looks at whether a probiotic called Lactobacillus paracasei LC-19 can help overweight or obese adults lose weight and improve their metabolism. Over 12 weeks, participants will follow a reduced-calorie diet and exercise plan, and also take either the probiotic, a weigh…

This study looks at how well a weight-loss procedure called endoscopic sleeve gastroplasty (ESG) works over the long term. Researchers are following 100 adults who had ESG at least 5 years ago to see if they kept the weight off. The goal is to understand if this minimally invasiv…

This study tests whether a behavioral program combined with a smartphone app can help young adults (ages 18-40) who are overweight or obese lose weight. Researchers will track weight changes over 6 months. The goal is to find a more effective way to help people manage their weigh…

This study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30 or higher) lose weight and improve their fertility. About 98 men aged 22-40, whose partners are also in the study, will follow the program while undergoing assisted…

This study looks at whether a program where parents and children work together can help them lose weight and be healthier. About 90 families will join a weight management program that focuses on healthy eating, physical activity, and positive communication. The goal is to see if …

This study looks at whether adding protein supplements to a weight-loss plan (diet and the drug semaglutide) helps overweight or obese adults lose more weight, keep muscle, and avoid gaining weight back. About 140 people will take part, with some getting just diet, some diet plus…

This study aims to find the best combination of strategies to help people maintain weight loss after losing weight. Over 500 adults with obesity will first lose weight through a 16-week program, then try different support methods—like limiting food variety, home strength training…

This study is testing a family-centered program to help Hispanic families lose weight and prevent obesity. Parents and their children ages 8-12 will work together to build healthy habits. The goal is to find the best way to support families using text messages and other tools.

This study tests whether a mild electrical current applied to the scalp (TDCS) can reduce food intake and help with weight loss. About 148 obese adults will receive either real or fake TDCS sessions over 4 weeks, combined with a reduced-calorie diet. The goal is to see if stimula…

This study is testing a smartphone app designed to help teenagers with obesity lose weight. The app is based on the idea that replacing unhealthy coping behaviors with healthy ones can stop overeating. Researchers will enroll 38 teens aged 14-21 to see if the app is easy to use a…

This study tests whether megestrol acetate, a drug that boosts appetite, can help prevent weight loss in people with locally advanced colorectal cancer who are receiving chemotherapy before surgery. About 60 adults will take either megestrol or a placebo during their chemo. The g…

This study looks at how GLP-1 weight-loss medications affect people's attitudes toward food and what they choose to eat. Researchers will use a virtual reality buffet to measure changes in food selection before starting the medication and after three months. The goal is to unders…

This study looks at whether intravenous (IV) fluids given to mothers before delivery are linked to weight loss in newborns during their first two days of life. Researchers will review medical records of 200 mothers and their full-term, formula-fed babies. The goal is to understan…

This study looks at whether eating peanuts every day can improve bone health, metabolic health, and weight loss in overweight adults aged 50-75. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free snack for 24 weeks while following a weight los…

This study looks at how tirzepatide, a weight-loss drug, affects muscle mass and strength in adults aged 50 and older with obesity. Researchers want to know if losing weight with this drug also leads to muscle loss, which could cause weakness or frailty. About 20 participants wil…

This study looks at how quickly losing water weight (dehydration) affects combat athletes' sleep, thinking skills, and leg muscle strength. Twelve athletes with experience in rapid weight loss will be monitored using sleep trackers, strength tests, and thinking quizzes. The goal …

This study looks at how GLP-1 weight loss drugs (like semaglutide) change taste, eating habits, and behavior in adults with obesity. Researchers will review medical records and surveys from 150 people aged 18-60 in Italy. The goal is to understand why these drugs help people eat …

This study explores whether tiny particles released from fat cells can serve as early warning signs for blood vessel damage in people with obesity. Researchers will compare these particles in normal-weight and obese adults, then see if weight loss reduces the particles and improv…

This study is a registry that gathers information from medical records and patient visits about endoscopic bariatric therapies (EBTs), which are non-surgical procedures to help with weight loss. It includes adults who have had or plan to have an EBT within six months. The goal is…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…